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Reviewed, UniProtKB/Swiss-Prot P29441 (XYLA_CLOTS)

Last modified September 22, 2009. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Xylose isomerase
    EC=5.3.1.5
Gene names
Name: xylA
OrganismClostridium thermosaccharolyticum (Thermoanaerobacterium thermosaccharolyticum)
Taxonomic identifier1517 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacterales Family III. Incertae Sedis › Thermoanaerobacterium

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Protein attributes

Sequence length439 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

D-xylose = D-xylulose. HAMAP MF_00455

Cofactor

Binds 2 magnesium ions per subunit By similarity.

Subunit structure

Homotetramer. HAMAP MF_00455

Subcellular location

Cytoplasm. HAMAP MF_00455

Sequence similarities

Belongs to the xylose isomerase family.

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Ontologies

Keywords
   Biological processCarbohydrate metabolism
Pentose shunt
Xylose metabolism
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionIsomerase
Gene Ontology (GO)
   Biological processD-xylose metabolic process

Inferred from electronic annotation. Source: HAMAP

pentose-phosphate shunt

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionmagnesium ion binding

Inferred from electronic annotation. Source: HAMAP

xylose isomerase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 439439Xylose isomerase HAMAP MF_00455
PRO_0000195773

Sites

Active site1011 By similarity
Active site1041 By similarity
Metal binding2321Magnesium 1 By similarity
Metal binding2681Magnesium 1 By similarity
Metal binding2681Magnesium 2 By similarity
Metal binding2711Magnesium 2 By similarity
Metal binding2961Magnesium 1 By similarity
Metal binding3071Magnesium 2 By similarity
Metal binding3091Magnesium 2 By similarity
Metal binding3391Magnesium 1 By similarity

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Sequences

Sequence LengthMass (Da)Tools
P29441-1 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: A15F49E65EB628B5

FASTA43950,229
        10         20         30         40         50         60 
MSKYFEKVSK IKYEGPKSNN PYAFKFYNPE EVIDGKTMEE HLRFSIAYWH TFTADGTDQF 

        70         80         90        100        110        120 
GKATMQRPWN HLTDPMDIAK ARVEAAFEFF DKINAPFFCF HDRDIAPEGD TLRETNKNLD 

       130        140        150        160        170        180 
IIVAMIKDYL KTSKTKVLWG TANLFSNPRF VHGASTSCNA DVFAYSAAQV KKALEITKEL 

       190        200        210        220        230        240 
GGQNYVFWGG REGYETLLNT DMELELDNFA RFLHMAVDYA KEIGFEGQFL IEPKPKEPTK 

       250        260        270        280        290        300 
HQYDFDVANV LAFLRKYDLD KYLKVNIEAN HATLAAHDFQ HELRYARING VLGSIDANTG 

       310        320        330        340        350        360 
DMLLGWDTDQ FPTDIRMTTL AMYEVIKMGG FDKGGLNFDA KVRRASFEPE DLFLGHIAGM 

       370        380        390        400        410        420 
DAFAKGFKVA YKLVKDAEFD KFIEERYASY KDGIGADIVS GKADFKSLEK YALEHSEIVT 

       430 
NQVDKKCLNQ YSIQYLFTE

« Hide

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References

[1]"The xylose isomerase-encoding gene (xylA) of Clostridium thermosaccharolyticum: cloning, sequencing and phylogeny of XylA enzymes."
Meaden P.G., Aduse-Opoku J., Reizer J., Reizer A., Lanceman Y.A., Martin M.F., Mitchell W.J.
Gene 141:97-101(1994) [PubMed: 8163183] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 7956 / DSM 571 / LMG 2811 / NCA 3814 / NCIB 9385.

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Cross-references

Sequence databases

M91248 Genomic DNA. Translation: AAA79035.1.
PIRI40806.

3D structure databases

HSSPHSSP built from PDB template 1A0C based on UniProtKB P19148.
SMRP29441. Positions 2-437.
ModBaseSearch...

Enzyme and pathway databases

BRENDA5.3.1.5. 486.

Family and domain databases

HAMAPMF_00455.
[Tree]
InterProIPR013022. Xyl_isomerase-like_TIM-brl.
IPR012307. Xyl_isomerase_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
IPR018115. Xylose_isomerase_AS.
[Graphical view]
Gene3DG3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
PfamPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSPR00688. XYLOSISMRASE.
TIGRFAMsTIGR02630. xylose_isom_A. 1 hit.
PROSITEPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameXYLA_CLOTS
AccessionPrimary (citable) accession number: P29441
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: September 22, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents