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Protein

Interleukin-10

Gene

Il10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.By similarity

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • interleukin-10 receptor binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-RNO-6783783 Interleukin-10 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-10
Short name:
IL-10
Alternative name(s):
Cytokine synthesis inhibitory factor
Short name:
CSIF
Gene namesi
Name:Il10
Synonyms:Il-10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi2886 Il10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001537219 – 178Interleukin-10Add BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi30 ↔ 126By similarity
Disulfide bondi80 ↔ 132By similarity
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP29456
PRIDEiP29456

Expressioni

Gene expression databases

BgeeiENSRNOG00000004647
GenevisibleiP29456 RN

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • interleukin-10 receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006246

Structurei

3D structure databases

ProteinModelPortaliP29456
SMRiP29456
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYFW Eukaryota
ENOG4111PXC LUCA
GeneTreeiENSGT00510000048535
HOGENOMiHOG000072692
HOVERGENiHBG004110
InParanoidiP29456
KOiK05443
OMAiPHMLREL
OrthoDBiEOG091G0Y3M
PhylomeDBiP29456
TreeFamiTF333253

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000098 IL-10
IPR020443 IL-10/19/20/22/24/26_fam
IPR020423 IL-10_CS
PfamiView protein in Pfam
PF00726 IL10, 1 hit
PRINTSiPR01294 INTRLEUKIN10
SMARTiView protein in SMART
SM00188 IL10, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00520 INTERLEUKIN_10, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29456-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGSALLCCL LLLAGVKTSK GHSIRGDNNC THFPVSQTHM LRELRAAFSQ
60 70 80 90 100
VKTFFQKKDQ LDNILLTDSL LQDFKGYLGC QALSEMIKFY LVEVMPQAEN
110 120 130 140 150
HGPEIKEHLN SLGEKLKTLW IQLRRCHRFL PCENKSKAVE QVKNDFNKLQ
160 170
DKGVYKAMNE FDIFINCIEA YVTLKMKN
Length:178
Mass (Da):20,426
Last modified:April 1, 1993 - v1
Checksum:i0225AA6C63DAB70B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2P → L in CAA43090 (PubMed:8484757).Curated1
Sequence conflicti65L → V in CAA43090 (PubMed:8484757).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02926 mRNA Translation: AAA41425.1
X60675 mRNA Translation: CAA43090.1
PIRiJN0475
RefSeqiNP_036986.2, NM_012854.2
UniGeneiRn.9868

Genome annotation databases

EnsembliENSRNOT00000006246; ENSRNOP00000006246; ENSRNOG00000004647
GeneIDi25325
KEGGirno:25325
UCSCiRGD:2886 rat

Similar proteinsi

Entry informationi

Entry nameiIL10_RAT
AccessioniPrimary (citable) accession number: P29456
Secondary accession number(s): Q63263
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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