Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Catalase

Gene

katA

Organism
Micrococcus luteus (Micrococcus lysodeikticus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.

Catalytic activityi

2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei611
Active sitei1331
Metal bindingi343Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding, NADP

Enzyme and pathway databases

SABIO-RKP29422.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase (EC:1.11.1.6)
Gene namesi
Name:katA
OrganismiMicrococcus luteus (Micrococcus lysodeikticus)
Taxonomic identifieri1270 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeMicrococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000849901 – 503CatalaseAdd BLAST503

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi465515.MlutN2_010100004891.

Structurei

Secondary structure

1503
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi18 – 20Combined sources3
Turni31 – 33Combined sources3
Helixi41 – 50Combined sources10
Beta strandi63 – 73Combined sources11
Turni78 – 80Combined sources3
Helixi84 – 86Combined sources3
Beta strandi91 – 99Combined sources9
Beta strandi101 – 103Combined sources3
Beta strandi111 – 113Combined sources3
Beta strandi116 – 123Combined sources8
Beta strandi126 – 136Combined sources11
Helixi143 – 145Combined sources3
Helixi146 – 153Combined sources8
Turni157 – 159Combined sources3
Helixi164 – 172Combined sources9
Helixi175 – 177Combined sources3
Helixi178 – 185Combined sources8
Helixi187 – 189Combined sources3
Beta strandi190 – 192Combined sources3
Helixi194 – 196Combined sources3
Beta strandi205 – 208Combined sources4
Beta strandi214 – 223Combined sources10
Helixi232 – 241Combined sources10
Helixi245 – 255Combined sources11
Beta strandi261 – 270Combined sources10
Helixi273 – 276Combined sources4
Turni290 – 292Combined sources3
Beta strandi296 – 305Combined sources10
Helixi310 – 313Combined sources4
Turni314 – 316Combined sources3
Helixi334 – 350Combined sources17
Helixi355 – 357Combined sources3
Helixi359 – 361Combined sources3
Beta strandi386 – 389Combined sources4
Beta strandi391 – 393Combined sources3
Helixi428 – 436Combined sources9
Helixi440 – 454Combined sources15
Helixi459 – 472Combined sources14
Helixi474 – 485Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GWEX-ray0.88A1-502[»]
1GWFX-ray1.96A1-502[»]
1GWHX-ray1.74A1-502[»]
1HBZX-ray1.50A6-502[»]
ProteinModelPortaliP29422.
SMRiP29422.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29422.

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.Curated

Phylogenomic databases

eggNOGiENOG4105CH6. Bacteria.
COG0753. LUCA.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29422-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHQKTTPHA TGSTRQNGAP AVSDRQSLTV GSEGPIVLHD THLLETHQHF
60 70 80 90 100
NRMNIPERRP HAKGSGAFGE FEVTEDVSKY TKALVFQPGT KTETLLRFST
110 120 130 140 150
VAGELGSPDT WRDVRGFALR FYTEEGNYDL VGNNTPIFFL RDPMKFTHFI
160 170 180 190 200
RSQKRLPDSG LRDATMQWDF WTNNPESAHQ VTYLMGPRGL PRTWREMNGY
210 220 230 240 250
GSHTYLWVNA QGEKHWVKYH FISQQGVHNL SNDEATKIAG ENADFHRQDL
260 270 280 290 300
FESIAKGDHP KWDLYIQAIP YEEGKTYRFN PFDLTKTISQ KDYPRIKVGT
310 320 330 340 350
LTLNRNPENH FAQIESAAFS PSNTVPGIGL SPDRMLLGRA FAYHDAQLYR
360 370 380 390 400
VGAHVNQLPV NRPKNAVHNY AFEGQMWYDH TGDRSTYVPN SNGDSWSDET
410 420 430 440 450
GPVDDGWEAD GTLTREAQAL RADDDDFGQA GTLVREVFSD QERDDFVETV
460 470 480 490 500
AGALKGVRQD VQARAFEYWK NVDATIGQRI EDEVKRHEGD GIPGVEAGGE

ARM
Length:503
Mass (Da):56,906
Last modified:December 6, 2002 - v2
Checksum:i8C60ADEFC0E46A09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ438208 Genomic DNA. Translation: CAD27348.1.
PIRiS27264.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ438208 Genomic DNA. Translation: CAD27348.1.
PIRiS27264.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GWEX-ray0.88A1-502[»]
1GWFX-ray1.96A1-502[»]
1GWHX-ray1.74A1-502[»]
1HBZX-ray1.50A6-502[»]
ProteinModelPortaliP29422.
SMRiP29422.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi465515.MlutN2_010100004891.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105CH6. Bacteria.
COG0753. LUCA.

Enzyme and pathway databases

SABIO-RKP29422.

Miscellaneous databases

EvolutionaryTraceiP29422.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCATA_MICLU
AccessioniPrimary (citable) accession number: P29422
Secondary accession number(s): Q8RK91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: December 6, 2002
Last modified: November 2, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.