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P29503

- NEUR_DROME

UniProt

P29503 - NEUR_DROME

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Protein
Protein neuralized
Gene
neur, neu, CG11988
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in neurogenesis. Interacts with other neurogenic proteins in the specification of the neuroblast versus epidermoblast cell fate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri701 – 74242RING-type
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. phosphatidylinositol phosphate binding Source: FlyBase
  3. protein binding Source: FlyBase
  4. ubiquitin-protein transferase activity Source: FlyBase
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. asymmetric cell division Source: FlyBase
  2. brain morphogenesis Source: FlyBase
  3. compound eye development Source: FlyBase
  4. ectoderm development Source: FlyBase
  5. germ-line stem cell maintenance Source: FlyBase
  6. imaginal disc-derived wing morphogenesis Source: FlyBase
  7. inter-male aggressive behavior Source: FlyBase
  8. lateral inhibition Source: FlyBase
  9. locomotion involved in locomotory behavior Source: FlyBase
  10. long-term memory Source: FlyBase
  11. mesoderm development Source: FlyBase
  12. nervous system development Source: FlyBase
  13. olfactory behavior Source: FlyBase
  14. ovarian follicle cell development Source: FlyBase
  15. peripheral nervous system development Source: FlyBase
  16. positive regulation of Notch signaling pathway Source: FlyBase
  17. protein homooligomerization Source: FlyBase
  18. protein localization Source: FlyBase
  19. protein ubiquitination Source: GOC
  20. regulation of Notch signaling pathway Source: FlyBase
  21. regulation of compound eye photoreceptor development Source: FlyBase
  22. regulation of photoreceptor cell differentiation Source: FlyBase
  23. sensory organ development Source: FlyBase
  24. sensory organ precursor cell fate determination Source: FlyBase
  25. startle response Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_221100. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_225574. Activated NOTCH1 Transmits Signal to the Nucleus.
SignaLinkiP29503.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein neuralized
Gene namesi
Name:neur
Synonyms:neu
ORF Names:CG11988
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0002932. neur.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: FlyBase
  2. cytosol Source: Reactome
  3. nucleus Source: UniProtKB-SubCell
  4. perinuclear region of cytoplasm Source: FlyBase
  5. plasma membrane Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 754754Protein neuralized
PRO_0000055975Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei338 – 3381Phosphoserine1 Publication
Modified residuei341 – 3411Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP29503.

Expressioni

Gene expression databases

BgeeiP29503.

Interactioni

Protein-protein interaction databases

BioGridi66253. 15 interactions.
DIPiDIP-17176N.
IntActiP29503. 3 interactions.
MINTiMINT-336530.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi109 – 1135
Beta strandi117 – 1193
Beta strandi125 – 1284
Beta strandi130 – 1334
Beta strandi136 – 1416
Beta strandi149 – 1568
Beta strandi158 – 1625
Beta strandi165 – 1717
Helixi173 – 1764
Helixi184 – 1885
Beta strandi194 – 1985
Helixi201 – 2033
Beta strandi209 – 2146
Beta strandi220 – 2245
Beta strandi227 – 2337
Beta strandi242 – 2476
Beta strandi250 – 2578
Helixi260 – 2634

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YUENMR-A106-266[»]
4KG0X-ray2.10A105-260[»]
ProteinModelPortaliP29503.
SMRiP29503. Positions 106-266, 362-525, 699-747.

Miscellaneous databases

EvolutionaryTraceiP29503.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini106 – 260155NHR 1
Add
BLAST
Domaini368 – 523156NHR 2
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi23 – 5533Gln-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG145384.
GeneTreeiENSGT00530000063117.
InParanoidiP29503.
KOiK01931.
OMAiAIPCGPR.
OrthoDBiEOG7C2R0S.
PhylomeDBiP29503.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR006573. Neu_Z.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF07177. Neuralized. 2 hits.
[Graphical view]
SMARTiSM00588. NEUZ. 2 hits.
SM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS51065. NHR. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P29503-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGLSDIPANY MQGSHPHLTL HPQQQHHQNQ QHLQHLQQMQ QLHNAMPTPA    50
QQAAQVLAME SNELLMSTKD KLSSKKKMHL LKKIKKRFGL VRRSPSSCPG 100
PNNLPPLQFH SVHGDNIRIS RDGTLARRFE SFCRAITFSA RPVRINERIC 150
VKFAEISNNW NGGIRFGFTS NDPVTLEGTL PKYACPDLTN RPGFWAKALH 200
EQYCEKDNIL YYYVNGAGDV IYGINNEEKG VILTGIDTRS LLWTVIDIYG 250
NCTGIEFLDS RIYMYQQQPA AIPMATVPAQ QQQMPQPAAN ASSALNSHHP 300
HQQSRRSLPG HTAAIEHDLE RHVMPSLQSL HLAGNGGSVA SVEQAAIAHD 350
LANGLPPLRY NANGRLIPVP FHNTKGRNVR LSQDRFVASR TESDFCQGYV 400
FTARPIRIGE KLIVQVLKTE QMYVGALALG LTSCNPAMLQ PNDLPNDSDF 450
LLDRPEYWVV SKDIAAAPQR GDEIAFFVAP NGEVSISKNN GPAVVVMHVD 500
QSLQLWAFLD VYGSTQSLRM FRQQLPNMVA YPSQPQVNVN ASSSSACNAA 550
STSRMLPMTE SMSSLNAGAT AKLLHHPSQL SVAQSTSTLA SAGGVNGSRM 600
ISMPSNGDIL QIQPNGGGTV LVVNLPPASS SHDINGQLAA RPTATVTSSG 650
VLAGACSSGT LISTTSSQYI EQPIANSTNN AANKWKDSLS DQQSTDSSAE 700
CTICYENPID SVLYMCGHMC MCYDCAIEQW RGVGGGQCPL CRAVIRDVIR 750
TYTT 754
Length:754
Mass (Da):82,325
Last modified:August 22, 2003 - v2
Checksum:iA2887404502D70BF
GO
Isoform 2 (identifier: P29503-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     672-672: Missing.

Show »
Length:753
Mass (Da):82,197
Checksum:i0BEE640647D6AA6B
GO
Isoform 3 (identifier: P29503-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: MGLSDIPANY...LKKIKKRFGL → MGQSAGKI

Show »
Length:672
Mass (Da):72,753
Checksum:i7D667F45BDC26916
GO
Isoform 4 (identifier: P29503-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: MGLSDIPANY...LKKIKKRFGL → MGQSAGKI
     672-672: Missing.

Show »
Length:671
Mass (Da):72,625
Checksum:i95E525EBA8CF03EE
GO

Sequence cautioni

The sequence CAA43806.1 differs from that shown. Reason: Frameshift at positions 406, 518, 554 and 709.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9090MGLSD…KRFGL → MGQSAGKI in isoform 3 and isoform 4.
VSP_008045Add
BLAST
Alternative sequencei672 – 6721Missing in isoform 2 and isoform 4.
VSP_008046

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti234 – 2341T → S in CAA43806. 1 Publication
Sequence conflicti270 – 2701A → V in AAB27151. 1 Publication
Sequence conflicti588 – 5881T → N in AAB27151. 1 Publication
Sequence conflicti694 – 6941S → R in AAB27151. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61617 Genomic DNA. Translation: CAA43806.1. Frameshift.
S62597 mRNA. Translation: AAB27151.1.
S62583 mRNA. Translation: AAB27147.1.
L12218 mRNA. Translation: AAA28403.1.
AE014297 Genomic DNA. Translation: AAF54330.1.
AE014297 Genomic DNA. Translation: AAF54326.2.
AE014297 Genomic DNA. Translation: AAN13406.1.
AE014297 Genomic DNA. Translation: AAN13407.1.
AY051987 mRNA. Translation: AAK93411.1.
BT003772 mRNA. Translation: AAO41451.1.
PIRiS35371.
S35503.
RefSeqiNP_001163563.1. NM_001170092.2. [P29503-3]
NP_476652.1. NM_057304.4. [P29503-1]
NP_731309.1. NM_169255.2. [P29503-4]
NP_731310.1. NM_169256.2. [P29503-3]
NP_731311.1. NM_169257.2. [P29503-2]
UniGeneiDm.1114.

Genome annotation databases

EnsemblMetazoaiFBtr0082003; FBpp0081481; FBgn0002932. [P29503-1]
GeneIDi41085.
KEGGidme:Dmel_CG11988.
UCSCiCG11988-RA. d. melanogaster. [P29503-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61617 Genomic DNA. Translation: CAA43806.1 . Frameshift.
S62597 mRNA. Translation: AAB27151.1 .
S62583 mRNA. Translation: AAB27147.1 .
L12218 mRNA. Translation: AAA28403.1 .
AE014297 Genomic DNA. Translation: AAF54330.1 .
AE014297 Genomic DNA. Translation: AAF54326.2 .
AE014297 Genomic DNA. Translation: AAN13406.1 .
AE014297 Genomic DNA. Translation: AAN13407.1 .
AY051987 mRNA. Translation: AAK93411.1 .
BT003772 mRNA. Translation: AAO41451.1 .
PIRi S35371.
S35503.
RefSeqi NP_001163563.1. NM_001170092.2. [P29503-3 ]
NP_476652.1. NM_057304.4. [P29503-1 ]
NP_731309.1. NM_169255.2. [P29503-4 ]
NP_731310.1. NM_169256.2. [P29503-3 ]
NP_731311.1. NM_169257.2. [P29503-2 ]
UniGenei Dm.1114.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2YUE NMR - A 106-266 [» ]
4KG0 X-ray 2.10 A 105-260 [» ]
ProteinModelPortali P29503.
SMRi P29503. Positions 106-266, 362-525, 699-747.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 66253. 15 interactions.
DIPi DIP-17176N.
IntActi P29503. 3 interactions.
MINTi MINT-336530.

Proteomic databases

PaxDbi P29503.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0082003 ; FBpp0081481 ; FBgn0002932 . [P29503-1 ]
GeneIDi 41085.
KEGGi dme:Dmel_CG11988.
UCSCi CG11988-RA. d. melanogaster. [P29503-1 ]

Organism-specific databases

CTDi 41085.
FlyBasei FBgn0002932. neur.

Phylogenomic databases

eggNOGi NOG145384.
GeneTreei ENSGT00530000063117.
InParanoidi P29503.
KOi K01931.
OMAi AIPCGPR.
OrthoDBi EOG7C2R0S.
PhylomeDBi P29503.

Enzyme and pathway databases

Reactomei REACT_221100. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_225574. Activated NOTCH1 Transmits Signal to the Nucleus.
SignaLinki P29503.

Miscellaneous databases

ChiTaRSi Nrt. drosophila.
EvolutionaryTracei P29503.
GenomeRNAii 41085.
NextBioi 822080.

Gene expression databases

Bgeei P29503.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR006573. Neu_Z.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF07177. Neuralized. 2 hits.
[Graphical view ]
SMARTi SM00588. NEUZ. 2 hits.
SM00184. RING. 1 hit.
[Graphical view ]
PROSITEi PS51065. NHR. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons."
    Boulianne G.L., de la Concha A., Campos-Ortega J.A., Jan L.Y., Jan Y.N.
    EMBO J. 10:2975-2983(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2).
    Strain: Oregon-R.
  2. "The Drosophila neuralized gene encodes a C3HC4 zinc finger."
    Price B.D., Chang Z., Smith R., Bockheim S., Laughon A.
    EMBO J. 12:2411-2418(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Strain: Berkeley.
  6. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-338 AND SER-341, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.
  7. "Solution structure of the neuz (NHR) domain in neuralized from Drosophila melanogaster."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 106-266.

Entry informationi

Entry nameiNEUR_DROME
AccessioniPrimary (citable) accession number: P29503
Secondary accession number(s): Q26306
, Q27273, Q8INP6, Q8INP7, Q960M1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: August 22, 2003
Last modified: September 3, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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