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P29443 (XYLA_LACBR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 31, 2011. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Xylose isomerase
EC=5.3.1.5
Gene names
Name:xylA
OrganismLactobacillus brevis
Taxonomic identifier1580 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-xylose = D-xylulose. HAMAP MF_00455

Cofactor

Binds 2 magnesium ions per subunit By similarity. HAMAP MF_00455

Subunit structure

Homotetramer By similarity. HAMAP MF_00455

Subcellular location

Cytoplasm By similarity HAMAP MF_00455.

Sequence similarities

Belongs to the xylose isomerase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Pentose shunt
Xylose metabolism
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionIsomerase
Gene Ontology (GO)
   Biological processD-xylose metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

pentose-phosphate shunt

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

xylose isomerase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 449449Xylose isomerase HAMAP MF_00455
PRO_0000195781

Sites

Active site1031 By similarity
Active site1061 By similarity
Metal binding2341Magnesium 1 By similarity
Metal binding2701Magnesium 1 By similarity
Metal binding2701Magnesium 2 By similarity
Metal binding2731Magnesium 2 By similarity
Metal binding2981Magnesium 1 By similarity
Metal binding3091Magnesium 2 By similarity
Metal binding3111Magnesium 2 By similarity
Metal binding3421Magnesium 1 By similarity

Sequences

Sequence LengthMass (Da)Tools
P29443 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 37170CFB5C435E4E

FASTA44950,757
        10         20         30         40         50         60 
MTEEYWKGVD KIQYVGHQDK KSGLGFQYYN PEEEIMGKKM KDWLRFAVAY WHTFDQRLVD 

        70         80         90        100        110        120 
PFGDGTAQRP YDKYTDPMDL ALAKVDAAFE FYQKLGVDYL CFHDRDLAPE GDTLRETNAN 

       130        140        150        160        170        180 
LDKVVDKIVE YQKTSGMKVL WNTSNMFTNP RFVEGAATSP YADVFAYSAA QLKHSLEIGK 

       190        200        210        220        230        240 
RVGSENYVFW GGREGYESLW NTNMKQEQEH AAKIFHMAKD YANEIGFDAQ MLLEPKPKEP 

       250        260        270        280        290        300 
TTHQYDFDAA TTIAFMKEYD LDKDFKLNLE GNHANLAGHT YQHEIRVARE AGLLGSLDAN 

       310        320        330        340        350        360 
QGDKLIGWDI DEYPSNLYET TAAMYEVVEN GSIGPRGGLN FDAKPRRSAF APEDLFLGHI 

       370        380        390        400        410        420 
VGMDSFAAGL RVAAAMKQDG FLDNLKADRY SSYKSGVGAD IESGKADLKS LEAYAIDKPQ 

       430        440 
SELIAATHSD HLEEIKDTIN HYIIDTLSK

« Hide

References

[1]"Cloning and sequencing the Lactobacillus brevis gene encoding xylose isomerase."
Bor Y.-C., Moraes C., Lee S.-P., Crosby W.L., Sinskey A.J., Batt C.A.
Gene 114:127-131(1992) [PubMed: 1587475] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Bor Y.-C., Batt C.A.
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M84564 Genomic DNA. Translation: AAA25256.1.
AF045552 Genomic DNA. Translation: AAC95125.1.
PIRJC1137.

3D structure databases

ProteinModelPortalP29443.
SMRP29443. Positions 3-444.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

HAMAPMF_00455. Xylose_isom_A.
[Tree]
InterProIPR013022. Xyl_isomerase-like_TIM-brl.
IPR012307. Xyl_isomerase_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
Gene3DG3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
PfamPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSPR00688. XYLOSISMRASE.
SUPFAMSSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMsTIGR02630. Xylose_isom_A. 1 hit.
PROSITEPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameXYLA_LACBR
AccessionPrimary (citable) accession number: P29443
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 31, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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