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P29408 (PGK1_MACEU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase 1

EC=2.7.2.3
Gene names
Name:PGK1
Synonyms:PGK-1
OrganismMacropus eugenii (Tammar wallaby)
Taxonomic identifier9315 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDiprotodontiaMacropodidaeMacropus

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   PTMAcetylation
Phosphoprotein
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

phosphorylation

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from sequence or structural similarity. Source: UniProtKB

phosphoglycerate kinase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 417416Phosphoglycerate kinase 1 HAMAP-Rule MF_00145
PRO_0000145833

Regions

Nucleotide binding373 – 3764ATP By similarity
Region24 – 263Substrate binding By similarity
Region63 – 664Substrate binding By similarity

Sites

Binding site391Substrate By similarity
Binding site1231Substrate By similarity
Binding site1711Substrate By similarity
Binding site2201ATP By similarity
Binding site3131ATP; via carbonyl oxygen By similarity
Binding site3441ATP By similarity

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue61N6-succinyllysine By similarity
Modified residue111N6-acetyllysine By similarity
Modified residue751N6-acetyllysine By similarity
Modified residue761Phosphotyrosine By similarity
Modified residue861N6-acetyllysine By similarity
Modified residue911N6-acetyllysine By similarity
Modified residue971N6-acetyllysine By similarity
Modified residue1311N6-acetyllysine; alternate By similarity
Modified residue1311N6-malonyllysine; alternate By similarity
Modified residue1461N6-acetyllysine By similarity
Modified residue1911N6-succinyllysine By similarity
Modified residue1961Phosphotyrosine By similarity
Modified residue1991N6-acetyllysine By similarity
Modified residue2031Phosphoserine By similarity
Modified residue2671N6-acetyllysine By similarity
Modified residue2911N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P29408 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 2D1EEDA32D7A0BB6

FASTA41744,978
        10         20         30         40         50         60 
MSLSKKLTLD KVDLKGKRVI MRVDFNVPMK NKEITNNQRI KAALPSINYC LDNGAKSVVL 

        70         80         90        100        110        120 
MSHLGRPDGV PMPDKYSLEP VAAELKSLLG KDVLFLKDCV GPEVEQACAN PPNGSIILLE 

       130        140        150        160        170        180 
NLRFHVEEEG KGKDASGNKI KAEPAKMEAF QASLSKLGDV YVNDAFGTAH RAHSSMVGVN 

       190        200        210        220        230        240 
LPQKACGFLM KKELTYFAKA LDSPERPFLA ILGGAKVADK IQLINNMLDK VNEMIIGGGM 

       250        260        270        280        290        300 
GFTFLKVLNN MEIGTSLFDE EGAKIVKDLM AKAEKNGVKI TLPVDFVTAD KFDENAKTGQ 

       310        320        330        340        350        360 
ATLASGIPAG WMGLDCGPKS SKKYVEVVTW AKQIVWNGPV GVFEWEEFAR GTKELMNNVV 

       370        380        390        400        410 
EATKRGCITI IGGGDTATCC AKWNTEDKVS HVSTGGGASL ELLEGKVLPG VSTLNNV 

« Hide

References

[1]"PCR derived cDNA clones for X-linked phosphoglycerate kinase-1 in a marsupial, the tammar wallaby (Macropus eugenii)."
Zehavi-Feferman T., Cooper D.W.
Biochem. Biophys. Res. Commun. 187:26-31(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X64296 mRNA. Translation: CAA45574.1.
PIRPC1118.

3D structure databases

ProteinModelPortalP29408.
SMRP29408. Positions 2-417.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP29408.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG008177.

Enzyme and pathway databases

UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK1_MACEU
AccessionPrimary (citable) accession number: P29408
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways