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P29515

- TBB7_ARATH

UniProt

P29515 - TBB7_ARATH

Protein

Tubulin beta-7 chain

Gene

TUBB7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi140 – 1467GTPSequence Analysis

    GO - Molecular functioni

    1. GTPase activity Source: InterPro
    2. GTP binding Source: UniProtKB-KW
    3. structural constituent of cytoskeleton Source: TAIR

    GO - Biological processi

    1. microtubule-based process Source: TAIR
    2. protein polymerization Source: InterPro
    3. response to cadmium ion Source: TAIR
    4. response to salt stress Source: TAIR

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_216620. Post-chaperonin tubulin folding pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tubulin beta-7 chain
    Alternative name(s):
    Beta-7-tubulin
    Gene namesi
    Name:TUBB7
    Synonyms:TUB7
    Ordered Locus Names:At2g29550
    ORF Names:F16P2.7
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G29550.

    Subcellular locationi

    GO - Cellular componenti

    1. cell wall Source: TAIR
    2. cytosol Source: TAIR
    3. Golgi apparatus Source: TAIR
    4. microtubule Source: UniProtKB-KW
    5. plasma membrane Source: TAIR
    6. plasmodesma Source: TAIR
    7. tubulin complex Source: TAIR
    8. vacuole Source: TAIR

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 449449Tubulin beta-7 chainPRO_0000048326Add
    BLAST

    Proteomic databases

    PRIDEiP29515.

    Expressioni

    Gene expression databases

    GenevestigatoriP29515.

    Interactioni

    Subunit structurei

    Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

    Protein-protein interaction databases

    BioGridi2854. 2 interactions.
    IntActiP29515. 1 interaction.
    STRINGi3702.AT2G29550.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliP29515.
    SMRiP29515. Positions 2-427.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tubulin family.Curated

    Phylogenomic databases

    HOGENOMiHOG000165710.
    InParanoidiP29515.
    KOiK07375.
    OMAiWEVVNLE.
    PhylomeDBiP29515.

    Family and domain databases

    Gene3Di1.10.287.600. 1 hit.
    3.30.1330.20. 1 hit.
    3.40.50.1440. 1 hit.
    InterProiIPR013838. Beta-tubulin_BS.
    IPR002453. Beta_tubulin.
    IPR008280. Tub_FtsZ_C.
    IPR000217. Tubulin.
    IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
    IPR023123. Tubulin_C.
    IPR017975. Tubulin_CS.
    IPR003008. Tubulin_FtsZ_GTPase.
    [Graphical view]
    PANTHERiPTHR11588. PTHR11588. 1 hit.
    PfamiPF00091. Tubulin. 1 hit.
    PF03953. Tubulin_C. 1 hit.
    [Graphical view]
    PRINTSiPR01163. BETATUBULIN.
    PR01161. TUBULIN.
    SMARTiSM00864. Tubulin. 1 hit.
    SM00865. Tubulin_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF52490. SSF52490. 1 hit.
    SSF55307. SSF55307. 1 hit.
    PROSITEiPS00227. TUBULIN. 1 hit.
    PS00228. TUBULIN_B_AUTOREG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P29515-1 [UniParc]FASTAAdd to Basket

    « Hide

    MREILHIQGG QCGNQIGSKF WEVVNLEHGI DQTGRYVGDS ELQLERVNVY    50
    YNEASCGRYV PRAVLMDLEP GTMDSVRSGP YGQIFRPDNF VFGQSGAGNN 100
    WAKGHYTEGA ELIDSVLDVV RKEAENCDCL QGFQVCHSLG GGTGSGMGTL 150
    LISKIREEYP DRMMMTFSVF PSPKVSDTVV EPYNATLSVH QLVENADECM 200
    VLDNEALYDI CFRTLKLSTP SFGDLNHLIS ATMSGVTCCL RFPGQLNSDL 250
    RKLAVNLIPF PRLHFFMVGF APLTSRGSQQ YRNLTVPELT QQMWDAKNMM 300
    CAADPRHGRY LTASAMFRGK MSTKEVDEQM LNVQNKNSSY FVEWIPNNVK 350
    STVCDIPPTG LKMASTFIGN STSIQEMFRR VSEQFTAMFR RKAFLHWYTG 400
    EGMDEMEFTE AESNMNDLVS EYQQYQDATA DEEGEYEEEE AEYEQEETY 449
    Length:449
    Mass (Da):50,747
    Last modified:April 1, 1993 - v1
    Checksum:iCB61368BF21A77B0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M84704 Genomic DNA. Translation: AAA32885.1.
    AC004561 Genomic DNA. Translation: AAC95184.1.
    CP002685 Genomic DNA. Translation: AEC08272.1.
    AF370568 mRNA. Translation: AAK49574.1.
    AY090345 mRNA. Translation: AAL91251.1.
    BT001121 mRNA. Translation: AAN64512.1.
    AY085710 mRNA. Translation: AAM62928.1.
    PIRiJQ1591.
    RefSeqiNP_180515.1. NM_128508.2.
    UniGeneiAt.24046.
    At.329.

    Genome annotation databases

    EnsemblPlantsiAT2G29550.1; AT2G29550.1; AT2G29550.
    GeneIDi817504.
    KEGGiath:AT2G29550.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M84704 Genomic DNA. Translation: AAA32885.1 .
    AC004561 Genomic DNA. Translation: AAC95184.1 .
    CP002685 Genomic DNA. Translation: AEC08272.1 .
    AF370568 mRNA. Translation: AAK49574.1 .
    AY090345 mRNA. Translation: AAL91251.1 .
    BT001121 mRNA. Translation: AAN64512.1 .
    AY085710 mRNA. Translation: AAM62928.1 .
    PIRi JQ1591.
    RefSeqi NP_180515.1. NM_128508.2.
    UniGenei At.24046.
    At.329.

    3D structure databases

    ProteinModelPortali P29515.
    SMRi P29515. Positions 2-427.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 2854. 2 interactions.
    IntActi P29515. 1 interaction.
    STRINGi 3702.AT2G29550.1-P.

    Proteomic databases

    PRIDEi P29515.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G29550.1 ; AT2G29550.1 ; AT2G29550 .
    GeneIDi 817504.
    KEGGi ath:AT2G29550.

    Organism-specific databases

    TAIRi AT2G29550.

    Phylogenomic databases

    HOGENOMi HOG000165710.
    InParanoidi P29515.
    KOi K07375.
    OMAi WEVVNLE.
    PhylomeDBi P29515.

    Enzyme and pathway databases

    Reactomei REACT_216620. Post-chaperonin tubulin folding pathway.

    Gene expression databases

    Genevestigatori P29515.

    Family and domain databases

    Gene3Di 1.10.287.600. 1 hit.
    3.30.1330.20. 1 hit.
    3.40.50.1440. 1 hit.
    InterProi IPR013838. Beta-tubulin_BS.
    IPR002453. Beta_tubulin.
    IPR008280. Tub_FtsZ_C.
    IPR000217. Tubulin.
    IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
    IPR023123. Tubulin_C.
    IPR017975. Tubulin_CS.
    IPR003008. Tubulin_FtsZ_GTPase.
    [Graphical view ]
    PANTHERi PTHR11588. PTHR11588. 1 hit.
    Pfami PF00091. Tubulin. 1 hit.
    PF03953. Tubulin_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01163. BETATUBULIN.
    PR01161. TUBULIN.
    SMARTi SM00864. Tubulin. 1 hit.
    SM00865. Tubulin_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52490. SSF52490. 1 hit.
    SSF55307. SSF55307. 1 hit.
    PROSITEi PS00227. TUBULIN. 1 hit.
    PS00228. TUBULIN_B_AUTOREG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The small genome of Arabidopsis contains at least nine expressed beta-tubulin genes."
      Snustad D.P., Haas N.A., Kopczak S.D., Silflow C.D.
      Plant Cell 4:549-556(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: cv. Columbia.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiTBB7_ARATH
    AccessioniPrimary (citable) accession number: P29515
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are nine genes coding for beta-tubulin.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3