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P29467 (MEI4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Meiosis-specific protein MEI4
Gene names
Name:MEI4
Ordered Locus Names:YER044C-A
ORF Names:YER044BC
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length408 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for meiotic induction of recombination, viable spore production and chromosome synapsis. Component of the MER2-MEI4-REC114 complex which seems to be required for meiotic double-strand break (DSB) formation. Ref.5

Subunit structure

Interacts with MER2 and REC114. Component of the MER2-MEI4-REC114 complex. Ref.4 Ref.5

Subcellular location

Nucleus. Chromosome. Note: Localizes to chromosomes. Ref.5

Developmental stage

Expressed only in meiosis.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 408408Meiosis-specific protein MEI4
PRO_0000096402

Experimental info

Sequence conflict3291P → T in M84764. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P29467 [UniParc].

Last modified August 31, 2004. Version 2.
Checksum: 86CE544E7567FDD6

FASTA40848,215
        10         20         30         40         50         60 
MSRGKLEDME QKETSEVDWI ICFALIQSRN PTLWKRALSR KKGDVEDVGA LKSEKNLKIN 

        70         80         90        100        110        120 
PRENSKHIYK WVAPFENGFL NNKSLFAHLE PIYNFLCQNK YKSFEDAVGL KELQSFSKDV 

       130        140        150        160        170        180 
STADINNWFL PRYKILLKIL SLKTKEIDFR GLSQVFQTLQ ILLVSHYSHR IDSDSSFKRT 

       190        200        210        220        230        240 
LIDVHVFNFI AKFLFNRILL KKNQNDPKWL QNFYDQGDGK HLCDKVDYKR LCSLHFTLIY 

       250        260        270        280        290        300 
SIINIQLIKI KTNQTFEPQI LKYVSVLKLI EHILIIIESL IHVLIRFVSK HKLICINRKK 

       310        320        330        340        350        360 
AYCRVYLERE LSLKKTYLKN FYSVISGVPE KELGGLLKIL KIVILSLLET FESIEWQHLK 

       370        380        390        400 
PFLEKFPAHE ISLQKKRKYI QAALLITAER NLIARFRLSR WFNETENI 

« Hide

References

« Hide 'large scale' references
[1]"MEI4, a meiosis-specific yeast gene required for chromosome synapsis."
Menees T.M., Ross-Macdonald P.B., Roeder G.S.
Mol. Cell. Biol. 12:1340-1351(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: ATCC 204508 / S288c.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome V."
Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E., Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W. expand/collapse author list , Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X., Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y., Botstein D., Davis R.W.
Nature 387:78-81(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Antiviral protein Ski8 is a direct partner of Spo11 in meiotic DNA break formation, independent of its cytoplasmic role in RNA metabolism."
Arora C., Kee K., Maleki S., Keeney S.
Mol. Cell 13:549-559(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MER2 AND REC114.
[5]"Saccharomyces cerevisiae Mer2, Mei4 and Rec114 form a complex required for meiotic double-strand break formation."
Li J., Hooker G.W., Roeder G.S.
Genetics 173:1969-1981(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE MER2-MEI4-REC114 COMPLEX, FUNCTION OF THE MER2-MEI4-REC114 COMPLEX, INTERACTION WITH MER2 AND REC114, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M84764 mRNA. No translation available.
M84765 Genomic DNA. No translation available.
U18796 Genomic DNA. Translation: AAB64589.1.
BK006939 Genomic DNA. Translation: DAA07699.1.
PIRS78084.
RefSeqNP_010963.1. NM_001180023.1.

3D structure databases

ProteinModelPortalP29467.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36781. 14 interactions.
IntActP29467. 2 interactions.
STRING4932.YER044C-A.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYER044C-A; YER044C-A; YER044C-A.
GeneID856768.
KEGGsce:YER044C-A.

Organism-specific databases

CYGDYER044c-a.
SGDS000001954. MEI4.

Phylogenomic databases

eggNOGNOG304714.
OrthoDBEOG773XVP.

Enzyme and pathway databases

BioCycYEAST:G3O-30346-MONOMER.

Gene expression databases

GenevestigatorP29467.

Family and domain databases

InterProIPR025888. MEI4.
[Graphical view]
PfamPF13971. Mei4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio982953.

Entry information

Entry nameMEI4_YEAST
AccessionPrimary (citable) accession number: P29467
Secondary accession number(s): D3DLU5, P87265
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: August 31, 2004
Last modified: May 14, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome V

Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD