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Protein

Leiomodin-1

Gene

LMOD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates nucleation of actin filaments.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163431-MONOMER.
ReactomeiR-HSA-445355. Smooth Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Leiomodin-1
Alternative name(s):
64 kDa autoantigen 1D
64 kDa autoantigen 1D3
64 kDa autoantigen D11 Publication
Leiomodin, muscle form
Smooth muscle leiomodin
Short name:
SM-Lmod
Thyroid-associated ophthalmopathy autoantigen
Gene namesi
Name:LMOD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:6647. LMOD1.

Subcellular locationi

  • Cytoplasmmyofibrilsarcomere 1 Publication
  • Cytoplasmcytoskeleton By similarity

  • Note: Colocalizes with actin filaments in sarcomeres.By similarity

GO - Cellular componenti

  • actin filament Source: UniProtKB
  • cytoplasm Source: HPA
  • cytosol Source: Reactome
  • membrane Source: ProtInc
  • myofibril Source: UniProtKB
  • sarcomere Source: UniProtKB
  • striated muscle thin filament Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi25802.
OpenTargetsiENSG00000163431.
PharmGKBiPA30413.

Polymorphism and mutation databases

BioMutaiLMOD1.
DMDMi325511399.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000844531 – 600Leiomodin-1Add BLAST600

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineBy similarity1
Modified residuei85PhosphoserineBy similarity1
Modified residuei135PhosphoserineBy similarity1
Modified residuei555PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP29536.
PaxDbiP29536.
PeptideAtlasiP29536.
PRIDEiP29536.

PTM databases

iPTMnetiP29536.
PhosphoSitePlusiP29536.

Expressioni

Tissue specificityi

Detected in lung vascular smooth muscle (at protein level) (PubMed:27144530). Detected in thyroid and extraocular smooth muscle, but not skeletal muscle (PubMed:2026759). Detected in heart, aorta, skeletal muscle, colon, urinary bladder, uterus, stomach, and small intestine (PubMed:11318603).2 Publications

Gene expression databases

BgeeiENSG00000163431.
CleanExiHS_LMOD1.
ExpressionAtlasiP29536. baseline and differential.
GenevisibleiP29536. HS.

Organism-specific databases

HPAiHPA028325.
HPA028435.
HPA030097.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP29536. 1 interactor.
STRINGi9606.ENSP00000356257.

Structurei

Secondary structure

1600
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi319 – 326Combined sources8
Beta strandi334 – 336Combined sources3
Helixi345 – 355Combined sources11
Beta strandi363 – 365Combined sources3
Helixi373 – 385Combined sources13
Beta strandi391 – 393Combined sources3
Helixi401 – 410Combined sources10
Helixi411 – 413Combined sources3
Beta strandi419 – 421Combined sources3
Helixi431 – 441Combined sources11
Beta strandi449 – 451Combined sources3
Helixi457 – 484Combined sources28

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Z79X-ray1.54A299-486[»]
4Z8GX-ray2.10A364-486[»]
4Z94X-ray2.40G364-486[»]
ProteinModelPortaliP29536.
SMRiP29536.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati165 – 1801Add BLAST16
Repeati181 – 1962Add BLAST16
Repeati197 – 2123Add BLAST16
Repeati213 – 2284Add BLAST16
Repeati229 – 2445Add BLAST16
Repeati245 – 2606Add BLAST16
Repeati261 – 2767Add BLAST16
Repeati277 – 2938Add BLAST17
Domaini574 – 593WH2PROSITE-ProRule annotationAdd BLAST20

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni165 – 2938 X approximate tandem repeatsAdd BLAST129
Regioni508 – 5275 X 4 AA approximate tandem repeatsAdd BLAST20

Sequence similaritiesi

Belongs to the tropomodulin family.Curated
Contains 1 WH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3735. Eukaryota.
ENOG410YAHM. LUCA.
GeneTreeiENSGT00760000119226.
HOGENOMiHOG000261624.
HOVERGENiHBG006280.
InParanoidiP29536.
OMAiRNQTDKQ.
OrthoDBiEOG091G0C3H.
PhylomeDBiP29536.
TreeFamiTF315841.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR030136. LMOD1.
IPR004934. TMOD.
IPR003124. WH2_dom.
[Graphical view]
PANTHERiPTHR10901. PTHR10901. 2 hits.
PTHR10901:SF5. PTHR10901:SF5. 2 hits.
PfamiPF03250. Tropomodulin. 1 hit.
PF02205. WH2. 1 hit.
[Graphical view]
SMARTiSM00246. WH2. 1 hit.
[Graphical view]
PROSITEiPS51082. WH2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P29536-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRVAKYRRQ VSEDPDIDSL LETLSPEEME ELEKELDVVD PDGSVPVGLR
60 70 80 90 100
QRNQTEKQST GVYNREAMLN FCEKETKKLM QREMSMDESK QVETKTDAKN
110 120 130 140 150
GEERGRDASK KALGPRRDSD LGKEPKRGGL KKSFSRDRDE AGGKSGEKPK
160 170 180 190 200
EEKIIRGIDK GRVRAAVDKK EAGKDGRGEE RAVATKKEEE KKGSDRNTGL
210 220 230 240 250
SRDKDKKREE MKEVAKKEDD EKVKGERRNT DTRKEGEKMK RAGGNTDMKK
260 270 280 290 300
EDEKVKRGTG NTDTKKDDEK VKKNEPLHEK EAKDDSKTKT PEKQTPSGPT
310 320 330 340 350
KPSEGPAKVE EEAAPSIFDE PLERVKNNDP EMTEVNVNNS DCITNEILVR
360 370 380 390 400
FTEALEFNTV VKLFALANTR ADDHVAFAIA IMLKANKTIT SLNLDSNHIT
410 420 430 440 450
GKGILAIFRA LLQNNTLTEL RFHNQRHICG GKTEMEIAKL LKENTTLLKL
460 470 480 490 500
GYHFELAGPR MTVTNLLSRN MDKQRQKRLQ EQRQAQEAKG EKKDLLEVPK
510 520 530 540 550
AGAVAKGSPK PSPQPSPKPS PKNSPKKGGA PAAPPPPPPP LAPPLIMENL
560 570 580 590 600
KNSLSPATQR KMGDKVLPAQ EKNSRDQLLA AIRSSNLKQL KKVEVPKLLQ
Length:600
Mass (Da):67,030
Last modified:March 8, 2011 - v3
Checksum:i79103ED8AB8231D4
GO
Isoform 2 (identifier: P29536-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.

Show »
Length:572
Mass (Da):63,783
Checksum:iECF0D0E2C239DDA8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102E → Q in CAA38101 (PubMed:2026759).Curated1
Sequence conflicti118D → N in CAA38101 (PubMed:2026759).Curated1
Sequence conflicti194S → G in CAA38101 (PubMed:2026759).Curated1
Sequence conflicti446T → S in CAA38101 (PubMed:2026759).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021839295T → M.Corresponds to variant rs2820312dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0357451 – 28Missing in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54162 mRNA. Translation: CAA38101.1.
AL513217, AC099676 Genomic DNA. Translation: CAH72278.2.
BC080187 mRNA. Translation: AAH80187.1.
CCDSiCCDS53457.1. [P29536-1]
PIRiS18732.
RefSeqiNP_036266.2. NM_012134.2. [P29536-1]
UniGeneiHs.519075.

Genome annotation databases

EnsembliENST00000367288; ENSP00000356257; ENSG00000163431. [P29536-1]
GeneIDi25802.
KEGGihsa:25802.
UCSCiuc057oju.1. human. [P29536-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54162 mRNA. Translation: CAA38101.1.
AL513217, AC099676 Genomic DNA. Translation: CAH72278.2.
BC080187 mRNA. Translation: AAH80187.1.
CCDSiCCDS53457.1. [P29536-1]
PIRiS18732.
RefSeqiNP_036266.2. NM_012134.2. [P29536-1]
UniGeneiHs.519075.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Z79X-ray1.54A299-486[»]
4Z8GX-ray2.10A364-486[»]
4Z94X-ray2.40G364-486[»]
ProteinModelPortaliP29536.
SMRiP29536.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP29536. 1 interactor.
STRINGi9606.ENSP00000356257.

PTM databases

iPTMnetiP29536.
PhosphoSitePlusiP29536.

Polymorphism and mutation databases

BioMutaiLMOD1.
DMDMi325511399.

Proteomic databases

MaxQBiP29536.
PaxDbiP29536.
PeptideAtlasiP29536.
PRIDEiP29536.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367288; ENSP00000356257; ENSG00000163431. [P29536-1]
GeneIDi25802.
KEGGihsa:25802.
UCSCiuc057oju.1. human. [P29536-1]

Organism-specific databases

CTDi25802.
DisGeNETi25802.
GeneCardsiLMOD1.
HGNCiHGNC:6647. LMOD1.
HPAiHPA028325.
HPA028435.
HPA030097.
MIMi602715. gene.
neXtProtiNX_P29536.
OpenTargetsiENSG00000163431.
PharmGKBiPA30413.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3735. Eukaryota.
ENOG410YAHM. LUCA.
GeneTreeiENSGT00760000119226.
HOGENOMiHOG000261624.
HOVERGENiHBG006280.
InParanoidiP29536.
OMAiRNQTDKQ.
OrthoDBiEOG091G0C3H.
PhylomeDBiP29536.
TreeFamiTF315841.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163431-MONOMER.
ReactomeiR-HSA-445355. Smooth Muscle Contraction.

Miscellaneous databases

ChiTaRSiLMOD1. human.
GenomeRNAii25802.
PROiP29536.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163431.
CleanExiHS_LMOD1.
ExpressionAtlasiP29536. baseline and differential.
GenevisibleiP29536. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR030136. LMOD1.
IPR004934. TMOD.
IPR003124. WH2_dom.
[Graphical view]
PANTHERiPTHR10901. PTHR10901. 2 hits.
PTHR10901:SF5. PTHR10901:SF5. 2 hits.
PfamiPF03250. Tropomodulin. 1 hit.
PF02205. WH2. 1 hit.
[Graphical view]
SMARTiSM00246. WH2. 1 hit.
[Graphical view]
PROSITEiPS51082. WH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLMOD1_HUMAN
AccessioniPrimary (citable) accession number: P29536
Secondary accession number(s): B1APV6, C4AMB1, Q68EN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: March 8, 2011
Last modified: November 2, 2016
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.