Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P29467

- MEI4_YEAST

UniProt

P29467 - MEI4_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Meiosis-specific protein MEI4

Gene

MEI4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Required for meiotic induction of recombination, viable spore production and chromosome synapsis. Component of the MER2-MEI4-REC114 complex which seems to be required for meiotic double-strand break (DSB) formation.1 Publication

GO - Biological processi

  1. DNA recombination Source: UniProtKB-KW
  2. meiotic DNA double-strand break formation Source: SGD
  3. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

DNA recombination, Meiosis, Sporulation

Enzyme and pathway databases

BioCyciYEAST:G3O-30346-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Meiosis-specific protein MEI4
Gene namesi
Name:MEI4
Ordered Locus Names:YER044C-A
ORF Names:YER044BC
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome V

Organism-specific databases

CYGDiYER044c-a.
SGDiS000001954. MEI4.

Subcellular locationi

Nucleus 1 Publication. Chromosome 1 Publication
Note: Localizes to chromosomes.

GO - Cellular componenti

  1. condensed nuclear chromosome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 408408Meiosis-specific protein MEI4PRO_0000096402Add
BLAST

Expressioni

Developmental stagei

Expressed only in meiosis.

Gene expression databases

GenevestigatoriP29467.

Interactioni

Subunit structurei

Interacts with MER2 and REC114. Component of the MER2-MEI4-REC114 complex.2 Publications

Protein-protein interaction databases

BioGridi36781. 14 interactions.
IntActiP29467. 2 interactions.
STRINGi4932.YER044C-A.

Structurei

3D structure databases

ProteinModelPortaliP29467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG304714.
InParanoidiP29467.
OrthoDBiEOG773XVP.

Family and domain databases

InterProiIPR025888. MEI4.
[Graphical view]
PfamiPF13971. Mei4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29467-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRGKLEDME QKETSEVDWI ICFALIQSRN PTLWKRALSR KKGDVEDVGA
60 70 80 90 100
LKSEKNLKIN PRENSKHIYK WVAPFENGFL NNKSLFAHLE PIYNFLCQNK
110 120 130 140 150
YKSFEDAVGL KELQSFSKDV STADINNWFL PRYKILLKIL SLKTKEIDFR
160 170 180 190 200
GLSQVFQTLQ ILLVSHYSHR IDSDSSFKRT LIDVHVFNFI AKFLFNRILL
210 220 230 240 250
KKNQNDPKWL QNFYDQGDGK HLCDKVDYKR LCSLHFTLIY SIINIQLIKI
260 270 280 290 300
KTNQTFEPQI LKYVSVLKLI EHILIIIESL IHVLIRFVSK HKLICINRKK
310 320 330 340 350
AYCRVYLERE LSLKKTYLKN FYSVISGVPE KELGGLLKIL KIVILSLLET
360 370 380 390 400
FESIEWQHLK PFLEKFPAHE ISLQKKRKYI QAALLITAER NLIARFRLSR

WFNETENI
Length:408
Mass (Da):48,215
Last modified:August 31, 2004 - v2
Checksum:i86CE544E7567FDD6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti329 – 3291P → T in M84764. (PubMed:1545815)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M84764 mRNA. No translation available.
M84765 Genomic DNA. No translation available.
U18796 Genomic DNA. Translation: AAB64589.1.
BK006939 Genomic DNA. Translation: DAA07699.1.
PIRiS78084.
RefSeqiNP_010963.1. NM_001180023.1.

Genome annotation databases

EnsemblFungiiYER044C-A; YER044C-A; YER044C-A.
GeneIDi856768.
KEGGisce:YER044C-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M84764 mRNA. No translation available.
M84765 Genomic DNA. No translation available.
U18796 Genomic DNA. Translation: AAB64589.1 .
BK006939 Genomic DNA. Translation: DAA07699.1 .
PIRi S78084.
RefSeqi NP_010963.1. NM_001180023.1.

3D structure databases

ProteinModelPortali P29467.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36781. 14 interactions.
IntActi P29467. 2 interactions.
STRINGi 4932.YER044C-A.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YER044C-A ; YER044C-A ; YER044C-A .
GeneIDi 856768.
KEGGi sce:YER044C-A.

Organism-specific databases

CYGDi YER044c-a.
SGDi S000001954. MEI4.

Phylogenomic databases

eggNOGi NOG304714.
InParanoidi P29467.
OrthoDBi EOG773XVP.

Enzyme and pathway databases

BioCyci YEAST:G3O-30346-MONOMER.

Miscellaneous databases

NextBioi 982953.

Gene expression databases

Genevestigatori P29467.

Family and domain databases

InterProi IPR025888. MEI4.
[Graphical view ]
Pfami PF13971. Mei4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "MEI4, a meiosis-specific yeast gene required for chromosome synapsis."
    Menees T.M., Ross-Macdonald P.B., Roeder G.S.
    Mol. Cell. Biol. 12:1340-1351(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism."
    Arora C., Kee K., Maleki S., Keeney S.
    Mol. Cell 13:549-559(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MER2 AND REC114.
  5. "Saccharomyces cerevisiae Mer2, Mei4 and Rec114 form a complex required for meiotic double-strand break formation."
    Li J., Hooker G.W., Roeder G.S.
    Genetics 173:1969-1981(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE MER2-MEI4-REC114 COMPLEX, FUNCTION OF THE MER2-MEI4-REC114 COMPLEX, INTERACTION WITH MER2 AND REC114, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiMEI4_YEAST
AccessioniPrimary (citable) accession number: P29467
Secondary accession number(s): D3DLU5, P87265
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: August 31, 2004
Last modified: October 29, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome V
    Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

External Data

Dasty 3