P29431 (YIDC_BUCAP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Membrane protein insertase YidC

Alternative name(s):
Foldase YidC
Membrane integrase YidC
Membrane protein YidC

Gene names

Name:	yidC
Ordered Locus Names:	BUsg_016

Organism

Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) [Complete proteome] [HAMAP]

Taxonomic identifier

198804 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	536 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins By similarity.
Subunit structure	Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01810.
Sequence similarities	Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
Sequence caution	The sequence AAM67588.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein insertion into membrane Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 536	536	Membrane protein insertase YidC		PRO_0000124697
Regions
	Transmembrane	7 – 27	21	Helical; Potential
	Transmembrane	338 – 358	21	Helical; Potential
	Transmembrane	419 – 439	21	Helical; Potential
	Transmembrane	453 – 473	21	Helical; Potential
	Transmembrane	494 – 514	21	Helical; Potential
Experimental info
	Sequence conflict	367	1	L → V in BAA12844. Ref.1
	Sequence conflict	367	1	L → V in AAC38102. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P29431 [UniParc]. Last modified August 30, 2002. Version 3. Checksum: 27A7C397679D7707	FASTA	536	62,660
	10 20 30 40 50 60 MELQRNFFIF AFLFVSFLLW QAWQSQSLKK NKKNEETNSF FHLNHKKEDK NQIIIKNDVL 70 80 90 100 110 120 RLVINMYGGD IEEASLLDYK TQLNSPENLK LLETKSDFVY QAQSGLIGKD GLDNSINKIR 130 140 150 160 170 180 PLYSAKKNFF ELGHNEKELR VPITFIAKNG ITYIKNFILK PGKYNVEVEY DINNLSNKKL 190 200 210 220 230 240 ELNIFGQLKQ TVKLPKNRDI YSGNFALQTF RGAAYSSSDA KYEKYKFDNI ANHEHLHIIT 250 260 270 280 290 300 HHGWIAMLQQ YFVVAWVPDT NISSSNIIYT SYLDNDGIAI IGYKSSLINI PSNSRYIIKS 310 320 330 340 350 360 KLWIGPEKQQ EMALVAPNLD LTVDYGFLWF LSQPLFKLLS TIHNFIGNWG FSIILITFMM 370 380 390 400 410 420 KAITYPLTKA QYTSMSKMRE LQPKINELKK NFGHDKQRMS KEIMALYKKE KINPLGGCLP 430 440 450 460 470 480 VFIQMPIFLS LYYMLIGSVE LRHAPFLFWI KDLSDQDPYY VLPIFMGLTM FFIQRTSSNN 490 500 510 520 530 ISDPFQQKIM HFMPFIFTVF FLWFPSGLVL YYIVSNLVTI IQQKYILSNF KKNQKR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of 60K, tdhF, groES and groEL genes of Buchnera aphidicola." Anwarul H.K., Moriya S., Baumann P., Yoshikawa H., Ogasawara N. Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequence analysis of a 34.7-kb DNA segment from the genome of Buchnera aphidicola (endosymbiont of aphids) containing groEL, dnaA, the atp operon, gidA, and rho." Clark M.A., Baumann L., Baumann P. Curr. Microbiol. 36:158-163(1998) [PubMed: 9516544] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"50 million years of genomic stasis in endosymbiotic bacteria." Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E. Science 296:2376-2379(2002) [PubMed: 12089438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Sg.
[4]	"Genetic analysis of an aphid endosymbiont DNA fragment homologous to the rnpA-rpmH-dnaA-dnaN-gyrB region of eubacteria." Lai C.-Y., Baumann P. Gene 113:175-181(1992) [PubMed: 1572539] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-273.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D85628 Genomic DNA. Translation: BAA12844.1. AF008210 Genomic DNA. Translation: AAC38102.1. AE013218 Genomic DNA. Translation: AAM67588.1. Different initiation. M80817 Genomic DNA. Translation: AAA73145.1.
PIR	JC1157.
RefSeq	NP_660377.1. NC_004061.1.
3D structure databases
ProteinModelPortal	P29431.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBUCT00000000398; EBBUCP00000000398; EBBUCG00000000398.
GeneID	1005832.
GenomeReviews	Gene locus BUsg_016 in contig AE013218_GR.
KEGG	bas:BUsg016.
PATRIC	21246787. VBIBucAph100086_0016.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000007702.
HOGENOM	HBG507812.
OMA	TYRGAAF.
ProtClustDB	CLSK315002.
Enzyme and pathway databases
BioCyc	BAPH198804:BUSG016-MONOMER.
Family and domain databases
HAMAP	MF_01810. YidC_type1. [Tree]
InterPro	IPR019998. Membr_insert_OxaA/YidC_bac. IPR001708. Membrane_insertion_OxaA/YidC. [Graphical view]
KO	K03217.
PANTHER	PTHR12428. Innermemb_insert. 1 hit.
Pfam	PF02096. 60KD_IMP. 1 hit. [Graphical view]
PRINTS	PR00701. 60KDINNERMP. PR01900. YIDCPROTEIN.
TIGRFAMs	TIGR03593. YidC_nterm. 1 hit. TIGR03592. YidC_oxa1_C. 1 hit.
ProtoNet	Search...

Entry information

Entry name

YIDC_BUCAP

Accession

Primary (citable) accession number: P29431

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	August 30, 2002
Last modified:	January 25, 2012
This is version 75 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program