Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

50S ribosomal protein L7/L12

Gene

rplL

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L7/L12UniRule annotation
Gene namesi
Name:rplLUniRule annotation
Ordered Locus Names:TM_0457
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001575961 – 12850S ribosomal protein L7/L12Add BLAST128

Interactioni

Subunit structurei

Homodimer. Part of the 50S ribosomal subunit; present in 6 copies per ribosome. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which 3 L12 dimers bind in a sequential fashion.2 Publications

Protein-protein interaction databases

STRINGi243274.TM0457.

Structurei

Secondary structure

1128
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 12Combined sources10
Helixi15 – 28Combined sources14
Helixi31 – 54Combined sources24
Beta strandi57 – 65Combined sources9
Helixi70 – 81Combined sources12
Helixi85 – 92Combined sources8
Turni93 – 96Combined sources4
Beta strandi101 – 106Combined sources6
Helixi108 – 120Combined sources13
Beta strandi124 – 128Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DD3X-ray2.00A/B1-128[»]
C/D1-32[»]
1DD4X-ray2.40A/B1-128[»]
C/D1-40[»]
1L1Umodel-3/41-128[»]
1ZAVX-ray1.90U/V/W/X/Y/Z1-30[»]
1ZAWX-ray2.30U/V/W/X/Y/Z1-30[»]
1ZAXX-ray2.10U/V/W/X/Y/Z1-30[»]
ProteinModelPortaliP29396.
SMRiP29396.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29396.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L7/L12P family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105KBC. Bacteria.
COG0222. LUCA.
InParanoidiP29396.
KOiK02935.
OMAiEFISNMT.

Family and domain databases

CDDicd00387. Ribosomal_L7_L12. 1 hit.
Gene3Di3.30.1390.10. 1 hit.
HAMAPiMF_00368. Ribosomal_L7_L12. 1 hit.
InterProiIPR000206. Ribosomal_L7/12.
IPR014719. Ribosomal_L7/12_C/ClpS-like.
IPR013823. Ribosomal_L7/L12_C.
IPR008932. Ribosomal_L7/L12_oligo.
[Graphical view]
PfamiPF00542. Ribosomal_L12. 1 hit.
PF16320. Ribosomal_L12_N. 1 hit.
[Graphical view]
ProDomiPD001326. Ribosomal_L7/L12_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF48300. SSF48300. 1 hit.
SSF54736. SSF54736. 1 hit.
TIGRFAMsiTIGR00855. L12. 1 hit.

Sequencei

Sequence statusi: Complete.

P29396-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIDEIIEAI EKLTVSELAE LVKKLEDKFG VTAAAPVAVA AAPVAGAAAG
60 70 80 90 100
AAQEEKTEFD VVLKSFGQNK IQVIKVVREI TGLGLKEAKD LVEKAGSPDA
110 120
VIKSGVSKEE AEEIKKKLEE AGAEVELK
Length:128
Mass (Da):13,458
Last modified:December 1, 1992 - v1
Checksum:iFCA849CFE85906BE
GO

Sequence cautioni

The sequence AAD35540 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Mass spectrometryi

Molecular mass is 101376±8 Da from positions 2 - 128. Determined by ESI. Isolated L10(L12)6.1 Publication
Molecular mass is 13477±2 Da from positions 2 - 128. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11839 Genomic DNA. Translation: CAA77862.1.
X72695 Genomic DNA. Translation: CAA51245.1.
AE000512 Genomic DNA. Translation: AAD35540.1. Different initiation.
PIRiE44466. R7HG12.
RefSeqiNP_228267.1. NC_000853.1.
WP_004081509.1. NZ_CP011107.1.
WP_008192101.1. NC_000853.1.

Genome annotation databases

EnsemblBacteriaiAAD35540; AAD35540; TM_0457.
GeneIDi897487.
KEGGitma:TM0457.
PATRICi23935811. VBITheMar51294_0464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11839 Genomic DNA. Translation: CAA77862.1.
X72695 Genomic DNA. Translation: CAA51245.1.
AE000512 Genomic DNA. Translation: AAD35540.1. Different initiation.
PIRiE44466. R7HG12.
RefSeqiNP_228267.1. NC_000853.1.
WP_004081509.1. NZ_CP011107.1.
WP_008192101.1. NC_000853.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DD3X-ray2.00A/B1-128[»]
C/D1-32[»]
1DD4X-ray2.40A/B1-128[»]
C/D1-40[»]
1L1Umodel-3/41-128[»]
1ZAVX-ray1.90U/V/W/X/Y/Z1-30[»]
1ZAWX-ray2.30U/V/W/X/Y/Z1-30[»]
1ZAXX-ray2.10U/V/W/X/Y/Z1-30[»]
ProteinModelPortaliP29396.
SMRiP29396.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243274.TM0457.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35540; AAD35540; TM_0457.
GeneIDi897487.
KEGGitma:TM0457.
PATRICi23935811. VBITheMar51294_0464.

Phylogenomic databases

eggNOGiENOG4105KBC. Bacteria.
COG0222. LUCA.
InParanoidiP29396.
KOiK02935.
OMAiEFISNMT.

Miscellaneous databases

EvolutionaryTraceiP29396.

Family and domain databases

CDDicd00387. Ribosomal_L7_L12. 1 hit.
Gene3Di3.30.1390.10. 1 hit.
HAMAPiMF_00368. Ribosomal_L7_L12. 1 hit.
InterProiIPR000206. Ribosomal_L7/12.
IPR014719. Ribosomal_L7/12_C/ClpS-like.
IPR013823. Ribosomal_L7/L12_C.
IPR008932. Ribosomal_L7/L12_oligo.
[Graphical view]
PfamiPF00542. Ribosomal_L12. 1 hit.
PF16320. Ribosomal_L12_N. 1 hit.
[Graphical view]
ProDomiPD001326. Ribosomal_L7/L12_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF48300. SSF48300. 1 hit.
SSF54736. SSF54736. 1 hit.
TIGRFAMsiTIGR00855. L12. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRL7_THEMA
AccessioniPrimary (citable) accession number: P29396
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.