Reviewed,
UniProtKB/Swiss-Prot P29495 (PFP_PROFR)
Last modified
June 16, 2009.
Version 59.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Pyrophosphate--fructose 6-phosphate 1-phosphotransferase EC=2.7.1.90 Alternative name(s): 6-phosphofructokinase, pyrophosphate dependent Pyrophosphate-dependent 6-phosphofructose-1-kinase PPi-dependent phosphofructokinase Short name=PPi-PFK | ||||
| Gene names |
| ||||
| Organism | Propionibacterium freudenreichii subsp. shermanii | ||||
| Taxonomic identifier | 1752 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Propionibacterineae › Propionibacteriaceae › Propionibacterium |
Protein attributes
| Sequence length | 404 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | Diphosphate + D-fructose 6-phosphate = phosphate + D-fructose 1,6-bisphosphate. |
| Enzyme regulation | Non-allosteric. |
| Pathway | |
| Subunit structure | Homodimer. |
| Sequence similarities | Belongs to the phosphofructokinase family. PFP subfamily. |
Ontologies
| Keywords | |
|---|---|
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | glycolysis Inferred from electronic annotation. Source: InterPro |
| Cellular component | 6-phosphofructokinase complex Inferred from electronic annotation. Source: InterPro |
| Molecular function | 6-phosphofructokinase activity Inferred from electronic annotation. Source: InterPro ATP bindingInferred from electronic annotation. Source: UniProtKB-KW diphosphate-fructose-6-phosphate 1-phosphotransferase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed | ||||||
| Chain | 2 – 404 | 403 | Pyrophosphate--fructose 6-phosphate 1-phosphotransferase | PRO_0000112013 | |||||
Regions | |||||||||
| Nucleotide binding | 22 – 26 | 5 | ATP By similarity | ||||||
| Nucleotide binding | 121 – 126 | 6 | Pyrophosphate Potential | ||||||
| Nucleotide binding | 179 – 183 | 5 | ATP By similarity | ||||||
| Nucleotide binding | 196 – 232 | 37 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 151 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 326 | 1 | Substrate By similarity | ||||||
Sequences
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References
| [1] | "Cloning, sequencing, and expression of pyrophosphate-dependent phosphofructokinase from Propionibacterium freudenreichii." Ladror U.S., Gollapudi L., Tripathi R.L., Latshaw S.P., Kemp R.G. J. Biol. Chem. 266:16550-16555(1991) [PubMed: 1653240] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE. |
| [2] | "Identification of critical lysyl residues in the pyrophosphate-dependent phosphofructo-1-kinase of Propionibacterium freudenreichii." Green P.C., Latshaw S.P., Ladror U.S., Kemp R.G. Biochemistry 31:4815-4821(1992) [PubMed: 1317210] [Abstract] Cited for: IDENTIFICATION OF CRITICAL LYSYL RESIDUES. |
Cross-references
Sequence databases | |
|---|---|
| M67447 Genomic DNA. Translation: AAA25675.1. | |
| PIR | A41169. |
3D structure databases | |
| ModBase | Search... |
Enzyme and pathway databases | |
| BRENDA | 2.7.1.90. 4086. |
Family and domain databases | |
| InterPro | IPR000023. Phosphofructokinase. IPR011405. PPi-PFK_SMc01852. [Graphical view] |
| Pfam | PF00365. PFK. 1 hit. [Graphical view] |
| PIRSF | PIRSF036484. PPi-PFK_SMc01852. 1 hit. |
| PRINTS | PR00476. PHFRCTKINASE. |
| ProDom | PD000707. Ppfruckinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| ProtoNet | Search... |
Entry information
| Entry name | PFP_PROFR | ||||||||
| Accession | Primary (citable) accession number: P29495 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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