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P29457

- SERPH_RAT

UniProt

P29457 - SERPH_RAT

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Protein

Serpin H1

Gene

Serpinh1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei376 – 3772Reactive bond homologBy similarity

GO - Molecular functioni

  1. collagen binding Source: RGD
  2. serine-type endopeptidase inhibitor activity Source: RefGenome

GO - Biological processi

  1. negative regulation of endopeptidase activity Source: RefGenome
  2. regulation of proteolysis Source: RefGenome
  3. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Protein family/group databases

MEROPSiI04.036.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin H1
Alternative name(s):
47 kDa heat shock protein
Collagen-binding protein
Short name:
Colligin
GP46
Gene namesi
Name:Serpinh1
Synonyms:Cbp1, Hsp47
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi69302. Serpinh1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. endoplasmic reticulum Source: UniProtKB-KW
  3. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 17172 PublicationsAdd
BLAST
Chaini18 – 417400Serpin H1PRO_0000032518Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei93 – 931N6-succinyllysineBy similarity
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence Analysis
Modified residuei206 – 2061N6-acetyllysineBy similarity
Modified residuei295 – 2951N6-succinyllysineBy similarity
Modified residuei318 – 3181N6-acetyllysineBy similarity
Glycosylationi394 – 3941N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

PaxDbiP29457.
PRIDEiP29457.

PTM databases

PhosphoSiteiP29457.

Expressioni

Inductioni

By heat shock and retinoic acid.

Gene expression databases

GenevestigatoriP29457.

Interactioni

Protein-protein interaction databases

BioGridi248001. 1 interaction.
IntActiP29457. 1 interaction.
MINTiMINT-1775477.
STRINGi10116.ENSRNOP00000022983.

Structurei

3D structure databases

ProteinModelPortaliP29457.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi414 – 4174Prevents secretion from ERCurated

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
HOGENOMiHOG000238519.
HOVERGENiHBG104930.
InParanoidiP29457.
KOiK09501.
PhylomeDBiP29457.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29457-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRSLLLGTLC LLAVALAAEV KKPVEAAAPG TAEKLSSKAT TLAERSTGLA
60 70 80 90 100
FSLYQAMAKD QAVENILLSP LVVASSLGLV SLGGKATTAS QAKAVLSAEK
110 120 130 140 150
LRDEEVHTGL GELVRSLSNS TARNVTWKLG SRLYGPSSVS FADDFVRSSK
160 170 180 190 200
QHYNCEHSKI NFRDKRSALQ SINEWASQTT DGKLPEVTKD VERTDGALLV
210 220 230 240 250
NAMFFKPHWD EKFHHKMVDN RGFMVTRSYT VGVTMMHRTG LYNYYDDEKE
260 270 280 290 300
KLQLVEMPLA HKLSSLIILM PHHVEPLERL EKLLTKEQLK TWMGKMQKKA
310 320 330 340 350
VAISLPKGVV EVTHDLQKHL AGLGLTEAID KNKADLSRMS GKKDLYLASV
360 370 380 390 400
FHATAFEWDT EGNPFDQDIY GREELRSPKL FYADHPFIFL VRDNQSGSLL
410
FIGRLVRPKG DKMRDEL
Length:417
Mass (Da):46,518
Last modified:April 1, 1993 - v1
Checksum:i859C4E16B15E7DC1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M69246 mRNA. Translation: AAA41270.1.
PIRiA40968.
RefSeqiNP_058869.1. NM_017173.1.
UniGeneiRn.98199.

Genome annotation databases

GeneIDi29345.
KEGGirno:29345.
UCSCiRGD:69302. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M69246 mRNA. Translation: AAA41270.1 .
PIRi A40968.
RefSeqi NP_058869.1. NM_017173.1.
UniGenei Rn.98199.

3D structure databases

ProteinModelPortali P29457.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 248001. 1 interaction.
IntActi P29457. 1 interaction.
MINTi MINT-1775477.
STRINGi 10116.ENSRNOP00000022983.

Protein family/group databases

MEROPSi I04.036.

PTM databases

PhosphoSitei P29457.

Proteomic databases

PaxDbi P29457.
PRIDEi P29457.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 29345.
KEGGi rno:29345.
UCSCi RGD:69302. rat.

Organism-specific databases

CTDi 871.
RGDi 69302. Serpinh1.

Phylogenomic databases

eggNOGi COG4826.
HOGENOMi HOG000238519.
HOVERGENi HBG104930.
InParanoidi P29457.
KOi K09501.
PhylomeDBi P29457.

Miscellaneous databases

NextBioi 608840.
PROi P29457.

Gene expression databases

Genevestigatori P29457.

Family and domain databases

InterProi IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A collagen-binding protein in the endoplasmic reticulum of myoblasts exhibits relationship with serine protease inhibitors."
    Clarke E.P., Cates G.A., Ball E.H., Sanwal B.D.
    J. Biol. Chem. 266:17230-17235(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 18-41; 167-192 AND 339-352.
  2. "Partial characterization of a collagen-binding, differentiation-related glycoprotein from skeletal myoblasts."
    Nanden D., Cates G.A., Ball E.H., Sanwal B.D.
    Arch. Biochem. Biophys. 278:291-296(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 18-33.

Entry informationi

Entry nameiSERPH_RAT
AccessioniPrimary (citable) accession number: P29457
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: October 29, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3