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Protein

Interleukin-10

Gene

Il10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.By similarity

GO - Molecular functioni

  • interleukin-10 receptor binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-10
Short name:
IL-10
Alternative name(s):
Cytokine synthesis inhibitory factor
Short name:
CSIF
Gene namesi
Name:Il10
Synonyms:Il-10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi2886. Il10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 178160Interleukin-10PRO_0000015372Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence analysis
Disulfide bondi30 ↔ 126By similarity
Disulfide bondi80 ↔ 132By similarity
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP29456.
PRIDEiP29456.

Expressioni

Gene expression databases

GenevisibleiP29456. RN.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

  • interleukin-10 receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006246.

Structurei

3D structure databases

ProteinModelPortaliP29456.
SMRiP29456. Positions 25-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYFW. Eukaryota.
ENOG4111PXC. LUCA.
GeneTreeiENSGT00510000048535.
HOGENOMiHOG000072692.
HOVERGENiHBG004110.
InParanoidiP29456.
KOiK05443.
OMAiPHMLREL.
OrthoDBiEOG7C2R33.
PhylomeDBiP29456.
TreeFamiTF333253.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000098. IL-10.
IPR020443. IL-10/19/20/22/24/26_fam.
IPR020423. IL-10_CS.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF00726. IL10. 1 hit.
[Graphical view]
PRINTSiPR01294. INTRLEUKIN10.
SMARTiSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29456-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGSALLCCL LLLAGVKTSK GHSIRGDNNC THFPVSQTHM LRELRAAFSQ
60 70 80 90 100
VKTFFQKKDQ LDNILLTDSL LQDFKGYLGC QALSEMIKFY LVEVMPQAEN
110 120 130 140 150
HGPEIKEHLN SLGEKLKTLW IQLRRCHRFL PCENKSKAVE QVKNDFNKLQ
160 170
DKGVYKAMNE FDIFINCIEA YVTLKMKN
Length:178
Mass (Da):20,426
Last modified:April 1, 1993 - v1
Checksum:i0225AA6C63DAB70B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21P → L in CAA43090 (PubMed:8484757).Curated
Sequence conflicti65 – 651L → V in CAA43090 (PubMed:8484757).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02926 mRNA. Translation: AAA41425.1.
X60675 mRNA. Translation: CAA43090.1.
PIRiJN0475.
RefSeqiNP_036986.2. NM_012854.2.
UniGeneiRn.9868.

Genome annotation databases

EnsembliENSRNOT00000006246; ENSRNOP00000006246; ENSRNOG00000004647.
GeneIDi25325.
KEGGirno:25325.
UCSCiRGD:2886. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L02926 mRNA. Translation: AAA41425.1.
X60675 mRNA. Translation: CAA43090.1.
PIRiJN0475.
RefSeqiNP_036986.2. NM_012854.2.
UniGeneiRn.9868.

3D structure databases

ProteinModelPortaliP29456.
SMRiP29456. Positions 25-178.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006246.

Proteomic databases

PaxDbiP29456.
PRIDEiP29456.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006246; ENSRNOP00000006246; ENSRNOG00000004647.
GeneIDi25325.
KEGGirno:25325.
UCSCiRGD:2886. rat.

Organism-specific databases

CTDi3586.
RGDi2886. Il10.

Phylogenomic databases

eggNOGiENOG410IYFW. Eukaryota.
ENOG4111PXC. LUCA.
GeneTreeiENSGT00510000048535.
HOGENOMiHOG000072692.
HOVERGENiHBG004110.
InParanoidiP29456.
KOiK05443.
OMAiPHMLREL.
OrthoDBiEOG7C2R33.
PhylomeDBiP29456.
TreeFamiTF333253.

Miscellaneous databases

NextBioi606181.
PROiP29456.

Gene expression databases

GenevisibleiP29456. RN.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000098. IL-10.
IPR020443. IL-10/19/20/22/24/26_fam.
IPR020423. IL-10_CS.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF00726. IL10. 1 hit.
[Graphical view]
PRINTSiPR01294. INTRLEUKIN10.
SMARTiSM00188. IL10. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Synthesis and characterization of rat interleukin-10 (IL-10) cDNA clones from the RNA of cultured OX8-OX22-thoracic duct T cells."
    Goodman R.E., Oblak J., Bell R.G.
    Biochem. Biophys. Res. Commun. 189:1-7(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning of rat cytokine synthesis inhibitory factor (IL-10) cDNA and expression in spleen and macrophages."
    Feng L., Tang W.W., Chang J.C.C., Wilson C.B.
    Biochem. Biophys. Res. Commun. 192:452-458(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Fischer 344.
    Tissue: Macrophage.

Entry informationi

Entry nameiIL10_RAT
AccessioniPrimary (citable) accession number: P29456
Secondary accession number(s): Q63263
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 11, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.