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Protein

Thioredoxin H1

Gene

TRX1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Thiol-disulfide oxidoreductase involved in the redox regulation of a number of cytosolic enzymes. Activates the cytosolic malate dehydrogenase (MDH) probably by reducing an interchain disulfide bond of the inactive MDH homodimer. Possesses insulin disulfide bonds reducing activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei34Deprotonates C-terminal active site CysBy similarity1
Active sitei40NucleophileBy similarity1
Sitei41Contributes to redox potential valueBy similarity1
Sitei42Contributes to redox potential valueBy similarity1
Active sitei43NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin H1
Short name:
AtTrxh1
Alternative name(s):
Thioredoxin 1
Short name:
AtTRX1
Gene namesi
Name:TRX1
Ordered Locus Names:At3g51030
ORF Names:F24M12.70
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G51030.
TAIRilocus:2080963. AT3G51030.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001200462 – 114Thioredoxin H1Add BLAST113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Disulfide bondi40 ↔ 43Redox-activePROSITE-ProRule annotation1 Publication

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

PaxDbiP29448.

Expressioni

Gene expression databases

ExpressionAtlasiP29448. baseline and differential.
GenevisibleiP29448. AT.

Interactioni

Subunit structurei

Interacts with FBA6.1 Publication

Protein-protein interaction databases

IntActiP29448. 45 interactors.
STRINGi3702.AT3G51030.1.

Structurei

Secondary structure

1114
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 13Combined sources5
Helixi14 – 26Combined sources13
Beta strandi30 – 36Combined sources7
Helixi41 – 56Combined sources16
Beta strandi58 – 66Combined sources9
Turni67 – 69Combined sources3
Helixi71 – 76Combined sources6
Beta strandi81 – 89Combined sources9
Beta strandi92 – 99Combined sources8
Helixi102 – 112Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XFLNMR-A1-114[»]
ProteinModelPortaliP29448.
SMRiP29448.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29448.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 114ThioredoxinPROSITE-ProRule annotationAdd BLAST113

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG0907. Eukaryota.
COG0526. LUCA.
HOGENOMiHOG000292977.
InParanoidiP29448.
KOiK03671.
OMAiDANQEFA.
OrthoDBiEOG09360XJ5.
PhylomeDBiP29448.

Family and domain databases

InterProiView protein in InterPro
IPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiView protein in Pfam
PF00085. Thioredoxin. 1 hit.
PIRSFiPIRSF000077. Thioredoxin. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29448-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASEEGQVIA CHTVETWNEQ LQKANESKTL VVVDFTASWC GPCRFIAPFF
60 70 80 90 100
ADLAKKLPNV LFLKVDTDEL KSVASDWAIQ AMPTFMFLKE GKILDKVVGA
110
KKDELQSTIA KHLA
Length:114
Mass (Da):12,673
Last modified:April 1, 1993 - v1
Checksum:iE090761B2187F1F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z14084 mRNA. Translation: CAA78462.1.
U35827 Genomic DNA. Translation: AAC49354.1.
AL132980 Genomic DNA. Translation: CAB62625.1.
CP002686 Genomic DNA. Translation: AEE78739.1.
AY088687 mRNA. Translation: AAM67008.1.
PIRiJQ2242.
RefSeqiNP_190672.1. NM_114963.5.
UniGeneiAt.193.

Genome annotation databases

EnsemblPlantsiAT3G51030.1; AT3G51030.1; AT3G51030.
GeneIDi824267.
GrameneiAT3G51030.1; AT3G51030.1; AT3G51030.
KEGGiath:AT3G51030.

Similar proteinsi

Entry informationi

Entry nameiTRXH1_ARATH
AccessioniPrimary (citable) accession number: P29448
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: August 30, 2017
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families