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P29524 (PAI2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Plasminogen activator inhibitor 2 type A

Short name=PAI-2
Short name=PAI2A
Alternative name(s):
Serpin B2
Gene names
Name:Serpinb2
Synonyms:Pai2, Planh2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits urokinase-type plasminogen activator.

Subunit structure

Interacts with PSMB1 By similarity.

Subcellular location

Cytoplasm By similarity. Secretedextracellular space By similarity.

Post-translational modification

The signal sequence is not cleaved By similarity.

Sequence similarities

Belongs to the serpin family. Ov-serpin subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 416416Plasminogen activator inhibitor 2 type A
PRO_0000223298
Signal peptide1 – ?Not cleaved By similarity

Sites

Site381 – 3822Reactive bond By similarity

Amino acid modifications

Glycosylation231N-linked (GlcNAc...) Potential
Glycosylation2281N-linked (GlcNAc...) Potential
Glycosylation2621N-linked (GlcNAc...) Potential
Glycosylation4021N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P29524 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 2877EDFB6AF8B81F

FASTA41647,248
        10         20         30         40         50         60 
MEELSMANTM FALNLLKQIE QSNSTQNIFI SPWSISSTLA IVFLGAQANT EEQMAKVLNF 

        70         80         90        100        110        120 
DKIGSYDLTP GNPENFHGCD FAQHIQRDNY PVAILQAQAR DKIHSAFSSL SSTINTPRLG 

       130        140        150        160        170        180 
DYLLESANKL FGEKSARFKE EYIQRCKKYY STEPEAVDFL ECANEARKKI NSWVKTQTKG 

       190        200        210        220        230        240 
EIPNLLPEGS VDEDTKMVLV NTIYFKGRWK TPFQKRLNGL YPFRVNLNES KPVQMMYLRE 

       250        260        270        280        290        300 
KLNIGYIKDL KTQILELPYI GNISMFLLLP DEIEDSSTGL EMLEREINFD NFNKWISKET 

       310        320        330        340        350        360 
LDEDDVLVYI PKFKLAQNYE LKPILQRMGM EDAFNKGKAD FSGMSESNDL FLSEVFHQAT 

       370        380        390        400        410 
VDVNEEGTVA AGGTGAVMTG RTGHGGPQFV ADHPFLFFIM NNITRTILFV GRFSSP 

« Hide

References

[1]Grundmann U., Rein T.
Submitted (FEB-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X64563 mRNA. Translation: CAA45864.1.
PIRS19896.
RefSeqNP_067728.1. NM_021696.2.
XP_006249701.1. XM_006249639.1.
UniGeneRn.42912.

3D structure databases

ProteinModelPortalP29524.
SMRP29524. Positions 3-416.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000003409.

Protein family/group databases

MEROPSI04.007.

Proteomic databases

PaxDbP29524.
PRIDEP29524.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000003409; ENSRNOP00000003409; ENSRNOG00000002460.
GeneID60325.
KEGGrno:60325.
UCSCRGD:621823. rat.

Organism-specific databases

CTD5055.
RGD621823. Serpinb2.

Phylogenomic databases

eggNOGCOG4826.
GeneTreeENSGT00740000115232.
HOGENOMHOG000238519.
HOVERGENHBG005957.
InParanoidP29524.
KOK13963.
OMAKWLSEDT.
OrthoDBEOG7327PB.
PhylomeDBP29524.
TreeFamTF352619.

Gene expression databases

GenevestigatorP29524.

Family and domain databases

InterProIPR015556. PAI-2.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF61. PTHR11461:SF61. 1 hit.
PfamPF00079. Serpin. 1 hit.
[Graphical view]
SMARTSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMSSF56574. SSF56574. 2 hits.
PROSITEPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio611945.
PROP29524.

Entry information

Entry namePAI2_RAT
AccessionPrimary (citable) accession number: P29524
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 14, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families