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P29407 (PGK_YARLI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:PGK1
Ordered Locus Names:YALI0D12400g
OrganismYarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica) [Reference proteome]
Taxonomic identifier284591 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDipodascaceaeYarrowia

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 417417Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000145892

Regions

Nucleotide binding372 – 3754ATP By similarity
Region24 – 263Substrate binding By similarity
Region63 – 664Substrate binding By similarity

Sites

Binding site391Substrate By similarity
Binding site1221Substrate By similarity
Binding site1701Substrate By similarity
Binding site2191ATP By similarity
Binding site3121ATP; via carbonyl oxygen By similarity
Binding site3431ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P29407 [UniParc].

Last modified April 1, 1993. Version 1.
Checksum: 3F308467FCC730BF

FASTA41744,772
        10         20         30         40         50         60 
MSLTNKLSIK DLDLKNKRVF IRVDFNVPLD GTTITNNQRI VAALPSIKYA IDQGAKAVIL 

        70         80         90        100        110        120 
ASHLGRPNGQ RVEKYSLKPV QAELSKLLGK PVTFLDDCVG PKVEEEVSKA KDGEVILLEN 

       130        140        150        160        170        180 
LRFHPEEEGS HKDADGKKIK ADPAKVEEFR KSLTSLADVY VNDAFGTAHR AHSSMVGIEL 

       190        200        210        220        230        240 
PQRAAGFLVA KELEFFAKAL EHPERPFLAI LGGAKVSDKI QLIDNLLDKV NALIIGGGMA 

       250        260        270        280        290        300 
FTFKKTLENV KIGNSLFDED GSKIVAGLVE KAKKNNVKLV FPVDYVTADK FSKDAKVGHA 

       310        320        330        340        350        360 
TDAEGIPDGW QGLDCGPKSI EEFQKVIGES KTILWNGPPG VFEFDNFAKG TKAVLDACVK 

       370        380        390        400        410 
AVDNGATVII GGGDTATVAK KYGAEDKLSH VSTGGGASLE LLEGKTLPGV AALSEKK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M91598 Genomic DNA. Translation: AAC37504.1.
CR382130 Genomic DNA. Translation: CAG80930.1.
PIRS68151.
RefSeqXP_502742.1. XM_502742.1.

3D structure databases

ProteinModelPortalP29407.
SMRP29407. Positions 2-417.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING4952.P29407.

Proteomic databases

PRIDEP29407.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCAG80930; CAG80930; YALI0_D12400g.
GeneID2910137.
KEGGyli:YALI0D12400g.

Phylogenomic databases

eggNOGCOG0126.
HOGENOMHOG000227107.
KOK00927.
OrthoDBEOG71K6D7.

Enzyme and pathway databases

UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_YARLI
AccessionPrimary (citable) accession number: P29407
Secondary accession number(s): Q6C9C0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: June 11, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways