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P29507

- DHE4_SCHOC

UniProt

P29507 - DHE4_SCHOC

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Protein

NADP-specific glutamate dehydrogenase

Gene

GDHA

Organism
Schwanniomyces occidentalis (Yeast) (Debaryomyces occidentalis)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei116 – 1161PROSITE-ProRule annotation

GO - Molecular functioni

  1. glutamate dehydrogenase (NADP+) activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular amino acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-specific glutamate dehydrogenase (EC:1.4.1.4)
Short name:
NADP-GDH
Alternative name(s):
NADP-dependent glutamate dehydrogenase
Gene namesi
Name:GDHA
OrganismiSchwanniomyces occidentalis (Yeast) (Debaryomyces occidentalis)
Taxonomic identifieri27300 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeSchwanniomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 459459NADP-specific glutamate dehydrogenasePRO_0000182796Add
BLAST

Interactioni

Subunit structurei

Homohexamer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP29507.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29507-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIKNGLPHEP EFQQAYNELV SALEESTLFT EKPEYKKVIP VVSIPERIIQ
60 70 80 90 100
FRVAWENDNG DVEVNNGFRV QFNSSLGPYK GGLRFHPSVN LSILKFLGFE
110 120 130 140 150
QIFKNALTGL SMGGGKGGCD FNPKGRSDGE IRRFCVAFMR QLARYIGADT
160 170 180 190 200
DVPAGDIGVG GREIGYLFGA YKQMQNNWYG VLTGKGLTWG GSLIRPEATG
210 220 230 240 250
YVSFTTLKKM IEKATNGKES FKGKRVELSG SGNVAQYAAL KVIELGGIVV
260 270 280 290 300
SLSDSKGSIV SKNGIVPEQV LEIAAAKLKF KSLEEITKES VKLFSGENSV
310 320 330 340 350
EYLAGVRPWA KVGHFDVALP SATQKEVSGE EEAKALVEAG CKYIAEGSNM
360 370 380 390 400
GSTKEAIDVF EANRSNNVWY APGKAANCGG VAVSGLEMAQ NSQRVQWSAE
410 420 430 440 450
EVDAKLKNIM YTCFDNCYDP AIKYSAEKNA DGLPSLLKGA NIASFIKVAD

AMFDQGDVY
Length:459
Mass (Da):49,831
Last modified:April 1, 1993 - v1
Checksum:i03047D3D1C05B79C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S64476 Genomic DNA. Translation: AAB20267.1.
PIRiS17907.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S64476 Genomic DNA. Translation: AAB20267.1 .
PIRi S17907.

3D structure databases

ProteinModelPortali P29507.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000185. Glu_DH. 1 hit.
PRINTSi PR00082. GLFDHDRGNASE.
SMARTi SM00839. ELFV_dehydrog. 1 hit.
[Graphical view ]
PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning, sequencing and expression of the Schwanniomyces occidentalis NADP-dependent glutamate dehydrogenase gene."
    de Zoysa P.A., Connerton I.F., Watson D.C., Johnston J.R.
    Curr. Genet. 20:219-224(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiDHE4_SCHOC
AccessioniPrimary (citable) accession number: P29507
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 1, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3