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P29457 (SERPH_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serpin H1
Alternative name(s):
47 kDa heat shock protein
Collagen-binding protein
Short name=Colligin
GP46
Gene names
Name:Serpinh1
Synonyms:Cbp1, Hsp47
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

Subcellular location

Endoplasmic reticulum lumen.

Induction

By heat shock and retinoic acid.

Sequence similarities

Belongs to the serpin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Ref.1 Ref.2
Chain18 – 417400Serpin H1
PRO_0000032518

Regions

Motif414 – 4174Prevents secretion from ER Probable

Sites

Site376 – 3772Reactive bond homolog By similarity

Amino acid modifications

Glycosylation1191N-linked (GlcNAc...) Potential
Glycosylation1241N-linked (GlcNAc...) Potential
Glycosylation3941N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P29457 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 859C4E16B15E7DC1

FASTA41746,518
        10         20         30         40         50         60 
MRSLLLGTLC LLAVALAAEV KKPVEAAAPG TAEKLSSKAT TLAERSTGLA FSLYQAMAKD 

        70         80         90        100        110        120 
QAVENILLSP LVVASSLGLV SLGGKATTAS QAKAVLSAEK LRDEEVHTGL GELVRSLSNS 

       130        140        150        160        170        180 
TARNVTWKLG SRLYGPSSVS FADDFVRSSK QHYNCEHSKI NFRDKRSALQ SINEWASQTT 

       190        200        210        220        230        240 
DGKLPEVTKD VERTDGALLV NAMFFKPHWD EKFHHKMVDN RGFMVTRSYT VGVTMMHRTG 

       250        260        270        280        290        300 
LYNYYDDEKE KLQLVEMPLA HKLSSLIILM PHHVEPLERL EKLLTKEQLK TWMGKMQKKA 

       310        320        330        340        350        360 
VAISLPKGVV EVTHDLQKHL AGLGLTEAID KNKADLSRMS GKKDLYLASV FHATAFEWDT 

       370        380        390        400        410 
EGNPFDQDIY GREELRSPKL FYADHPFIFL VRDNQSGSLL FIGRLVRPKG DKMRDEL

« Hide

References

[1]"A collagen-binding protein in the endoplasmic reticulum of myoblasts exhibits relationship with serine protease inhibitors."
Clarke E.P., Cates G.A., Ball E.H., Sanwal B.D.
J. Biol. Chem. 266:17230-17235(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 18-41; 167-192 AND 339-352.
[2]"Partial characterization of a collagen-binding, differentiation-related glycoprotein from skeletal myoblasts."
Nanden D., Cates G.A., Ball E.H., Sanwal B.D.
Arch. Biochem. Biophys. 278:291-296(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 18-33.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M69246 mRNA. Translation: AAA41270.1.
IPIIPI00204703.
PIRA40968.
RefSeqNP_058869.1. NM_017173.1.
UniGeneRn.98199.

3D structure databases

ProteinModelPortalP29457.
ModBaseSearch...

Protein-protein interaction databases

IntActP29457. 1 interaction.
MINTMINT-1775477.
STRING10116.ENSRNOP00000022983.

Protein family/group databases

MEROPSI04.035.

PTM databases

PhosphoSiteP29457.

Proteomic databases

PaxDbP29457.
PRIDEP29457.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID29345.
KEGGrno:29345.
UCSCRGD:69302. rat.

Organism-specific databases

CTD871.
RGD69302. Serpinh1.

Phylogenomic databases

eggNOGCOG4826.
HOGENOMHOG000238519.
HOVERGENHBG104930.
InParanoidP29457.
KOK09501.
OrthoDBEOG43FGX2.

Gene expression databases

ArrayExpressP29457.
GenevestigatorP29457.
GermOnlineENSRNOG00000016831. Rattus norvegicus.

Family and domain databases

InterProIPR023795. Protease_inhib_I4_serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERPTHR11461. PTHR11461. 1 hit.
PfamPF00079. Serpin. 1 hit.
[Graphical view]
SMARTSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMSSF56574. Prot_inh_serpin. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
PS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio608840.

Entry information

Entry nameSERPH_RAT
AccessionPrimary (citable) accession number: P29457
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 3, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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