Reviewed, UniProtKB/Swiss-Prot P29433 (RNPA_BUCAP)

Names and origin

Protein names

Recommended name:
    Ribonuclease P protein component
      Short name=RNaseP protein
      Short name=RNase P protein
    EC=3.1.26.5
Alternative name(s):
    Protein C5

Gene names

Name:	rnpA
Ordered Locus Names:	BUsg_014

Organism

Buchnera aphidicola subsp. Schizaphis graminum [Complete proteome] [HAMAP]

Taxonomic identifier

98794 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	114 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme By similarity.
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. HAMAP MF_00227
Subunit structure	Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit By similarity.
Sequence similarities	Belongs to the rnpA family.

Ontologies

Keywords
Biological process	tRNA processing
Ligand	RNA-binding
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tRNA 5'-leader removal Inferred from electronic annotation. Source: HAMAP
Molecular function	ribonuclease P activity Inferred from electronic annotation. Source: HAMAP tRNA binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 114	114	Ribonuclease P protein component HAMAP MF_00227		PRO_0000198436

Sequences

	Sequence		Length	Mass (Da)
	P29433-1 [UniParc]. Last modified April 1, 1993. Version 1. Checksum: 3FFFFDA2262D95CA	FASTA	114	13,784
	10 20 30 40 50 60 MLNYFFKKKS KLLKSTNFQY VFSNPCNKNT FHINILGRSN LLGHPRLGLS ISRKNIKHAY 70 80 90 100 110 RRNKIKRLIR ETFRLLQHRL ISMDFVVIAK KNIVYLNNKK IVNILEYIWS NYQR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genetic analysis of an aphid endosymbiont DNA fragment homologous to the rnpA-rpmH-dnaA-dnaN-gyrB region of eubacteria." Lai C.-Y., Baumann P. Gene 113:175-181(1992) [PubMed: 1572539] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequence analysis of a 34.7-kb DNA segment from the genome of Buchnera aphidicola (endosymbiont of aphids) containing groEL, dnaA, the atp operon, gidA, and rho." Clark M.A., Baumann L., Baumann P. Curr. Microbiol. 36:158-163(1998) [PubMed: 9516544] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	M80817 Genomic DNA. Translation: AAA73147.1. AF008210 Genomic DNA. Translation: AAC38104.1. AE013218 Genomic DNA. Translation: AAM67586.1.
PIR	JC1155.
RefSeq	NP_660375.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1005830.
GenomeReviews	Gene locus BUsg_014 in contig AE013218_GR.
KEGG	bas:BUsg014.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P29433.
OMA	PRIGLAI
Enzyme and pathway databases
BioCyc	BAPH198804:BUSG014-MON.
Family and domain databases
HAMAP	MF_00227. [Tree]
InterPro	IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. IPR000100. RNase_P. IPR020539. RNase_P_CS. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
Pfam	PF00825. Ribonuclease_P. 1 hit. [Graphical view]
ProDom	PD003629. Ribonuclease_P. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00188. rnpA. 1 hit.
PROSITE	PS00648. RIBONUCLEASE_P. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RNPA_BUCAP

Accession

Primary (citable) accession number: P29433

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	April 1, 1993
Last modified:	November 24, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)