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Protein

14 kDa fatty acid-binding protein

Gene
N/A
Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the transport of fatty acids. Binds various fatty acids, such as arachidonic, oleic, palmitic and linolenic acid (in vitro).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei107Fatty acid1

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
14 kDa fatty acid-binding protein
Alternative name(s):
Sm14
OrganismiSchistosoma mansoni (Blood fluke)
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

DrugBankiDB04224. Oleic Acid.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000673581 – 13314 kDa fatty acid-binding proteinAdd BLAST133

Expressioni

Tissue specificityi

Tubercles, muscle layers and body.

Interactioni

Protein-protein interaction databases

STRINGi6183.Smp_095360.1__mRNA.

Structurei

Secondary structure

1133
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 4Combined sources3
Beta strandi6 – 15Combined sources10
Helixi16 – 22Combined sources7
Helixi27 – 33Combined sources7
Beta strandi39 – 45Combined sources7
Beta strandi48 – 54Combined sources7
Beta strandi60 – 64Combined sources5
Beta strandi66 – 68Combined sources3
Beta strandi70 – 73Combined sources4
Turni75 – 77Combined sources3
Beta strandi79 – 88Combined sources10
Beta strandi91 – 97Combined sources7
Beta strandi102 – 110Combined sources9
Beta strandi113 – 120Combined sources8
Beta strandi123 – 131Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VYFX-ray1.85A1-133[»]
1VYGX-ray2.40A1-133[»]
2POANMR-A1-133[»]
ProteinModelPortaliP29498.
SMRiP29498.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29498.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni127 – 129Fatty acid binding3

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
HOGENOMiHOG000004829.
OMAiNGKFISH.
OrthoDBiEOG091G0QSV.
PhylomeDBiP29498.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P29498-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSFLGKWKL SESHNFDAVM SKLGVSWATR QIGNTVTPTV TFTMDGDKMT
60 70 80 90 100
MLTESTFKNL SCTFKFGEEF DEKTSDGRNV KSVVEKNSES KLTQTQVDPK
110 120 130
NTTVIVREVD GDTMKTTVTV GDVTAIRNYK RLS
Length:133
Mass (Da):14,848
Last modified:April 1, 1993 - v1
Checksum:i1A1E0E262C59D76F
GO
Isoform 2 (identifier: P29498-2) [UniParc]FASTAAdd to basket
Also known as: Delta E3

The sequence of this isoform differs from the canonical sequence as follows:
     82-116: Missing.

Show »
Length:98
Mass (Da):10,987
Checksum:iB72F9D6037C63C64
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti20M → T.1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01023482 – 116Missing in isoform 2. CuratedAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60895 mRNA. Translation: AAA63516.1.
AY055467 Genomic DNA. Translation: AAL15461.1.
AF492389 mRNA. Translation: AAM18480.1.
AF492390 mRNA. Translation: AAM18481.1.
PIRiA39818.

Genome annotation databases

EnsemblMetazoaiSmp_095360.1; Smp_095360.1:pep; Smp_095360. [P29498-1]
GeneDBiSmp_095360.1:pep.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60895 mRNA. Translation: AAA63516.1.
AY055467 Genomic DNA. Translation: AAL15461.1.
AF492389 mRNA. Translation: AAM18480.1.
AF492390 mRNA. Translation: AAM18481.1.
PIRiA39818.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VYFX-ray1.85A1-133[»]
1VYGX-ray2.40A1-133[»]
2POANMR-A1-133[»]
ProteinModelPortaliP29498.
SMRiP29498.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6183.Smp_095360.1__mRNA.

Chemistry databases

DrugBankiDB04224. Oleic Acid.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiSmp_095360.1; Smp_095360.1:pep; Smp_095360. [P29498-1]
GeneDBiSmp_095360.1:pep.

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
HOGENOMiHOG000004829.
OMAiNGKFISH.
OrthoDBiEOG091G0QSV.
PhylomeDBiP29498.

Miscellaneous databases

EvolutionaryTraceiP29498.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFABP_SCHMA
AccessioniPrimary (citable) accession number: P29498
Secondary accession number(s): Q8T5U8, Q8T5U9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.