Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P29467

- MEI4_YEAST

UniProt

P29467 - MEI4_YEAST

Protein

Meiosis-specific protein MEI4

Gene

MEI4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (31 Aug 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Required for meiotic induction of recombination, viable spore production and chromosome synapsis. Component of the MER2-MEI4-REC114 complex which seems to be required for meiotic double-strand break (DSB) formation.1 Publication

    GO - Biological processi

    1. DNA recombination Source: UniProtKB-KW
    2. meiotic DNA double-strand break formation Source: SGD
    3. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW

    Keywords - Biological processi

    DNA recombination, Meiosis, Sporulation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30346-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Meiosis-specific protein MEI4
    Gene namesi
    Name:MEI4
    Ordered Locus Names:YER044C-A
    ORF Names:YER044BC
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome V

    Organism-specific databases

    CYGDiYER044c-a.
    SGDiS000001954. MEI4.

    Subcellular locationi

    Nucleus 1 Publication. Chromosome 1 Publication
    Note: Localizes to chromosomes.

    GO - Cellular componenti

    1. condensed nuclear chromosome Source: SGD

    Keywords - Cellular componenti

    Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 408408Meiosis-specific protein MEI4PRO_0000096402Add
    BLAST

    Expressioni

    Developmental stagei

    Expressed only in meiosis.

    Gene expression databases

    GenevestigatoriP29467.

    Interactioni

    Subunit structurei

    Interacts with MER2 and REC114. Component of the MER2-MEI4-REC114 complex.2 Publications

    Protein-protein interaction databases

    BioGridi36781. 14 interactions.
    IntActiP29467. 2 interactions.
    STRINGi4932.YER044C-A.

    Structurei

    3D structure databases

    ProteinModelPortaliP29467.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG304714.
    OrthoDBiEOG773XVP.

    Family and domain databases

    InterProiIPR025888. MEI4.
    [Graphical view]
    PfamiPF13971. Mei4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P29467-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRGKLEDME QKETSEVDWI ICFALIQSRN PTLWKRALSR KKGDVEDVGA    50
    LKSEKNLKIN PRENSKHIYK WVAPFENGFL NNKSLFAHLE PIYNFLCQNK 100
    YKSFEDAVGL KELQSFSKDV STADINNWFL PRYKILLKIL SLKTKEIDFR 150
    GLSQVFQTLQ ILLVSHYSHR IDSDSSFKRT LIDVHVFNFI AKFLFNRILL 200
    KKNQNDPKWL QNFYDQGDGK HLCDKVDYKR LCSLHFTLIY SIINIQLIKI 250
    KTNQTFEPQI LKYVSVLKLI EHILIIIESL IHVLIRFVSK HKLICINRKK 300
    AYCRVYLERE LSLKKTYLKN FYSVISGVPE KELGGLLKIL KIVILSLLET 350
    FESIEWQHLK PFLEKFPAHE ISLQKKRKYI QAALLITAER NLIARFRLSR 400
    WFNETENI 408
    Length:408
    Mass (Da):48,215
    Last modified:August 31, 2004 - v2
    Checksum:i86CE544E7567FDD6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti329 – 3291P → T in M84764. (PubMed:1545815)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M84764 mRNA. No translation available.
    M84765 Genomic DNA. No translation available.
    U18796 Genomic DNA. Translation: AAB64589.1.
    BK006939 Genomic DNA. Translation: DAA07699.1.
    PIRiS78084.
    RefSeqiNP_010963.1. NM_001180023.1.

    Genome annotation databases

    EnsemblFungiiYER044C-A; YER044C-A; YER044C-A.
    GeneIDi856768.
    KEGGisce:YER044C-A.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M84764 mRNA. No translation available.
    M84765 Genomic DNA. No translation available.
    U18796 Genomic DNA. Translation: AAB64589.1 .
    BK006939 Genomic DNA. Translation: DAA07699.1 .
    PIRi S78084.
    RefSeqi NP_010963.1. NM_001180023.1.

    3D structure databases

    ProteinModelPortali P29467.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36781. 14 interactions.
    IntActi P29467. 2 interactions.
    STRINGi 4932.YER044C-A.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YER044C-A ; YER044C-A ; YER044C-A .
    GeneIDi 856768.
    KEGGi sce:YER044C-A.

    Organism-specific databases

    CYGDi YER044c-a.
    SGDi S000001954. MEI4.

    Phylogenomic databases

    eggNOGi NOG304714.
    OrthoDBi EOG773XVP.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30346-MONOMER.

    Miscellaneous databases

    NextBioi 982953.

    Gene expression databases

    Genevestigatori P29467.

    Family and domain databases

    InterProi IPR025888. MEI4.
    [Graphical view ]
    Pfami PF13971. Mei4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "MEI4, a meiosis-specific yeast gene required for chromosome synapsis."
      Menees T.M., Ross-Macdonald P.B., Roeder G.S.
      Mol. Cell. Biol. 12:1340-1351(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism."
      Arora C., Kee K., Maleki S., Keeney S.
      Mol. Cell 13:549-559(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MER2 AND REC114.
    5. "Saccharomyces cerevisiae Mer2, Mei4 and Rec114 form a complex required for meiotic double-strand break formation."
      Li J., Hooker G.W., Roeder G.S.
      Genetics 173:1969-1981(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE MER2-MEI4-REC114 COMPLEX, FUNCTION OF THE MER2-MEI4-REC114 COMPLEX, INTERACTION WITH MER2 AND REC114, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiMEI4_YEAST
    AccessioniPrimary (citable) accession number: P29467
    Secondary accession number(s): D3DLU5, P87265
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: August 31, 2004
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome V
      Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

    External Data

    Dasty 3