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Protein

Gap junction alpha-3 protein

Gene

Gja3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Molecular functioni

  • gap junction channel activity Source: RGD
  • identical protein binding Source: RGD

GO - Biological processi

  • cell communication Source: InterPro
  • response to hydrogen peroxide Source: RGD
  • response to pH Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-3 protein
Alternative name(s):
Connexin-46
Short name:
Cx46
Gene namesi
Name:Gja3
Synonyms:Cxn-46
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621820. Gja3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919CytoplasmicSequence analysisAdd
BLAST
Transmembranei20 – 4021HelicalSequence analysisAdd
BLAST
Topological domaini41 – 7636ExtracellularSequence analysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence analysisAdd
BLAST
Topological domaini98 – 15861CytoplasmicSequence analysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence analysisAdd
BLAST
Topological domaini180 – 20728ExtracellularSequence analysisAdd
BLAST
Transmembranei208 – 22821HelicalSequence analysisAdd
BLAST
Topological domaini229 – 416188CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • connexon complex Source: InterPro
  • gap junction Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • membrane raft Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Gap junction alpha-3 proteinPRO_0000057812Add
BLAST

Proteomic databases

PaxDbiP29414.
PRIDEiP29414.

Expressioni

Tissue specificityi

Most abundant in lens, but also present in heart and kidney.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. This particular connexin is a component of lens fiber gap junctions, can form both junctional and non-junctional ("hemi-") channels.

GO - Molecular functioni

  • identical protein binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011699.

Structurei

3D structure databases

ProteinModelPortaliP29414.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF3Z. Eukaryota.
ENOG410ZC96. LUCA.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiP29414.
KOiK07612.
PhylomeDBiP29414.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002262. Connexin46.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 2 hits.
PTHR11984:SF12. PTHR11984:SF12. 2 hits.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01133. CONNEXINA3.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29414-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWSFLGRL LENAQEHSTV IGKVWLTVLF IFRILVLGAA AEEVWGDEQS
60 70 80 90 100
DFTCNTQQPG CENVCYDRAF PISHIRFWAL QIIFVSTPTL IYLGHVLHIV
110 120 130 140 150
RMEEKKKERE EELLRRDNPQ HGRGREPMRT GSPRDPPLRD DRGKVRIAGA
160 170 180 190 200
LLRTYVFNII FKTLFEVGFI AGQYFLYGFQ LQPLYRCDRW PCPNTVDCFI
210 220 230 240 250
SRPTEKTIFV IFMLAVACAS LVLNMLEIYH LGWKKLKQGV TNHFNPDASE
260 270 280 290 300
VRHKPLDPLS EAANSGPPSV SIGLPPYYTH PACPTVQGKA TGFPGAPLLP
310 320 330 340 350
ADFTVVTLND AQGRGHPVKH CNGHHLTTEQ NWASLGAEPQ TPASKPSSAA
360 370 380 390 400
SSPHGRKGLT DSSGSSLEES ALVVTPEGEQ ALATTVEMHS PPLVLLDPER
410
SSKSSSGRAR PGDLAI
Length:416
Mass (Da):46,013
Last modified:January 23, 2007 - v2
Checksum:i8232B98E0C3A1F8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57970 mRNA. Translation: CAA41036.1.
PIRiS25764.
RefSeqiNP_077352.1. NM_024376.2.
UniGeneiRn.10345.

Genome annotation databases

GeneIDi79217.
KEGGirno:79217.
UCSCiRGD:621820. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57970 mRNA. Translation: CAA41036.1.
PIRiS25764.
RefSeqiNP_077352.1. NM_024376.2.
UniGeneiRn.10345.

3D structure databases

ProteinModelPortaliP29414.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011699.

Proteomic databases

PaxDbiP29414.
PRIDEiP29414.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi79217.
KEGGirno:79217.
UCSCiRGD:621820. rat.

Organism-specific databases

CTDi2700.
RGDi621820. Gja3.

Phylogenomic databases

eggNOGiENOG410IF3Z. Eukaryota.
ENOG410ZC96. LUCA.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiP29414.
KOiK07612.
PhylomeDBiP29414.

Miscellaneous databases

PROiP29414.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002262. Connexin46.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 2 hits.
PTHR11984:SF12. PTHR11984:SF12. 2 hits.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01133. CONNEXINA3.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Connexin46, a novel lens gap junction protein, induces voltage-gated currents in nonjunctional plasma membrane of Xenopus oocytes."
    Paul D.L., Ebihara L., Takemoto L.J., Swenson K.I., Goodenough D.A.
    J. Cell Biol. 115:1077-1089(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD Charles River.
    Tissue: Lens.

Entry informationi

Entry nameiCXA3_RAT
AccessioniPrimary (citable) accession number: P29414
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.