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Protein

50S ribosomal protein L7/L12

Gene

rplL

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L7/L12UniRule annotation
Gene namesi
Name:rplLUniRule annotation
Ordered Locus Names:TM_0457
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001575961 – 12850S ribosomal protein L7/L12Add BLAST128

Interactioni

Subunit structurei

Homodimer. Part of the 50S ribosomal subunit; present in 6 copies per ribosome. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which 3 L12 dimers bind in a sequential fashion.2 Publications

Protein-protein interaction databases

STRINGi243274.TM0457.

Structurei

Secondary structure

1128
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 12Combined sources10
Helixi15 – 28Combined sources14
Helixi31 – 54Combined sources24
Beta strandi57 – 65Combined sources9
Helixi70 – 81Combined sources12
Helixi85 – 92Combined sources8
Turni93 – 96Combined sources4
Beta strandi101 – 106Combined sources6
Helixi108 – 120Combined sources13
Beta strandi124 – 128Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DD3X-ray2.00A/B1-128[»]
C/D1-32[»]
1DD4X-ray2.40A/B1-128[»]
C/D1-40[»]
1L1Umodel-3/41-128[»]
1ZAVX-ray1.90U/V/W/X/Y/Z1-30[»]
1ZAWX-ray2.30U/V/W/X/Y/Z1-30[»]
1ZAXX-ray2.10U/V/W/X/Y/Z1-30[»]
ProteinModelPortaliP29396.
SMRiP29396.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29396.

Family & Domainsi

Sequence similaritiesi

Belongs to the bacterial ribosomal protein bL12 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105KBC. Bacteria.
COG0222. LUCA.
InParanoidiP29396.
KOiK02935.
OMAiVDNAPKP.

Family and domain databases

CDDicd00387. Ribosomal_L7_L12. 1 hit.
Gene3Di3.30.1390.10. 1 hit.
HAMAPiMF_00368. Ribosomal_L7_L12. 1 hit.
InterProiView protein in InterPro
IPR000206. Ribosomal_L7/12.
IPR014719. Ribosomal_L7/12_C/ClpS-like.
IPR013823. Ribosomal_L7/L12_C.
IPR008932. Ribosomal_L7/L12_oligo.
PANTHERiPTHR24089:SF404. PTHR24089:SF404. 1 hit.
PfamiView protein in Pfam
PF00542. Ribosomal_L12. 1 hit.
PF16320. Ribosomal_L12_N. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001326. Ribosomal_L7/L12_C. 1 hit.
SUPFAMiSSF48300. SSF48300. 1 hit.
SSF54736. SSF54736. 1 hit.
TIGRFAMsiTIGR00855. L12. 1 hit.

Sequencei

Sequence statusi: Complete.

P29396-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIDEIIEAI EKLTVSELAE LVKKLEDKFG VTAAAPVAVA AAPVAGAAAG
60 70 80 90 100
AAQEEKTEFD VVLKSFGQNK IQVIKVVREI TGLGLKEAKD LVEKAGSPDA
110 120
VIKSGVSKEE AEEIKKKLEE AGAEVELK
Length:128
Mass (Da):13,458
Last modified:December 1, 1992 - v1
Checksum:iFCA849CFE85906BE
GO

Sequence cautioni

The sequence AAD35540 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Mass spectrometryi

Molecular mass is 101376±8 Da from positions 2 - 128. Determined by ESI. Isolated L10(L12)6.1 Publication
Molecular mass is 13477±2 Da from positions 2 - 128. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11839 Genomic DNA. Translation: CAA77862.1.
X72695 Genomic DNA. Translation: CAA51245.1.
AE000512 Genomic DNA. Translation: AAD35540.1. Different initiation.
PIRiE44466. R7HG12.
RefSeqiNP_228267.1. NC_000853.1.

Genome annotation databases

EnsemblBacteriaiAAD35540; AAD35540; TM_0457.
GeneIDi897487.
KEGGitma:TM0457.
PATRICifig|243274.5.peg.464.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRL7_THEMA
AccessioniPrimary (citable) accession number: P29396
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: July 5, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families