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P29524

- PAI2_RAT

UniProt

P29524 - PAI2_RAT

Protein

Plasminogen activator inhibitor 2 type A

Gene

Serpinb2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Inhibits urokinase-type plasminogen activator.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei381 – 3822Reactive bondBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: RefGenome

    GO - Biological processi

    1. negative regulation of apoptotic process Source: InterPro
    2. negative regulation of endopeptidase activity Source: RefGenome
    3. regulation of proteolysis Source: RefGenome
    4. wound healing Source: RGD

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Keywords - Biological processi

    Plasminogen activation

    Protein family/group databases

    MEROPSiI04.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Plasminogen activator inhibitor 2 type A
    Short name:
    PAI-2
    Short name:
    PAI2A
    Alternative name(s):
    Serpin B2
    Gene namesi
    Name:Serpinb2
    Synonyms:Pai2, Planh2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 13

    Organism-specific databases

    RGDi621823. Serpinb2.

    Subcellular locationi

    Cytoplasm By similarity. Secretedextracellular space By similarity

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 416416Plasminogen activator inhibitor 2 type APRO_0000223298Add
    BLAST
    Signal peptidei1 – ?Not cleavedBy similarity

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi228 – 2281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi262 – 2621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi402 – 4021N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    The signal sequence is not cleaved.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP29524.
    PRIDEiP29524.

    Expressioni

    Gene expression databases

    GenevestigatoriP29524.

    Interactioni

    Subunit structurei

    Interacts with PSMB1.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000003409.

    Structurei

    3D structure databases

    ProteinModelPortaliP29524.
    SMRiP29524. Positions 3-416.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family. Ov-serpin subfamily.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    GeneTreeiENSGT00740000115232.
    HOGENOMiHOG000238519.
    HOVERGENiHBG005957.
    InParanoidiP29524.
    KOiK13963.
    OMAiKWLSEDT.
    OrthoDBiEOG7327PB.
    PhylomeDBiP29524.
    TreeFamiTF352619.

    Family and domain databases

    InterProiIPR015556. PAI-2.
    IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PTHR11461:SF61. PTHR11461:SF61. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 2 hits.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P29524-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEELSMANTM FALNLLKQIE QSNSTQNIFI SPWSISSTLA IVFLGAQANT    50
    EEQMAKVLNF DKIGSYDLTP GNPENFHGCD FAQHIQRDNY PVAILQAQAR 100
    DKIHSAFSSL SSTINTPRLG DYLLESANKL FGEKSARFKE EYIQRCKKYY 150
    STEPEAVDFL ECANEARKKI NSWVKTQTKG EIPNLLPEGS VDEDTKMVLV 200
    NTIYFKGRWK TPFQKRLNGL YPFRVNLNES KPVQMMYLRE KLNIGYIKDL 250
    KTQILELPYI GNISMFLLLP DEIEDSSTGL EMLEREINFD NFNKWISKET 300
    LDEDDVLVYI PKFKLAQNYE LKPILQRMGM EDAFNKGKAD FSGMSESNDL 350
    FLSEVFHQAT VDVNEEGTVA AGGTGAVMTG RTGHGGPQFV ADHPFLFFIM 400
    NNITRTILFV GRFSSP 416
    Length:416
    Mass (Da):47,248
    Last modified:April 1, 1993 - v1
    Checksum:i2877EDFB6AF8B81F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X64563 mRNA. Translation: CAA45864.1.
    PIRiS19896.
    RefSeqiNP_067728.1. NM_021696.2.
    XP_006249701.1. XM_006249639.1.
    UniGeneiRn.42912.

    Genome annotation databases

    EnsembliENSRNOT00000003409; ENSRNOP00000003409; ENSRNOG00000002460.
    GeneIDi60325.
    KEGGirno:60325.
    UCSCiRGD:621823. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X64563 mRNA. Translation: CAA45864.1 .
    PIRi S19896.
    RefSeqi NP_067728.1. NM_021696.2.
    XP_006249701.1. XM_006249639.1.
    UniGenei Rn.42912.

    3D structure databases

    ProteinModelPortali P29524.
    SMRi P29524. Positions 3-416.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000003409.

    Protein family/group databases

    MEROPSi I04.007.

    Proteomic databases

    PaxDbi P29524.
    PRIDEi P29524.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000003409 ; ENSRNOP00000003409 ; ENSRNOG00000002460 .
    GeneIDi 60325.
    KEGGi rno:60325.
    UCSCi RGD:621823. rat.

    Organism-specific databases

    CTDi 5055.
    RGDi 621823. Serpinb2.

    Phylogenomic databases

    eggNOGi COG4826.
    GeneTreei ENSGT00740000115232.
    HOGENOMi HOG000238519.
    HOVERGENi HBG005957.
    InParanoidi P29524.
    KOi K13963.
    OMAi KWLSEDT.
    OrthoDBi EOG7327PB.
    PhylomeDBi P29524.
    TreeFami TF352619.

    Miscellaneous databases

    NextBioi 611945.
    PROi P29524.

    Gene expression databases

    Genevestigatori P29524.

    Family and domain databases

    InterProi IPR015556. PAI-2.
    IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    PTHR11461:SF61. PTHR11461:SF61. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 2 hits.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Grundmann U., Rein T.
      Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiPAI2_RAT
    AccessioniPrimary (citable) accession number: P29524
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3