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Protein

ATP synthase subunit e, mitochondrial

Gene

Atp5i

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.

GO - Molecular functioni

GO - Biological processi

  • ATP metabolic process Source: RGD
  • ATP synthesis coupled proton transport Source: InterPro

Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-163210 Formation of ATP by chemiosmotic coupling
R-RNO-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit e, mitochondrial
Short name:
ATPase subunit e
Gene namesi
Name:Atp5i
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi621377 Atp5i

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000716882 – 71ATP synthase subunit e, mitochondrialAdd BLAST70

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34N6-acetyllysineBy similarity1
Modified residuei68PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP29419
PRIDEiP29419

PTM databases

iPTMnetiP29419
PhosphoSitePlusiP29419
SwissPalmiP29419

Expressioni

Gene expression databases

BgeeiENSRNOG00000000064

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5MC1, ATP5F1E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5O, ATP5L, USMG5 and MP68.1 Publication

Protein-protein interaction databases

CORUMiP29419
IntActiP29419, 1 interactor
STRINGi10116.ENSRNOP00000000072

Structurei

3D structure databases

SMRiP29419
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase e subunit family.Curated

Phylogenomic databases

eggNOGiKOG4326 Eukaryota
ENOG410XYSS LUCA
GeneTreeiENSGT00390000005102
HOGENOMiHOG000231826
HOVERGENiHBG050613
InParanoidiP29419
KOiK02129
OMAiEQERIYK
OrthoDBiEOG091G13NK
PhylomeDBiP29419
TreeFamiTF314719

Family and domain databases

InterProiView protein in InterPro
IPR008386 ATP_synth_F0_esu_mt
PfamiView protein in Pfam
PF05680 ATP-synt_E, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29419-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPPVQVSPL IKFGRYSALI LGMAYGAKRY SYLKPRAEEE RRIAAEEKKR
60 70
LDELKRIERE LAEAEDVSIF K
Length:71
Mass (Da):8,255
Last modified:January 23, 2007 - v3
Checksum:i0377253CE2B422D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13121 mRNA Translation: BAA02423.1
BC058449 mRNA Translation: AAH58449.1
PIRiA44246
RefSeqiNP_536729.1, NM_080481.1
UniGeneiRn.66347

Genome annotation databases

EnsembliENSRNOT00000000072; ENSRNOP00000000072; ENSRNOG00000000064
GeneIDi140608
KEGGirno:140608
UCSCiRGD:621377 rat

Similar proteinsi

Entry informationi

Entry nameiATP5I_RAT
AccessioniPrimary (citable) accession number: P29419
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 121 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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