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P29515

- TBB7_ARATH

UniProt

P29515 - TBB7_ARATH

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Protein

Tubulin beta-7 chain

Gene

TUBB7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi140 – 1467GTPSequence Analysis

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-KW
  3. structural constituent of cytoskeleton Source: TAIR

GO - Biological processi

  1. microtubule-based process Source: TAIR
  2. protein polymerization Source: InterPro
  3. response to cadmium ion Source: TAIR
  4. response to salt stress Source: TAIR
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_216620. Post-chaperonin tubulin folding pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin beta-7 chain
Alternative name(s):
Beta-7-tubulin
Gene namesi
Name:TUBB7
Synonyms:TUB7
Ordered Locus Names:At2g29550
ORF Names:F16P2.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G29550.

Subcellular locationi

GO - Cellular componenti

  1. cell wall Source: TAIR
  2. cytosol Source: TAIR
  3. Golgi apparatus Source: TAIR
  4. microtubule Source: UniProtKB-KW
  5. plasma membrane Source: TAIR
  6. plasmodesma Source: TAIR
  7. tubulin complex Source: TAIR
  8. vacuole Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Tubulin beta-7 chainPRO_0000048326Add
BLAST

Proteomic databases

PRIDEiP29515.

Expressioni

Gene expression databases

GenevestigatoriP29515.

Interactioni

Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

Protein-protein interaction databases

BioGridi2854. 2 interactions.
IntActiP29515. 1 interaction.
STRINGi3702.AT2G29550.1-P.

Structurei

3D structure databases

ProteinModelPortaliP29515.
SMRiP29515. Positions 2-427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

HOGENOMiHOG000165710.
InParanoidiP29515.
KOiK07375.
OMAiWEVVNLE.
PhylomeDBiP29515.

Family and domain databases

Gene3Di1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR013838. Beta-tubulin_BS.
IPR002453. Beta_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSiPR01163. BETATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
PS00228. TUBULIN_B_AUTOREG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29515-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MREILHIQGG QCGNQIGSKF WEVVNLEHGI DQTGRYVGDS ELQLERVNVY
60 70 80 90 100
YNEASCGRYV PRAVLMDLEP GTMDSVRSGP YGQIFRPDNF VFGQSGAGNN
110 120 130 140 150
WAKGHYTEGA ELIDSVLDVV RKEAENCDCL QGFQVCHSLG GGTGSGMGTL
160 170 180 190 200
LISKIREEYP DRMMMTFSVF PSPKVSDTVV EPYNATLSVH QLVENADECM
210 220 230 240 250
VLDNEALYDI CFRTLKLSTP SFGDLNHLIS ATMSGVTCCL RFPGQLNSDL
260 270 280 290 300
RKLAVNLIPF PRLHFFMVGF APLTSRGSQQ YRNLTVPELT QQMWDAKNMM
310 320 330 340 350
CAADPRHGRY LTASAMFRGK MSTKEVDEQM LNVQNKNSSY FVEWIPNNVK
360 370 380 390 400
STVCDIPPTG LKMASTFIGN STSIQEMFRR VSEQFTAMFR RKAFLHWYTG
410 420 430 440
EGMDEMEFTE AESNMNDLVS EYQQYQDATA DEEGEYEEEE AEYEQEETY
Length:449
Mass (Da):50,747
Last modified:April 1, 1993 - v1
Checksum:iCB61368BF21A77B0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M84704 Genomic DNA. Translation: AAA32885.1.
AC004561 Genomic DNA. Translation: AAC95184.1.
CP002685 Genomic DNA. Translation: AEC08272.1.
AF370568 mRNA. Translation: AAK49574.1.
AY090345 mRNA. Translation: AAL91251.1.
BT001121 mRNA. Translation: AAN64512.1.
AY085710 mRNA. Translation: AAM62928.1.
PIRiJQ1591.
RefSeqiNP_180515.1. NM_128508.2.
UniGeneiAt.24046.
At.329.

Genome annotation databases

EnsemblPlantsiAT2G29550.1; AT2G29550.1; AT2G29550.
GeneIDi817504.
KEGGiath:AT2G29550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M84704 Genomic DNA. Translation: AAA32885.1 .
AC004561 Genomic DNA. Translation: AAC95184.1 .
CP002685 Genomic DNA. Translation: AEC08272.1 .
AF370568 mRNA. Translation: AAK49574.1 .
AY090345 mRNA. Translation: AAL91251.1 .
BT001121 mRNA. Translation: AAN64512.1 .
AY085710 mRNA. Translation: AAM62928.1 .
PIRi JQ1591.
RefSeqi NP_180515.1. NM_128508.2.
UniGenei At.24046.
At.329.

3D structure databases

ProteinModelPortali P29515.
SMRi P29515. Positions 2-427.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 2854. 2 interactions.
IntActi P29515. 1 interaction.
STRINGi 3702.AT2G29550.1-P.

Proteomic databases

PRIDEi P29515.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G29550.1 ; AT2G29550.1 ; AT2G29550 .
GeneIDi 817504.
KEGGi ath:AT2G29550.

Organism-specific databases

TAIRi AT2G29550.

Phylogenomic databases

HOGENOMi HOG000165710.
InParanoidi P29515.
KOi K07375.
OMAi WEVVNLE.
PhylomeDBi P29515.

Enzyme and pathway databases

Reactomei REACT_216620. Post-chaperonin tubulin folding pathway.

Gene expression databases

Genevestigatori P29515.

Family and domain databases

Gene3Di 1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProi IPR013838. Beta-tubulin_BS.
IPR002453. Beta_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view ]
PANTHERi PTHR11588. PTHR11588. 1 hit.
Pfami PF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view ]
PRINTSi PR01163. BETATUBULIN.
PR01161. TUBULIN.
SMARTi SM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view ]
SUPFAMi SSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEi PS00227. TUBULIN. 1 hit.
PS00228. TUBULIN_B_AUTOREG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The small genome of Arabidopsis contains at least nine expressed beta-tubulin genes."
    Snustad D.P., Haas N.A., Kopczak S.D., Silflow C.D.
    Plant Cell 4:549-556(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. Columbia.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiTBB7_ARATH
AccessioniPrimary (citable) accession number: P29515
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 1, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

There are nine genes coding for beta-tubulin.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3