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P29508

- SPB3_HUMAN

UniProt

P29508 - SPB3_HUMAN

Protein

Serpin B3

Gene

SERPINB3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 2 (23 Jan 2002)
      Previous versions | rss
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    Functioni

    May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1).1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei354 – 3552Reactive bond

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: UniProtKB
    2. virus receptor activity Source: UniProtKB

    GO - Biological processi

    1. negative regulation of catalytic activity Source: UniProtKB
    2. negative regulation of endopeptidase activity Source: RefGenome
    3. negative regulation of peptidase activity Source: UniProtKB
    4. negative regulation of proteolysis Source: UniProtKB
    5. regulation of proteolysis Source: RefGenome
    6. response to virus Source: GOC

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serpin B3
    Alternative name(s):
    Protein T4-A
    Squamous cell carcinoma antigen 1
    Short name:
    SCCA-1
    Gene namesi
    Name:SERPINB3
    Synonyms:SCCA, SCCA1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:10569. SERPINB3.

    Subcellular locationi

    Cytoplasm 2 Publications
    Note: Seems to also be secreted in plasma by cancerous cells but at a low level.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular region Source: RefGenome
    3. extracellular space Source: InterPro
    4. extracellular vesicular exosome Source: UniProt
    5. nucleus Source: UniProt
    6. vesicle Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi341 – 3411A → R: Loss of inhibitory activity. 1 Publication
    Mutagenesisi352 – 3521F → A: Loss of inhibitory activity. 2 Publications
    Mutagenesisi352 – 3521F → G: Loss of inhibitory activity to papain but does not decrease the suppression activity to MAPK8. 2 Publications
    Mutagenesisi354 – 3552SS → PP: Loss of inhibitory activity.

    Organism-specific databases

    PharmGKBiPA35538.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 390390Serpin B3PRO_0000094103Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP29508.
    PaxDbiP29508.
    PRIDEiP29508.

    2D gel databases

    SWISS-2DPAGEP29508.
    UCD-2DPAGEP29508.

    PTM databases

    PhosphoSiteiP29508.

    Expressioni

    Tissue specificityi

    Squamous cells. Expressed in some hepatocellular carcinoma (at protein level).1 Publication

    Developmental stagei

    Its expression is closely related to cellular differentiation in both normal and malignant squamous cells.

    Inductioni

    Strongly up-regulated in the upper epidermis of sun-exposed skin.1 Publication

    Gene expression databases

    ArrayExpressiP29508.
    BgeeiP29508.
    GenevestigatoriP29508.

    Organism-specific databases

    HPAiCAB018772.

    Interactioni

    Subunit structurei

    Interacts with MAPK8/JNK1.1 Publication

    Protein-protein interaction databases

    BioGridi112223. 11 interactions.
    IntActiP29508. 5 interactions.
    MINTiMINT-1139917.

    Structurei

    Secondary structure

    1
    390
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi3 – 2220
    Beta strandi27 – 293
    Helixi31 – 4313
    Helixi48 – 569
    Helixi82 – 9312
    Beta strandi101 – 1044
    Beta strandi107 – 1104
    Helixi117 – 12711
    Beta strandi131 – 1344
    Turni136 – 1383
    Helixi140 – 15415
    Turni155 – 1573
    Turni165 – 1673
    Beta strandi174 – 1829
    Beta strandi186 – 1883
    Beta strandi194 – 2007
    Beta strandi202 – 2054
    Beta strandi208 – 22114
    Turni225 – 2284
    Beta strandi229 – 2368
    Beta strandi239 – 25012
    Helixi254 – 2607
    Helixi263 – 2697
    Helixi272 – 2743
    Beta strandi276 – 28510
    Beta strandi288 – 2947
    Helixi296 – 3016
    Helixi306 – 3083
    Helixi315 – 3184
    Beta strandi319 – 3213
    Beta strandi325 – 33511
    Beta strandi361 – 3644
    Beta strandi369 – 3735
    Turni376 – 3794
    Beta strandi384 – 3874

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2ZV6X-ray2.70A/B/C2-390[»]
    ProteinModelPortaliP29508.
    SMRiP29508. Positions 2-390.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP29508.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family. Ov-serpin subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG4826.
    HOVERGENiHBG005957.
    InParanoidiP29508.
    KOiK13963.
    OMAiKSIQMMR.
    OrthoDBiEOG7327PB.
    PhylomeDBiP29508.
    TreeFamiTF352619.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P29508-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNSLSEANTK FMFDLFQQFR KSKENNIFYS PISITSALGM VLLGAKDNTA    50
    QQIKKVLHFD QVTENTTGKA ATYHVDRSGN VHHQFQKLLT EFNKSTDAYE 100
    LKIANKLFGE KTYLFLQEYL DAIKKFYQTS VESVDFANAP EESRKKINSW 150
    VESQTNEKIK NLIPEGNIGS NTTLVLVNAI YFKGQWEKKF NKEDTKEEKF 200
    WPNKNTYKSI QMMRQYTSFH FASLEDVQAK VLEIPYKGKD LSMIVLLPNE 250
    IDGLQKLEEK LTAEKLMEWT SLQNMRETRV DLHLPRFKVE ESYDLKDTLR 300
    TMGMVDIFNG DADLSGMTGS RGLVLSGVLH KAFVEVTEEG AEAAAATAVV 350
    GFGSSPTSTN EEFHCNHPFL FFIRQNKTNS ILFYGRFSSP 390
    Length:390
    Mass (Da):44,565
    Last modified:January 23, 2002 - v2
    Checksum:iE5F27F986C752CFA
    GO
    Isoform 2 (identifier: P29508-2) [UniParc]FASTAAdd to Basket

    Also known as: SCCA1b

    The sequence of this isoform differs from the canonical sequence as follows:
         205-256: Missing.

    Show »
    Length:338
    Mass (Da):38,550
    Checksum:i5AA4782FF0C1ABDF
    GO

    Sequence cautioni

    The sequence AAO11731.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti16 – 161F → S in CAD56658. (PubMed:12975381)Curated
    Sequence conflicti47 – 471D → N in CAD56658. (PubMed:12975381)Curated
    Sequence conflicti105 – 1051N → T in CAD56658. (PubMed:12975381)Curated
    Sequence conflicti185 – 1851Q → R in AAO92272. 1 PublicationCurated
    Sequence conflicti202 – 2021P → S in AAO92272. 1 PublicationCurated
    Sequence conflicti278 – 2781T → A in AAO92269. 1 PublicationCurated
    Sequence conflicti349 – 3491V → E in AAO92272. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti351 – 3511G → A Increased antiprotease activity and increased MAPK8 inhibition activity. 4 Publications
    Corresponds to variant rs3180227 [ dbSNP | Ensembl ].
    VAR_024351
    Natural varianti357 – 3571T → A.3 Publications
    Corresponds to variant rs1065205 [ dbSNP | Ensembl ].
    VAR_024352

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei205 – 25652Missing in isoform 2. 1 PublicationVSP_032657Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S66896 mRNA. Translation: AAB20405.1.
    U19556 mRNA. Translation: AAA97552.1.
    U19568
    , U19559, U19560, U19562, U19565, U19567 Genomic DNA. Translation: AAA86317.1.
    U19562, U19559, U19560 Genomic DNA. Translation: AAA86316.1.
    AB046399 mRNA. Translation: BAB40772.1.
    AJ515706 mRNA. Translation: CAD56658.1.
    AY245778 mRNA. Translation: AAO92269.1.
    AY245781 mRNA. Translation: AAO92272.1.
    EU852041 mRNA. Translation: ACF21012.1.
    BT006748 mRNA. Translation: AAP35394.1.
    AK222746 mRNA. Translation: BAD96466.1.
    AK222753 mRNA. Translation: BAD96473.1.
    AK314805 mRNA. Translation: BAG37332.1.
    AC069356 Genomic DNA. No translation available.
    CH471096 Genomic DNA. Translation: EAW63156.1.
    CH471096 Genomic DNA. Translation: EAW63157.1.
    BC005224 mRNA. Translation: AAH05224.1.
    AY190327 mRNA. Translation: AAO11731.1. Different initiation.
    CCDSiCCDS11987.1. [P29508-1]
    PIRiI38201.
    RefSeqiNP_008850.1. NM_006919.2. [P29508-1]
    UniGeneiHs.227948.

    Genome annotation databases

    EnsembliENST00000283752; ENSP00000283752; ENSG00000057149. [P29508-1]
    ENST00000332821; ENSP00000329498; ENSG00000057149. [P29508-2]
    GeneIDi6317.
    KEGGihsa:6317.
    UCSCiuc002lji.3. human. [P29508-1]
    uc010dqa.3. human. [P29508-2]

    Polymorphism databases

    DMDMi20141712.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S66896 mRNA. Translation: AAB20405.1 .
    U19556 mRNA. Translation: AAA97552.1 .
    U19568
    , U19559 , U19560 , U19562 , U19565 , U19567 Genomic DNA. Translation: AAA86317.1 .
    U19562 , U19559 , U19560 Genomic DNA. Translation: AAA86316.1 .
    AB046399 mRNA. Translation: BAB40772.1 .
    AJ515706 mRNA. Translation: CAD56658.1 .
    AY245778 mRNA. Translation: AAO92269.1 .
    AY245781 mRNA. Translation: AAO92272.1 .
    EU852041 mRNA. Translation: ACF21012.1 .
    BT006748 mRNA. Translation: AAP35394.1 .
    AK222746 mRNA. Translation: BAD96466.1 .
    AK222753 mRNA. Translation: BAD96473.1 .
    AK314805 mRNA. Translation: BAG37332.1 .
    AC069356 Genomic DNA. No translation available.
    CH471096 Genomic DNA. Translation: EAW63156.1 .
    CH471096 Genomic DNA. Translation: EAW63157.1 .
    BC005224 mRNA. Translation: AAH05224.1 .
    AY190327 mRNA. Translation: AAO11731.1 . Different initiation.
    CCDSi CCDS11987.1. [P29508-1 ]
    PIRi I38201.
    RefSeqi NP_008850.1. NM_006919.2. [P29508-1 ]
    UniGenei Hs.227948.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2ZV6 X-ray 2.70 A/B/C 2-390 [» ]
    ProteinModelPortali P29508.
    SMRi P29508. Positions 2-390.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112223. 11 interactions.
    IntActi P29508. 5 interactions.
    MINTi MINT-1139917.

    PTM databases

    PhosphoSitei P29508.

    Polymorphism databases

    DMDMi 20141712.

    2D gel databases

    SWISS-2DPAGE P29508.
    UCD-2DPAGE P29508.

    Proteomic databases

    MaxQBi P29508.
    PaxDbi P29508.
    PRIDEi P29508.

    Protocols and materials databases

    DNASUi 6317.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000283752 ; ENSP00000283752 ; ENSG00000057149 . [P29508-1 ]
    ENST00000332821 ; ENSP00000329498 ; ENSG00000057149 . [P29508-2 ]
    GeneIDi 6317.
    KEGGi hsa:6317.
    UCSCi uc002lji.3. human. [P29508-1 ]
    uc010dqa.3. human. [P29508-2 ]

    Organism-specific databases

    CTDi 6317.
    GeneCardsi GC18M061295.
    HGNCi HGNC:10569. SERPINB3.
    HPAi CAB018772.
    MIMi 600517. gene.
    neXtProti NX_P29508.
    PharmGKBi PA35538.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4826.
    HOVERGENi HBG005957.
    InParanoidi P29508.
    KOi K13963.
    OMAi KSIQMMR.
    OrthoDBi EOG7327PB.
    PhylomeDBi P29508.
    TreeFami TF352619.

    Miscellaneous databases

    EvolutionaryTracei P29508.
    GeneWikii SERPINB3.
    GenomeRNAii 6317.
    NextBioi 24512.
    PROi P29508.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P29508.
    Bgeei P29508.
    Genevestigatori P29508.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Squamous cell carcinoma antigen is a new member of the serine protease inhibitors."
      Suminami Y., Kishi F., Sekiguchi K., Kato H.
      Biochem. Biophys. Res. Commun. 181:51-58(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL PROTEIN SEQUENCE, VARIANT ALA-357.
    2. "A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene."
      Schneider S.S., Schick C., Fish K.E., Miller E., Pena J.C., Treter S.D., Hui S.M., Silverman G.A.
      Proc. Natl. Acad. Sci. U.S.A. 92:3147-3151(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    3. "Novel forms of SCC antigen transcripts produced by alternative splicing."
      Suminami Y., Kishi F., Murakami A., Sakaguchi Y., Kato H.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT ALA-357.
    4. "Squamous cell carcinoma antigen 1-mediated binding of hepatitis B virus to hepatocytes does not involve the hepatic serpin clearance system."
      Moore P.L., Ong S., Harrison T.J.
      J. Biol. Chem. 278:46709-46717(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-351, MUTAGENESIS OF ALA-341; PHE-352 AND 354-SER-SER-355.
      Tissue: Hepatoma.
    5. "SCCA1 mRNA sequence from human hepatocellular carcinoma cell line HepG2, complete cds."
      Tong C., Chenyu X., Jun Z., Ningshao X.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Hepatoma.
    6. "Characterization of the new isoform of squamous cell carcinoma antigen-1 (SCCA-PD) detected in hepatocellular carcinoma."
      Turato C., Biasiolo A., Quarta S., Beneduce L., Zuin J., Fassina G., Gatta A., Pontisso P.
      Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-351.
      Tissue: Liver.
    7. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Trachea.
    9. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-357.
      Tissue: Dermoid cancer.
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    13. Bienvenut W.V., Bensaad K., Vousden K.H.
      Submitted (FEB-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 1-21; 88-94; 112-125; 147-160; 215-260; 266-300; 322-331 AND 378-386, ACETYLATION AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Osteosarcoma.
    14. "Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma."
      Pontisso P., Calabrese F., Benvegnu L., Lise M., Belluco C., Ruvoletto M.G., De Falco S., Marino M., Valente M., Nitti D., Gatta A., Fassina G.
      Br. J. Cancer 90:833-837(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 109-390 (ISOFORM 1), VARIANT ALA-351, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Liver cancer.
    15. "Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells."
      Uemura Y., Pak S.C., Luke C., Cataltepe S., Tsu C., Schick C., Kamachi Y., Pomeroy S.L., Perlmutter D.H., Silverman G.A.
      Int. J. Cancer 89:368-377(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "Crystal structure of SCCA1 and insight about the interaction with JNK1."
      Zheng B., Matoba Y., Kumagai T., Katagiri C., Hibino T., Sugiyama M.
      Biochem. Biophys. Res. Commun. 380:143-147(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 2-390, FUNCTION, INDUCTION, MUTAGENESIS OF PHE-352, INTERACTION WITH MAPK8.
    18. Cited for: VARIANT ALA-351.

    Entry informationi

    Entry nameiSPB3_HUMAN
    AccessioniPrimary (citable) accession number: P29508
    Secondary accession number(s): A6NDM2
    , B2RBT5, B3W5Y6, Q53H28, Q53YB5, Q86VF3, Q86W04, Q8IWL4, Q8IXI3, Q96J21, Q9BYF8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: January 23, 2002
    Last modified: October 1, 2014
    This is version 145 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3