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P29503

- NEUR_DROME

UniProt

P29503 - NEUR_DROME

Protein

Protein neuralized

Gene

neur

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 2 (22 Aug 2003)
      Previous versions | rss
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    Functioni

    Involved in neurogenesis. Interacts with other neurogenic proteins in the specification of the neuroblast versus epidermoblast cell fate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri701 – 74242RING-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. phosphatidylinositol phosphate binding Source: FlyBase
    3. protein binding Source: FlyBase
    4. ubiquitin-protein transferase activity Source: FlyBase
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. asymmetric cell division Source: FlyBase
    2. brain morphogenesis Source: FlyBase
    3. compound eye development Source: FlyBase
    4. ectoderm development Source: FlyBase
    5. germ-line stem cell maintenance Source: FlyBase
    6. imaginal disc-derived wing morphogenesis Source: FlyBase
    7. inter-male aggressive behavior Source: FlyBase
    8. lateral inhibition Source: FlyBase
    9. locomotion involved in locomotory behavior Source: FlyBase
    10. long-term memory Source: FlyBase
    11. mesoderm development Source: FlyBase
    12. nervous system development Source: FlyBase
    13. olfactory behavior Source: FlyBase
    14. ovarian follicle cell development Source: FlyBase
    15. peripheral nervous system development Source: FlyBase
    16. positive regulation of Notch signaling pathway Source: FlyBase
    17. protein homooligomerization Source: FlyBase
    18. protein localization Source: FlyBase
    19. protein ubiquitination Source: GOC
    20. regulation of compound eye photoreceptor development Source: FlyBase
    21. regulation of Notch signaling pathway Source: FlyBase
    22. regulation of photoreceptor cell differentiation Source: FlyBase
    23. sensory organ development Source: FlyBase
    24. sensory organ precursor cell fate determination Source: FlyBase
    25. startle response Source: FlyBase

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_221100. NOTCH2 Activation and Transmission of Signal to the Nucleus.
    REACT_225574. Activated NOTCH1 Transmits Signal to the Nucleus.
    SignaLinkiP29503.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein neuralized
    Gene namesi
    Name:neur
    Synonyms:neu
    ORF Names:CG11988
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3R

    Organism-specific databases

    FlyBaseiFBgn0002932. neur.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. cytoplasm Source: FlyBase
    2. cytosol Source: Reactome
    3. nucleus Source: UniProtKB-SubCell
    4. perinuclear region of cytoplasm Source: FlyBase
    5. plasma membrane Source: FlyBase

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 754754Protein neuralizedPRO_0000055975Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei338 – 3381Phosphoserine1 Publication
    Modified residuei341 – 3411Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP29503.

    Expressioni

    Gene expression databases

    BgeeiP29503.

    Interactioni

    Protein-protein interaction databases

    BioGridi66253. 15 interactions.
    DIPiDIP-17176N.
    IntActiP29503. 3 interactions.
    MINTiMINT-336530.

    Structurei

    Secondary structure

    1
    754
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi109 – 1135
    Beta strandi117 – 1193
    Beta strandi125 – 1284
    Beta strandi130 – 1334
    Beta strandi136 – 1416
    Beta strandi149 – 1568
    Beta strandi158 – 1625
    Beta strandi165 – 1717
    Helixi173 – 1764
    Helixi184 – 1885
    Beta strandi194 – 1985
    Helixi201 – 2033
    Beta strandi209 – 2146
    Beta strandi220 – 2245
    Beta strandi227 – 2337
    Beta strandi242 – 2476
    Beta strandi250 – 2578
    Helixi260 – 2634

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2YUENMR-A106-266[»]
    4KG0X-ray2.10A105-260[»]
    ProteinModelPortaliP29503.
    SMRiP29503. Positions 106-266, 362-525, 699-747.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP29503.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini106 – 260155NHR 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini368 – 523156NHR 2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi23 – 5533Gln-richAdd
    BLAST

    Sequence similaritiesi

    Contains 2 NHR (neuralized homology repeat) domains.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri701 – 74242RING-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG145384.
    GeneTreeiENSGT00530000063117.
    InParanoidiP29503.
    KOiK01931.
    OMAiAIPCGPR.
    OrthoDBiEOG7C2R0S.
    PhylomeDBiP29503.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR006573. Neu_Z.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF07177. Neuralized. 2 hits.
    [Graphical view]
    SMARTiSM00588. NEUZ. 2 hits.
    SM00184. RING. 1 hit.
    [Graphical view]
    PROSITEiPS51065. NHR. 2 hits.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P29503-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGLSDIPANY MQGSHPHLTL HPQQQHHQNQ QHLQHLQQMQ QLHNAMPTPA    50
    QQAAQVLAME SNELLMSTKD KLSSKKKMHL LKKIKKRFGL VRRSPSSCPG 100
    PNNLPPLQFH SVHGDNIRIS RDGTLARRFE SFCRAITFSA RPVRINERIC 150
    VKFAEISNNW NGGIRFGFTS NDPVTLEGTL PKYACPDLTN RPGFWAKALH 200
    EQYCEKDNIL YYYVNGAGDV IYGINNEEKG VILTGIDTRS LLWTVIDIYG 250
    NCTGIEFLDS RIYMYQQQPA AIPMATVPAQ QQQMPQPAAN ASSALNSHHP 300
    HQQSRRSLPG HTAAIEHDLE RHVMPSLQSL HLAGNGGSVA SVEQAAIAHD 350
    LANGLPPLRY NANGRLIPVP FHNTKGRNVR LSQDRFVASR TESDFCQGYV 400
    FTARPIRIGE KLIVQVLKTE QMYVGALALG LTSCNPAMLQ PNDLPNDSDF 450
    LLDRPEYWVV SKDIAAAPQR GDEIAFFVAP NGEVSISKNN GPAVVVMHVD 500
    QSLQLWAFLD VYGSTQSLRM FRQQLPNMVA YPSQPQVNVN ASSSSACNAA 550
    STSRMLPMTE SMSSLNAGAT AKLLHHPSQL SVAQSTSTLA SAGGVNGSRM 600
    ISMPSNGDIL QIQPNGGGTV LVVNLPPASS SHDINGQLAA RPTATVTSSG 650
    VLAGACSSGT LISTTSSQYI EQPIANSTNN AANKWKDSLS DQQSTDSSAE 700
    CTICYENPID SVLYMCGHMC MCYDCAIEQW RGVGGGQCPL CRAVIRDVIR 750
    TYTT 754
    Length:754
    Mass (Da):82,325
    Last modified:August 22, 2003 - v2
    Checksum:iA2887404502D70BF
    GO
    Isoform 2 (identifier: P29503-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         672-672: Missing.

    Show »
    Length:753
    Mass (Da):82,197
    Checksum:i0BEE640647D6AA6B
    GO
    Isoform 3 (identifier: P29503-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-90: MGLSDIPANY...LKKIKKRFGL → MGQSAGKI

    Show »
    Length:672
    Mass (Da):72,753
    Checksum:i7D667F45BDC26916
    GO
    Isoform 4 (identifier: P29503-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-90: MGLSDIPANY...LKKIKKRFGL → MGQSAGKI
         672-672: Missing.

    Show »
    Length:671
    Mass (Da):72,625
    Checksum:i95E525EBA8CF03EE
    GO

    Sequence cautioni

    The sequence CAA43806.1 differs from that shown. Reason: Frameshift at positions 406, 518, 554 and 709.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti234 – 2341T → S in CAA43806. (PubMed:1717258)Curated
    Sequence conflicti270 – 2701A → V in AAB27151. (PubMed:8508767)Curated
    Sequence conflicti588 – 5881T → N in AAB27151. (PubMed:8508767)Curated
    Sequence conflicti694 – 6941S → R in AAB27151. (PubMed:8508767)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9090MGLSD…KRFGL → MGQSAGKI in isoform 3 and isoform 4. 1 PublicationVSP_008045Add
    BLAST
    Alternative sequencei672 – 6721Missing in isoform 2 and isoform 4. 2 PublicationsVSP_008046

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X61617 Genomic DNA. Translation: CAA43806.1. Frameshift.
    S62597 mRNA. Translation: AAB27151.1.
    S62583 mRNA. Translation: AAB27147.1.
    L12218 mRNA. Translation: AAA28403.1.
    AE014297 Genomic DNA. Translation: AAF54330.1.
    AE014297 Genomic DNA. Translation: AAF54326.2.
    AE014297 Genomic DNA. Translation: AAN13406.1.
    AE014297 Genomic DNA. Translation: AAN13407.1.
    AY051987 mRNA. Translation: AAK93411.1.
    BT003772 mRNA. Translation: AAO41451.1.
    PIRiS35371.
    S35503.
    RefSeqiNP_001163563.1. NM_001170092.2. [P29503-3]
    NP_476652.1. NM_057304.4. [P29503-1]
    NP_731309.1. NM_169255.2. [P29503-4]
    NP_731310.1. NM_169256.2. [P29503-3]
    NP_731311.1. NM_169257.2. [P29503-2]
    UniGeneiDm.1114.

    Genome annotation databases

    EnsemblMetazoaiFBtr0082003; FBpp0081481; FBgn0002932. [P29503-1]
    GeneIDi41085.
    KEGGidme:Dmel_CG11988.
    UCSCiCG11988-RA. d. melanogaster. [P29503-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X61617 Genomic DNA. Translation: CAA43806.1 . Frameshift.
    S62597 mRNA. Translation: AAB27151.1 .
    S62583 mRNA. Translation: AAB27147.1 .
    L12218 mRNA. Translation: AAA28403.1 .
    AE014297 Genomic DNA. Translation: AAF54330.1 .
    AE014297 Genomic DNA. Translation: AAF54326.2 .
    AE014297 Genomic DNA. Translation: AAN13406.1 .
    AE014297 Genomic DNA. Translation: AAN13407.1 .
    AY051987 mRNA. Translation: AAK93411.1 .
    BT003772 mRNA. Translation: AAO41451.1 .
    PIRi S35371.
    S35503.
    RefSeqi NP_001163563.1. NM_001170092.2. [P29503-3 ]
    NP_476652.1. NM_057304.4. [P29503-1 ]
    NP_731309.1. NM_169255.2. [P29503-4 ]
    NP_731310.1. NM_169256.2. [P29503-3 ]
    NP_731311.1. NM_169257.2. [P29503-2 ]
    UniGenei Dm.1114.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2YUE NMR - A 106-266 [» ]
    4KG0 X-ray 2.10 A 105-260 [» ]
    ProteinModelPortali P29503.
    SMRi P29503. Positions 106-266, 362-525, 699-747.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 66253. 15 interactions.
    DIPi DIP-17176N.
    IntActi P29503. 3 interactions.
    MINTi MINT-336530.

    Proteomic databases

    PaxDbi P29503.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0082003 ; FBpp0081481 ; FBgn0002932 . [P29503-1 ]
    GeneIDi 41085.
    KEGGi dme:Dmel_CG11988.
    UCSCi CG11988-RA. d. melanogaster. [P29503-1 ]

    Organism-specific databases

    CTDi 41085.
    FlyBasei FBgn0002932. neur.

    Phylogenomic databases

    eggNOGi NOG145384.
    GeneTreei ENSGT00530000063117.
    InParanoidi P29503.
    KOi K01931.
    OMAi AIPCGPR.
    OrthoDBi EOG7C2R0S.
    PhylomeDBi P29503.

    Enzyme and pathway databases

    Reactomei REACT_221100. NOTCH2 Activation and Transmission of Signal to the Nucleus.
    REACT_225574. Activated NOTCH1 Transmits Signal to the Nucleus.
    SignaLinki P29503.

    Miscellaneous databases

    ChiTaRSi Nrt. drosophila.
    EvolutionaryTracei P29503.
    GenomeRNAii 41085.
    NextBioi 822080.

    Gene expression databases

    Bgeei P29503.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR006573. Neu_Z.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF07177. Neuralized. 2 hits.
    [Graphical view ]
    SMARTi SM00588. NEUZ. 2 hits.
    SM00184. RING. 1 hit.
    [Graphical view ]
    PROSITEi PS51065. NHR. 2 hits.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons."
      Boulianne G.L., de la Concha A., Campos-Ortega J.A., Jan L.Y., Jan Y.N.
      EMBO J. 10:2975-2983(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2).
      Strain: Oregon-R.
    2. "The Drosophila neuralized gene encodes a C3HC4 zinc finger."
      Price B.D., Chang Z., Smith R., Bockheim S., Laughon A.
      EMBO J. 12:2411-2418(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    4. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Strain: Berkeley.
    6. "Phosphoproteome analysis of Drosophila melanogaster embryos."
      Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
      J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-338 AND SER-341, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Embryo.
    7. "Solution structure of the neuz (NHR) domain in neuralized from Drosophila melanogaster."
      RIKEN structural genomics initiative (RSGI)
      Submitted (OCT-2007) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 106-266.

    Entry informationi

    Entry nameiNEUR_DROME
    AccessioniPrimary (citable) accession number: P29503
    Secondary accession number(s): Q26306
    , Q27273, Q8INP6, Q8INP7, Q960M1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: August 22, 2003
    Last modified: October 1, 2014
    This is version 133 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3