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P29460 (IL12B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 170. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-12 subunit beta

Short name=IL-12B
Alternative name(s):
Cytotoxic lymphocyte maturation factor 40 kDa subunit
Short name=CLMF p40
IL-12 subunit p40
NK cell stimulatory factor chain 2
Short name=NKSF2
Gene names
Name:IL12B
Synonyms:NKSF2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Ref.12

Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Ref.12

Subunit structure

Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer. Ref.9 Ref.16 Ref.18

Subcellular location

Secreted.

Post-translational modification

Known to be C-mannosylated in the recombinant protein; it is not yet known for sure if the wild-type protein is also modified.

Involvement in disease

Mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]: This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.11 Ref.13

Psoriasis 11 (PSORS11) [MIM:612599]: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.11 Ref.13

Sequence similarities

Belongs to the type I cytokine receptor family. Type 3 subfamily.

Contains 1 fibronectin type-III domain.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainImmunoglobulin domain
Signal
   Molecular functionCytokine
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processT-helper 1 type immune response

Traceable author statement Ref.2. Source: UniProtKB

T-helper cell differentiation

Inferred from direct assay Ref.2. Source: UniProtKB

cell cycle arrest

Inferred from direct assay PubMed 16942485. Source: BHF-UCL

cell migration

Inferred from direct assay PubMed 7903063. Source: UniProtKB

cellular response to interferon-gamma

Inferred from electronic annotation. Source: Ensembl

cellular response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

defense response to Gram-negative bacterium

Inferred from direct assay PubMed 15114670PubMed 20027291. Source: BHF-UCL

defense response to protozoan

Inferred from electronic annotation. Source: Ensembl

defense response to virus

Inferred from electronic annotation. Source: Ensembl

interferon-gamma biosynthetic process

Traceable author statement Ref.2. Source: UniProtKB

natural killer cell activation

Inferred from direct assay Ref.2. Source: UniProtKB

natural killer cell activation involved in immune response

Inferred from electronic annotation. Source: Ensembl

negative regulation of growth of symbiont in host

Inferred from electronic annotation. Source: Ensembl

negative regulation of inflammatory response to antigenic stimulus

Inferred from electronic annotation. Source: Ensembl

negative regulation of interleukin-10 production

Inferred from mutant phenotype PubMed 16751425. Source: BHF-UCL

negative regulation of interleukin-17 production

Inferred from direct assay PubMed 16482511. Source: BHF-UCL

negative regulation of smooth muscle cell proliferation

Inferred from direct assay PubMed 16942485. Source: BHF-UCL

positive regulation of NF-kappaB import into nucleus

Traceable author statement PubMed 20428758. Source: BHF-UCL

positive regulation of NK T cell activation

Inferred from direct assay PubMed 19088061. Source: BHF-UCL

positive regulation of NK T cell proliferation

Inferred from direct assay PubMed 19088061. Source: BHF-UCL

positive regulation of T cell mediated cytotoxicity

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of T cell proliferation

Inferred from direct assay PubMed 12023369. Source: BHF-UCL

positive regulation of T-helper 1 type immune response

Inferred from direct assay PubMed 15114670. Source: BHF-UCL

positive regulation of T-helper 17 cell lineage commitment

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of T-helper 17 type immune response

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of activated T cell proliferation

Inferred from direct assay Ref.1. Source: UniProtKB

positive regulation of activation of JAK2 kinase activity

Inferred from direct assay PubMed 12023369. Source: BHF-UCL

positive regulation of cell adhesion

Inferred from direct assay PubMed 7903063. Source: UniProtKB

positive regulation of defense response to virus by host

Inferred from direct assay PubMed 12421946. Source: BHF-UCL

positive regulation of granulocyte macrophage colony-stimulating factor production

Inferred from direct assay PubMed 20027291. Source: BHF-UCL

positive regulation of inflammatory response

Inferred by curator PubMed 16482511. Source: BHF-UCL

positive regulation of interferon-gamma biosynthetic process

Traceable author statement Ref.2. Source: UniProtKB

positive regulation of interferon-gamma production

Inferred from direct assay Ref.1. Source: UniProtKB

positive regulation of interleukin-10 production

Inferred from direct assay PubMed 15265908. Source: BHF-UCL

positive regulation of interleukin-12 production

Inferred from direct assay PubMed 20027291. Source: BHF-UCL

positive regulation of interleukin-17 production

Inferred from direct assay PubMed 16482511PubMed 16751425PubMed 17888176. Source: BHF-UCL

positive regulation of lymphocyte proliferation

Inferred from direct assay Ref.1. Source: UniProtKB

positive regulation of memory T cell differentiation

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of mononuclear cell proliferation

Inferred from mutant phenotype PubMed 11023671. Source: AgBase

positive regulation of natural killer cell activation

Inferred from direct assay Ref.1. Source: UniProtKB

positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

Inferred from direct assay PubMed 7903063. Source: UniProtKB

positive regulation of natural killer cell proliferation

Inferred from direct assay PubMed 19088061. Source: BHF-UCL

positive regulation of osteoclast differentiation

Inferred from direct assay PubMed 17888176. Source: BHF-UCL

positive regulation of smooth muscle cell apoptotic process

Inferred from direct assay PubMed 16942485. Source: BHF-UCL

positive regulation of tissue remodeling

Inferred by curator PubMed 16482511. Source: BHF-UCL

positive regulation of tumor necrosis factor production

Inferred from mutant phenotype PubMed 16751425. Source: BHF-UCL

positive regulation of tyrosine phosphorylation of Stat3 protein

Inferred from direct assay PubMed 12023369. Source: BHF-UCL

positive regulation of tyrosine phosphorylation of Stat4 protein

Inferred from direct assay Ref.12PubMed 12023369PubMed 19088061. Source: BHF-UCL

positive regulation of tyrosine phosphorylation of Stat5 protein

Inferred from direct assay PubMed 12023369. Source: BHF-UCL

regulation of cytokine biosynthetic process

Traceable author statement Ref.2. Source: UniProtKB

regulation of tyrosine phosphorylation of Stat1 protein

Inferred from direct assay PubMed 12023369. Source: BHF-UCL

response to UV-B

Inferred from direct assay PubMed 8992506. Source: UniProtKB

sensory perception of pain

Inferred from electronic annotation. Source: Ensembl

sexual reproduction

Traceable author statement PubMed 16772281. Source: BHF-UCL

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

extracellular space

Traceable author statement Ref.2. Source: UniProtKB

interleukin-12 complex

Inferred from direct assay Ref.1. Source: UniProtKB

interleukin-23 complex

Inferred from direct assay Ref.12. Source: BHF-UCL

membrane

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncytokine receptor activity

Inferred from electronic annotation. Source: InterPro

identical protein binding

Inferred from physical interaction PubMed 7527811. Source: IntAct

interleukin-12 alpha subunit binding

Inferred from physical interaction PubMed 11023671. Source: AgBase

interleukin-12 receptor binding

Traceable author statement Ref.1. Source: UniProtKB

protein binding

Inferred from physical interaction Ref.16Ref.12PubMed 7527811. Source: IntAct

protein heterodimerization activity

Inferred from physical interaction Ref.1. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself2EBI-1029614,EBI-1029614
IL12AP294592EBI-1029614,EBI-1029636
Il23aQ9EQ142EBI-1029614,EBI-2481329From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Ref.7
Chain23 – 328306Interleukin-12 subunit beta
PRO_0000010930

Regions

Domain23 – 10684Ig-like C2-type
Domain237 – 32892Fibronectin type-III

Amino acid modifications

Glycosylation1351N-linked (GlcNAc...) Potential
Glycosylation2221N-linked (GlcNAc...) Ref.16
Glycosylation3191C-linked (Man) Ref.10
CAR_000187
Disulfide bond50 ↔ 90 Ref.16
Disulfide bond131 ↔ 142 Ref.16
Disulfide bond170 ↔ 193 Ref.16
Disulfide bond199Interchain (with C-96 in IL12A) Ref.16
Disulfide bond300 ↔ 327 Ref.16

Natural variations

Natural variant331V → I. Ref.5
Corresponds to variant rs3213096 [ dbSNP | Ensembl ].
VAR_020001
Natural variant2981V → F. Ref.5
Corresponds to variant rs3213119 [ dbSNP | Ensembl ].
VAR_049170

Experimental info

Sequence conflict2391K → N in AAA59938. Ref.2

Secondary structure

.............................................................. 328
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P29460 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 118FA801B8F5BB2F

FASTA32837,169
        10         20         30         40         50         60 
MCHQQLVISW FSLVFLASPL VAIWELKKDV YVVELDWYPD APGEMVVLTC DTPEEDGITW 

        70         80         90        100        110        120 
TLDQSSEVLG SGKTLTIQVK EFGDAGQYTC HKGGEVLSHS LLLLHKKEDG IWSTDILKDQ 

       130        140        150        160        170        180 
KEPKNKTFLR CEAKNYSGRF TCWWLTTIST DLTFSVKSSR GSSDPQGVTC GAATLSAERV 

       190        200        210        220        230        240 
RGDNKEYEYS VECQEDSACP AAEESLPIEV MVDAVHKLKY ENYTSSFFIR DIIKPDPPKN 

       250        260        270        280        290        300 
LQLKPLKNSR QVEVSWEYPD TWSTPHSYFS LTFCVQVQGK SKREKKDRVF TDKTSATVIC 

       310        320 
RKNASISVRA QDRYYSSSWS EWASVPCS 

« Hide

References

« Hide 'large scale' references
[1]"Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor."
Gubler U., Chua A.O., Schoenhaut D.S., Dwyer C.M., McComas W., Motyka R., Nabavi N., Wolitzky A.G., Quinn P.M., Familletti P.C., Gately M.K.
Proc. Natl. Acad. Sci. U.S.A. 88:4143-4147(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells."
Wolf S.F., Temple P.A., Kobayashi M., Young D., Dicig M., Lowe L., Dzialo R., Fitz L., Ferenz C., Hewick R.M., Kelleher K., Herrmann S.H., Clark S.C., Azzoni L., Chan S.H., Trinchieri G., Perussia B.
J. Immunol. 146:3074-3081(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Complete primary structure, chromosomal localization, and definition of polymorphisms of the gene encoding the human interleukin 12 p40 subunit."
Huang D., Cancilla M.R., Morahan G.
Genes Immun. 1:515-520(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Cloning and sequence analysis of IL-12 cDNA from Chinese."
Hongyuan J., Meiyun Z.
Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]SeattleSNPs variation discovery resource
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-33 AND PHE-298.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[7]"Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells."
Stern A.S., Podlaski F.J., Hulmes J.D., Pan Y.C.E., Quinn P.M., Wolitzky A.G., Familletti P.C., Stremlo D.L., Truitt T., Chizzonite R., Gately M.K.
Proc. Natl. Acad. Sci. U.S.A. 87:6808-6812(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 23-45.
[8]"Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor."
Gearing D.P., Cosman D.
Cell 66:9-10(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: SIMILARITY TO IL-6 RECEPTOR.
[9]"Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production."
D'Andrea A., Ma X., Aste-Amezaga M., Paganin C., Trinchieri G.
J. Exp. Med. 181:537-546(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT.
[10]"Recombinant human interleukin-12 is the second example of a C-mannosylated protein."
Doucey M.A., Hess D., Blommers M.J., Hofsteenge J.
Glycobiology 9:435-441(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT TRP-319.
[11]"Inherited interleukin 12 deficiency in a child with bacille Calmette-Guerin and Salmonella enteritidis disseminated infection."
Altare F., Lammas D., Revy P., Jouanguy E., Doeffinger R., Lamhamedi-Cherradi S.-E., Drysdale P., Scheel-Toellner D., Girdlestone J., Darbyshire P., Wadhwa M., Dockrell H., Salmon M., Fischer A., Durandy A., Casanova J.-L., Kumararatne D.S.
J. Clin. Invest. 102:2035-2040(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN MENDELIAN SUSCEPTIBILITY TO MYCOBACTERIAL DISEASE.
[12]"Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12."
Oppmann B., Lesley R., Blom B., Timans J.C., Xu Y., Hunte B., Vega F., Yu N., Wang J., Singh K.P., Zonin F., Vaisberg E., Churakova T., Liu M.-R., Gorman D., Wagner J., Zurawski S., Liu Y.-J. expand/collapse author list , Abrams J.S., Moore K.W., Rennick D.M., de Waal-Malefyt R., Hannum C., Bazan J.F., Kastelein R.A.
Immunity 13:715-725(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH IL23A.
[13]"Inherited interleukin-12 deficiency: IL12B genotype and clinical phenotype of 13 patients from six kindreds."
Picard C., Fieschi C., Altare F., Al-Jumaah S., Al-Hajjar S., Feinberg J., Dupuis S., Soudais C., Al-Mohsen I.Z., Genin E., Lammas D., Kumararatne D.S., Leclerc T., Rafii A., Frayha H., Murugasu B., Wah L.B., Sinniah R. expand/collapse author list , Loubser M., Okamoto E., Al-Ghonaium A., Tufenkeji H., Abel L., Casanova J.-L.
Am. J. Hum. Genet. 70:336-348(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN MENDELIAN SUSCEPTIBILITY TO MYCOBACTERIAL DISEASE.
[14]"Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis."
Capon F., Di Meglio P., Szaub J., Prescott N.J., Dunster C., Baumber L., Timms K., Gutin A., Abkevic V., Burden A.D., Lanchbury J., Barker J.N., Trembath R.C., Nestle F.O.
Hum. Genet. 122:201-206(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: ASSOCIATION WITH PSORIASIS.
[15]"Genetic variants of the IL-23R pathway: association with psoriatic arthritis and psoriasis vulgaris, but no specific risk factor for arthritis."
Huffmeier U., Lascorz J., Bohm B., Lohmann J., Wendler J., Mossner R., Reich K., Traupe H., Kurrat W., Burkhardt H., Reis A.
J. Invest. Dermatol. 129:355-358(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ASSOCIATION WITH PSORIASIS.
[16]"Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12."
Yoon C., Johnston S.C., Tang J., Stahl M., Tobin J.F., Somers W.S.
EMBO J. 19:3530-3541(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 23-328 ALONE AND IN COMPLEX WITH IL12A, GLYCOSYLATION AT ASN-222, DISULFIDE BONDS.
[17]"Crystal structures of the pro-inflammatory cytokine interleukin-23 and its complex with a high-affinity neutralizing antibody."
Beyer B.M., Ingram R., Ramanathan L., Reichert P., Le H.V., Madison V., Orth P.
J. Mol. Biol. 382:942-955(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 23-328 IN COMPLEX WITH IL23A AND ANTIBODY.
[18]"The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12."
Lupardus P.J., Garcia K.C.
J. Mol. Biol. 382:931-941(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 23-328 IN COMPLEX WITH IL23A, SUBUNIT.
+Additional computationally mapped references.

Web resources

IL12Bbase

IL12B mutation db

SeattleSNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M65272 mRNA. Translation: AAA35695.1.
M65290 mRNA. Translation: AAA59938.1.
AY008847 Genomic DNA. Translation: AAG32620.1.
AF180563 mRNA. Translation: AAD56386.1.
AF512686 Genomic DNA. Translation: AAM34792.1.
BC067498 mRNA. Translation: AAH67498.1.
BC067499 mRNA. Translation: AAH67499.1.
BC067500 mRNA. Translation: AAH67500.1.
BC067501 mRNA. Translation: AAH67501.1.
BC067502 mRNA. Translation: AAH67502.1.
BC074723 mRNA. Translation: AAH74723.1.
CCDSCCDS4346.1.
PIRA38957.
RefSeqNP_002178.2. NM_002187.2.
UniGeneHs.674.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1F42X-ray2.50A23-328[»]
1F45X-ray2.80A23-328[»]
3D85X-ray1.90D23-328[»]
3D87X-ray2.90B/D23-328[»]
3DUHX-ray2.30A/B23-328[»]
3HMXX-ray3.00A23-328[»]
3QWRX-ray3.25A23-328[»]
4GRWX-ray2.55B/D1-328[»]
ProteinModelPortalP29460.
SMRP29460. Positions 23-328.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109807. 2 interactions.
DIPDIP-3774N.
IntActP29460. 4 interactions.
STRING9606.ENSP00000231228.

Chemistry

ChEMBLCHEMBL2364153.

PTM databases

PhosphoSiteP29460.
UniCarbKBP29460.

Polymorphism databases

DMDM266320.

Proteomic databases

PaxDbP29460.
PRIDEP29460.

Protocols and materials databases

DNASU3593.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000231228; ENSP00000231228; ENSG00000113302.
GeneID3593.
KEGGhsa:3593.
UCSCuc003lxr.1. human.

Organism-specific databases

CTD3593.
GeneCardsGC05M158741.
HGNCHGNC:5970. IL12B.
HPAHPA040970.
MIM161561. gene.
209950. phenotype.
612599. phenotype.
neXtProtNX_P29460.
Orphanet319558. Mendelian susceptibility to mycobacterial diseases due to complete IL12B deficiency.
3287. Takayasu arteritis.
PharmGKBPA29785.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45642.
HOGENOMHOG000113027.
HOVERGENHBG052094.
InParanoidP29460.
KOK05425.
OMAWSTPHSY.
OrthoDBEOG7TBC2K.
PhylomeDBP29460.
TreeFamTF334829.

Gene expression databases

ArrayExpressP29460.
BgeeP29460.
CleanExHS_IL12B.
GenevestigatorP29460.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
InterProIPR003961. Fibronectin_type3.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR015528. IL-12_beta.
IPR019482. IL-12_beta_cen-dom.
[Graphical view]
PANTHERPTHR11321. PTHR11321. 1 hit.
PfamPF10420. IL12p40_C. 1 hit.
[Graphical view]
PIRSFPIRSF038007. IL_12_beta. 1 hit.
PRINTSPR01928. INTRLEUKN12B.
SMARTSM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMSSF49265. SSF49265. 2 hits.
PROSITEPS50853. FN3. 1 hit.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP29460.
GeneWikiInterleukin-12_subunit_beta.
GenomeRNAi3593.
NextBio14039.
PMAP-CutDBP29460.
PROP29460.
SOURCESearch...

Entry information

Entry nameIL12B_HUMAN
AccessionPrimary (citable) accession number: P29460
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: July 9, 2014
This is version 170 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM