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P29457

- SERPH_RAT

UniProt

P29457 - SERPH_RAT

Protein

Serpin H1

Gene

Serpinh1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei376 – 3772Reactive bond homologBy similarity

    GO - Molecular functioni

    1. collagen binding Source: RGD
    2. serine-type endopeptidase inhibitor activity Source: RefGenome

    GO - Biological processi

    1. negative regulation of endopeptidase activity Source: RefGenome
    2. regulation of proteolysis Source: RefGenome
    3. response to stress Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Stress response

    Protein family/group databases

    MEROPSiI04.035.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serpin H1
    Alternative name(s):
    47 kDa heat shock protein
    Collagen-binding protein
    Short name:
    Colligin
    GP46
    Gene namesi
    Name:Serpinh1
    Synonyms:Cbp1, Hsp47
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi69302. Serpinh1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. endoplasmic reticulum lumen Source: UniProtKB-SubCell
    3. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 17172 PublicationsAdd
    BLAST
    Chaini18 – 417400Serpin H1PRO_0000032518Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei93 – 931N6-succinyllysineBy similarity
    Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence Analysis
    Modified residuei206 – 2061N6-acetyllysineBy similarity
    Modified residuei295 – 2951N6-succinyllysineBy similarity
    Modified residuei318 – 3181N6-acetyllysineBy similarity
    Glycosylationi394 – 3941N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Acetylation, Glycoprotein

    Proteomic databases

    PaxDbiP29457.
    PRIDEiP29457.

    PTM databases

    PhosphoSiteiP29457.

    Expressioni

    Inductioni

    By heat shock and retinoic acid.

    Gene expression databases

    GenevestigatoriP29457.

    Interactioni

    Protein-protein interaction databases

    BioGridi248001. 1 interaction.
    IntActiP29457. 1 interaction.
    MINTiMINT-1775477.
    STRINGi10116.ENSRNOP00000022983.

    Structurei

    3D structure databases

    ProteinModelPortaliP29457.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi414 – 4174Prevents secretion from ERCurated

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    HOGENOMiHOG000238519.
    HOVERGENiHBG104930.
    InParanoidiP29457.
    KOiK09501.
    PhylomeDBiP29457.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P29457-1 [UniParc]FASTAAdd to Basket

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    MRSLLLGTLC LLAVALAAEV KKPVEAAAPG TAEKLSSKAT TLAERSTGLA    50
    FSLYQAMAKD QAVENILLSP LVVASSLGLV SLGGKATTAS QAKAVLSAEK 100
    LRDEEVHTGL GELVRSLSNS TARNVTWKLG SRLYGPSSVS FADDFVRSSK 150
    QHYNCEHSKI NFRDKRSALQ SINEWASQTT DGKLPEVTKD VERTDGALLV 200
    NAMFFKPHWD EKFHHKMVDN RGFMVTRSYT VGVTMMHRTG LYNYYDDEKE 250
    KLQLVEMPLA HKLSSLIILM PHHVEPLERL EKLLTKEQLK TWMGKMQKKA 300
    VAISLPKGVV EVTHDLQKHL AGLGLTEAID KNKADLSRMS GKKDLYLASV 350
    FHATAFEWDT EGNPFDQDIY GREELRSPKL FYADHPFIFL VRDNQSGSLL 400
    FIGRLVRPKG DKMRDEL 417
    Length:417
    Mass (Da):46,518
    Last modified:April 1, 1993 - v1
    Checksum:i859C4E16B15E7DC1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M69246 mRNA. Translation: AAA41270.1.
    PIRiA40968.
    RefSeqiNP_058869.1. NM_017173.1.
    UniGeneiRn.98199.

    Genome annotation databases

    GeneIDi29345.
    KEGGirno:29345.
    UCSCiRGD:69302. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M69246 mRNA. Translation: AAA41270.1 .
    PIRi A40968.
    RefSeqi NP_058869.1. NM_017173.1.
    UniGenei Rn.98199.

    3D structure databases

    ProteinModelPortali P29457.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 248001. 1 interaction.
    IntActi P29457. 1 interaction.
    MINTi MINT-1775477.
    STRINGi 10116.ENSRNOP00000022983.

    Protein family/group databases

    MEROPSi I04.035.

    PTM databases

    PhosphoSitei P29457.

    Proteomic databases

    PaxDbi P29457.
    PRIDEi P29457.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 29345.
    KEGGi rno:29345.
    UCSCi RGD:69302. rat.

    Organism-specific databases

    CTDi 871.
    RGDi 69302. Serpinh1.

    Phylogenomic databases

    eggNOGi COG4826.
    HOGENOMi HOG000238519.
    HOVERGENi HBG104930.
    InParanoidi P29457.
    KOi K09501.
    PhylomeDBi P29457.

    Miscellaneous databases

    NextBioi 608840.
    PROi P29457.

    Gene expression databases

    Genevestigatori P29457.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A collagen-binding protein in the endoplasmic reticulum of myoblasts exhibits relationship with serine protease inhibitors."
      Clarke E.P., Cates G.A., Ball E.H., Sanwal B.D.
      J. Biol. Chem. 266:17230-17235(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 18-41; 167-192 AND 339-352.
    2. "Partial characterization of a collagen-binding, differentiation-related glycoprotein from skeletal myoblasts."
      Nanden D., Cates G.A., Ball E.H., Sanwal B.D.
      Arch. Biochem. Biophys. 278:291-296(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 18-33.

    Entry informationi

    Entry nameiSERPH_RAT
    AccessioniPrimary (citable) accession number: P29457
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1993
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3