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Protein

Tyrosine-protein phosphatase 2

Gene

PTP2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Major phosphatase responsible with PTP3 for tyrosine dephosphorylation of MAP kinase HOG1 to inactivate its activity. May also be involved in the regulation of MAP kinase FUS3. May be implicated in the ubiquitin-mediated protein degradation.2 Publications

Miscellaneous

Present with 149 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei666Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • protein tyrosine phosphatase activity Source: SGD

GO - Biological processi

  • inactivation of MAPK activity Source: SGD
  • inactivation of MAPK activity involved in cell wall organization or biogenesis Source: SGD
  • peptidyl-tyrosine dephosphorylation Source: SGD
  • regulation of protein localization Source: SGD
  • regulation of sporulation Source: SGD

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciYEAST:YOR208W-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase 2 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase 2
Short name:
PTPase 2
Gene namesi
Name:PTP2
Ordered Locus Names:YOR208W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

EuPathDBiFungiDB:YOR208W
SGDiS000005734 PTP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000948561 – 750Tyrosine-protein phosphatase 2Add BLAST750

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei258PhosphoserineCombined sources1
Modified residuei430PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP29461
PaxDbiP29461
PRIDEiP29461

PTM databases

iPTMnetiP29461

Interactioni

Subunit structurei

Interacts with HOG1.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi3460377 interactors.
DIPiDIP-2369N
IntActiP29461 6 interactors.
MINTiP29461
STRINGi4932.YOR208W

Structurei

3D structure databases

ProteinModelPortaliP29461
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini383 – 737Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST355

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00910000144174
HOGENOMiHOG000115780
InParanoidiP29461
KOiK19806
OrthoDBiEOG092C2NNG

Family and domain databases

Gene3Di3.90.190.101 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00102 Y_phosphatase, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 3 hits
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

P29461-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRIAQQYRN GKRDNNGNRM ASSAISEKGH IQVNQTRTPG QMPVYRGETI
60 70 80 90 100
NLSNLPQNQI KPCKDLDDVN IRRNNSNRHS KILLLDLCAG PNTNSFLGNT
110 120 130 140 150
NAKDITVLSL PLPSTLVKRS NYPFENLLKN YLGSDEKYIE FTKIIKDYDI
160 170 180 190 200
FIFSDSFSRI SSCLKTTFCL IEKFKKFICH FFPSPYLKFF LLEGSLNDSK
210 220 230 240 250
APSLGKNKKN CILPKLDLNL NVNLTSRSTL NLRINIPPPN DSNKIFLQSL
260 270 280 290 300
KKDLIHYSPN SLQKFFQFNM PADLAPNDTI LPNWLKFCSV KENEKVILKK
310 320 330 340 350
LFNNFETLEN FEMQRLEKCL KFKKKPLHQK QLSQKQRGPQ STDDSKLYSL
360 370 380 390 400
TSLQRQYKSS LKSNIQKNQK LKLIIPKNNT SSSPSPLSSD DTIMSPINDY
410 420 430 440 450
ELTEGIQSFT KNRYSNILPY EHSRVKLPHS PKPPAVSEAS TTETKTDKSY
460 470 480 490 500
PMCPVDAKNH SCKPNDYINA NYLKLTQINP DFKYIATQAP LPSTMDDFWK
510 520 530 540 550
VITLNKVKVI ISLNSDDELN LRKWDIYWNN LSYSNHTIKL QNTWENICNI
560 570 580 590 600
NGCVLRVFQV KKTAPQNDNI SQDCDLPHNG DLTSITMAVS EPFIVYQLQY
610 620 630 640 650
KNWLDSCGVD MNDIIKLHKV KNSLLFNPQS FITSLEKDVC KPDLIDDNNS
660 670 680 690 700
ELHLDTANSS PLLVHCSAGC GRTGVFVTLD FLLSILSPTT NHSNKIDVWN
710 720 730 740 750
MTQDLIFIIV NELRKQRISM VQNLTQYIAC YEALLNYFAL QKQIKNALPC
Length:750
Mass (Da):85,868
Last modified:April 1, 1993 - v1
Checksum:i1033D2F0AA23BD35
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti371L → S in AAB59323 (PubMed:1452018).Curated1
Sequence conflicti474 – 475KL → NV (PubMed:1577774).Curated2
Sequence conflicti660 – 661SP → GA in AAB59323 (PubMed:1452018).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85287 Genomic DNA No translation available.
M82872 Genomic DNA Translation: AAA34922.1
M38723 Genomic DNA Translation: AAB59323.1
Z75116 Genomic DNA Translation: CAA99423.1
BK006948 Genomic DNA Translation: DAA10980.1
PIRiS67100
RefSeqiNP_014851.3, NM_001183627.3

Genome annotation databases

EnsemblFungiiYOR208W; YOR208W; YOR208W
GeneIDi854383
KEGGisce:YOR208W

Similar proteinsi

Entry informationi

Entry nameiPTP2_YEAST
AccessioniPrimary (citable) accession number: P29461
Secondary accession number(s): D6W2R4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 25, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome