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Protein

Tubulin beta-6 chain

Gene

TUBB6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Miscellaneous

There are nine genes coding for beta-tubulin.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi140 – 146GTPSequence analysis7

GO - Molecular functioni

  • GTPase activity Source: InterPro
  • GTP binding Source: UniProtKB-KW
  • structural constituent of cytoskeleton Source: TAIR

GO - Biological processi

  • microtubule-based process Source: TAIR
  • response to cold Source: TAIR
  • response to salt stress Source: TAIR

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-5617833 Cilium Assembly
R-ATH-6798695 Neutrophil degranulation
R-ATH-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-ATH-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin beta-6 chain
Alternative name(s):
Beta-6-tubulin
Gene namesi
Name:TUBB6
Synonyms:TUB6
Ordered Locus Names:At5g12250
ORF Names:MXC9.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G12250
TAIRilocus:2177003 AT5G12250

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2424501

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000483251 – 449Tubulin beta-6 chainAdd BLAST449

Proteomic databases

PaxDbiP29514
PRIDEiP29514

Expressioni

Gene expression databases

ExpressionAtlasiP29514 baseline and differential
GenevisibleiP29514 AT

Interactioni

Subunit structurei

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

Protein-protein interaction databases

BioGridi16378, 3 interactors
STRINGi3702.AT5G12250.1

Structurei

3D structure databases

ProteinModelPortaliP29514
SMRiP29514
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

eggNOGiKOG1375 Eukaryota
COG5023 LUCA
HOGENOMiHOG000165710
InParanoidiP29514
KOiK07375
OMAiAVFRGPM
OrthoDBiEOG093609OI
PhylomeDBiP29514

Family and domain databases

Gene3Di1.10.287.600, 1 hit
3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR013838 Beta-tubulin_BS
IPR002453 Beta_tubulin
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PF03953 Tubulin_C, 1 hit
PRINTSiPR01163 BETATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit
PS00228 TUBULIN_B_AUTOREG, 1 hit

Sequencei

Sequence statusi: Complete.

P29514-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREILHIQGG QCGNQIGSKF WEVVCDEHGI DPTGRYVGNS DLQLERVNVY
60 70 80 90 100
YNEASCGRYV PRAILMDLEP GTMDSVRTGP YGQIFRPDNF VFGQSGAGNN
110 120 130 140 150
WAKGHYTEGA ELIDAVLDVV RKEAENCDCL QGFQVCHSLG GGTGSGMGTL
160 170 180 190 200
LISKIREEYP DRMMLTFSVF PSPKVSDTVV EPYNATLSVH QLVENADECM
210 220 230 240 250
VLDNEALYDI CFRTLKLTTP SFGDLNHLIS ATMSGVTCCL RFPGQLNSDL
260 270 280 290 300
RKLAVNLIPF PRLHFFMVGF APLTSRGSQQ YRALTVPELT QQMWDSKNMM
310 320 330 340 350
CAADPRHGRY LTASAMFRGK MSTKEVDEQM INVQNKNSSY FVEWIPNNVK
360 370 380 390 400
SSVCDIAPRG LSMASTFIGN STSIQEMFRR VSEQFTAMFR RKAFLHWYTG
410 420 430 440
EGMDEMEFTE AESNMNDLVS EYQQYQDATA DDEGEYEEDE DEEEILDHE
Length:449
Mass (Da):50,586
Last modified:April 1, 1993 - v1
Checksum:i946DB710BC8FF540
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84703 Genomic DNA Translation: AAA32884.1
AB007727 Genomic DNA Translation: BAB10043.1
CP002688 Genomic DNA Translation: AED91783.1
AF360260 mRNA Translation: AAK25970.1
AY040074 mRNA Translation: AAK64132.1
PIRiJQ1590
RefSeqiNP_196786.1, NM_121263.4
UniGeneiAt.23425
At.72672
At.74848

Genome annotation databases

EnsemblPlantsiAT5G12250.1; AT5G12250.1; AT5G12250
GeneIDi831100
GrameneiAT5G12250.1; AT5G12250.1; AT5G12250
KEGGiath:AT5G12250

Similar proteinsi

Entry informationi

Entry nameiTBB6_ARATH
AccessioniPrimary (citable) accession number: P29514
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 25, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health