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Protein

Serpin H1

Gene

Serpinh1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei376 – 377Reactive bond homologBy similarity2

GO - Molecular functioni

  • collagen binding Source: RGD
  • serine-type endopeptidase inhibitor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response

Protein family/group databases

MEROPSiI04.035.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin H1
Alternative name(s):
47 kDa heat shock protein
Collagen-binding protein
Short name:
Colligin
GP46
Gene namesi
Name:Serpinh1
Synonyms:Cbp1, Hsp47
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69302. Serpinh1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 172 PublicationsAdd BLAST17
ChainiPRO_000003251818 – 417Serpin H1Add BLAST400

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei93N6-succinyllysineBy similarity1
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei140PhosphoserineBy similarity1
Modified residuei206N6-acetyllysineBy similarity1
Modified residuei295N6-succinyllysineBy similarity1
Modified residuei318N6-acetyllysineBy similarity1
Glycosylationi394N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP29457.
PRIDEiP29457.

PTM databases

iPTMnetiP29457.
PhosphoSitePlusiP29457.
SwissPalmiP29457.

Expressioni

Inductioni

By heat shock and retinoic acid.

Interactioni

GO - Molecular functioni

  • collagen binding Source: RGD

Protein-protein interaction databases

BioGridi248001. 1 interactor.
IntActiP29457. 1 interactor.
MINTiMINT-1775477.
STRINGi10116.ENSRNOP00000022983.

Structurei

3D structure databases

ProteinModelPortaliP29457.
SMRiP29457.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi414 – 417Prevents secretion from ERCurated4

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
HOGENOMiHOG000238519.
HOVERGENiHBG104930.
InParanoidiP29457.
KOiK09501.
PhylomeDBiP29457.

Family and domain databases

CDDicd02046. hsp47. 1 hit.
InterProiView protein in InterPro
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
IPR033830. Serpin_H1_domain.
IPR033547. SERPINH1.
PANTHERiPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF220. PTHR11461:SF220. 1 hit.
PfamiView protein in Pfam
PF00079. Serpin. 1 hit.
SMARTiView protein in SMART
SM00093. SERPIN. 1 hit.
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiView protein in PROSITE
PS00014. ER_TARGET. 1 hit.
PS00284. SERPIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29457-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSLLLGTLC LLAVALAAEV KKPVEAAAPG TAEKLSSKAT TLAERSTGLA
60 70 80 90 100
FSLYQAMAKD QAVENILLSP LVVASSLGLV SLGGKATTAS QAKAVLSAEK
110 120 130 140 150
LRDEEVHTGL GELVRSLSNS TARNVTWKLG SRLYGPSSVS FADDFVRSSK
160 170 180 190 200
QHYNCEHSKI NFRDKRSALQ SINEWASQTT DGKLPEVTKD VERTDGALLV
210 220 230 240 250
NAMFFKPHWD EKFHHKMVDN RGFMVTRSYT VGVTMMHRTG LYNYYDDEKE
260 270 280 290 300
KLQLVEMPLA HKLSSLIILM PHHVEPLERL EKLLTKEQLK TWMGKMQKKA
310 320 330 340 350
VAISLPKGVV EVTHDLQKHL AGLGLTEAID KNKADLSRMS GKKDLYLASV
360 370 380 390 400
FHATAFEWDT EGNPFDQDIY GREELRSPKL FYADHPFIFL VRDNQSGSLL
410
FIGRLVRPKG DKMRDEL
Length:417
Mass (Da):46,518
Last modified:April 1, 1993 - v1
Checksum:i859C4E16B15E7DC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69246 mRNA. Translation: AAA41270.1.
PIRiA40968.
RefSeqiNP_058869.1. NM_017173.1.
UniGeneiRn.98199.

Genome annotation databases

GeneIDi29345.
KEGGirno:29345.
UCSCiRGD:69302. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSERPH_RAT
AccessioniPrimary (citable) accession number: P29457
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 10, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families