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Protein

Homeobox protein abdominal-A

Gene

abd-A

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for segmental identity of the second through eighth abdominal segments. Once a pattern of abd-A expression is turned on in a given parasegment, it remains on the more posterior parasegment, so that the complex pattern of expression is built up in the successive parasegments. Appears to repress expression of Ubx whenever they appear in the same cell, but abd-A is repressed by Abd-B only in the eight and ninth abdominal segments.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi398 – 457HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • activating transcription factor binding Source: CAFA
  • sequence-specific DNA binding Source: FlyBase
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: FlyBase
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

  • anterior/posterior pattern specification Source: UniProtKB
  • apoptotic process Source: FlyBase
  • cardiac muscle tissue development Source: FlyBase
  • cardioblast differentiation Source: FlyBase
  • determination of genital disc primordium Source: FlyBase
  • dorsal vessel heart proper cell fate commitment Source: FlyBase
  • genital disc anterior/posterior pattern formation Source: FlyBase
  • genitalia development Source: FlyBase
  • germ cell migration Source: FlyBase
  • gonadal mesoderm development Source: FlyBase
  • gonad development Source: FlyBase
  • heart development Source: FlyBase
  • mesodermal cell fate specification Source: FlyBase
  • midgut development Source: FlyBase
  • muscle cell fate specification Source: FlyBase
  • nervous system development Source: FlyBase
  • neuroblast development Source: FlyBase
  • neuroblast fate determination Source: FlyBase
  • oenocyte development Source: FlyBase
  • peripheral nervous system development Source: FlyBase
  • pole cell migration Source: FlyBase
  • positive regulation of muscle organ development Source: FlyBase
  • positive regulation of transcription, DNA-templated Source: CAFA
  • positive regulation of transcription from RNA polymerase II promoter Source: FlyBase
  • regulation of transcription, DNA-templated Source: UniProtKB

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Enzyme and pathway databases

SignaLinkiP29555.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein abdominal-A
Gene namesi
Name:abd-A
ORF Names:CG10325
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0000014. abd-A.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002491 – 590Homeobox protein abdominal-AAdd BLAST590

Proteomic databases

PaxDbiP29555.
PRIDEiP29555.

Expressioni

Gene expression databases

BgeeiFBgn0000014.
ExpressionAtlasiP29555. differential.
GenevisibleiP29555. DM.

Interactioni

GO - Molecular functioni

  • activating transcription factor binding Source: CAFA

Protein-protein interaction databases

BioGridi67081. 51 interactors.
DIPiDIP-17987N.
IntActiP29555. 1 interactor.
STRINGi7227.FBpp0082829.

Structurei

3D structure databases

ProteinModelPortaliP29555.
SMRiP29555.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi368 – 373Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi35 – 50Poly-AlaAdd BLAST16
Compositional biasi51 – 119Ser-richAdd BLAST69
Compositional biasi136 – 139Poly-Gln (OPA repeat)4
Compositional biasi144 – 147Poly-Gln (OPA repeat)4
Compositional biasi160 – 165Poly-Gln (OPA repeat)6
Compositional biasi172 – 177Poly-Ala6
Compositional biasi240 – 250Poly-AlaAdd BLAST11
Compositional biasi425 – 428Poly-Arg4
Compositional biasi491 – 518Poly-Gln (OPA repeat)Add BLAST28

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00900000140772.
InParanoidiP29555.
KOiK09311.
OMAiTDWMGSP.
OrthoDBiEOG091G09XD.
PhylomeDBiP29555.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
Gene3Di1.10.565.10. 1 hit.
2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR022132. Abdominal-A.
IPR009057. Homeobox-like_sf.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR035500. NHR_like_dom_sf.
IPR015943. WD40/YVTN_repeat-like_dom_sf.
PfamiView protein in Pfam
PF12407. Abdominal-A. 1 hit.
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Abd-A2 (identifier: P29555-1) [UniParc]FASTAAdd to basket
Also known as: ABD-AII, B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKFVFDSML PKYPQFQPFI SSHHLTTTPP NSSSAAVAAA LAAAAASASA
60 70 80 90 100
SVSASSSSNN NSSNTIAGSN TSNTNNSSSS PSSSSNNNSN LNLSGGSLSP
110 120 130 140 150
SHLSQHLGQS PHSPVSSSSP FQQHHPQVQQ QHLNHQQQQH LHHQQQQHHH
160 170 180 190 200
QYSSLSAALQ LQQQQHHISK LAAAAVASHG HAHQQLLLTP PSAGNSQAGD
210 220 230 240 250
SSCSPSPSAS GSSSLHRSLN DNSPGSASAS ASASAASSVA AAAAAAAAAA
260 270 280 290 300
SSSFAIPTSK MYPYVSNHPS SHGGLSGMAG FTGLEDKSCS RYTDTVMNSY
310 320 330 340 350
QSMSVPASAS AQFAQFYQHA TAAASAVSAA SAGAIGVDSL GNACTQPASG
360 370 380 390 400
VMPGAGGAGG AGIADLPRYP WMTLTDWMGS PFERVVCGDF NGPNGCPRRR
410 420 430 440 450
GRQTYTRFQT LELEKEFHFN HYLTRRRRIE IAHALCLTER QIKIWFQNRR
460 470 480 490 500
MKLKKELRAV KEINEQARRD REEQEKMKAQ ETMKSAQQNK QVQQQQQQQQ
510 520 530 540 550
QQQQQQQQQH QQQQQQPQDH HSIIAHNPGH LHHSVVGQND LKLGLGMGVG
560 570 580 590
VGVGGIGPGI GGGLGGNLGM MSALDKSNHD LLKAVSKVNS
Length:590
Mass (Da):62,410
Last modified:October 1, 1996 - v2
Checksum:iFF080CC2D71ECA82
GO
Isoform Abd-A1 (identifier: P29555-2) [UniParc]FASTAAdd to basket
Also known as: ABD-AI, A

The sequence of this isoform differs from the canonical sequence as follows:
     1-260: Missing.

Show »
Length:330
Mass (Da):36,180
Checksum:i30C665D1F817AA10
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0023941 – 260Missing in isoform Abd-A1. 2 PublicationsAdd BLAST260

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54453 mRNA. Translation: CAA38321.1.
U31961 Genomic DNA. Translation: AAA84405.1.
U31961 Genomic DNA. Translation: AAA84406.1.
AE014297 Genomic DNA. Translation: AAF55359.1.
AE014297 Genomic DNA. Translation: AAF55360.2.
BT016031 mRNA. Translation: AAV36916.1.
PIRiA35915.
RefSeqiNP_001163632.1. NM_001170161.2. [P29555-2]
NP_001247145.1. NM_001260216.2. [P29555-2]
NP_476693.1. NM_057345.5. [P29555-2]
NP_732176.1. NM_169733.5. [P29555-1]
UniGeneiDm.3286.

Genome annotation databases

EnsemblMetazoaiFBtr0083387; FBpp0082828; FBgn0000014. [P29555-2]
FBtr0083388; FBpp0082829; FBgn0000014. [P29555-1]
FBtr0300485; FBpp0289712; FBgn0000014. [P29555-2]
FBtr0306337; FBpp0297433; FBgn0000014. [P29555-2]
GeneIDi42037.
KEGGidme:Dmel_CG10325.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiABDA_DROME
AccessioniPrimary (citable) accession number: P29555
Secondary accession number(s): Q5U161, Q9VER1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: October 1, 1996
Last modified: November 22, 2017
This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families