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Reviewed, UniProtKB/Swiss-Prot P29442 (XYLA_KLEPN)

Last modified September 22, 2009. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Xylose isomerase
      Short name=XI
    EC=5.3.1.5
Gene names
Name: xylA
OrganismKlebsiella pneumoniae
Taxonomic identifier573 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Klebsiella

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Protein attributes

Sequence length440 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

D-xylose = D-xylulose. HAMAP MF_00455

Cofactor

Binds 2 magnesium ions per subunit By similarity.

Subunit structure

Homotetramer. HAMAP MF_00455

Subcellular location

Cytoplasm. HAMAP MF_00455

Sequence similarities

Belongs to the xylose isomerase family.

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Ontologies

Keywords
   Biological processCarbohydrate metabolism
Pentose shunt
Xylose metabolism
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionIsomerase
Gene Ontology (GO)
   Biological processD-xylose metabolic process

Inferred from electronic annotation. Source: HAMAP

pentose-phosphate shunt

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionmagnesium ion binding

Inferred from electronic annotation. Source: HAMAP

xylose isomerase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 440440Xylose isomerase HAMAP MF_00455
PRO_0000195780

Sites

Active site1011 By similarity
Active site1041 By similarity
Metal binding2321Magnesium 1 By similarity
Metal binding2681Magnesium 1 By similarity
Metal binding2681Magnesium 2 By similarity
Metal binding2711Magnesium 2 By similarity
Metal binding2961Magnesium 1 By similarity
Metal binding3071Magnesium 2 By similarity
Metal binding3091Magnesium 2 By similarity
Metal binding3391Magnesium 1 By similarity

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Sequences

Sequence LengthMass (Da)Tools
P29442-1 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 7F6D98831F4774C3

FASTA44049,919
        10         20         30         40         50         60 
MQTYFDQLDR VRYEGPKSTN PLAFRHYNPD ELVLGKRMED HLRFAACYWH TFCWNGADMF 

        70         80         90        100        110        120 
GVGSFDRPWQ QPGDALEMAK RKADVAFEFF HKLNVPYYCF HDVDVSPEGA SLKEYSNNFA 

       130        140        150        160        170        180 
RMVEVLAEKQ QQSGVKLLWG TANCFTNPRY GAGAATNPDP EVFSWAATQV VTAMNATHQL 

       190        200        210        220        230        240 
GGENYVLWGG REGYETLLNT DLRQEREQLG RLLQLVVEHK HKIGFKGTLL IEPKPQEPTK 

       250        260        270        280        290        300 
HQYDYDASTV YGFLKQFGLE KEIKLNIEAN HATLAGHSFH HEIATAIALG LFGSVDANRG 

       310        320        330        340        350        360 
DPQLGWDTDQ FPNRVEEDAL VMYEIFKAGG FTTGGLNFDA KVRRQSTDKY DLFYGHIGAM 

       370        380        390        400        410        420 
DTMAVSLKVA ARMIEDGELD KRVARRYAGW NGELGQQILN GQMTLSDIAQ YAAQHQLAPQ 

       430        440 
HRSGQQEQLE NLVNHYLFDK

« Hide

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References

[1]"Cloning and expression of the genes for xylose isomerase and xylulokinase from Klebsiella pneumoniae 1033 in Escherichia coli K12."
Feldmann S.D., Sahm H., Sprenger G.A.
Mol. Gen. Genet. 234:201-210(1992) [PubMed: 1324398] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 1033-5P14 / KAY2026.

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Cross-references

Sequence databases

X61059 Genomic DNA. Translation: CAA43389.1.
PIRISKBX. S25069.

3D structure databases

HSSPHSSP built from PDB template 1A0E based on UniProtKB P45687.
ModBaseSearch...

Enzyme and pathway databases

BRENDA5.3.1.5. 758.

Family and domain databases

HAMAPMF_00455.
[Tree]
InterProIPR013022. Xyl_isomerase-like_TIM-brl.
IPR012307. Xyl_isomerase_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
IPR018115. Xylose_isomerase_AS.
[Graphical view]
Gene3DG3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
PfamPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSPR00688. XYLOSISMRASE.
TIGRFAMsTIGR02630. xylose_isom_A. 1 hit.
PROSITEPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameXYLA_KLEPN
AccessionPrimary (citable) accession number: P29442
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: September 22, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents