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Protein

Phosphoglycerate kinase 1

Gene

PGK1

Organism
Rhizopus niveus
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase 1 (PGK1), Phosphoglycerate kinase 2 (PGK2)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39SubstrateBy similarity1
Binding sitei122SubstrateBy similarity1
Binding sitei169SubstrateBy similarity1
Binding sitei218ATPBy similarity1
Binding sitei311ATP; via carbonyl oxygenBy similarity1
Binding sitei342ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi372 – 375ATPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase 1 (EC:2.7.2.3)
Gene namesi
Name:PGK1
OrganismiRhizopus niveus
Taxonomic identifieri4844 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisMucoromycotaMucoromycotinaMucoralesMucorineaeRhizopodaceaeRhizopus

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001458871 – 417Phosphoglycerate kinase 1Add BLAST417

Proteomic databases

PRIDEiP29405

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliP29405
SMRiP29405
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 26Substrate bindingBy similarity3
Regioni63 – 66Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 4 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

P29405-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSNKLSIR DLNLKDKRVL IRVDFNVPMK DGAITNNNRI VQALPTVKYA
60 70 80 90 100
LDNGASAVIL MSHLGRPNGE AVAKYSLKPV AAEVEKLLGK PVEFLNDCVG
110 120 130 140 150
PDVEKACQSA KDGKVILLEN LRFHIEEEGS AKVDGQKVKA DAEAIKKFRA
160 170 180 190 200
SLTTLADIYI NDAFGTAHRA HSSMVGVDLS QRAAGFLMQK ELEYFAKALE
210 220 230 240 250
NPSRPFLAIL GGAKVSDKIQ LIENMLDKVN ALIICGGMAF TFKKTLDNVK
260 270 280 290 300
IGKSLFDEPG SKLVQNLVKK AAEKNVKIVF PVDFITADKF APDASTGYAT
310 320 330 340 350
DDDGIPDGWQ GLDCGERSNK LFREEILKSK TIVWNGPSGV FEFDAFSSGT
360 370 380 390 400
KAVLDAVINA TKEGATTIII GGGDTATAAL KWGAEGQVSH ISTGGGASLE
410
LLEGKELPGV TALSSKN
Length:417
Mass (Da):44,655
Last modified:April 1, 1993 - v1
Checksum:i8412E4177351153A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10155 Genomic DNA Translation: BAA01019.1
PIRiS44062

Similar proteinsi

Entry informationi

Entry nameiPGK1_RHINI
AccessioniPrimary (citable) accession number: P29405
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: April 1, 1993
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

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