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P29499

- MT1_HOMAM

UniProt

P29499 - MT1_HOMAM

Protein

Metallothionein-1

Gene
N/A
Organism
Homarus americanus (American lobster)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Metallothioneins have a high content of cysteine residues that bind various heavy metals. The different forms of lobster metallothioneins may have different biological functions. Class I MTS in marine crustacea are involved in the sequestration of elevated levels of heavy-metal ions. Binds 6 metal ions. Known to bind cadmium.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi4 – 41Divalent metal cation; cluster B
    Metal bindingi5 – 51Divalent metal cation; cluster B
    Metal bindingi9 – 91Divalent metal cation; cluster B
    Metal bindingi11 – 111Divalent metal cation; cluster B
    Metal bindingi16 – 161Divalent metal cation; cluster B
    Metal bindingi20 – 201Divalent metal cation; cluster B
    Metal bindingi22 – 221Divalent metal cation; cluster B
    Metal bindingi25 – 251Divalent metal cation; cluster B
    Metal bindingi27 – 271Divalent metal cation; cluster B
    Metal bindingi30 – 301Divalent metal cation; cluster A
    Metal bindingi33 – 331Divalent metal cation; cluster A
    Metal bindingi37 – 371Divalent metal cation; cluster A
    Metal bindingi39 – 391Divalent metal cation; cluster A
    Metal bindingi45 – 451Divalent metal cation; cluster A
    Metal bindingi49 – 491Divalent metal cation; cluster A
    Metal bindingi53 – 531Divalent metal cation; cluster A
    Metal bindingi55 – 551Divalent metal cation; cluster A
    Metal bindingi56 – 561Divalent metal cation; cluster A

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    Keywords - Ligandi

    Cadmium, Copper, Metal-binding, Metal-thiolate cluster

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metallothionein-1
    Alternative name(s):
    CuMT-1
    OrganismiHomarus americanus (American lobster)
    Taxonomic identifieri6706 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataAstacideaNephropoideaNephropidaeHomarus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5858Metallothionein-1PRO_0000197342Add
    BLAST

    Structurei

    Secondary structure

    1
    58
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi6 – 83
    Beta strandi11 – 144
    Helixi31 – 333
    Helixi45 – 484

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1J5LNMR-A29-56[»]
    1J5MNMR-A1-28[»]
    ProteinModelPortaliP29499.
    SMRiP29499. Positions 1-28.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP29499.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2828BetaAdd
    BLAST
    Regioni29 – 5830AlphaAdd
    BLAST

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR002045. Metalthion_3_crustacean.
    IPR017854. Metalthion_dom.
    IPR003019. Metalthion_sfam_euk.
    [Graphical view]
    PfamiPF00131. Metallothio. 1 hit.
    [Graphical view]
    PRINTSiPR00858. MTCRUSTACEAN.
    SUPFAMiSSF57868. SSF57868. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    P29499-1 [UniParc]FASTAAdd to Basket

    « Hide

    PGPCCKDKCE CAEGGCKTGC KCTSCRCAPC EKCTSGCKCP SKDECAKTCS   50
    KPCSCCXX 58
    Length:58
    Mass (Da):5,977
    Last modified:November 1, 1997 - v2
    Checksum:i176ABAAF60A32F96
    GO

    Sequence databases

    PIRiA37039.

    Cross-referencesi

    Sequence databases

    PIRi A37039.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1J5L NMR - A 29-56 [» ]
    1J5M NMR - A 1-28 [» ]
    ProteinModelPortali P29499.
    SMRi P29499. Positions 1-28.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P29499.

    Family and domain databases

    InterProi IPR002045. Metalthion_3_crustacean.
    IPR017854. Metalthion_dom.
    IPR003019. Metalthion_sfam_euk.
    [Graphical view ]
    Pfami PF00131. Metallothio. 1 hit.
    [Graphical view ]
    PRINTSi PR00858. MTCRUSTACEAN.
    SUPFAMi SSF57868. SSF57868. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Structural and functional diversity of copper-metallothioneins from the American lobster Homarus americanus."
      Brouwer M., Winge D.R., Gray W.R.
      J. Inorg. Biochem. 35:289-303(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Hepatopancreas.
    2. "Sequential proton resonance assignments and metal cluster topology of lobster metallothionein-1."
      Zhu Z., Derose E.F., Mullen G.P., Petering D.H., Shaw C.F. III
      Biochemistry 33:8858-8865(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR.

    Entry informationi

    Entry nameiMT1_HOMAM
    AccessioniPrimary (citable) accession number: P29499
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 65 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. Metallothioneins
      Classification of metallothioneins and list of entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3