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Protein

Transcription termination/antitermination protein NusG

Gene

nusG

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Participates in transcription elongation, termination and antitermination.UniRule annotation

Enzyme regulationi

Regulated by autoinhibition via interaction of the N-terminal and the C-terminal domains. Autoinhibition may prevent NusG from interacting prematurely with other components of the transcription complex or non-specific interactions with other cellular components.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription antitermination, Transcription regulation, Transcription termination

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination/antitermination protein NusGUniRule annotation
Gene namesi
Name:nusGUniRule annotation
Ordered Locus Names:TM_0453
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001139651 – 353Transcription termination/antitermination protein NusGAdd BLAST353

Interactioni

Protein-protein interaction databases

STRINGi243274.TM0453.

Structurei

Secondary structure

1353
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 9Combined sources6
Helixi15 – 29Combined sources15
Beta strandi33 – 39Combined sources7
Beta strandi42 – 46Combined sources5
Beta strandi52 – 57Combined sources6
Beta strandi62 – 64Combined sources3
Beta strandi76 – 80Combined sources5
Beta strandi89 – 103Combined sources15
Beta strandi110 – 116Combined sources7
Helixi117 – 119Combined sources3
Beta strandi135 – 138Combined sources4
Beta strandi147 – 163Combined sources17
Beta strandi169 – 175Combined sources7
Helixi176 – 178Combined sources3
Turni181 – 183Combined sources3
Beta strandi195 – 197Combined sources3
Beta strandi200 – 203Combined sources4
Beta strandi208 – 214Combined sources7
Beta strandi219 – 224Combined sources6
Beta strandi226 – 232Combined sources7
Beta strandi235 – 240Combined sources6
Helixi244 – 251Combined sources8
Beta strandi262 – 265Combined sources4
Helixi271 – 280Combined sources10
Beta strandi304 – 307Combined sources4
Turni311 – 314Combined sources4
Beta strandi316 – 323Combined sources8
Turni324 – 327Combined sources4
Beta strandi328 – 335Combined sources8
Beta strandi338 – 345Combined sources8
Helixi346 – 348Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LQ8NMR-A1-41[»]
A230-300[»]
2XHAX-ray1.91A/B41-233[»]
2XHCX-ray2.45A1-352[»]
ProteinModelPortaliP29397.
SMRiP29397.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29397.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini301 – 335KOWUniRule annotationAdd BLAST35

Domaini

The N-terminal domain interacts with RNAP and the C-terminal domain binds either to Rho or to RpsJ (NusE). Contains an additional, species-specific domain inserted into the N-terminal domain. The N-terminal and C-terminal domains can interact and form a closed conformation.1 Publication

Sequence similaritiesi

Belongs to the NusG family.UniRule annotation
Contains 1 KOW domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E5V. Bacteria.
COG0250. LUCA.
InParanoidiP29397.
KOiK02601.
OMAiMIMNDEF.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
3.30.70.940. 2 hits.
HAMAPiMF_00948. NusG. 1 hit.
InterProiIPR005824. KOW.
IPR006645. NGN_dom.
IPR014722. Rib_L2_dom2.
IPR001062. Transcrpt_antiterm_NusG.
IPR015869. Transcrpt_antiterm_NusG_bac_CS.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PfamiPF00467. KOW. 1 hit.
PF02357. NusG. 2 hits.
[Graphical view]
PRINTSiPR00338. NUSGTNSCPFCT.
SMARTiSM00739. KOW. 1 hit.
SM00738. NGN. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF82679. SSF82679. 2 hits.
TIGRFAMsiTIGR00922. nusG. 1 hit.
PROSITEiPS01014. NUSG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P29397-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKKWYIVLT MSGYEEKVKE NIEKKVEATG IKNLVGRIVI PEEVVLDATS
60 70 80 90 100
PSERLILSPK AKLHVNNGKD VNKGDLIAEE PPIYARRSGV IVDVKNVRKI
110 120 130 140 150
VVETIDRKYT KTYYIPESAG IEPGLRVGTK VKQGLPLSKN EEYICELDGK
160 170 180 190 200
IVEIERMKKV VVQTPDGEQD VYYIPLDVFD RDRIKKGKEV KQGEMLAEAR
210 220 230 240 250
KFFAKVSGRV EVVDYSTRKE IRIYKTKRRK LFPGYVFVEM IMNDEAYNFV
260 270 280 290 300
RSVPYVMGFV SSGGQPVPVK DREMRPILRL AGLEEYEEKK KPVKVELGFK
310 320 330 340 350
VGDMVKIISG PFEDFAGVIK EIDPERQELK VNVTIFGRET PVVLHVSEVE

KIE
Length:353
Mass (Da):40,327
Last modified:December 1, 1992 - v1
Checksum:i98DCB44B2E2CABB5
GO

Sequence cautioni

The sequence AAD35536 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11839 Genomic DNA. Translation: CAA77858.1.
AE000512 Genomic DNA. Translation: AAD35536.1. Different initiation.
PIRiF72375.
RefSeqiNP_228263.1. NC_000853.1.
WP_004081513.1. NZ_CP011107.1.

Genome annotation databases

EnsemblBacteriaiAAD35536; AAD35536; TM_0453.
GeneIDi897482.
KEGGitma:TM0453.
PATRICi23935801. VBITheMar51294_0459.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11839 Genomic DNA. Translation: CAA77858.1.
AE000512 Genomic DNA. Translation: AAD35536.1. Different initiation.
PIRiF72375.
RefSeqiNP_228263.1. NC_000853.1.
WP_004081513.1. NZ_CP011107.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LQ8NMR-A1-41[»]
A230-300[»]
2XHAX-ray1.91A/B41-233[»]
2XHCX-ray2.45A1-352[»]
ProteinModelPortaliP29397.
SMRiP29397.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM0453.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35536; AAD35536; TM_0453.
GeneIDi897482.
KEGGitma:TM0453.
PATRICi23935801. VBITheMar51294_0459.

Phylogenomic databases

eggNOGiENOG4105E5V. Bacteria.
COG0250. LUCA.
InParanoidiP29397.
KOiK02601.
OMAiMIMNDEF.

Miscellaneous databases

EvolutionaryTraceiP29397.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
3.30.70.940. 2 hits.
HAMAPiMF_00948. NusG. 1 hit.
InterProiIPR005824. KOW.
IPR006645. NGN_dom.
IPR014722. Rib_L2_dom2.
IPR001062. Transcrpt_antiterm_NusG.
IPR015869. Transcrpt_antiterm_NusG_bac_CS.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PfamiPF00467. KOW. 1 hit.
PF02357. NusG. 2 hits.
[Graphical view]
PRINTSiPR00338. NUSGTNSCPFCT.
SMARTiSM00739. KOW. 1 hit.
SM00738. NGN. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF82679. SSF82679. 2 hits.
TIGRFAMsiTIGR00922. nusG. 1 hit.
PROSITEiPS01014. NUSG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUSG_THEMA
AccessioniPrimary (citable) accession number: P29397
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.