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Protein

50S ribosomal protein L11

Gene

rplK

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.

GO - Molecular functioni

  1. large ribosomal subunit rRNA binding Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L11UniRule annotation
Gene namesi
Name:rplKUniRule annotation
Ordered Locus Names:TM_0454
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000008183 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. ribosome Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 14114050S ribosomal protein L11PRO_0000104397Add
BLAST

Post-translational modificationi

One or more lysine residues are methylated.UniRule annotation

Keywords - PTMi

Methylation

Interactioni

Subunit structurei

Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which 3 L12 dimers bind in a sequential fashion forming a heptameric L10(L12)2(L12)2(L12)2 complex.

Protein-protein interaction databases

MINTiMINT-208764.
STRINGi243274.TM0454.

Structurei

Secondary structure

1
141
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 146Combined sources
Turni21 – 255Combined sources
Helixi26 – 294Combined sources
Turni30 – 323Combined sources
Helixi35 – 4511Combined sources
Turni46 – 483Combined sources
Beta strandi51 – 6010Combined sources
Beta strandi62 – 643Combined sources
Beta strandi66 – 705Combined sources
Helixi75 – 839Combined sources
Turni92 – 943Combined sources
Beta strandi98 – 1014Combined sources
Helixi102 – 11211Combined sources
Helixi113 – 1153Combined sources
Helixi121 – 13212Combined sources
Turni133 – 1364Combined sources
Beta strandi137 – 1404Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1IP8model-G-[»]
1JQMelectron microscopy-A2-140[»]
1JQSelectron microscopy-A2-140[»]
1JQTelectron microscopy-A2-140[»]
1MMSX-ray2.57A/B2-141[»]
1MVRelectron microscopy12.80L2-141[»]
1OLNNMR-A2-141[»]
1PN7electron microscopy10.80L8-140[»]
1PN8electron microscopy10.80L8-140[»]
1R2Welectron microscopy9.00A2-141[»]
1R2Xelectron microscopy9.00A2-141[»]
2BCWelectron microscopy11.20A8-72[»]
2GKYmodel-A8-140[»]
2GKZmodel-A8-140[»]
2JQ7NMR-A1-141[»]
2K3FNMR-A1-141[»]
SMRiP29395. Positions 1-141.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29395.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L11P family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0080.
InParanoidiP29395.
KOiK02867.
OMAiKQFNAKT.
OrthoDBiEOG69PQ9D.

Family and domain databases

Gene3Di1.10.10.250. 1 hit.
3.30.1550.10. 1 hit.
HAMAPiMF_00736. Ribosomal_L11.
InterProiIPR000911. Ribosomal_L11/L12.
IPR006519. Ribosomal_L11_bac-typ.
IPR020783. Ribosomal_L11_C.
IPR020785. Ribosomal_L11_CS.
IPR020784. Ribosomal_L11_N.
[Graphical view]
PANTHERiPTHR11661. PTHR11661. 1 hit.
PfamiPF00298. Ribosomal_L11. 1 hit.
PF03946. Ribosomal_L11_N. 1 hit.
[Graphical view]
SMARTiSM00649. RL11. 1 hit.
[Graphical view]
SUPFAMiSSF46906. SSF46906. 1 hit.
SSF54747. SSF54747. 1 hit.
TIGRFAMsiTIGR01632. L11_bact. 1 hit.
PROSITEiPS00359. RIBOSOMAL_L11. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29395-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKKVAAQIK LQLPAGKATP APPVGPALGQ HGVNIMEFCK RFNAETADKA
60 70 80 90 100
GMILPVVITV YEDKSFTFII KTPPASFLLK KAAGIEKGSS EPKRKIVGKV
110 120 130 140
TRKQIEEIAK TKMPDLNANS LEAAMKIIEG TAKSMGIEVV D
Length:141
Mass (Da):15,089
Last modified:January 22, 2007 - v3
Checksum:i08AD83D090F651A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11839 Genomic DNA. Translation: CAA77859.1.
AE000512 Genomic DNA. Translation: AAD35537.1.
PIRiB44466. R5HG11.
RefSeqiNP_228264.1. NC_000853.1.
YP_007976801.1. NC_021214.1.
YP_008990576.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAAD35537; AAD35537; TM_0454.
GeneIDi897484.
KEGGitma:TM0454.
tmi:THEMA_02420.
PATRICi23935803. VBITheMar51294_0460.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11839 Genomic DNA. Translation: CAA77859.1.
AE000512 Genomic DNA. Translation: AAD35537.1.
PIRiB44466. R5HG11.
RefSeqiNP_228264.1. NC_000853.1.
YP_007976801.1. NC_021214.1.
YP_008990576.1. NC_023151.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1IP8model-G-[»]
1JQMelectron microscopy-A2-140[»]
1JQSelectron microscopy-A2-140[»]
1JQTelectron microscopy-A2-140[»]
1MMSX-ray2.57A/B2-141[»]
1MVRelectron microscopy12.80L2-141[»]
1OLNNMR-A2-141[»]
1PN7electron microscopy10.80L8-140[»]
1PN8electron microscopy10.80L8-140[»]
1R2Welectron microscopy9.00A2-141[»]
1R2Xelectron microscopy9.00A2-141[»]
2BCWelectron microscopy11.20A8-72[»]
2GKYmodel-A8-140[»]
2GKZmodel-A8-140[»]
2JQ7NMR-A1-141[»]
2K3FNMR-A1-141[»]
SMRiP29395. Positions 1-141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-208764.
STRINGi243274.TM0454.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD35537; AAD35537; TM_0454.
GeneIDi897484.
KEGGitma:TM0454.
tmi:THEMA_02420.
PATRICi23935803. VBITheMar51294_0460.

Phylogenomic databases

eggNOGiCOG0080.
InParanoidiP29395.
KOiK02867.
OMAiKQFNAKT.
OrthoDBiEOG69PQ9D.

Miscellaneous databases

EvolutionaryTraceiP29395.

Family and domain databases

Gene3Di1.10.10.250. 1 hit.
3.30.1550.10. 1 hit.
HAMAPiMF_00736. Ribosomal_L11.
InterProiIPR000911. Ribosomal_L11/L12.
IPR006519. Ribosomal_L11_bac-typ.
IPR020783. Ribosomal_L11_C.
IPR020785. Ribosomal_L11_CS.
IPR020784. Ribosomal_L11_N.
[Graphical view]
PANTHERiPTHR11661. PTHR11661. 1 hit.
PfamiPF00298. Ribosomal_L11. 1 hit.
PF03946. Ribosomal_L11_N. 1 hit.
[Graphical view]
SMARTiSM00649. RL11. 1 hit.
[Graphical view]
SUPFAMiSSF46906. SSF46906. 1 hit.
SSF54747. SSF54747. 1 hit.
TIGRFAMsiTIGR01632. L11_bact. 1 hit.
PROSITEiPS00359. RIBOSOMAL_L11. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The organization and expression of essential transcription translation component genes in the extremely thermophilic eubacterium Thermotoga maritima."
    Liao D., Dennis P.P.
    J. Biol. Chem. 267:22787-22797(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099.
  3. "A detailed view of a ribosomal active site: the structure of the L11-RNA complex."
    Wimberly B.T., Guymon R., McCutcheon J.P., White S.W., Ramakrishnan V.
    Cell 97:491-502(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.57 ANGSTROMS).

Entry informationi

Entry nameiRL11_THEMA
AccessioniPrimary (citable) accession number: P29395
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 1992
Last sequence update: January 22, 2007
Last modified: March 31, 2015
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.