Reviewed, UniProtKB/Swiss-Prot P29411 (KAD3_RAT)

Names and origin

Protein names

Recommended name:
    GTP:AMP phosphotransferase mitochondrial
    EC=2.7.4.10
Alternative name(s):
    Adenylate kinase 3
      Short name=AK 3
    Adenylate kinase 3 alpha-like 1

Gene names

Name:	Ak3
Synonyms:	Ak3l1, Akl3l

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	NTP + AMP = NDP + ADP.
Subunit structure	Monomer.
Subcellular location	Mitochondrion matrix.
Sequence similarities	Belongs to the adenylate kinase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Ligand	GTP-binding Nucleotide-binding
Molecular function	Kinase Transferase
PTM	Acetylation
Gene Ontology (GO)
Biological process	AMP phosphorylation Inferred from direct assay. Source: RGD
Cellular component	mitochondrial matrix Inferred from direct assay. Source: RGD
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro GTP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from direct assay. Source: RGD identical protein binding Inferred from direct assay. Source: RGD nucleoside triphosphate adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 227	226	GTP:AMP phosphotransferase mitochondrial		PRO_0000158925
Regions
	Nucleotide binding	14 – 22	9	GTP By similarity
	Nucleotide binding	91 – 98	8	AMP By similarity
Sites
	Binding site	38	1	AMP By similarity
Amino acid modifications
	Modified residue	34	1	N6-acetyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P29411-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: D2229F7E3BF65676	FASTA	227	25,438
	10 20 30 40 50 60 MGASGRLLRA VIMGAPGSGK GTGSSRITKH FELKHLSSGD LLRQNMLQGT EIAVLAKSFI 70 80 90 100 110 120 DQGKLIPDDD MTRLALHELK NLTQCSWLLD GFPRTLPQAE ALDRVYQIDT VINLNVPFEV 130 140 150 160 170 180 IKLRLTARWI HPASGRVYNI EFNPPKTVGI DDLTGEPLIQ REDDKPETVI KRLKAYEAQT 190 200 210 220 EPVLQYYQKK GVLETFSGTE TNKIRPHVYS FLQMKVPETI QKASVTP

References

[1]	"Tissue-specific and developmentally regulated expression of the genes encoding adenylate kinase isozymes." Tanabe T., Yamada M., Noma T., Kajii T., Nakazawa A. J. Biochem. 113:200-207(1993) [PubMed: 8468325] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D13062 mRNA. Translation: BAA02379.1.
IPI	IPI00362243.
PIR	JQ1945.
RefSeq	NP_037350.1.
UniGene	Rn.60
3D structure databases
HSSP	HSSP built from PDB template 2AK3 based on UniProtKB P08760.
SMR	P29411. Positions 2-227.
ModBase	Search...
Protein-protein interaction databases
STRING	P29411.
Genome annotation databases
Ensembl	ENSRNOT00000020744; ENSRNOP00000020744; ENSRNOG00000015273; Rattus norvegicus. [Genome view]
GeneID	26956.
KEGG	rno:26956.
UCSC	NM_013218. rat.
Organism-specific databases
CTD	26956.
RGD	619885. Ak3.
Phylogenomic databases
HOVERGEN	P29411.
Enzyme and pathway databases
BRENDA	2.7.4.10. 248.
Gene expression databases
ArrayExpress	P29411.
Genevestigator	P29411.
GermOnline	ENSRNOG00000015273. Rattus norvegicus.
Family and domain databases
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_Znf_lid. [Graphical view]
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. PF05191. ADK_lid. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
ProDom	PD000657. Adenylate_kin. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01351. adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	608029.

Entry information

Entry name

KAD3_RAT

Accession

Primary (citable) accession number: P29411

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1993
Last sequence update:	January 23, 2007
Last modified:	October 13, 2009
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)