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Protein

Vascular cell adhesion protein 1

Gene

Vcam1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.

GO - Molecular functioni

  • integrin binding Source: RGD
  • primary amine oxidase activity Source: Ensembl

GO - Biological processi

  • acute inflammatory response Source: RGD
  • aging Source: RGD
  • amine metabolic process Source: Ensembl
  • calcium-mediated signaling using intracellular calcium source Source: Ensembl
  • cell adhesion Source: RGD
  • cell chemotaxis Source: RGD
  • cell-matrix adhesion Source: Ensembl
  • cellular response to tumor necrosis factor Source: RGD
  • cellular response to vascular endothelial growth factor stimulus Source: RGD
  • chronic inflammatory response Source: RGD
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: Ensembl
  • leukocyte tethering or rolling Source: Ensembl
  • membrane to membrane docking Source: Ensembl
  • positive regulation of T cell proliferation Source: Ensembl
  • response to ethanol Source: RGD
  • response to hypoxia Source: RGD
  • response to ionizing radiation Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to nicotine Source: RGD
  • response to nutrient Source: RGD
  • response to zinc ion Source: RGD
  • viral process Source: UniProtKB-KW

Keywordsi

Biological processCell adhesion, Host-virus interaction

Enzyme and pathway databases

ReactomeiR-RNO-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-RNO-216083 Integrin cell surface interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular cell adhesion protein 1
Short name:
V-CAM 1
Short name:
VCAM-1
Alternative name(s):
CD_antigen: CD106
Gene namesi
Name:Vcam1
Synonyms:Vcam-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi3952 Vcam1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 698ExtracellularSequence analysisAdd BLAST674
Transmembranei699 – 720HelicalSequence analysisAdd BLAST22
Topological domaini721 – 739CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24CuratedAdd BLAST24
ChainiPRO_000001499925 – 739Vascular cell adhesion protein 1Add BLAST715

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 95PROSITE-ProRule annotation
Disulfide bondi52 ↔ 99PROSITE-ProRule annotation
Disulfide bondi137 ↔ 195PROSITE-ProRule annotation
Disulfide bondi246 ↔ 291PROSITE-ProRule annotation
Glycosylationi273N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi335 ↔ 383PROSITE-ProRule annotation
Glycosylationi424N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi531N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi534 ↔ 579PROSITE-ProRule annotation
Glycosylationi561N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi650N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP29534
PRIDEiP29534

PTM databases

CarbonylDBiP29534
PhosphoSitePlusiP29534

Expressioni

Tissue specificityi

Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.

Gene expression databases

BgeeiENSRNOG00000014333
ExpressionAtlasiP29534 baseline and differential
GenevisibleiP29534 RN

Interactioni

Subunit structurei

Binds to ECMV-D capsid proteins and acts as a receptor for this virus.By similarity

GO - Molecular functioni

  • integrin binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019377

Structurei

3D structure databases

ProteinModelPortaliP29534
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 111Ig-like C2-type 1Add BLAST87
Domaini119 – 212Ig-like C2-type 2Add BLAST94
Domaini223 – 309Ig-like C2-type 3Add BLAST87
Domaini312 – 397Ig-like C2-type 4Add BLAST86
Domaini408 – 506Ig-like C2-type 5Add BLAST99
Domaini514 – 595Ig-like C2-type 6Add BLAST82
Domaini601 – 682Ig-like C2-type 7Add BLAST82

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIKS Eukaryota
ENOG4111F4V LUCA
GeneTreeiENSGT00830000128299
HOGENOMiHOG000004820
HOVERGENiHBG053965
InParanoidiP29534
KOiK06527
OMAiGVYECES
OrthoDBiEOG091G0590
PhylomeDBiP29534
TreeFamiTF333571

Family and domain databases

Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR003987 ICAM_VCAM_N
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR008424 Ig_C2-set
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
IPR003989 VCAM-1
PANTHERiPTHR44644 PTHR44644, 1 hit
PfamiView protein in Pfam
PF05790 C2-set, 2 hits
PF07679 I-set, 2 hits
PF00047 ig, 1 hit
PRINTSiPR01472 ICAMVCAM1
PR01474 VCAM1
SMARTiView protein in SMART
SM00409 IG, 5 hits
SM00408 IGc2, 5 hits
SUPFAMiSSF48726 SSF48726, 7 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 5 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29534-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVKMVAIFG ASTVLWILFA VSQAFKIEIS PEYKTLAQIG DSMLLTCSTT
60 70 80 90 100
GCESPSFSWR TQIDSPLNGK VKTEGAKSVL TMDPVSFENE HSYLCTATCN
110 120 130 140 150
SGKLERGIQV DIYSFPKDPE IQFSGPLEVG KPVMVKCLAP DVYPIDRLEI
160 170 180 190 200
ELFKGDRLMK KQDFVDEMAK KSLETKSLEV IFTPVIEDIE KALVCRAKLY
210 220 230 240 250
IDQTDSIPKE RETVRELQVY TSPKNTEISV HPSTRLHEGA AVTMTCASEG
260 270 280 290 300
LPAPEIFWSK KLDNGVLQLL SGNATLTLIA MRMEDSGIYV CEGVNLVGRD
310 320 330 340 350
KTEVELIVQE KPFTVDISPG SQVAAQVGDS VVLTCAAVGC DSPSFSWRTQ
360 370 380 390 400
TDSPLNGEVR DEGATSTLTL SPVGVEDEHS YLCTVTCQRR KLEKTIQVEV
410 420 430 440 450
YSFPEDPEIE ISGPLVHGRP VTVNCTVPNV YPFDHLEIEL LKGETTLLNK
460 470 480 490 500
FLREEIGTKS LETKSLEMTF IPTAEDTGKA LVCLAKLHSS QMESEPKQRQ
510 520 530 540 550
STQTLYVNVA PKEPTIWVSP SPVPEEGSPV NLTCSSDGFP TPKILWSRQL
560 570 580 590 600
KNGELQPLSQ NTTLSFMATK MEDSGIYVCE GINEAGISKK SVELIIQGSS
610 620 630 640 650
KDIQLTVFPS KSVKEGDTVI ISCTCGSVPE IWIILKKKAK TGDMVLKSVN
660 670 680 690 700
GSYTIRKAQL QDAGVYECES KTEVGSQLRS LTLDVKGKEN NKDYFSPELL
710 720 730
ALYFASSLVI PAIGMIIYFA RKANMKGSYS LVEAQKSKV
Length:739
Mass (Da):81,246
Last modified:April 1, 1993 - v1
Checksum:i5C608E5A1A1B100C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3V → G in CAA45254 (PubMed:1377031).Curated1
Sequence conflicti122 – 123QF → HL in CAA45254 (PubMed:1377031).Curated2
Sequence conflicti166D → N in CAA45254 (PubMed:1377031).Curated1
Sequence conflicti739V → G in CAA45254 (PubMed:1377031).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84488 mRNA Translation: AAA42332.1
X63722 mRNA Translation: CAA45254.1
BC089812 mRNA Translation: AAH89812.1
PIRiJS0675
RefSeqiNP_037021.1, NM_012889.1
UniGeneiRn.11267

Genome annotation databases

EnsembliENSRNOT00000019377; ENSRNOP00000019377; ENSRNOG00000014333
ENSRNOT00000078806; ENSRNOP00000071423; ENSRNOG00000014333
GeneIDi25361
KEGGirno:25361
UCSCiRGD:3952 rat

Similar proteinsi

Entry informationi

Entry nameiVCAM1_RAT
AccessioniPrimary (citable) accession number: P29534
Secondary accession number(s): Q5FVS3, Q63669
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 23, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health