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P29397

- NUSG_THEMA

UniProt

P29397 - NUSG_THEMA

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Protein
Transcription termination/antitermination protein NusG
Gene
nusG, TM_0453
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Participates in transcription elongation, termination and antitermination By similarity.UniRule annotation

Enzyme regulationi

Regulated by autoinhibition via interaction of the N-terminal and the C-terminal domains. Autoinhibition may prevent NusG from interacting prematurely with other components of the transcription complex or non-specific interactions with other cellular components.1 Publication

GO - Biological processi

  1. DNA-templated transcription, elongation Source: UniProtKB-HAMAP
  2. DNA-templated transcription, termination Source: UniProtKB-HAMAP
  3. regulation of DNA-templated transcription, elongation Source: InterPro
  4. transcription antitermination Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription antitermination, Transcription regulation, Transcription termination

Enzyme and pathway databases

BioCyciTMAR243274:GC6P-473-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination/antitermination protein NusG
Gene namesi
Name:nusG
Ordered Locus Names:TM_0453
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 353353Transcription termination/antitermination protein NusGUniRule annotation
PRO_0000113965Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0453.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 96
Helixi15 – 2915
Beta strandi33 – 397
Beta strandi42 – 465
Beta strandi52 – 576
Beta strandi62 – 643
Beta strandi76 – 805
Beta strandi89 – 10315
Beta strandi110 – 1167
Helixi117 – 1193
Beta strandi135 – 1384
Beta strandi147 – 16317
Beta strandi169 – 1757
Helixi176 – 1783
Turni181 – 1833
Beta strandi195 – 1973
Beta strandi200 – 2034
Beta strandi208 – 2147
Beta strandi219 – 2246
Beta strandi226 – 2327
Beta strandi235 – 2406
Helixi244 – 2518
Beta strandi262 – 2654
Helixi271 – 28010
Beta strandi304 – 3074
Turni311 – 3144
Beta strandi316 – 3238
Turni324 – 3274
Beta strandi328 – 3358
Beta strandi338 – 3458
Helixi346 – 3483

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LQ8NMR-A1-41[»]
A230-300[»]
2XHAX-ray1.91A/B41-233[»]
2XHCX-ray2.45A1-352[»]
ProteinModelPortaliP29397.

Miscellaneous databases

EvolutionaryTraceiP29397.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini301 – 33535KOW
Add
BLAST

Domaini

The N-terminal domain interacts with RNAP and the C-terminal domain binds either to Rho or to RpsJ (NusE). Contains an additional, species-specific domain inserted into the N-terminal domain. The N-terminal and C-terminal domains can interact and form a closed conformation.1 Publication

Sequence similaritiesi

Belongs to the NusG family.
Contains 1 KOW domain.

Phylogenomic databases

eggNOGiCOG0250.
KOiK02601.
OMAiYLFVEMI.
OrthoDBiEOG6FFS95.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
3.30.70.940. 2 hits.
HAMAPiMF_00948. NusG.
InterProiIPR005824. KOW.
IPR006645. NGN_dom.
IPR014722. Rib_L2_dom2.
IPR001062. Transcrpt_antiterm_NusG.
IPR015869. Transcrpt_antiterm_NusG_bac_CS.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PfamiPF00467. KOW. 1 hit.
PF02357. NusG. 1 hit.
[Graphical view]
PRINTSiPR00338. NUSGTNSCPFCT.
SMARTiSM00739. KOW. 1 hit.
SM00738. NGN. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF82679. SSF82679. 2 hits.
TIGRFAMsiTIGR00922. nusG. 1 hit.
PROSITEiPS01014. NUSG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29397-1 [UniParc]FASTAAdd to Basket

« Hide

MKKKWYIVLT MSGYEEKVKE NIEKKVEATG IKNLVGRIVI PEEVVLDATS    50
PSERLILSPK AKLHVNNGKD VNKGDLIAEE PPIYARRSGV IVDVKNVRKI 100
VVETIDRKYT KTYYIPESAG IEPGLRVGTK VKQGLPLSKN EEYICELDGK 150
IVEIERMKKV VVQTPDGEQD VYYIPLDVFD RDRIKKGKEV KQGEMLAEAR 200
KFFAKVSGRV EVVDYSTRKE IRIYKTKRRK LFPGYVFVEM IMNDEAYNFV 250
RSVPYVMGFV SSGGQPVPVK DREMRPILRL AGLEEYEEKK KPVKVELGFK 300
VGDMVKIISG PFEDFAGVIK EIDPERQELK VNVTIFGRET PVVLHVSEVE 350
KIE 353
Length:353
Mass (Da):40,327
Last modified:December 1, 1992 - v1
Checksum:i98DCB44B2E2CABB5
GO

Sequence cautioni

The sequence AAD35536.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z11839 Genomic DNA. Translation: CAA77858.1.
AE000512 Genomic DNA. Translation: AAD35536.1. Different initiation.
PIRiF72375.
RefSeqiNP_228263.1. NC_000853.1.
YP_007976800.1. NC_021214.1.

Genome annotation databases

EnsemblBacteriaiAAD35536; AAD35536; TM_0453.
GeneIDi897482.
KEGGitma:TM0453.
tmm:Tmari_0450.
PATRICi23935801. VBITheMar51294_0459.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z11839 Genomic DNA. Translation: CAA77858.1 .
AE000512 Genomic DNA. Translation: AAD35536.1 . Different initiation.
PIRi F72375.
RefSeqi NP_228263.1. NC_000853.1.
YP_007976800.1. NC_021214.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2LQ8 NMR - A 1-41 [» ]
A 230-300 [» ]
2XHA X-ray 1.91 A/B 41-233 [» ]
2XHC X-ray 2.45 A 1-352 [» ]
ProteinModelPortali P29397.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243274.TM0453.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAD35536 ; AAD35536 ; TM_0453 .
GeneIDi 897482.
KEGGi tma:TM0453.
tmm:Tmari_0450.
PATRICi 23935801. VBITheMar51294_0459.

Phylogenomic databases

eggNOGi COG0250.
KOi K02601.
OMAi YLFVEMI.
OrthoDBi EOG6FFS95.

Enzyme and pathway databases

BioCyci TMAR243274:GC6P-473-MONOMER.

Miscellaneous databases

EvolutionaryTracei P29397.

Family and domain databases

Gene3Di 2.30.30.30. 1 hit.
3.30.70.940. 2 hits.
HAMAPi MF_00948. NusG.
InterProi IPR005824. KOW.
IPR006645. NGN_dom.
IPR014722. Rib_L2_dom2.
IPR001062. Transcrpt_antiterm_NusG.
IPR015869. Transcrpt_antiterm_NusG_bac_CS.
IPR008991. Translation_prot_SH3-like.
[Graphical view ]
Pfami PF00467. KOW. 1 hit.
PF02357. NusG. 1 hit.
[Graphical view ]
PRINTSi PR00338. NUSGTNSCPFCT.
SMARTi SM00739. KOW. 1 hit.
SM00738. NGN. 1 hit.
[Graphical view ]
SUPFAMi SSF50104. SSF50104. 1 hit.
SSF82679. SSF82679. 2 hits.
TIGRFAMsi TIGR00922. nusG. 1 hit.
PROSITEi PS01014. NUSG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The organization and expression of essential transcription translation component genes in the extremely thermophilic eubacterium Thermotoga maritima."
    Liao D., Dennis P.P.
    J. Biol. Chem. 267:22787-22797(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
  3. "Crystal structure of the antitermination factor Nusg from Thermotoga maritima."
    Stegmann C.M., Mandal A., Schweimer C., Burmann B., Roesch P., Wahl M.C.
    Submitted (JUN-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 1-352.
  4. Cited for: STRUCTURE BY NMR, ENZYME REGULATION, DOMAIN.

Entry informationi

Entry nameiNUSG_THEMA
AccessioniPrimary (citable) accession number: P29397
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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