P29524 (PAI2_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Plasminogen activator inhibitor 2 type A
Short name=PAI-2
Short name=PAI2A

Alternative name(s):
Serpin B2

Gene names

Name:	Serpinb2
Synonyms:	Pai2, Planh2

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Inhibits urokinase-type plasminogen activator.
Subunit structure	Interacts with PSMB1 By similarity.
Subcellular location	Cytoplasm By similarity. Secreted › extracellular space By similarity.
Post-translational modification	The signal sequence is not cleaved By similarity.
Sequence similarities	Belongs to the serpin family. Ov-serpin subfamily.

Ontologies

Keywords
Biological process	Plasminogen activation
Cellular component	Cytoplasm Secreted
Domain	Signal
Molecular function	Protease inhibitor Serine protease inhibitor
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of proteolysis Inferred from Biological aspect of Ancestor. Source: RefGenome wound healing Inferred from direct assay PubMed 11495131. Source: RGD
Cellular_component	cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	serine-type endopeptidase inhibitor activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 416	416	Plasminogen activator inhibitor 2 type A		PRO_0000223298
	Signal peptide	1 – ?		Not cleaved By similarity
Sites
	Site	381 – 382	2	Reactive bond By similarity
Amino acid modifications
	Glycosylation	23	1	N-linked (GlcNAc...) Potential
	Glycosylation	228	1	N-linked (GlcNAc...) Potential
	Glycosylation	262	1	N-linked (GlcNAc...) Potential
	Glycosylation	402	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P29524 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: 2877EDFB6AF8B81F	FASTA	416	47,248
	10 20 30 40 50 60 MEELSMANTM FALNLLKQIE QSNSTQNIFI SPWSISSTLA IVFLGAQANT EEQMAKVLNF 70 80 90 100 110 120 DKIGSYDLTP GNPENFHGCD FAQHIQRDNY PVAILQAQAR DKIHSAFSSL SSTINTPRLG 130 140 150 160 170 180 DYLLESANKL FGEKSARFKE EYIQRCKKYY STEPEAVDFL ECANEARKKI NSWVKTQTKG 190 200 210 220 230 240 EIPNLLPEGS VDEDTKMVLV NTIYFKGRWK TPFQKRLNGL YPFRVNLNES KPVQMMYLRE 250 260 270 280 290 300 KLNIGYIKDL KTQILELPYI GNISMFLLLP DEIEDSSTGL EMLEREINFD NFNKWISKET 310 320 330 340 350 360 LDEDDVLVYI PKFKLAQNYE LKPILQRMGM EDAFNKGKAD FSGMSESNDL FLSEVFHQAT 370 380 390 400 410 VDVNEEGTVA AGGTGAVMTG RTGHGGPQFV ADHPFLFFIM NNITRTILFV GRFSSP

References

[1]	Grundmann U., Rein T. Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X64563 mRNA. Translation: CAA45864.1.
IPI	IPI00205594.
PIR	S19896.
RefSeq	NP_067728.1. NM_021696.2.
UniGene	Rn.42912.
3D structure databases
ProteinModelPortal	P29524.
SMR	P29524. Positions 3-416.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000003409.
Protein family/group databases
MEROPS	I04.007.
Proteomic databases
PaxDb	P29524.
PRIDE	P29524.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000003409; ENSRNOP00000003409; ENSRNOG00000002460.
GeneID	60325.
KEGG	rno:60325.
UCSC	RGD:621823. rat.
Organism-specific databases
CTD	5055.
RGD	621823. Serpinb2.
Phylogenomic databases
eggNOG	COG4826.
GeneTree	ENSGT00700000104334.
HOGENOM	HOG000238519.
HOVERGEN	HBG005957.
InParanoid	P29524.
KO	K13963.
OMA	LFLIMHK.
OrthoDB	EOG4PC9S5.
Gene expression databases
Genevestigator	P29524.
GermOnline	ENSRNOG00000002460. Rattus norvegicus.
Family and domain databases
InterPro	IPR023795. Protease_inhib_I4_serpin_CS. IPR015556. Protease_inhib_serine_PAI-2. IPR023796. Serpin_dom. IPR000215. Serpin_fam. [Graphical view]
PANTHER	PTHR11461. PTHR11461. 1 hit. PTHR11461:SF61. PTHR11461:SF61. 1 hit.
Pfam	PF00079. Serpin. 1 hit. [Graphical view]
SMART	SM00093. SERPIN. 1 hit. [Graphical view]
SUPFAM	SSF56574. Prot_inh_serpin. 1 hit.
PROSITE	PS00284. SERPIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	611945.

Entry information

Entry name

PAI2_RAT

Accession

Primary (citable) accession number: P29524

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	April 3, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program