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Protein

Plasminogen activator inhibitor 2 type A

Gene

Serpinb2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits urokinase-type plasminogen activator.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei381 – 3822Reactive bondBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: GO_Central

GO - Biological processi

  1. negative regulation of apoptotic process Source: InterPro
  2. negative regulation of endopeptidase activity Source: GO_Central
  3. wound healing Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Plasminogen activation

Enzyme and pathway databases

ReactomeiREACT_324090. Dissolution of Fibrin Clot.

Protein family/group databases

MEROPSiI04.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Plasminogen activator inhibitor 2 type A
Short name:
PAI-2
Short name:
PAI2A
Alternative name(s):
Serpin B2
Gene namesi
Name:Serpinb2
Synonyms:Pai2, Planh2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi621823. Serpinb2.

Subcellular locationi

  1. Cytoplasm By similarity
  2. Secretedextracellular space By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Plasminogen activator inhibitor 2 type APRO_0000223298Add
BLAST
Signal peptidei1 – ?Not cleavedBy similarity

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi228 – 2281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi262 – 2621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi402 – 4021N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

The signal sequence is not cleaved.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP29524.
PRIDEiP29524.

Expressioni

Gene expression databases

GenevestigatoriP29524.

Interactioni

Subunit structurei

Interacts with PSMB1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003409.

Structurei

3D structure databases

ProteinModelPortaliP29524.
SMRiP29524. Positions 3-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiP29524.
KOiK13963.
OMAiQIRDTIH.
OrthoDBiEOG7327PB.
PhylomeDBiP29524.
TreeFamiTF352619.

Family and domain databases

InterProiIPR015556. PAI-2.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF61. PTHR11461:SF61. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 2 hits.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29524-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEELSMANTM FALNLLKQIE QSNSTQNIFI SPWSISSTLA IVFLGAQANT
60 70 80 90 100
EEQMAKVLNF DKIGSYDLTP GNPENFHGCD FAQHIQRDNY PVAILQAQAR
110 120 130 140 150
DKIHSAFSSL SSTINTPRLG DYLLESANKL FGEKSARFKE EYIQRCKKYY
160 170 180 190 200
STEPEAVDFL ECANEARKKI NSWVKTQTKG EIPNLLPEGS VDEDTKMVLV
210 220 230 240 250
NTIYFKGRWK TPFQKRLNGL YPFRVNLNES KPVQMMYLRE KLNIGYIKDL
260 270 280 290 300
KTQILELPYI GNISMFLLLP DEIEDSSTGL EMLEREINFD NFNKWISKET
310 320 330 340 350
LDEDDVLVYI PKFKLAQNYE LKPILQRMGM EDAFNKGKAD FSGMSESNDL
360 370 380 390 400
FLSEVFHQAT VDVNEEGTVA AGGTGAVMTG RTGHGGPQFV ADHPFLFFIM
410
NNITRTILFV GRFSSP
Length:416
Mass (Da):47,248
Last modified:April 1, 1993 - v1
Checksum:i2877EDFB6AF8B81F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64563 mRNA. Translation: CAA45864.1.
PIRiS19896.
RefSeqiNP_067728.1. NM_021696.2.
XP_006249701.1. XM_006249639.2.
XP_008767717.1. XM_008769495.1.
UniGeneiRn.42912.

Genome annotation databases

EnsembliENSRNOT00000003409; ENSRNOP00000003409; ENSRNOG00000002460.
GeneIDi60325.
KEGGirno:60325.
UCSCiRGD:621823. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64563 mRNA. Translation: CAA45864.1.
PIRiS19896.
RefSeqiNP_067728.1. NM_021696.2.
XP_006249701.1. XM_006249639.2.
XP_008767717.1. XM_008769495.1.
UniGeneiRn.42912.

3D structure databases

ProteinModelPortaliP29524.
SMRiP29524. Positions 3-416.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003409.

Protein family/group databases

MEROPSiI04.007.

Proteomic databases

PaxDbiP29524.
PRIDEiP29524.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003409; ENSRNOP00000003409; ENSRNOG00000002460.
GeneIDi60325.
KEGGirno:60325.
UCSCiRGD:621823. rat.

Organism-specific databases

CTDi5055.
RGDi621823. Serpinb2.

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiP29524.
KOiK13963.
OMAiQIRDTIH.
OrthoDBiEOG7327PB.
PhylomeDBiP29524.
TreeFamiTF352619.

Enzyme and pathway databases

ReactomeiREACT_324090. Dissolution of Fibrin Clot.

Miscellaneous databases

NextBioi611945.
PROiP29524.

Gene expression databases

GenevestigatoriP29524.

Family and domain databases

InterProiIPR015556. PAI-2.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF61. PTHR11461:SF61. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 2 hits.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Grundmann U., Rein T.
    Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPAI2_RAT
AccessioniPrimary (citable) accession number: P29524
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 1, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.