SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P29508

- SPB3_HUMAN

UniProt

P29508 - SPB3_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Serpin B3
Gene
SERPINB3, SCCA, SCCA1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1).1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei354 – 3552Reactive bond

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: UniProtKB
  2. virus receptor activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. negative regulation of catalytic activity Source: UniProtKB
  2. negative regulation of endopeptidase activity Source: RefGenome
  3. negative regulation of peptidase activity Source: UniProtKB
  4. negative regulation of proteolysis Source: UniProtKB
  5. regulation of proteolysis Source: RefGenome
  6. response to virus Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B3
Alternative name(s):
Protein T4-A
Squamous cell carcinoma antigen 1
Short name:
SCCA-1
Gene namesi
Synonyms:SCCA, SCCA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:10569. SERPINB3.

Subcellular locationi

Cytoplasm
Note: Seems to also be secreted in plasma by cancerous cells but at a low level.2 Publications

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular region Source: RefGenome
  3. extracellular space Source: InterPro
  4. extracellular vesicular exosome Source: UniProt
  5. nucleus Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi341 – 3411A → R: Loss of inhibitory activity. 1 Publication
Mutagenesisi352 – 3521F → A: Loss of inhibitory activity. 2 Publications
Mutagenesisi352 – 3521F → G: Loss of inhibitory activity to papain but does not decrease the suppression activity to MAPK8. 2 Publications
Mutagenesisi354 – 3552SS → PP: Loss of inhibitory activity.

Organism-specific databases

PharmGKBiPA35538.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390Serpin B3
PRO_0000094103Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP29508.
PaxDbiP29508.
PRIDEiP29508.

2D gel databases

SWISS-2DPAGEP29508.
UCD-2DPAGEP29508.

PTM databases

PhosphoSiteiP29508.

Expressioni

Tissue specificityi

Squamous cells. Expressed in some hepatocellular carcinoma (at protein level).1 Publication

Developmental stagei

Its expression is closely related to cellular differentiation in both normal and malignant squamous cells.

Inductioni

Strongly up-regulated in the upper epidermis of sun-exposed skin.1 Publication

Gene expression databases

ArrayExpressiP29508.
BgeeiP29508.
GenevestigatoriP29508.

Organism-specific databases

HPAiCAB018772.

Interactioni

Subunit structurei

Interacts with MAPK8/JNK1.1 Publication

Protein-protein interaction databases

BioGridi112223. 11 interactions.
IntActiP29508. 5 interactions.
MINTiMINT-1139917.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 2220
Beta strandi27 – 293
Helixi31 – 4313
Helixi48 – 569
Helixi82 – 9312
Beta strandi101 – 1044
Beta strandi107 – 1104
Helixi117 – 12711
Beta strandi131 – 1344
Turni136 – 1383
Helixi140 – 15415
Turni155 – 1573
Turni165 – 1673
Beta strandi174 – 1829
Beta strandi186 – 1883
Beta strandi194 – 2007
Beta strandi202 – 2054
Beta strandi208 – 22114
Turni225 – 2284
Beta strandi229 – 2368
Beta strandi239 – 25012
Helixi254 – 2607
Helixi263 – 2697
Helixi272 – 2743
Beta strandi276 – 28510
Beta strandi288 – 2947
Helixi296 – 3016
Helixi306 – 3083
Helixi315 – 3184
Beta strandi319 – 3213
Beta strandi325 – 33511
Beta strandi361 – 3644
Beta strandi369 – 3735
Turni376 – 3794
Beta strandi384 – 3874

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZV6X-ray2.70A/B/C2-390[»]
ProteinModelPortaliP29508.
SMRiP29508. Positions 2-390.

Miscellaneous databases

EvolutionaryTraceiP29508.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4826.
HOVERGENiHBG005957.
InParanoidiP29508.
KOiK13963.
OMAiKSIQMMR.
OrthoDBiEOG7327PB.
PhylomeDBiP29508.
TreeFamiTF352619.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P29508-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNSLSEANTK FMFDLFQQFR KSKENNIFYS PISITSALGM VLLGAKDNTA    50
QQIKKVLHFD QVTENTTGKA ATYHVDRSGN VHHQFQKLLT EFNKSTDAYE 100
LKIANKLFGE KTYLFLQEYL DAIKKFYQTS VESVDFANAP EESRKKINSW 150
VESQTNEKIK NLIPEGNIGS NTTLVLVNAI YFKGQWEKKF NKEDTKEEKF 200
WPNKNTYKSI QMMRQYTSFH FASLEDVQAK VLEIPYKGKD LSMIVLLPNE 250
IDGLQKLEEK LTAEKLMEWT SLQNMRETRV DLHLPRFKVE ESYDLKDTLR 300
TMGMVDIFNG DADLSGMTGS RGLVLSGVLH KAFVEVTEEG AEAAAATAVV 350
GFGSSPTSTN EEFHCNHPFL FFIRQNKTNS ILFYGRFSSP 390
Length:390
Mass (Da):44,565
Last modified:January 23, 2002 - v2
Checksum:iE5F27F986C752CFA
GO
Isoform 2 (identifier: P29508-2) [UniParc]FASTAAdd to Basket

Also known as: SCCA1b

The sequence of this isoform differs from the canonical sequence as follows:
     205-256: Missing.

Show »
Length:338
Mass (Da):38,550
Checksum:i5AA4782FF0C1ABDF
GO

Sequence cautioni

The sequence AAO11731.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti351 – 3511G → A Increased antiprotease activity and increased MAPK8 inhibition activity. 4 Publications
Corresponds to variant rs3180227 [ dbSNP | Ensembl ].
VAR_024351
Natural varianti357 – 3571T → A.3 Publications
Corresponds to variant rs1065205 [ dbSNP | Ensembl ].
VAR_024352

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei205 – 25652Missing in isoform 2.
VSP_032657Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161F → S in CAD56658. 1 Publication
Sequence conflicti47 – 471D → N in CAD56658. 1 Publication
Sequence conflicti105 – 1051N → T in CAD56658. 1 Publication
Sequence conflicti185 – 1851Q → R in AAO92272. 1 Publication
Sequence conflicti202 – 2021P → S in AAO92272. 1 Publication
Sequence conflicti278 – 2781T → A in AAO92269. 1 Publication
Sequence conflicti349 – 3491V → E in AAO92272. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S66896 mRNA. Translation: AAB20405.1.
U19556 mRNA. Translation: AAA97552.1.
U19568
, U19559, U19560, U19562, U19565, U19567 Genomic DNA. Translation: AAA86317.1.
U19562, U19559, U19560 Genomic DNA. Translation: AAA86316.1.
AB046399 mRNA. Translation: BAB40772.1.
AJ515706 mRNA. Translation: CAD56658.1.
AY245778 mRNA. Translation: AAO92269.1.
AY245781 mRNA. Translation: AAO92272.1.
EU852041 mRNA. Translation: ACF21012.1.
BT006748 mRNA. Translation: AAP35394.1.
AK222746 mRNA. Translation: BAD96466.1.
AK222753 mRNA. Translation: BAD96473.1.
AK314805 mRNA. Translation: BAG37332.1.
AC069356 Genomic DNA. No translation available.
CH471096 Genomic DNA. Translation: EAW63156.1.
CH471096 Genomic DNA. Translation: EAW63157.1.
BC005224 mRNA. Translation: AAH05224.1.
AY190327 mRNA. Translation: AAO11731.1. Different initiation.
CCDSiCCDS11987.1. [P29508-1]
PIRiI38201.
RefSeqiNP_008850.1. NM_006919.2. [P29508-1]
UniGeneiHs.227948.

Genome annotation databases

EnsembliENST00000283752; ENSP00000283752; ENSG00000057149. [P29508-1]
ENST00000332821; ENSP00000329498; ENSG00000057149. [P29508-2]
GeneIDi6317.
KEGGihsa:6317.
UCSCiuc002lji.3. human. [P29508-1]
uc010dqa.3. human. [P29508-2]

Polymorphism databases

DMDMi20141712.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S66896 mRNA. Translation: AAB20405.1 .
U19556 mRNA. Translation: AAA97552.1 .
U19568
, U19559 , U19560 , U19562 , U19565 , U19567 Genomic DNA. Translation: AAA86317.1 .
U19562 , U19559 , U19560 Genomic DNA. Translation: AAA86316.1 .
AB046399 mRNA. Translation: BAB40772.1 .
AJ515706 mRNA. Translation: CAD56658.1 .
AY245778 mRNA. Translation: AAO92269.1 .
AY245781 mRNA. Translation: AAO92272.1 .
EU852041 mRNA. Translation: ACF21012.1 .
BT006748 mRNA. Translation: AAP35394.1 .
AK222746 mRNA. Translation: BAD96466.1 .
AK222753 mRNA. Translation: BAD96473.1 .
AK314805 mRNA. Translation: BAG37332.1 .
AC069356 Genomic DNA. No translation available.
CH471096 Genomic DNA. Translation: EAW63156.1 .
CH471096 Genomic DNA. Translation: EAW63157.1 .
BC005224 mRNA. Translation: AAH05224.1 .
AY190327 mRNA. Translation: AAO11731.1 . Different initiation.
CCDSi CCDS11987.1. [P29508-1 ]
PIRi I38201.
RefSeqi NP_008850.1. NM_006919.2. [P29508-1 ]
UniGenei Hs.227948.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2ZV6 X-ray 2.70 A/B/C 2-390 [» ]
ProteinModelPortali P29508.
SMRi P29508. Positions 2-390.
ModBasei Search...

Protein-protein interaction databases

BioGridi 112223. 11 interactions.
IntActi P29508. 5 interactions.
MINTi MINT-1139917.

PTM databases

PhosphoSitei P29508.

Polymorphism databases

DMDMi 20141712.

2D gel databases

SWISS-2DPAGE P29508.
UCD-2DPAGE P29508.

Proteomic databases

MaxQBi P29508.
PaxDbi P29508.
PRIDEi P29508.

Protocols and materials databases

DNASUi 6317.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000283752 ; ENSP00000283752 ; ENSG00000057149 . [P29508-1 ]
ENST00000332821 ; ENSP00000329498 ; ENSG00000057149 . [P29508-2 ]
GeneIDi 6317.
KEGGi hsa:6317.
UCSCi uc002lji.3. human. [P29508-1 ]
uc010dqa.3. human. [P29508-2 ]

Organism-specific databases

CTDi 6317.
GeneCardsi GC18M061295.
HGNCi HGNC:10569. SERPINB3.
HPAi CAB018772.
MIMi 600517. gene.
neXtProti NX_P29508.
PharmGKBi PA35538.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4826.
HOVERGENi HBG005957.
InParanoidi P29508.
KOi K13963.
OMAi KSIQMMR.
OrthoDBi EOG7327PB.
PhylomeDBi P29508.
TreeFami TF352619.

Miscellaneous databases

EvolutionaryTracei P29508.
GeneWikii SERPINB3.
GenomeRNAii 6317.
NextBioi 24512.
PROi P29508.
SOURCEi Search...

Gene expression databases

ArrayExpressi P29508.
Bgeei P29508.
Genevestigatori P29508.

Family and domain databases

InterProi IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Squamous cell carcinoma antigen is a new member of the serine protease inhibitors."
    Suminami Y., Kishi F., Sekiguchi K., Kato H.
    Biochem. Biophys. Res. Commun. 181:51-58(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, VARIANT ALA-357.
  2. "A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene."
    Schneider S.S., Schick C., Fish K.E., Miller E., Pena J.C., Treter S.D., Hui S.M., Silverman G.A.
    Proc. Natl. Acad. Sci. U.S.A. 92:3147-3151(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
  3. "Novel forms of SCC antigen transcripts produced by alternative splicing."
    Suminami Y., Kishi F., Murakami A., Sakaguchi Y., Kato H.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ALA-357.
  4. "Squamous cell carcinoma antigen 1-mediated binding of hepatitis B virus to hepatocytes does not involve the hepatic serpin clearance system."
    Moore P.L., Ong S., Harrison T.J.
    J. Biol. Chem. 278:46709-46717(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-351, MUTAGENESIS OF ALA-341; PHE-352 AND 354-SER-SER-355.
    Tissue: Hepatoma.
  5. "SCCA1 mRNA sequence from human hepatocellular carcinoma cell line HepG2, complete cds."
    Tong C., Chenyu X., Jun Z., Ningshao X.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Hepatoma.
  6. "Characterization of the new isoform of squamous cell carcinoma antigen-1 (SCCA-PD) detected in hepatocellular carcinoma."
    Turato C., Biasiolo A., Quarta S., Beneduce L., Zuin J., Fassina G., Gatta A., Pontisso P.
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-351.
    Tissue: Liver.
  7. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Trachea.
  9. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-357.
    Tissue: Dermoid cancer.
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  13. Bienvenut W.V., Bensaad K., Vousden K.H.
    Submitted (FEB-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 1-21; 88-94; 112-125; 147-160; 215-260; 266-300; 322-331 AND 378-386, ACETYLATION AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Osteosarcoma.
  14. "Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma."
    Pontisso P., Calabrese F., Benvegnu L., Lise M., Belluco C., Ruvoletto M.G., De Falco S., Marino M., Valente M., Nitti D., Gatta A., Fassina G.
    Br. J. Cancer 90:833-837(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 109-390 (ISOFORM 1), VARIANT ALA-351, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Liver cancer.
  15. "Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells."
    Uemura Y., Pak S.C., Luke C., Cataltepe S., Tsu C., Schick C., Kamachi Y., Pomeroy S.L., Perlmutter D.H., Silverman G.A.
    Int. J. Cancer 89:368-377(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "Crystal structure of SCCA1 and insight about the interaction with JNK1."
    Zheng B., Matoba Y., Kumagai T., Katagiri C., Hibino T., Sugiyama M.
    Biochem. Biophys. Res. Commun. 380:143-147(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 2-390, FUNCTION, INDUCTION, MUTAGENESIS OF PHE-352, INTERACTION WITH MAPK8.
  18. Cited for: VARIANT ALA-351.

Entry informationi

Entry nameiSPB3_HUMAN
AccessioniPrimary (citable) accession number: P29508
Secondary accession number(s): A6NDM2
, B2RBT5, B3W5Y6, Q53H28, Q53YB5, Q86VF3, Q86W04, Q8IWL4, Q8IXI3, Q96J21, Q9BYF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2002
Last modified: July 9, 2014
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi