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P29507 (DHE4_SCHOC) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADP-specific glutamate dehydrogenase

Short name=NADP-GDH
EC=1.4.1.4
Alternative name(s):
NADP-dependent glutamate dehydrogenase
Gene names
Name:GDHA
OrganismSchwanniomyces occidentalis (Yeast) (Debaryomyces occidentalis)
Taxonomic identifier27300 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeSchwanniomyces

Protein attributes

Sequence length459 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Subunit structure

Homohexamer By similarity.

Sequence similarities

Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processcellular amino acid metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionglutamate dehydrogenase (NADP+) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 459459NADP-specific glutamate dehydrogenase
PRO_0000182796

Sites

Active site1161 By similarity

Sequences

Sequence LengthMass (Da)Tools
P29507 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 03047D3D1C05B79C

FASTA45949,831
        10         20         30         40         50         60 
MIKNGLPHEP EFQQAYNELV SALEESTLFT EKPEYKKVIP VVSIPERIIQ FRVAWENDNG 

        70         80         90        100        110        120 
DVEVNNGFRV QFNSSLGPYK GGLRFHPSVN LSILKFLGFE QIFKNALTGL SMGGGKGGCD 

       130        140        150        160        170        180 
FNPKGRSDGE IRRFCVAFMR QLARYIGADT DVPAGDIGVG GREIGYLFGA YKQMQNNWYG 

       190        200        210        220        230        240 
VLTGKGLTWG GSLIRPEATG YVSFTTLKKM IEKATNGKES FKGKRVELSG SGNVAQYAAL 

       250        260        270        280        290        300 
KVIELGGIVV SLSDSKGSIV SKNGIVPEQV LEIAAAKLKF KSLEEITKES VKLFSGENSV 

       310        320        330        340        350        360 
EYLAGVRPWA KVGHFDVALP SATQKEVSGE EEAKALVEAG CKYIAEGSNM GSTKEAIDVF 

       370        380        390        400        410        420 
EANRSNNVWY APGKAANCGG VAVSGLEMAQ NSQRVQWSAE EVDAKLKNIM YTCFDNCYDP 

       430        440        450 
AIKYSAEKNA DGLPSLLKGA NIASFIKVAD AMFDQGDVY 

« Hide

References

[1]"Cloning, sequencing and expression of the Schwanniomyces occidentalis NADP-dependent glutamate dehydrogenase gene."
de Zoysa P.A., Connerton I.F., Watson D.C., Johnston J.R.
Curr. Genet. 20:219-224(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S64476 Genomic DNA. Translation: AAB20267.1.
PIRS17907.

3D structure databases

ProteinModelPortalP29507.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFPIRSF000185. Glu_DH. 1 hit.
PRINTSPR00082. GLFDHDRGNASE.
SMARTSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHE4_SCHOC
AccessionPrimary (citable) accession number: P29507
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 16, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families