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Protein

Protein neuralized

Gene

neur

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in neurogenesis. Interacts with other neurogenic proteins in the specification of the neuroblast versus epidermoblast cell fate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri701 – 742RING-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

GO - Biological processi

  • asymmetric cell division Source: FlyBase
  • compound eye development Source: FlyBase
  • ectoderm development Source: FlyBase
  • germ-line stem cell population maintenance Source: FlyBase
  • imaginal disc-derived wing morphogenesis Source: FlyBase
  • long-term memory Source: FlyBase
  • mesoderm development Source: FlyBase
  • negative regulation of lamellocyte differentiation Source: FlyBase
  • nervous system development Source: FlyBase
  • ovarian follicle cell development Source: FlyBase
  • peripheral nervous system development Source: FlyBase
  • positive regulation of Notch signaling pathway Source: FlyBase
  • protein homooligomerization Source: FlyBase
  • protein localization Source: FlyBase
  • protein polyubiquitination Source: FlyBase
  • regulation of compound eye photoreceptor development Source: FlyBase
  • regulation of Notch signaling pathway Source: FlyBase
  • regulation of photoreceptor cell differentiation Source: FlyBase
  • sensory organ development Source: FlyBase
  • sensory organ precursor cell fate determination Source: FlyBase
  • ventral cord development Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLinkiP29503

Names & Taxonomyi

Protein namesi
Recommended name:
Protein neuralized
Gene namesi
Name:neur
Synonyms:neu
ORF Names:CG11988
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0002932 neur

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000559751 – 754Protein neuralizedAdd BLAST754

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei338Phosphoserine1 Publication1
Modified residuei341Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP29503
PRIDEiP29503

PTM databases

iPTMnetiP29503

Expressioni

Gene expression databases

BgeeiFBgn0002932
ExpressionAtlasiP29503 baseline and differential
GenevisibleiP29503 DM

Interactioni

Protein-protein interaction databases

BioGridi66253, 28 interactors
DIPiDIP-17176N
IntActiP29503, 4 interactors
MINTiP29503
STRINGi7227.FBpp0081481

Structurei

Secondary structure

1754
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi109 – 113Combined sources5
Beta strandi117 – 119Combined sources3
Beta strandi125 – 128Combined sources4
Beta strandi130 – 133Combined sources4
Beta strandi136 – 141Combined sources6
Beta strandi149 – 156Combined sources8
Beta strandi158 – 162Combined sources5
Beta strandi165 – 171Combined sources7
Helixi173 – 176Combined sources4
Helixi184 – 188Combined sources5
Beta strandi194 – 198Combined sources5
Helixi201 – 203Combined sources3
Beta strandi209 – 214Combined sources6
Beta strandi220 – 224Combined sources5
Beta strandi227 – 233Combined sources7
Beta strandi242 – 247Combined sources6
Beta strandi250 – 257Combined sources8
Helixi260 – 263Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YUENMR-A106-266[»]
4KG0X-ray2.10A105-260[»]
ProteinModelPortaliP29503
SMRiP29503
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29503

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini106 – 260NHR 1PROSITE-ProRule annotationAdd BLAST155
Domaini368 – 523NHR 2PROSITE-ProRule annotationAdd BLAST156

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi23 – 55Gln-richAdd BLAST33

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri701 – 742RING-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG4172 Eukaryota
KOG4625 Eukaryota
ENOG410ZMNG LUCA
GeneTreeiENSGT00530000063117
InParanoidiP29503
KOiK01931
OMAiCPPVLPG
OrthoDBiEOG091G05BB
PhylomeDBiP29503

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR037962 Neuralized
IPR006573 NHR_dom
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR12429 PTHR12429, 1 hit
PfamiView protein in Pfam
PF07177 Neuralized, 2 hits
SMARTiView protein in SMART
SM00588 NEUZ, 2 hits
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS51065 NHR, 2 hits
PS50089 ZF_RING_2, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P29503-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLSDIPANY MQGSHPHLTL HPQQQHHQNQ QHLQHLQQMQ QLHNAMPTPA
60 70 80 90 100
QQAAQVLAME SNELLMSTKD KLSSKKKMHL LKKIKKRFGL VRRSPSSCPG
110 120 130 140 150
PNNLPPLQFH SVHGDNIRIS RDGTLARRFE SFCRAITFSA RPVRINERIC
160 170 180 190 200
VKFAEISNNW NGGIRFGFTS NDPVTLEGTL PKYACPDLTN RPGFWAKALH
210 220 230 240 250
EQYCEKDNIL YYYVNGAGDV IYGINNEEKG VILTGIDTRS LLWTVIDIYG
260 270 280 290 300
NCTGIEFLDS RIYMYQQQPA AIPMATVPAQ QQQMPQPAAN ASSALNSHHP
310 320 330 340 350
HQQSRRSLPG HTAAIEHDLE RHVMPSLQSL HLAGNGGSVA SVEQAAIAHD
360 370 380 390 400
LANGLPPLRY NANGRLIPVP FHNTKGRNVR LSQDRFVASR TESDFCQGYV
410 420 430 440 450
FTARPIRIGE KLIVQVLKTE QMYVGALALG LTSCNPAMLQ PNDLPNDSDF
460 470 480 490 500
LLDRPEYWVV SKDIAAAPQR GDEIAFFVAP NGEVSISKNN GPAVVVMHVD
510 520 530 540 550
QSLQLWAFLD VYGSTQSLRM FRQQLPNMVA YPSQPQVNVN ASSSSACNAA
560 570 580 590 600
STSRMLPMTE SMSSLNAGAT AKLLHHPSQL SVAQSTSTLA SAGGVNGSRM
610 620 630 640 650
ISMPSNGDIL QIQPNGGGTV LVVNLPPASS SHDINGQLAA RPTATVTSSG
660 670 680 690 700
VLAGACSSGT LISTTSSQYI EQPIANSTNN AANKWKDSLS DQQSTDSSAE
710 720 730 740 750
CTICYENPID SVLYMCGHMC MCYDCAIEQW RGVGGGQCPL CRAVIRDVIR

TYTT
Length:754
Mass (Da):82,325
Last modified:August 22, 2003 - v2
Checksum:iA2887404502D70BF
GO
Isoform 2 (identifier: P29503-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     672-672: Missing.

Show »
Length:753
Mass (Da):82,197
Checksum:i0BEE640647D6AA6B
GO
Isoform 3 (identifier: P29503-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: MGLSDIPANY...LKKIKKRFGL → MGQSAGKI

Show »
Length:672
Mass (Da):72,753
Checksum:i7D667F45BDC26916
GO
Isoform 4 (identifier: P29503-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: MGLSDIPANY...LKKIKKRFGL → MGQSAGKI
     672-672: Missing.

Show »
Length:671
Mass (Da):72,625
Checksum:i95E525EBA8CF03EE
GO

Sequence cautioni

The sequence CAA43806 differs from that shown. Reason: Frameshift at positions 406, 518, 554 and 709.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti234T → S in CAA43806 (PubMed:1717258).Curated1
Sequence conflicti270A → V in AAB27151 (PubMed:8508767).Curated1
Sequence conflicti588T → N in AAB27151 (PubMed:8508767).Curated1
Sequence conflicti694S → R in AAB27151 (PubMed:8508767).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0080451 – 90MGLSD…KRFGL → MGQSAGKI in isoform 3 and isoform 4. 1 PublicationAdd BLAST90
Alternative sequenceiVSP_008046672Missing in isoform 2 and isoform 4. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61617 Genomic DNA Translation: CAA43806.1 Frameshift.
S62597 mRNA Translation: AAB27151.1
S62583 mRNA Translation: AAB27147.1
L12218 mRNA Translation: AAA28403.1
AE014297 Genomic DNA Translation: AAF54330.1
AE014297 Genomic DNA Translation: AAF54326.2
AE014297 Genomic DNA Translation: AAN13406.1
AE014297 Genomic DNA Translation: AAN13407.1
AY051987 mRNA Translation: AAK93411.1
BT003772 mRNA Translation: AAO41451.1
PIRiS35371
S35503
RefSeqiNP_001163563.1, NM_001170092.3 [P29503-3]
NP_476652.1, NM_057304.5 [P29503-1]
NP_731309.1, NM_169255.3 [P29503-4]
NP_731310.1, NM_169256.3 [P29503-3]
NP_731311.1, NM_169257.3 [P29503-2]
UniGeneiDm.1114

Genome annotation databases

EnsemblMetazoaiFBtr0082001; FBpp0081479; FBgn0002932 [P29503-3]
FBtr0082002; FBpp0081480; FBgn0002932 [P29503-4]
FBtr0082003; FBpp0081481; FBgn0002932 [P29503-1]
FBtr0082004; FBpp0081482; FBgn0002932 [P29503-2]
FBtr0300414; FBpp0289643; FBgn0002932 [P29503-3]
GeneIDi41085
KEGGidme:Dmel_CG11988
UCSCiCG11988-RA d. melanogaster [P29503-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNEUR_DROME
AccessioniPrimary (citable) accession number: P29503
Secondary accession number(s): Q26306
, Q27273, Q8INP6, Q8INP7, Q960M1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: August 22, 2003
Last modified: May 23, 2018
This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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