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P29503 (NEUR_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein neuralized
Gene names
Name:neur
Synonyms:neu
ORF Names:CG11988
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length754 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in neurogenesis. Interacts with other neurogenic proteins in the specification of the neuroblast versus epidermoblast cell fate.

Subcellular location

Nucleus Potential.

Sequence similarities

Contains 2 NHR (neuralized homology repeat) domains.

Contains 1 RING-type zinc finger.

Sequence caution

The sequence CAA43806.1 differs from that shown. Reason: Frameshift at positions 406, 518, 554 and 709.

Ontologies

Keywords
   Biological processDifferentiation
Neurogenesis
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionDevelopmental protein
   PTMPhosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processasymmetric cell division

Traceable author statement PubMed 15018932. Source: FlyBase

brain morphogenesis

Inferred from mutant phenotype PubMed 18713854. Source: FlyBase

compound eye development

Inferred from mutant phenotype PubMed 11344304. Source: FlyBase

ectoderm development

Traceable author statement PubMed 1913825. Source: FlyBase

germ-line stem cell maintenance

Inferred from mutant phenotype PubMed 17070683. Source: FlyBase

imaginal disc-derived wing morphogenesis

Inferred from mutant phenotype PubMed 15829515. Source: FlyBase

inter-male aggressive behavior

Inferred from mutant phenotype PubMed 19519879. Source: FlyBase

lateral inhibition

Inferred from mutant phenotype PubMed 19363474. Source: FlyBase

locomotion involved in locomotory behavior

Inferred from mutant phenotype PubMed 18713854. Source: FlyBase

long-term memory

Inferred from mutant phenotype PubMed 18794519. Source: FlyBase

mesoderm development

Inferred from mutant phenotype PubMed 1913825. Source: FlyBase

nervous system development

Inferred from mutant phenotype PubMed 11180964. Source: FlyBase

olfactory behavior

Inferred from mutant phenotype PubMed 17028343. Source: FlyBase

ovarian follicle cell development

Traceable author statement PubMed 10822261. Source: FlyBase

peripheral nervous system development

Inferred from mutant phenotype PubMed 11180964PubMed 8060613. Source: FlyBase

positive regulation of Notch signaling pathway

Traceable author statement PubMed 15018932PubMed 15324689. Source: FlyBase

protein homooligomerization

Inferred from physical interaction PubMed 23045391. Source: FlyBase

protein localization

Inferred from mutant phenotype PubMed 15901829. Source: FlyBase

protein ubiquitination

Inferred from direct assay PubMed 11696324PubMed 11740940. Source: GOC

regulation of Notch signaling pathway

Inferred from mutant phenotype PubMed 15930117. Source: FlyBase

regulation of compound eye photoreceptor development

Inferred from mutant phenotype PubMed 15113404. Source: FlyBase

regulation of photoreceptor cell differentiation

Inferred from mutant phenotype PubMed 15113404. Source: FlyBase

sensory organ development

Inferred from mutant phenotype PubMed 10970873. Source: FlyBase

sensory organ precursor cell fate determination

Inferred from mutant phenotype PubMed 10970873PubMed 15829515. Source: FlyBase

startle response

Inferred from mutant phenotype PubMed 18713854. Source: FlyBase

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 12852858PubMed 18061562. Source: FlyBase

cytosol

Traceable author statement. Source: Reactome

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

perinuclear region of cytoplasm

Inferred from direct assay PubMed 12852858. Source: FlyBase

plasma membrane

Inferred from direct assay PubMed 10970873PubMed 11696324PubMed 17065551PubMed 18061562. Source: FlyBase

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphatidylinositol phosphate binding

Inferred from direct assay PubMed 18061562. Source: FlyBase

ubiquitin-protein ligase activity

Inferred from direct assay PubMed 11696324PubMed 11740940. Source: FlyBase

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P29503-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P29503-2)

The sequence of this isoform differs from the canonical sequence as follows:
     672-672: Missing.
Isoform 3 (identifier: P29503-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: MGLSDIPANY...LKKIKKRFGL → MGQSAGKI
Isoform 4 (identifier: P29503-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: MGLSDIPANY...LKKIKKRFGL → MGQSAGKI
     672-672: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 754754Protein neuralized
PRO_0000055975

Regions

Domain106 – 260155NHR 1
Domain368 – 523156NHR 2
Zinc finger701 – 74242RING-type
Compositional bias23 – 5533Gln-rich

Amino acid modifications

Modified residue3381Phosphoserine Ref.7
Modified residue3411Phosphoserine Ref.7

Natural variations

Alternative sequence1 – 9090MGLSD…KRFGL → MGQSAGKI in isoform 3 and isoform 4.
VSP_008045
Alternative sequence6721Missing in isoform 2 and isoform 4.
VSP_008046

Experimental info

Sequence conflict2341T → S in CAA43806. Ref.1
Sequence conflict2701A → V in AAB27151. Ref.3
Sequence conflict5881T → N in AAB27151. Ref.3
Sequence conflict6941S → R in AAB27151. Ref.3

Secondary structure

..................................... 754
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 22, 2003. Version 2.
Checksum: A2887404502D70BF

FASTA75482,325
        10         20         30         40         50         60 
MGLSDIPANY MQGSHPHLTL HPQQQHHQNQ QHLQHLQQMQ QLHNAMPTPA QQAAQVLAME 

        70         80         90        100        110        120 
SNELLMSTKD KLSSKKKMHL LKKIKKRFGL VRRSPSSCPG PNNLPPLQFH SVHGDNIRIS 

       130        140        150        160        170        180 
RDGTLARRFE SFCRAITFSA RPVRINERIC VKFAEISNNW NGGIRFGFTS NDPVTLEGTL 

       190        200        210        220        230        240 
PKYACPDLTN RPGFWAKALH EQYCEKDNIL YYYVNGAGDV IYGINNEEKG VILTGIDTRS 

       250        260        270        280        290        300 
LLWTVIDIYG NCTGIEFLDS RIYMYQQQPA AIPMATVPAQ QQQMPQPAAN ASSALNSHHP 

       310        320        330        340        350        360 
HQQSRRSLPG HTAAIEHDLE RHVMPSLQSL HLAGNGGSVA SVEQAAIAHD LANGLPPLRY 

       370        380        390        400        410        420 
NANGRLIPVP FHNTKGRNVR LSQDRFVASR TESDFCQGYV FTARPIRIGE KLIVQVLKTE 

       430        440        450        460        470        480 
QMYVGALALG LTSCNPAMLQ PNDLPNDSDF LLDRPEYWVV SKDIAAAPQR GDEIAFFVAP 

       490        500        510        520        530        540 
NGEVSISKNN GPAVVVMHVD QSLQLWAFLD VYGSTQSLRM FRQQLPNMVA YPSQPQVNVN 

       550        560        570        580        590        600 
ASSSSACNAA STSRMLPMTE SMSSLNAGAT AKLLHHPSQL SVAQSTSTLA SAGGVNGSRM 

       610        620        630        640        650        660 
ISMPSNGDIL QIQPNGGGTV LVVNLPPASS SHDINGQLAA RPTATVTSSG VLAGACSSGT 

       670        680        690        700        710        720 
LISTTSSQYI EQPIANSTNN AANKWKDSLS DQQSTDSSAE CTICYENPID SVLYMCGHMC 

       730        740        750 
MCYDCAIEQW RGVGGGQCPL CRAVIRDVIR TYTT 

« Hide

Isoform 2 [UniParc].

Checksum: 0BEE640647D6AA6B
Show »

FASTA75382,197
Isoform 3 [UniParc].

Checksum: 7D667F45BDC26916
Show »

FASTA67272,753
Isoform 4 [UniParc].

Checksum: 95E525EBA8CF03EE
Show »

FASTA67172,625

References

« Hide 'large scale' references
[1]"The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons."
Boulianne G.L., de la Concha A., Campos-Ortega J.A., Jan L.Y., Jan Y.N.
EMBO J. 10:2975-2983(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2).
Strain: Oregon-R.
[2]Erratum
Boulianne G.L., de la Concha A., Campos-Ortega J.A., Jan L.Y., Jan Y.N.
EMBO J. 12:2586-2586(1993) [PubMed] [Europe PMC] [Abstract]
[3]"The Drosophila neuralized gene encodes a C3HC4 zinc finger."
Price B.D., Chang Z., Smith R., Bockheim S., Laughon A.
EMBO J. 12:2411-2418(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[5]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[6]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
Strain: Berkeley.
[7]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-338 AND SER-341, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Embryo.
[8]"Solution structure of the neuz (NHR) domain in neuralized from Drosophila melanogaster."
RIKEN structural genomics initiative (RSGI)
Submitted (OCT-2007) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 106-266.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X61617 Genomic DNA. Translation: CAA43806.1. Frameshift.
S62597 mRNA. Translation: AAB27151.1.
S62583 mRNA. Translation: AAB27147.1.
L12218 mRNA. Translation: AAA28403.1.
AE014297 Genomic DNA. Translation: AAF54330.1.
AE014297 Genomic DNA. Translation: AAF54326.2.
AE014297 Genomic DNA. Translation: AAN13406.1.
AE014297 Genomic DNA. Translation: AAN13407.1.
AY051987 mRNA. Translation: AAK93411.1.
BT003772 mRNA. Translation: AAO41451.1.
PIRS35371.
S35503.
RefSeqNP_001163563.1. NM_001170092.2.
NP_476652.1. NM_057304.4.
NP_731309.1. NM_169255.2.
NP_731310.1. NM_169256.2.
NP_731311.1. NM_169257.2.
UniGeneDm.1114.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2YUENMR-A106-266[»]
4KG0X-ray2.10A105-260[»]
ProteinModelPortalP29503.
SMRP29503. Positions 106-266, 362-525, 700-749.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid66253. 15 interactions.
DIPDIP-17176N.
IntActP29503. 3 interactions.
MINTMINT-336530.

Proteomic databases

PaxDbP29503.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0082003; FBpp0081481; FBgn0002932. [P29503-1]
GeneID41085.
KEGGdme:Dmel_CG11988.
UCSCCG11988-RA. d. melanogaster. [P29503-1]

Organism-specific databases

CTD41085.
FlyBaseFBgn0002932. neur.

Phylogenomic databases

eggNOGNOG145384.
GeneTreeENSGT00530000063117.
InParanoidP29503.
KOK01931.
OMAAIPCGPR.
OrthoDBEOG7C2R0S.
PhylomeDBP29503.

Enzyme and pathway databases

SignaLinkP29503.

Gene expression databases

BgeeP29503.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR006573. Neu_Z.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF07177. Neuralized. 2 hits.
[Graphical view]
SMARTSM00588. NEUZ. 2 hits.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEPS51065. NHR. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNrt. drosophila.
EvolutionaryTraceP29503.
GenomeRNAi41085.
NextBio822080.

Entry information

Entry nameNEUR_DROME
AccessionPrimary (citable) accession number: P29503
Secondary accession number(s): Q26306 expand/collapse secondary AC list , Q27273, Q8INP6, Q8INP7, Q960M1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: August 22, 2003
Last modified: April 16, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase