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Protein

14 kDa fatty acid-binding protein

Gene
N/A
Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the transport of fatty acids. Binds various fatty acids, such as arachidonic, oleic, palmitic and linolenic acid (in vitro).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei107 – 1071Fatty acid

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
14 kDa fatty acid-binding protein
Alternative name(s):
Sm14
OrganismiSchistosoma mansoni (Blood fluke)
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry

DrugBankiDB04224. Oleic Acid.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13313314 kDa fatty acid-binding proteinPRO_0000067358Add
BLAST

Expressioni

Tissue specificityi

Tubercles, muscle layers and body.

Interactioni

Protein-protein interaction databases

STRINGi6183.Smp_095360.1__mRNA.

Structurei

Secondary structure

1
133
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 43Combined sources
Beta strandi6 – 1510Combined sources
Helixi16 – 227Combined sources
Helixi27 – 337Combined sources
Beta strandi39 – 457Combined sources
Beta strandi48 – 547Combined sources
Beta strandi60 – 645Combined sources
Beta strandi66 – 683Combined sources
Beta strandi70 – 734Combined sources
Turni75 – 773Combined sources
Beta strandi79 – 8810Combined sources
Beta strandi91 – 977Combined sources
Beta strandi102 – 1109Combined sources
Beta strandi113 – 1208Combined sources
Beta strandi123 – 1319Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VYFX-ray1.85A1-133[»]
1VYGX-ray2.40A1-133[»]
2POANMR-A1-133[»]
ProteinModelPortaliP29498.
SMRiP29498. Positions 1-133.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29498.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni127 – 1293Fatty acid binding

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
HOGENOMiHOG000004829.
OMAiNGKFISH.
OrthoDBiEOG091G0QSV.
PhylomeDBiP29498.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P29498-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSFLGKWKL SESHNFDAVM SKLGVSWATR QIGNTVTPTV TFTMDGDKMT
60 70 80 90 100
MLTESTFKNL SCTFKFGEEF DEKTSDGRNV KSVVEKNSES KLTQTQVDPK
110 120 130
NTTVIVREVD GDTMKTTVTV GDVTAIRNYK RLS
Length:133
Mass (Da):14,848
Last modified:April 1, 1993 - v1
Checksum:i1A1E0E262C59D76F
GO
Isoform 2 (identifier: P29498-2) [UniParc]FASTAAdd to basket
Also known as: Delta E3

The sequence of this isoform differs from the canonical sequence as follows:
     82-116: Missing.

Show »
Length:98
Mass (Da):10,987
Checksum:iB72F9D6037C63C64
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti20 – 201M → T.1 Publication

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei82 – 11635Missing in isoform 2. CuratedVSP_010234Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60895 mRNA. Translation: AAA63516.1.
AY055467 Genomic DNA. Translation: AAL15461.1.
AF492389 mRNA. Translation: AAM18480.1.
AF492390 mRNA. Translation: AAM18481.1.
PIRiA39818.

Genome annotation databases

EnsemblMetazoaiSmp_095360.1; Smp_095360.1:pep; Smp_095360. [P29498-1]
GeneDBiSmp_095360.1:pep.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60895 mRNA. Translation: AAA63516.1.
AY055467 Genomic DNA. Translation: AAL15461.1.
AF492389 mRNA. Translation: AAM18480.1.
AF492390 mRNA. Translation: AAM18481.1.
PIRiA39818.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VYFX-ray1.85A1-133[»]
1VYGX-ray2.40A1-133[»]
2POANMR-A1-133[»]
ProteinModelPortaliP29498.
SMRiP29498. Positions 1-133.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6183.Smp_095360.1__mRNA.

Chemistry

DrugBankiDB04224. Oleic Acid.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiSmp_095360.1; Smp_095360.1:pep; Smp_095360. [P29498-1]
GeneDBiSmp_095360.1:pep.

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
HOGENOMiHOG000004829.
OMAiNGKFISH.
OrthoDBiEOG091G0QSV.
PhylomeDBiP29498.

Miscellaneous databases

EvolutionaryTraceiP29498.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFABP_SCHMA
AccessioniPrimary (citable) accession number: P29498
Secondary accession number(s): Q8T5U8, Q8T5U9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: September 7, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.