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Protein

Signal recognition particle subunit SEC65

Gene

SEC65

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SEC65 is required for SRP integrity.

GO - Molecular functioni

  • 7S RNA binding Source: SGD

GO - Biological processi

  • SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition Source: SGD
  • SRP-dependent cotranslational protein targeting to membrane, translocation Source: SGD

Keywordsi

Molecular functionRibonucleoprotein

Enzyme and pathway databases

BioCyciYEAST:G3O-32689-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle subunit SEC65
Gene namesi
Name:SEC65
Ordered Locus Names:YML105C
ORF Names:YM8339.14C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YML105C
SGDiS000004573 SEC65

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Signal recognition particle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001352121 – 273Signal recognition particle subunit SEC65Add BLAST273

Proteomic databases

MaxQBiP29478
PaxDbiP29478
PRIDEiP29478

Interactioni

Subunit structurei

Fungal signal recognition particle (SRP) complex consists of a 7S RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi35038, 380 interactors
DIPiDIP-3850N
IntActiP29478, 6 interactors
MINTiP29478
STRINGi4932.YML105C

Structurei

3D structure databases

ProteinModelPortaliP29478
SMRiP29478
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000248333
InParanoidiP29478
KOiK03105
OMAiPQDFGNP
OrthoDBiEOG092C4AQW

Family and domain databases

Gene3Di3.30.56.30, 1 hit
HAMAPiMF_00305 SRP19, 1 hit
InterProiView protein in InterPro
IPR002778 Signal_recog_particle_SRP19
IPR036521 SRP19-like_sf
IPR022938 SRP19_arc-type
PANTHERiPTHR17453 PTHR17453, 1 hit
PfamiView protein in Pfam
PF01922 SRP19, 1 hit
SUPFAMiSSF69695 SSF69695, 1 hit

Sequencei

Sequence statusi: Complete.

P29478-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRLEEIDDF NDIDDLDMEL AELDPSLRTP IAPKITPKVV RSQDQENPAF
60 70 80 90 100
LPGTNNNSNS NNNSSNEKEQ LSFINPKTGK VERSEAISKK DLEEVKRFQV
110 120 130 140 150
LYPCYFDINR SHKEGRRVPK ELAVENPLAK TMADAVRELG ILCIFEGEKC
160 170 180 190 200
HPQDFGNPGR IRVLFKENGQ LIGAATKFKG GKRQLMKAVG EYMKRHPTTI
210 220 230 240 250
ESLREIPYGP DFDNIEFKKI PRVKGFKMNE IVPLHSPFLM GHPMTKSVYE
260 270
TPKITAAEKS FKPPKNKYKV VRR
Length:273
Mass (Da):31,170
Last modified:April 1, 1993 - v1
Checksum:i4F4A6CBB9225E385
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65783 Genomic DNA Translation: CAA46666.1
Z49210 Genomic DNA Translation: CAA89113.1
AY693145 Genomic DNA Translation: AAT93164.1
BK006946 Genomic DNA Translation: DAA09793.1
PIRiS21731
RefSeqiNP_013602.1, NM_001182467.1

Genome annotation databases

EnsemblFungiiYML105C; YML105C; YML105C
GeneIDi854866
KEGGisce:YML105C

Similar proteinsi

Entry informationi

Entry nameiSEC65_YEAST
AccessioniPrimary (citable) accession number: P29478
Secondary accession number(s): D6W0H9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 23, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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