Reviewed,
UniProtKB/Swiss-Prot P29509 (TRXB1_YEAST)
Last modified
June 16, 2009.
Version 95.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Thioredoxin reductase 1 EC=1.8.1.9 | ||||||
| Gene names |
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| Organism | Saccharomyces cerevisiae (Baker's yeast) [Complete proteome] | ||||||
| Taxonomic identifier | 4932 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 319 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Acts on thioredoxins 1 and 2. |
| Catalytic activity | Thioredoxin + NADP+ = thioredoxin disulfide + NADPH. |
| Cofactor | Binds 1 FAD per subunit By similarity. |
| Subunit structure | Homodimer. |
| Subcellular location | |
| Miscellaneous | The active site is a redox-active disulfide bond. Present with 292000 molecules/cell in log phase SD medium. Ref.5 |
| Sequence similarities | Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed | ||||||||
| Chain | 2 – 319 | 318 | Thioredoxin reductase 1 | PRO_0000166770 | |||||||
Regions | |||||||||||
| Nucleotide binding | 33 – 45 | 13 | FAD By similarity | ||||||||
| Nucleotide binding | 288 – 297 | 10 | FAD By similarity | ||||||||
Amino acid modifications | |||||||||||
| Modified residue | 11 | 1 | Phosphoserine Ref.6 | ||||||||
| Modified residue | 94 | 1 | Phosphoserine Ref.6 | ||||||||
| Modified residue | 193 | 1 | Phosphothreonine Ref.6 | ||||||||
| Modified residue | 279 | 1 | Phosphoserine Ref.6 | ||||||||
| Modified residue | 300 | 1 | Phosphoserine Ref.6 | ||||||||
| Modified residue | 303 | 1 | Phosphoserine Ref.6 | ||||||||
| Disulfide bond | 142 ↔ 145 | Redox-active By similarity | |||||||||
Experimental info | |||||||||||
| Sequence conflict | 18 | 1 | A → V in AAA64747. Ref.1 | ||||||||
| Sequence conflict | 101 | 1 | T → A in AAA64747. Ref.1 | ||||||||
| Sequence conflict | 111 | 1 | T → A in AAA64747. Ref.1 | ||||||||
| Sequence conflict | 180 – 196 | 17 | VFMLV…STIMQ → CLCLSEKTICVLLPLCK in AAA64747. Ref.1 | ||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Thioredoxin-dependent peroxide reductase from yeast." Chae H.Z., Chung S.J., Rhee S.G. J. Biol. Chem. 269:27670-27678(1994) [PubMed: 7961686] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE. Strain: ATCC 200358 / YNN 295. |
| [2] | "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV." Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. Zaccaria P.Nature 387:75-78(1997) [PubMed: 9169867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972. |
| [3] | "Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. LaBaer J.Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c. |
| [4] | "The TRP4 gene of Saccharomyces cerevisiae: isolation and structural analysis." Furter R., Paravicini G., Aebi M., Braus G., Prantl F., Niederberger P., Huetter R. Nucleic Acids Res. 14:6357-6373(1986) [PubMed: 2428012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 261-319. |
| [5] | "Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. |
| [6] | "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11; SER-94; THR-193; SER-279; SER-300 AND SER-303, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| U10274 Genomic DNA. Translation: AAA64747.1. U28372 Genomic DNA. Translation: AAB64789.1. X04273 Genomic DNA. No translation available. AY557749 Genomic DNA. Translation: AAS56075.1. | |||||||||||||
| PIR | S61150. | ||||||||||||
| RefSeq | NP_010640.1. | ||||||||||||
3D structure databases | |||||||||||||
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| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| DIP | DIP:4319N. | ||||||||||||
| IntAct | P29509. 15 interactions. | ||||||||||||
Proteomic databases | |||||||||||||
| PeptideAtlas | P29509. | ||||||||||||
| PRIDE | P29509. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | YDR353W. Saccharomyces cerevisiae. [Contig view] | ||||||||||||
| GeneID | 851955. | ||||||||||||
| GenomeReviews | Gene locus YDR353W in contig Z71256_GR. | ||||||||||||
| KEGG | sce:YDR353W. | ||||||||||||
| NMPDR | fig|4932.3.peg.1406. | ||||||||||||
Organism-specific databases | |||||||||||||
| CYGD | YDR353w. | ||||||||||||
| SGD | S000002761. TRR1. | ||||||||||||
| Yeast-GFP | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOGENOM | P29509. | ||||||||||||
| OMA | P29509. YRNREVA. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| BRENDA | 1.8.1.9. 250. | ||||||||||||
Gene expression databases | |||||||||||||
| GermOnline | YDR353W. Saccharomyces cerevisiae. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR008255. Pyr_nucl-diS_OxRdtase_2_AS. IPR001327. Pyr_OxRdtase_NAD_bd. IPR000103. Pyridine_nuc-diS_OxRdtase_2. IPR005982. Thioredox_Rdtase. [Graphical view] | ||||||||||||
| Pfam | PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. [Graphical view] | ||||||||||||
| PRINTS | PR00368. FADPNR. PR00469. PNDRDTASEII. | ||||||||||||
| ProDom | PD000139. FAD_pyr_redox. 1 hit. [Graphical view] [Entries sharing at least one domain] | ||||||||||||
| TIGRFAMs | TIGR01292. TRX_reduct. 1 hit. | ||||||||||||
| PROSITE | PS00573. PYRIDINE_REDOX_2. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 970056. | ||||||||||||
Entry information
| Entry name | TRXB1_YEAST | ||||||||
| Accession | Primary (citable) accession number: P29509 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |

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