P29507 (DHE4_SCHOC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NADP-specific glutamate dehydrogenase
Short name=NADP-GDH
EC=1.4.1.4

Alternative name(s):
NADP-dependent glutamate dehydrogenase

Gene names

Name:

GDHA

Organism

Schwanniomyces occidentalis (Yeast) (Debaryomyces occidentalis)

Taxonomic identifier

27300 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Schwanniomyces

Protein attributes

Sequence length	459 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.
Subunit structure	Homohexamer By similarity.
Sequence similarities	Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Ontologies

Keywords
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	glutamate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 459	459	NADP-specific glutamate dehydrogenase		PRO_0000182796
Sites
	Active site	116	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P29507 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: 03047D3D1C05B79C	FASTA	459	49,831
	10 20 30 40 50 60 MIKNGLPHEP EFQQAYNELV SALEESTLFT EKPEYKKVIP VVSIPERIIQ FRVAWENDNG 70 80 90 100 110 120 DVEVNNGFRV QFNSSLGPYK GGLRFHPSVN LSILKFLGFE QIFKNALTGL SMGGGKGGCD 130 140 150 160 170 180 FNPKGRSDGE IRRFCVAFMR QLARYIGADT DVPAGDIGVG GREIGYLFGA YKQMQNNWYG 190 200 210 220 230 240 VLTGKGLTWG GSLIRPEATG YVSFTTLKKM IEKATNGKES FKGKRVELSG SGNVAQYAAL 250 260 270 280 290 300 KVIELGGIVV SLSDSKGSIV SKNGIVPEQV LEIAAAKLKF KSLEEITKES VKLFSGENSV 310 320 330 340 350 360 EYLAGVRPWA KVGHFDVALP SATQKEVSGE EEAKALVEAG CKYIAEGSNM GSTKEAIDVF 370 380 390 400 410 420 EANRSNNVWY APGKAANCGG VAVSGLEMAQ NSQRVQWSAE EVDAKLKNIM YTCFDNCYDP 430 440 450 AIKYSAEKNA DGLPSLLKGA NIASFIKVAD AMFDQGDVY

References

[1]	"Cloning, sequencing and expression of the Schwanniomyces occidentalis NADP-dependent glutamate dehydrogenase gene." de Zoysa P.A., Connerton I.F., Watson D.C., Johnston J.R. Curr. Genet. 20:219-224(1991) [PubMed: 1934128] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S64476 Genomic DNA. Translation: AAB20267.1.
PIR	S17907.
3D structure databases
ProteinModelPortal	P29507.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR006095. Glu/Leu/Phe/Val_DH. IPR006096. Glu/Leu/Phe/Val_DH_C. IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom. IPR014362. Glu_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF00208. ELFV_dehydrog. 1 hit. PF02812. ELFV_dehydrog_N. 1 hit. [Graphical view]
PIRSF	PIRSF000185. Glu_DH. 1 hit.
PRINTS	PR00082. GLFDHDRGNASE.
SMART	SM00839. ELFV_dehydrog. 1 hit. [Graphical view]
PROSITE	PS00074. GLFV_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHE4_SCHOC

Accession

Primary (citable) accession number: P29507

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	December 14, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program