Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Bacteriocin pediocin PA-1

Gene

pedA

Organism
Pediococcus acidilactici
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Bactericidal activity (effective inhibitor of L.monocytogenes).

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Bacteriocin

Protein family/group databases

TCDBi1.C.24.1.1. the pediocin (pediocin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Bacteriocin pediocin PA-1
Alternative name(s):
Pediocin ACH
Gene namesi
Name:pedA
Synonyms:pap, papA
Encoded oniPlasmid pSRQ112 Publications
Plasmid pSMB741 Publication
OrganismiPediococcus acidilactici
Taxonomic identifieri1254 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaePediococcusPediococcus acidilactici group

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 18182 PublicationsPRO_0000002745Add
BLAST
Chaini19 – 6244Bacteriocin pediocin PA-1PRO_0000002746Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 321 Publication
Disulfide bondi42 ↔ 621 Publication

Keywords - PTMi

Disulfide bond

Miscellaneous databases

PMAP-CutDBP29430.

Structurei

3D structure databases

ProteinModelPortaliP29430.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni40 – 5213HydrophobicAdd
BLAST

Sequence similaritiesi

Belongs to the bacteriocin class IIA/YGNGV family.Curated

Family and domain databases

Gene3Di1.20.5.130. 1 hit.
InterProiIPR002633. Bacteriocin_IIa.
IPR023384. Bacteriocin_IIa_CS.
IPR023388. Bacteriocin_IIa_dom.
IPR010133. Bacteriocin_signal_seq.
[Graphical view]
PfamiPF01721. Bacteriocin_II. 1 hit.
[Graphical view]
ProDomiPD004452. Bacteriocin_II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR01847. bacteriocin_sig. 1 hit.
PROSITEiPS60030. BACTERIOCIN_IIA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29430-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKIEKLTEK EMANIIGGKY YGNGVTCGKH SCSVDWGKAT TCIINNGAMA
60
WATGGHQGNH KC
Length:62
Mass (Da):6,644
Last modified:June 1, 1994 - v2
Checksum:i8E6F10D49FA87BA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83924 Genomic DNA. Translation: AAA25559.1.
M90679 Genomic DNA. Translation: AAA98337.1.
U02482 Genomic DNA. Translation: AAC43293.1.
PIRiA48941.
RefSeqiNP_857602.1. NC_004832.1.
WP_002834575.1. NC_004832.1.

Genome annotation databases

GeneIDi1090329.
KEGGipg:1090329.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83924 Genomic DNA. Translation: AAA25559.1.
M90679 Genomic DNA. Translation: AAA98337.1.
U02482 Genomic DNA. Translation: AAC43293.1.
PIRiA48941.
RefSeqiNP_857602.1. NC_004832.1.
WP_002834575.1. NC_004832.1.

3D structure databases

ProteinModelPortaliP29430.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi1.C.24.1.1. the pediocin (pediocin) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1090329.
KEGGipg:1090329.

Miscellaneous databases

PMAP-CutDBP29430.

Family and domain databases

Gene3Di1.20.5.130. 1 hit.
InterProiIPR002633. Bacteriocin_IIa.
IPR023384. Bacteriocin_IIa_CS.
IPR023388. Bacteriocin_IIa_dom.
IPR010133. Bacteriocin_signal_seq.
[Graphical view]
PfamiPF01721. Bacteriocin_II. 1 hit.
[Graphical view]
ProDomiPD004452. Bacteriocin_II. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsiTIGR01847. bacteriocin_sig. 1 hit.
PROSITEiPS60030. BACTERIOCIN_IIA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning, expression, and nucleotide sequence of genes involved in production of pediocin PA-1, and bacteriocin from Pediococcus acidilactici PAC1.0."
    Marugg J.D., Gonzalez C.F., Kunka B.S., Ledeboer A.M., Pucci M.J., Toonen M.Y., Walker S.A., Zoetmulder L.C.M., Vandenbergh P.A.
    Appl. Environ. Microbiol. 58:2360-2367(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: PAC-1.0.
    Plasmid: pSRQ11
  2. "Complete nucleotide sequence of pSMB 74, a plasmid encoding the production of pediocin AcH in Pediococcus acidilactici."
    Motlagh A.M., Bukhtiyarova M.B., Ray B.R.
    Lett. Appl. Microbiol. 18:305-312(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: H.
    Plasmid: pSMB74
  3. "Purification and primary structure of pediocin PA-1 produced by Pediococcus acidilactici PAC-1.0."
    Henderson J.T., Chopko A.L., van Wassenaar P.D.
    Arch. Biochem. Biophys. 295:5-12(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 19-62, DISULFIDE BONDS.
    Strain: PAC-1.0.
    Plasmid: pSRQ11
  4. "Purification and amino acid sequence of a bacteriocin produced by Pediococcus acidilactici."
    Lozano J.C.N., Meyer J.N., Sletten K., Pelaz C., Nes I.F.
    J. Gen. Microbiol. 138:1985-1990(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 19-61.

Entry informationi

Entry nameiPPA1_PEDAC
AccessioniPrimary (citable) accession number: P29430
Secondary accession number(s): P34912
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: June 1, 1994
Last modified: September 16, 2015
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.