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Protein

Spermadhesin-1

Gene

SPADH1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates cell division and progesterone secretion of bovine granulosa cells in vitro in a potent and dose dependent manner. This protein appears to be a potent growth factor with effects on ovarian granulosa cells.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Spermadhesin-1
Alternative name(s):
Acidic seminal fluid protein
Short name:
ASFP
Gene namesi
Name:SPADH1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000003318721 – 134Spermadhesin-1Add BLAST114

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 51PROSITE-ProRule annotation1 Publication
Disulfide bondi74 ↔ 95PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP29392.
PRIDEiP29392.

Expressioni

Tissue specificityi

Seminal vesicle tissue, ampulla and weakly in tissue of epididymis.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014297.

Structurei

Secondary structure

1134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi32 – 34Combined sources3
Beta strandi37 – 42Combined sources6
Beta strandi49 – 56Combined sources8
Beta strandi62 – 71Combined sources10
Turni74 – 76Combined sources3
Beta strandi77 – 85Combined sources9
Beta strandi90 – 103Combined sources14
Beta strandi105 – 115Combined sources11
Beta strandi125 – 132Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SFPX-ray1.90A21-134[»]
ProteinModelPortaliP29392.
SMRiP29392.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29392.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 131CUBPROSITE-ProRule annotationAdd BLAST102

Sequence similaritiesi

Belongs to the spermadhesin family.Curated
Contains 1 CUB domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JGFV. Eukaryota.
ENOG41118AQ. LUCA.
HOGENOMiHOG000168451.
HOVERGENiHBG004277.
InParanoidiP29392.

Family and domain databases

CDDicd00041. CUB. 1 hit.
Gene3Di2.60.120.290. 1 hit.
InterProiIPR000859. CUB_dom.
IPR000124. Spermadhesin.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
[Graphical view]
SMARTiSM00042. CUB. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS00985. SPERMADHESIN_1. 1 hit.
PS00986. SPERMADHESIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29392-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLSSVIPWA LLLSTATVDS MDWLPRNTNC GGILKEESGV IATYYGPKTN
60 70 80 90 100
CVWTIQMPPE YHVRVSIQYL QLNCNKESLE IIDGLPGSPV LGKICEGSLM
110 120 130
DYRSSGSIMT VKYIREPEHP ASFYEVLYFQ DPQA
Length:134
Mass (Da):15,036
Last modified:December 1, 1992 - v1
Checksum:i339BCFF8637D64C0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43T → H AA sequence (PubMed:1898381).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84603 mRNA. Translation: AAA30745.1.
BC110191 mRNA. Translation: AAI10192.1.
PIRiJQ1403.
RefSeqiNP_777041.1. NM_174616.3.
UniGeneiBt.457.

Genome annotation databases

GeneIDi282373.
KEGGibta:282373.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84603 mRNA. Translation: AAA30745.1.
BC110191 mRNA. Translation: AAI10192.1.
PIRiJQ1403.
RefSeqiNP_777041.1. NM_174616.3.
UniGeneiBt.457.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SFPX-ray1.90A21-134[»]
ProteinModelPortaliP29392.
SMRiP29392.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014297.

Proteomic databases

PaxDbiP29392.
PRIDEiP29392.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi282373.
KEGGibta:282373.

Organism-specific databases

CTDi282373.

Phylogenomic databases

eggNOGiENOG410JGFV. Eukaryota.
ENOG41118AQ. LUCA.
HOGENOMiHOG000168451.
HOVERGENiHBG004277.
InParanoidiP29392.

Miscellaneous databases

EvolutionaryTraceiP29392.

Family and domain databases

CDDicd00041. CUB. 1 hit.
Gene3Di2.60.120.290. 1 hit.
InterProiIPR000859. CUB_dom.
IPR000124. Spermadhesin.
[Graphical view]
PfamiPF00431. CUB. 1 hit.
[Graphical view]
SMARTiSM00042. CUB. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 1 hit.
PROSITEiPS01180. CUB. 1 hit.
PS00985. SPERMADHESIN_1. 1 hit.
PS00986. SPERMADHESIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPAD1_BOVIN
AccessioniPrimary (citable) accession number: P29392
Secondary accession number(s): Q2YDJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.