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P29408

- PGK1_MACEU

UniProt

P29408 - PGK1_MACEU

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Protein
Phosphoglycerate kinase 1
Gene
PGK1, PGK-1
Organism
Macropus eugenii (Tammar wallaby)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391Substrate By similarity
Binding sitei123 – 1231Substrate By similarity
Binding sitei171 – 1711Substrate By similarity
Binding sitei220 – 2201ATP By similarity
Binding sitei313 – 3131ATP; via carbonyl oxygen By similarity
Binding sitei344 – 3441ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi373 – 3764ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. phosphoglycerate kinase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
  2. phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase 1 (EC:2.7.2.3)
Gene namesi
Name:PGK1
Synonyms:PGK-1
OrganismiMacropus eugenii (Tammar wallaby)
Taxonomic identifieri9315 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDiprotodontiaMacropodidaeMacropus

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 417416Phosphoglycerate kinase 1UniRule annotation
PRO_0000145833Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei6 – 61N6-succinyllysine By similarity
Modified residuei11 – 111N6-acetyllysine By similarity
Modified residuei75 – 751N6-acetyllysine By similarity
Modified residuei76 – 761Phosphotyrosine By similarity
Modified residuei86 – 861N6-acetyllysine By similarity
Modified residuei91 – 911N6-acetyllysine By similarity
Modified residuei97 – 971N6-acetyllysine By similarity
Modified residuei131 – 1311N6-acetyllysine; alternate By similarity
Modified residuei131 – 1311N6-malonyllysine; alternate By similarity
Modified residuei146 – 1461N6-acetyllysine By similarity
Modified residuei191 – 1911N6-succinyllysine By similarity
Modified residuei196 – 1961Phosphotyrosine By similarity
Modified residuei199 – 1991N6-acetyllysine By similarity
Modified residuei203 – 2031Phosphoserine By similarity
Modified residuei267 – 2671N6-acetyllysine By similarity
Modified residuei291 – 2911N6-acetyllysine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiP29408.

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP29408.
SMRiP29408. Positions 2-417.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 263Substrate binding By similarity
Regioni63 – 664Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG008177.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29408-1 [UniParc]FASTAAdd to Basket

« Hide

MSLSKKLTLD KVDLKGKRVI MRVDFNVPMK NKEITNNQRI KAALPSINYC    50
LDNGAKSVVL MSHLGRPDGV PMPDKYSLEP VAAELKSLLG KDVLFLKDCV 100
GPEVEQACAN PPNGSIILLE NLRFHVEEEG KGKDASGNKI KAEPAKMEAF 150
QASLSKLGDV YVNDAFGTAH RAHSSMVGVN LPQKACGFLM KKELTYFAKA 200
LDSPERPFLA ILGGAKVADK IQLINNMLDK VNEMIIGGGM GFTFLKVLNN 250
MEIGTSLFDE EGAKIVKDLM AKAEKNGVKI TLPVDFVTAD KFDENAKTGQ 300
ATLASGIPAG WMGLDCGPKS SKKYVEVVTW AKQIVWNGPV GVFEWEEFAR 350
GTKELMNNVV EATKRGCITI IGGGDTATCC AKWNTEDKVS HVSTGGGASL 400
ELLEGKVLPG VSTLNNV 417
Length:417
Mass (Da):44,978
Last modified:January 23, 2007 - v2
Checksum:i2D1EEDA32D7A0BB6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64296 mRNA. Translation: CAA45574.1.
PIRiPC1118.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X64296 mRNA. Translation: CAA45574.1 .
PIRi PC1118.

3D structure databases

ProteinModelPortali P29408.
SMRi P29408. Positions 2-417.
ModBasei Search...

Proteomic databases

PRIDEi P29408.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG008177.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "PCR derived cDNA clones for X-linked phosphoglycerate kinase-1 in a marsupial, the tammar wallaby (Macropus eugenii)."
    Zehavi-Feferman T., Cooper D.W.
    Biochem. Biophys. Res. Commun. 187:26-31(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPGK1_MACEU
AccessioniPrimary (citable) accession number: P29408
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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