UniProtKB - P29461 (PTP2_YEAST)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
Tyrosine-protein phosphatase 2
Gene
PTP2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Major phosphatase responsible with PTP3 for tyrosine dephosphorylation of MAP kinase HOG1 to inactivate its activity. May also be involved in the regulation of MAP kinase FUS3. May be implicated in the ubiquitin-mediated protein degradation.2 Publications
Miscellaneous
Present with 149 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 666 | Phosphocysteine intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- protein tyrosine phosphatase activity Source: SGD
GO - Biological processi
- inactivation of MAPK activity Source: SGD
- inactivation of MAPK activity involved in cell wall organization or biogenesis Source: SGD
- peptidyl-tyrosine dephosphorylation Source: SGD
- regulation of protein localization Source: SGD
- regulation of sporulation Source: SGD
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Enzyme and pathway databases
BioCyci | YEAST:YOR208W-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Tyrosine-protein phosphatase 2 (EC:3.1.3.48)Alternative name(s): Protein-tyrosine phosphatase 2 Short name: PTPase 2 |
Gene namesi | Name:PTP2 Ordered Locus Names:YOR208W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YOR208W |
SGDi | S000005734 PTP2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000094856 | 1 – 750 | Tyrosine-protein phosphatase 2Add BLAST | 750 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 258 | PhosphoserineCombined sources | 1 | |
Modified residuei | 430 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P29461 |
PaxDbi | P29461 |
PRIDEi | P29461 |
PTM databases
iPTMneti | P29461 |
Interactioni
Subunit structurei
Interacts with HOG1.2 Publications
Binary interactionsi
Protein-protein interaction databases
BioGridi | 3460377 interactors. |
DIPi | DIP-2369N |
IntActi | P29461 6 interactors. |
MINTi | P29461 |
STRINGi | 4932.YOR208W |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 383 – 737 | Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST | 355 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00910000144174 |
HOGENOMi | HOG000115780 |
InParanoidi | P29461 |
KOi | K19806 |
OrthoDBi | EOG092C2NNG |
Family and domain databases
Gene3Di | 3.90.190.101 hit |
InterProi | View protein in InterPro IPR029021 Prot-tyrosine_phosphatase-like IPR000242 PTPase_domain IPR016130 Tyr_Pase_AS IPR003595 Tyr_Pase_cat IPR000387 TYR_PHOSPHATASE_dom |
Pfami | View protein in Pfam PF00102 Y_phosphatase, 1 hit |
PRINTSi | PR00700 PRTYPHPHTASE |
SMARTi | View protein in SMART SM00194 PTPc, 1 hit SM00404 PTPc_motif, 1 hit |
SUPFAMi | SSF52799 SSF52799, 3 hits |
PROSITEi | View protein in PROSITE PS00383 TYR_PHOSPHATASE_1, 1 hit PS50056 TYR_PHOSPHATASE_2, 1 hit PS50055 TYR_PHOSPHATASE_PTP, 1 hit |
i Sequence
Sequence statusi: Complete.
P29461-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDRIAQQYRN GKRDNNGNRM ASSAISEKGH IQVNQTRTPG QMPVYRGETI
60 70 80 90 100
NLSNLPQNQI KPCKDLDDVN IRRNNSNRHS KILLLDLCAG PNTNSFLGNT
110 120 130 140 150
NAKDITVLSL PLPSTLVKRS NYPFENLLKN YLGSDEKYIE FTKIIKDYDI
160 170 180 190 200
FIFSDSFSRI SSCLKTTFCL IEKFKKFICH FFPSPYLKFF LLEGSLNDSK
210 220 230 240 250
APSLGKNKKN CILPKLDLNL NVNLTSRSTL NLRINIPPPN DSNKIFLQSL
260 270 280 290 300
KKDLIHYSPN SLQKFFQFNM PADLAPNDTI LPNWLKFCSV KENEKVILKK
310 320 330 340 350
LFNNFETLEN FEMQRLEKCL KFKKKPLHQK QLSQKQRGPQ STDDSKLYSL
360 370 380 390 400
TSLQRQYKSS LKSNIQKNQK LKLIIPKNNT SSSPSPLSSD DTIMSPINDY
410 420 430 440 450
ELTEGIQSFT KNRYSNILPY EHSRVKLPHS PKPPAVSEAS TTETKTDKSY
460 470 480 490 500
PMCPVDAKNH SCKPNDYINA NYLKLTQINP DFKYIATQAP LPSTMDDFWK
510 520 530 540 550
VITLNKVKVI ISLNSDDELN LRKWDIYWNN LSYSNHTIKL QNTWENICNI
560 570 580 590 600
NGCVLRVFQV KKTAPQNDNI SQDCDLPHNG DLTSITMAVS EPFIVYQLQY
610 620 630 640 650
KNWLDSCGVD MNDIIKLHKV KNSLLFNPQS FITSLEKDVC KPDLIDDNNS
660 670 680 690 700
ELHLDTANSS PLLVHCSAGC GRTGVFVTLD FLLSILSPTT NHSNKIDVWN
710 720 730 740 750
MTQDLIFIIV NELRKQRISM VQNLTQYIAC YEALLNYFAL QKQIKNALPC
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 371 | L → S in AAB59323 (PubMed:1452018).Curated | 1 | |
Sequence conflicti | 474 – 475 | KL → NV (PubMed:1577774).Curated | 2 | |
Sequence conflicti | 660 – 661 | SP → GA in AAB59323 (PubMed:1452018).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M85287 Genomic DNA No translation available. M82872 Genomic DNA Translation: AAA34922.1 M38723 Genomic DNA Translation: AAB59323.1 Z75116 Genomic DNA Translation: CAA99423.1 BK006948 Genomic DNA Translation: DAA10980.1 |
PIRi | S67100 |
RefSeqi | NP_014851.3, NM_001183627.3 |
Genome annotation databases
EnsemblFungii | YOR208W; YOR208W; YOR208W |
GeneIDi | 854383 |
KEGGi | sce:YOR208W |
Similar proteinsi
Entry informationi
Entry namei | PTP2_YEAST | |
Accessioni | P29461Primary (citable) accession number: P29461 Secondary accession number(s): D6W2R4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 1, 1993 |
Last sequence update: | April 1, 1993 | |
Last modified: | April 25, 2018 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |