Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P29524

- PAI2_RAT

UniProt

P29524 - PAI2_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Plasminogen activator inhibitor 2 type A

Gene

Serpinb2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Inhibits urokinase-type plasminogen activator.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei381 – 3822Reactive bondBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: RefGenome

GO - Biological processi

  1. negative regulation of apoptotic process Source: InterPro
  2. negative regulation of endopeptidase activity Source: RefGenome
  3. regulation of proteolysis Source: RefGenome
  4. wound healing Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Plasminogen activation

Protein family/group databases

MEROPSiI04.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasminogen activator inhibitor 2 type A
Short name:
PAI-2
Short name:
PAI2A
Alternative name(s):
Serpin B2
Gene namesi
Name:Serpinb2
Synonyms:Pai2, Planh2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi621823. Serpinb2.

Subcellular locationi

Cytoplasm By similarity. Secretedextracellular space By similarity

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Plasminogen activator inhibitor 2 type APRO_0000223298Add
BLAST
Signal peptidei1 – ?Not cleavedBy similarity

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi228 – 2281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi262 – 2621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi402 – 4021N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

The signal sequence is not cleaved.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP29524.
PRIDEiP29524.

Expressioni

Gene expression databases

GenevestigatoriP29524.

Interactioni

Subunit structurei

Interacts with PSMB1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003409.

Structurei

3D structure databases

ProteinModelPortaliP29524.
SMRiP29524. Positions 3-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiP29524.
KOiK13963.
OMAiKWLSEDT.
OrthoDBiEOG7327PB.
PhylomeDBiP29524.
TreeFamiTF352619.

Family and domain databases

InterProiIPR015556. PAI-2.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF61. PTHR11461:SF61. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 2 hits.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29524-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEELSMANTM FALNLLKQIE QSNSTQNIFI SPWSISSTLA IVFLGAQANT
60 70 80 90 100
EEQMAKVLNF DKIGSYDLTP GNPENFHGCD FAQHIQRDNY PVAILQAQAR
110 120 130 140 150
DKIHSAFSSL SSTINTPRLG DYLLESANKL FGEKSARFKE EYIQRCKKYY
160 170 180 190 200
STEPEAVDFL ECANEARKKI NSWVKTQTKG EIPNLLPEGS VDEDTKMVLV
210 220 230 240 250
NTIYFKGRWK TPFQKRLNGL YPFRVNLNES KPVQMMYLRE KLNIGYIKDL
260 270 280 290 300
KTQILELPYI GNISMFLLLP DEIEDSSTGL EMLEREINFD NFNKWISKET
310 320 330 340 350
LDEDDVLVYI PKFKLAQNYE LKPILQRMGM EDAFNKGKAD FSGMSESNDL
360 370 380 390 400
FLSEVFHQAT VDVNEEGTVA AGGTGAVMTG RTGHGGPQFV ADHPFLFFIM
410
NNITRTILFV GRFSSP
Length:416
Mass (Da):47,248
Last modified:April 1, 1993 - v1
Checksum:i2877EDFB6AF8B81F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64563 mRNA. Translation: CAA45864.1.
PIRiS19896.
RefSeqiNP_067728.1. NM_021696.2.
XP_006249701.1. XM_006249639.2.
UniGeneiRn.42912.

Genome annotation databases

EnsembliENSRNOT00000003409; ENSRNOP00000003409; ENSRNOG00000002460.
GeneIDi60325.
KEGGirno:60325.
UCSCiRGD:621823. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64563 mRNA. Translation: CAA45864.1 .
PIRi S19896.
RefSeqi NP_067728.1. NM_021696.2.
XP_006249701.1. XM_006249639.2.
UniGenei Rn.42912.

3D structure databases

ProteinModelPortali P29524.
SMRi P29524. Positions 3-416.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000003409.

Protein family/group databases

MEROPSi I04.007.

Proteomic databases

PaxDbi P29524.
PRIDEi P29524.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000003409 ; ENSRNOP00000003409 ; ENSRNOG00000002460 .
GeneIDi 60325.
KEGGi rno:60325.
UCSCi RGD:621823. rat.

Organism-specific databases

CTDi 5055.
RGDi 621823. Serpinb2.

Phylogenomic databases

eggNOGi COG4826.
GeneTreei ENSGT00760000118789.
HOGENOMi HOG000238519.
HOVERGENi HBG005957.
InParanoidi P29524.
KOi K13963.
OMAi KWLSEDT.
OrthoDBi EOG7327PB.
PhylomeDBi P29524.
TreeFami TF352619.

Miscellaneous databases

NextBioi 611945.
PROi P29524.

Gene expression databases

Genevestigatori P29524.

Family and domain databases

InterProi IPR015556. PAI-2.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
PTHR11461:SF61. PTHR11461:SF61. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 2 hits.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Grundmann U., Rein T.
    Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPAI2_RAT
AccessioniPrimary (citable) accession number: P29524
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3