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Protein

Phosphoglycerate kinase 2

Gene

PGK2

Organism
Rhizopus niveus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391SubstrateBy similarity
Binding sitei122 – 1221SubstrateBy similarity
Binding sitei169 – 1691SubstrateBy similarity
Binding sitei218 – 2181ATPBy similarity
Binding sitei312 – 3121ATP; via carbonyl oxygenBy similarity
Binding sitei343 – 3431ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi372 – 3754ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase 2 (EC:2.7.2.3)
Gene namesi
Name:PGK2
OrganismiRhizopus niveus
Taxonomic identifieri4844 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisEarly diverging fungal lineagesMucoromycotinaMucoralesMucorineaeRhizopodaceaeRhizopus

Subcellular locationi

  1. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 417417Phosphoglycerate kinase 2PRO_0000145888Add
BLAST

Proteomic databases

PRIDEiP29406.

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliP29406.
SMRiP29406. Positions 2-415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 263Substrate bindingBy similarity
Regioni63 – 664Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29406-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSNKLSIR DLDLKNKRVL IRVDFNVPMK DGAITNNNRI VQALPTVKYA
60 70 80 90 100
LDNGASAVIL MSHLGRPNGE AVAKYSLKPV AAEVEKLLGK PVEFLNDCVG
110 120 130 140 150
PDVEKACQSA TGGKVILLEN LRFHIEEEGS AKVRWSKVKA DAEAVKKFRA
160 170 180 190 200
SLTALADIYV NDAFGTAHRA HSSMVGVDLS QRAAGFLMQK ELEYFAKALE
210 220 230 240 250
NPARPFLAIL GGAKVSDKIQ LIENMLDKVN ALIVCGGMAF TFKKTLDNVK
260 270 280 290 300
QIGKSLFDEA GSKLVRNLVK KAAEKNVKLV FPVDFVTADK FAPDANTGYA
310 320 330 340 350
TDADGIPDEW EGLDCGKKSS ELFREEILKS KTIVWNGPSG VFEFDAFANG
360 370 380 390 400
TKSVLNAVIE ATKEGATTII GGGDTATAAL KWGAEGKVSH ISTGGGASLE
410
LLEGKELPGV TALSSKN
Length:417
Mass (Da):44,656
Last modified:April 1, 1993 - v1
Checksum:i45AC26C03CF01776
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10156 Genomic DNA. Translation: BAA01020.1.
PIRiS44063.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10156 Genomic DNA. Translation: BAA01020.1.
PIRiS44063.

3D structure databases

ProteinModelPortaliP29406.
SMRiP29406. Positions 2-415.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP29406.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of two 3-phosphoglycerate kinase genes of Rhizopus niveus and heterologous gene expression using their promoters."
    Yanai K., Tanaka N., Horiuchi H., Ohta A., Takagi M.
    Curr. Genet. 25:524-530(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NBRC 4810 / AS 3.4817.

Entry informationi

Entry nameiPGK2_RHINI
AccessioniPrimary (citable) accession number: P29406
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: January 7, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.