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P29434 (DNAA_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chromosomal replication initiator protein DnaA
Gene names
Name:dnaA
Ordered Locus Names:BUsg_012
OrganismBuchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]
Taxonomic identifier198804 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera

Protein attributes

Sequence length454 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP-Rule MF_00377

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00377.

Sequence similarities

Belongs to the DnaA family.

Ontologies

Keywords
   Biological processDNA replication
   Cellular componentCytoplasm
   LigandATP-binding
DNA-binding
Nucleotide-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processDNA replication initiation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

regulation of DNA replication

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

DNA replication origin binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleoside-triphosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 454454Chromosomal replication initiator protein DnaA HAMAP-Rule MF_00377
PRO_0000114149

Regions

Nucleotide binding159 – 1668ATP Potential

Sequences

Sequence LengthMass (Da)Tools
P29434 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: A989508297256C3C

FASTA45452,527
        10         20         30         40         50         60 
MSLCLWKQCL DRLQSELPST EFSMWIRSLK AKLNNNILEI YAPNQFILDW VKDKYLIHFK 

        70         80         90        100        110        120 
KILQDFCGSN SPFIKFKVYQ TSKEKKFKKN ILQKIQNLNA KPIWDKIPIF KKSSHRSNIN 

       130        140        150        160        170        180 
KKHSFENFIE GKSNQLARAA ASQVAKNPGN SYNPLFLYGG TGLGKTHLLH AIGNGILAYK 

       190        200        210        220        230        240 
YNVKIIYMHS ERFVQDMVKA LQNNAIEKFK LYYRSVDALL IDDIQFFAHK ERSQEEFFHT 

       250        260        270        280        290        300 
FNALLEGNQQ IILTSDRYPK EINGVEDRLK SRFGWGLTVA IDPPELETRV AILIKKADEN 

       310        320        330        340        350        360 
NIVLSDEVAF FIAKHLRSNV RELEGALNRV IVNANFTHRS ITVEFVREAL RDILALQEKL 

       370        380        390        400        410        420 
VTIANIQKTV AEYYKIKVAD LLSRRRSRSV ARPRQMAMAM AKELTNHSLP EIGDAFSGRD 

       430        440        450 
HTTVLHACRK IEQLRKENHD IKEDFSNLIR TLSV 

« Hide

References

« Hide 'large scale' references
[1]"Genetic analysis of an aphid endosymbiont DNA fragment homologous to the rnpA-rpmH-dnaA-dnaN-gyrB region of eubacteria."
Lai C.-Y., Baumann P.
Gene 113:175-181(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Sequence analysis of a 34.7-kb DNA segment from the genome of Buchnera aphidicola (endosymbiont of aphids) containing groEL, dnaA, the atp operon, gidA, and rho."
Clark M.A., Baumann L., Baumann P.
Curr. Microbiol. 36:158-163(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"50 million years of genomic stasis in endosymbiotic bacteria."
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.
Science 296:2376-2379(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Sg.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M80817 Genomic DNA. Translation: AAA73149.1. Sequence problems.
AF008210 Genomic DNA. Translation: AAC38106.1.
AE013218 Genomic DNA. Translation: AAM67584.1.
PIRIQJVBA. JC1158.
RefSeqNP_660373.1. NC_004061.1.

3D structure databases

ProteinModelPortalP29434.
SMRP29434. Positions 2-79, 361-453.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING198804.BUsg012.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM67584; AAM67584; BUsg_012.
GeneID1005828.
KEGGbas:BUsg012.
PATRIC21246779. VBIBucAph100086_0012.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0593.
KOK02313.
OMAHSSISKM.
OrthoDBEOG689HR1.
ProtClustDBPRK00149.

Enzyme and pathway databases

BioCycBAPH198804:GHMG-12-MONOMER.

Family and domain databases

Gene3D1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00377. DnaA_bact.
InterProIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013159. DnaA_C.
IPR013317. DnaA_Hda.
IPR024633. DnaA_N_dom.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
PF11638. DnaA_N. 1 hit.
[Graphical view]
PRINTSPR00051. DNAA.
SMARTSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00362. DnaA. 1 hit.
PROSITEPS01008. DNAA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNAA_BUCAP
AccessionPrimary (citable) accession number: P29434
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Buchnera aphidicola (subsp. Schizaphis graminum)

Buchnera aphidicola (subsp. Schizaphis graminum): entries and gene names