ID NEUR_DROME Reviewed; 754 AA. AC P29503; Q26306; Q27273; Q8INP6; Q8INP7; Q960M1; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 22-AUG-2003, sequence version 2. DT 27-MAR-2024, entry version 196. DE RecName: Full=Protein neuralized; GN Name=neur; Synonyms=neu; ORFNames=CG11988; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2). RC STRAIN=Oregon-R; RX PubMed=1717258; DOI=10.1002/j.1460-2075.1991.tb07848.x; RA Boulianne G.L., de la Concha A., Campos-Ortega J.A., Jan L.Y., Jan Y.N.; RT "The Drosophila neurogenic gene neuralized encodes a novel protein and is RT expressed in precursors of larval and adult neurons."; RL EMBO J. 10:2975-2983(1991). RN [2] RP ERRATUM OF PUBMED:1717258. RX PubMed=8508781; DOI=10.1002/j.1460-2075.1993.tb05914.x; RA Boulianne G.L., de la Concha A., Campos-Ortega J.A., Jan L.Y., Jan Y.N.; RL EMBO J. 12:2586-2586(1993). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RX PubMed=8508767; DOI=10.1002/j.1460-2075.1993.tb05895.x; RA Price B.D., Chang Z., Smith R., Bockheim S., Laughon A.; RT "The Drosophila neuralized gene encodes a C3HC4 zinc finger."; RL EMBO J. 12:2411-2418(1993). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., RA Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [5] RP GENOME REANNOTATION. RC STRAIN=Berkeley; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). RC STRAIN=Berkeley; RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080; RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., RA Celniker S.E.; RT "A Drosophila full-length cDNA resource."; RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002). RN [7] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-338 AND SER-341, AND RP IDENTIFICATION BY MASS SPECTROMETRY. RC TISSUE=Embryo; RX PubMed=18327897; DOI=10.1021/pr700696a; RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; RT "Phosphoproteome analysis of Drosophila melanogaster embryos."; RL J. Proteome Res. 7:1675-1682(2008). RN [8] RP STRUCTURE BY NMR OF 106-266. RG RIKEN structural genomics initiative (RSGI); RT "Solution structure of the neuz (NHR) domain in neuralized from Drosophila RT melanogaster."; RL Submitted (OCT-2007) to the PDB data bank. CC -!- FUNCTION: Involved in neurogenesis. Interacts with other neurogenic CC proteins in the specification of the neuroblast versus epidermoblast CC cell fate. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Name=1; CC IsoId=P29503-1; Sequence=Displayed; CC Name=2; CC IsoId=P29503-2; Sequence=VSP_008046; CC Name=3; CC IsoId=P29503-3; Sequence=VSP_008045; CC Name=4; CC IsoId=P29503-4; Sequence=VSP_008045, VSP_008046; CC -!- SEQUENCE CAUTION: CC Sequence=CAA43806.1; Type=Frameshift; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X61617; CAA43806.1; ALT_FRAME; Genomic_DNA. DR EMBL; S62597; AAB27151.1; -; mRNA. DR EMBL; S62583; AAB27147.1; -; mRNA. DR EMBL; L12218; AAA28403.1; -; mRNA. DR EMBL; AE014297; AAF54330.1; -; Genomic_DNA. DR EMBL; AE014297; AAF54326.2; -; Genomic_DNA. DR EMBL; AE014297; AAN13406.1; -; Genomic_DNA. DR EMBL; AE014297; AAN13407.1; -; Genomic_DNA. DR EMBL; AY051987; AAK93411.1; -; mRNA. DR EMBL; BT003772; AAO41451.1; -; mRNA. DR PIR; S35371; S35371. DR PIR; S35503; S35503. DR RefSeq; NP_001163563.1; NM_001170092.3. [P29503-3] DR RefSeq; NP_476652.1; NM_057304.5. [P29503-1] DR RefSeq; NP_731309.1; NM_169255.3. [P29503-4] DR RefSeq; NP_731310.1; NM_169256.3. [P29503-3] DR RefSeq; NP_731311.1; NM_169257.3. [P29503-2] DR PDB; 2YUE; NMR; -; A=106-266. DR PDB; 4KG0; X-ray; 2.10 A; A=105-260. DR PDBsum; 2YUE; -. DR PDBsum; 4KG0; -. DR AlphaFoldDB; P29503; -. DR SMR; P29503; -. DR BioGRID; 66253; 29. DR DIP; DIP-17176N; -. DR IntAct; P29503; 4. DR MINT; P29503; -. DR STRING; 7227.FBpp0081481; -. DR iPTMnet; P29503; -. DR PaxDb; 7227-FBpp0081481; -. DR DNASU; 41085; -. DR EnsemblMetazoa; FBtr0082001; FBpp0081479; FBgn0002932. [P29503-3] DR EnsemblMetazoa; FBtr0082002; FBpp0081480; FBgn0002932. [P29503-4] DR EnsemblMetazoa; FBtr0082003; FBpp0081481; FBgn0002932. [P29503-1] DR EnsemblMetazoa; FBtr0082004; FBpp0081482; FBgn0002932. [P29503-2] DR EnsemblMetazoa; FBtr0300414; FBpp0289643; FBgn0002932. [P29503-3] DR GeneID; 41085; -. DR KEGG; dme:Dmel_CG11988; -. DR UCSC; CG11988-RA; d. melanogaster. [P29503-1] DR AGR; FB:FBgn0002932; -. DR CTD; 41085; -. DR FlyBase; FBgn0002932; neur. DR VEuPathDB; VectorBase:FBgn0002932; -. DR eggNOG; KOG4172; Eukaryota. DR eggNOG; KOG4625; Eukaryota. DR GeneTree; ENSGT00940000166233; -. DR InParanoid; P29503; -. DR OMA; ASCPIPQ; -. DR OrthoDB; 5471056at2759; -. DR PhylomeDB; P29503; -. DR SignaLink; P29503; -. DR BioGRID-ORCS; 41085; 0 hits in 3 CRISPR screens. DR EvolutionaryTrace; P29503; -. DR GenomeRNAi; 41085; -. DR PRO; PR:P29503; -. DR Proteomes; UP000000803; Chromosome 3R. DR Bgee; FBgn0002932; Expressed in mesectoderm and 85 other cell types or tissues. DR ExpressionAtlas; P29503; baseline and differential. DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase. DR GO; GO:0005829; C:cytosol; TAS:Reactome. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:FlyBase. DR GO; GO:0005886; C:plasma membrane; IDA:FlyBase. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:1901981; F:phosphatidylinositol phosphate binding; IDA:FlyBase. DR GO; GO:0061630; F:ubiquitin protein ligase activity; IDA:FlyBase. DR GO; GO:0004842; F:ubiquitin-protein transferase activity; TAS:Reactome. DR GO; GO:0008270; F:zinc ion binding; ISM:FlyBase. DR GO; GO:0008356; P:asymmetric cell division; IMP:FlyBase. DR GO; GO:0048749; P:compound eye development; IMP:FlyBase. DR GO; GO:0030718; P:germ-line stem cell population maintenance; IMP:FlyBase. DR GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase. DR GO; GO:0007616; P:long-term memory; IMP:FlyBase. DR GO; GO:0007498; P:mesoderm development; IMP:FlyBase. DR GO; GO:0035204; P:negative regulation of lamellocyte differentiation; IMP:FlyBase. DR GO; GO:0007399; P:nervous system development; IMP:FlyBase. DR GO; GO:0007400; P:neuroblast fate determination; IMP:FlyBase. DR GO; GO:0007422; P:peripheral nervous system development; IMP:FlyBase. DR GO; GO:0045807; P:positive regulation of endocytosis; IMP:FlyBase. DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; IMP:FlyBase. DR GO; GO:0008104; P:protein localization; IMP:FlyBase. DR GO; GO:0000209; P:protein polyubiquitination; IDA:FlyBase. DR GO; GO:0045314; P:regulation of compound eye photoreceptor development; IMP:FlyBase. DR GO; GO:0046532; P:regulation of photoreceptor cell differentiation; IMP:FlyBase. DR GO; GO:0007423; P:sensory organ development; IMP:FlyBase. DR GO; GO:0016360; P:sensory organ precursor cell fate determination; IDA:FlyBase. DR GO; GO:0007419; P:ventral cord development; HMP:FlyBase. DR CDD; cd16647; mRING-HC-C3HC5_NEU1; 1. DR Gene3D; 2.60.120.920; -; 2. DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1. DR InterPro; IPR043136; B30.2/SPRY_sf. DR InterPro; IPR037962; Neuralized. DR InterPro; IPR006573; NHR_dom. DR InterPro; IPR001841; Znf_RING. DR InterPro; IPR013083; Znf_RING/FYVE/PHD. DR PANTHER; PTHR12429; NEURALIZED; 1. DR PANTHER; PTHR12429:SF6; PROTEIN NEURALIZED; 1. DR Pfam; PF07177; Neuralized; 2. DR Pfam; PF13920; zf-C3HC4_3; 1. DR SMART; SM00588; NEUZ; 2. DR SMART; SM00184; RING; 1. DR SUPFAM; SSF57850; RING/U-box; 1. DR PROSITE; PS51065; NHR; 2. DR PROSITE; PS50089; ZF_RING_2; 1. DR Genevisible; P29503; DM. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; Developmental protein; Differentiation; KW DNA-binding; Metal-binding; Neurogenesis; Nucleus; Phosphoprotein; KW Reference proteome; Repeat; Zinc; Zinc-finger. FT CHAIN 1..754 FT /note="Protein neuralized" FT /id="PRO_0000055975" FT DOMAIN 106..260 FT /note="NHR 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00400" FT DOMAIN 368..523 FT /note="NHR 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00400" FT ZN_FING 701..742 FT /note="RING-type" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175" FT REGION 280..308 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 338 FT /note="Phosphoserine" FT /evidence="ECO:0000269|PubMed:18327897" FT MOD_RES 341 FT /note="Phosphoserine" FT /evidence="ECO:0000269|PubMed:18327897" FT VAR_SEQ 1..90 FT /note="MGLSDIPANYMQGSHPHLTLHPQQQHHQNQQHLQHLQQMQQLHNAMPTPAQQ FT AAQVLAMESNELLMSTKDKLSSKKKMHLLKKIKKRFGL -> MGQSAGKI (in FT isoform 3 and isoform 4)" FT /evidence="ECO:0000303|PubMed:12537569" FT /id="VSP_008045" FT VAR_SEQ 672 FT /note="Missing (in isoform 2 and isoform 4)" FT /evidence="ECO:0000303|PubMed:12537569, FT ECO:0000303|PubMed:1717258" FT /id="VSP_008046" FT CONFLICT 234 FT /note="T -> S (in Ref. 1; CAA43806)" FT /evidence="ECO:0000305" FT CONFLICT 270 FT /note="A -> V (in Ref. 3; AAB27151)" FT /evidence="ECO:0000305" FT CONFLICT 588 FT /note="T -> N (in Ref. 3; AAB27151)" FT /evidence="ECO:0000305" FT CONFLICT 694 FT /note="S -> R (in Ref. 3; AAB27151)" FT /evidence="ECO:0000305" FT STRAND 109..113 FT /evidence="ECO:0007829|PDB:2YUE" FT STRAND 117..119 FT /evidence="ECO:0007829|PDB:4KG0" FT STRAND 125..128 FT /evidence="ECO:0007829|PDB:4KG0" FT STRAND 130..133 FT /evidence="ECO:0007829|PDB:4KG0" FT STRAND 136..141 FT /evidence="ECO:0007829|PDB:4KG0" FT STRAND 149..156 FT /evidence="ECO:0007829|PDB:4KG0" FT STRAND 158..162 FT /evidence="ECO:0007829|PDB:2YUE" FT STRAND 165..171 FT /evidence="ECO:0007829|PDB:4KG0" FT HELIX 173..176 FT /evidence="ECO:0007829|PDB:4KG0" FT HELIX 184..188 FT /evidence="ECO:0007829|PDB:4KG0" FT STRAND 194..198 FT /evidence="ECO:0007829|PDB:4KG0" FT HELIX 201..203 FT /evidence="ECO:0007829|PDB:4KG0" FT STRAND 209..214 FT /evidence="ECO:0007829|PDB:4KG0" FT STRAND 220..224 FT /evidence="ECO:0007829|PDB:4KG0" FT STRAND 227..233 FT /evidence="ECO:0007829|PDB:4KG0" FT STRAND 242..247 FT /evidence="ECO:0007829|PDB:4KG0" FT STRAND 250..257 FT /evidence="ECO:0007829|PDB:4KG0" FT HELIX 260..263 FT /evidence="ECO:0007829|PDB:2YUE" SQ SEQUENCE 754 AA; 82325 MW; A2887404502D70BF CRC64; MGLSDIPANY MQGSHPHLTL HPQQQHHQNQ QHLQHLQQMQ QLHNAMPTPA QQAAQVLAME SNELLMSTKD KLSSKKKMHL LKKIKKRFGL VRRSPSSCPG PNNLPPLQFH SVHGDNIRIS RDGTLARRFE SFCRAITFSA RPVRINERIC VKFAEISNNW NGGIRFGFTS NDPVTLEGTL PKYACPDLTN RPGFWAKALH EQYCEKDNIL YYYVNGAGDV IYGINNEEKG VILTGIDTRS LLWTVIDIYG NCTGIEFLDS RIYMYQQQPA AIPMATVPAQ QQQMPQPAAN ASSALNSHHP HQQSRRSLPG HTAAIEHDLE RHVMPSLQSL HLAGNGGSVA SVEQAAIAHD LANGLPPLRY NANGRLIPVP FHNTKGRNVR LSQDRFVASR TESDFCQGYV FTARPIRIGE KLIVQVLKTE QMYVGALALG LTSCNPAMLQ PNDLPNDSDF LLDRPEYWVV SKDIAAAPQR GDEIAFFVAP NGEVSISKNN GPAVVVMHVD QSLQLWAFLD VYGSTQSLRM FRQQLPNMVA YPSQPQVNVN ASSSSACNAA STSRMLPMTE SMSSLNAGAT AKLLHHPSQL SVAQSTSTLA SAGGVNGSRM ISMPSNGDIL QIQPNGGGTV LVVNLPPASS SHDINGQLAA RPTATVTSSG VLAGACSSGT LISTTSSQYI EQPIANSTNN AANKWKDSLS DQQSTDSSAE CTICYENPID SVLYMCGHMC MCYDCAIEQW RGVGGGQCPL CRAVIRDVIR TYTT //