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P29499 (MT1_HOMAM) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Metallothionein-1
Alternative name(s):
CuMT-1
OrganismHomarus americanus (American lobster)
Taxonomic identifier6706 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataAstacideaNephropoideaNephropidaeHomarus

Protein attributes

Sequence length58 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Metallothioneins have a high content of cysteine residues that bind various heavy metals. The different forms of lobster metallothioneins may have different biological functions. Class I MTS in marine crustacea are involved in the sequestration of elevated levels of heavy-metal ions. Binds 6 metal ions. Known to bind cadmium.

Sequence similarities

Belongs to the metallothionein superfamily. Type 3 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 5858Metallothionein-1
PRO_0000197342

Regions

Region1 – 2828Beta
Region29 – 5830Alpha

Sites

Metal binding41Divalent metal cation; cluster B
Metal binding51Divalent metal cation; cluster B
Metal binding91Divalent metal cation; cluster B
Metal binding111Divalent metal cation; cluster B
Metal binding161Divalent metal cation; cluster B
Metal binding201Divalent metal cation; cluster B
Metal binding221Divalent metal cation; cluster B
Metal binding251Divalent metal cation; cluster B
Metal binding271Divalent metal cation; cluster B
Metal binding301Divalent metal cation; cluster A
Metal binding331Divalent metal cation; cluster A
Metal binding371Divalent metal cation; cluster A
Metal binding391Divalent metal cation; cluster A
Metal binding451Divalent metal cation; cluster A
Metal binding491Divalent metal cation; cluster A
Metal binding531Divalent metal cation; cluster A
Metal binding551Divalent metal cation; cluster A
Metal binding561Divalent metal cation; cluster A

Secondary structure

......... 58
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P29499 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 176ABAAF60A32F96

FASTA585,977
        10         20         30         40         50 
PGPCCKDKCE CAEGGCKTGC KCTSCRCAPC EKCTSGCKCP SKDECAKTCS KPCSCCXX 

« Hide

References

[1]"Structural and functional diversity of copper-metallothioneins from the American lobster Homarus americanus."
Brouwer M., Winge D.R., Gray W.R.
J. Inorg. Biochem. 35:289-303(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Hepatopancreas.
[2]"Sequential proton resonance assignments and metal cluster topology of lobster metallothionein-1."
Zhu Z., Derose E.F., Mullen G.P., Petering D.H., Shaw C.F. III
Biochemistry 33:8858-8865(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR.
+Additional computationally mapped references.

Cross-references

Sequence databases

PIRA37039.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1J5LNMR-A29-56[»]
1J5MNMR-A1-28[»]
ProteinModelPortalP29499.
SMRP29499. Positions 1-28.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002045. Metalthion_3_crustacean.
IPR017854. Metalthion_dom.
IPR003019. Metalthion_sfam_euk.
[Graphical view]
PfamPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSPR00858. MTCRUSTACEAN.
SUPFAMSSF57868. SSF57868. 2 hits.
ProtoNetSearch...

Other

EvolutionaryTraceP29499.

Entry information

Entry nameMT1_HOMAM
AccessionPrimary (citable) accession number: P29499
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: November 1, 1997
Last modified: October 16, 2013
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Metallothioneins

Classification of metallothioneins and list of entries