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P29390

- FRI2_MAIZE

UniProt

P29390 - FRI2_MAIZE

Protein

Ferritin-2, chloroplastic

Gene

FER2

Organism
Zea mays (Maize)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (11 Apr 2003)
      Previous versions | rss
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    Functioni

    Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

    Catalytic activityi

    4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi98 – 981Iron 1PROSITE-ProRule annotation
    Metal bindingi133 – 1331Iron 1PROSITE-ProRule annotation
    Metal bindingi133 – 1331Iron 2PROSITE-ProRule annotation
    Metal bindingi136 – 1361Iron 1PROSITE-ProRule annotation
    Metal bindingi182 – 1821Iron 2PROSITE-ProRule annotation
    Metal bindingi216 – 2161Iron 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ferric iron binding Source: InterPro
    2. ferroxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular iron ion homeostasis Source: UniProtKB-KW
    2. iron ion transport Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Iron storage

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ferritin-2, chloroplastic (EC:1.16.3.1)
    Alternative name(s):
    ZmFer2
    Gene namesi
    Name:FER2
    OrganismiZea mays (Maize)
    Taxonomic identifieri4577 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

    Organism-specific databases

    GrameneiP29390.
    MaizeGDBi25278.

    Subcellular locationi

    GO - Cellular componenti

    1. chloroplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chloroplast, Plastid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4343Chloroplast1 PublicationAdd
    BLAST
    Chaini44 – 252209Ferritin-2, chloroplasticPRO_0000008860Add
    BLAST

    Proteomic databases

    PRIDEiP29390.

    Expressioni

    Tissue specificityi

    Ferritins accumulate in seed during maturation. Then, they are degraded during the first days of germination. Present in roots and leaves after iron treatment.

    Inductioni

    By iron.

    Interactioni

    Subunit structurei

    Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

    Structurei

    3D structure databases

    ProteinModelPortaliP29390.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini81 – 234154Ferritin-like diironPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni44 – 8037Extension peptide (EP)Add
    BLAST

    Sequence similaritiesi

    Belongs to the ferritin family.Curated
    Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    KOiK00522.

    Family and domain databases

    Gene3Di1.20.1260.10. 1 hit.
    InterProiIPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR014034. Ferritin_CS.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view]
    PANTHERiPTHR11431. PTHR11431. 1 hit.
    PfamiPF00210. Ferritin. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00540. FERRITIN_1. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P29390-1 [UniParc]FASTAAdd to Basket

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    MMLRVSSSPA AAVANHLSGG AAATTAPARV TAQRSGVSLS AAAAAGKGKE    50
    VLSGVVFQPF EEIKGELALV PQSPDRSLAR HKFVDDCEAA INEQINVEYN 100
    ASYAYHSLFA YFDRDNVALK GFAKFFKESS DEEREHAEKL MEYQNKRGGR 150
    VRLQSIVAPL TEFDHPEKGD ALYAMELTLA LEKLVNEKLH SLHGVATRCN 200
    DPQLIDFIES EFLEEQGEAI NKVSKYVAQL RRVGNKGHGV WHFDQMLLQE 250
    AA 252
    Length:252
    Mass (Da):27,749
    Last modified:April 11, 2003 - v2
    Checksum:iD181B4A8A86ADED0
    GO

    Sequence cautioni

    The sequence CAA43664.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti217 – 2171G → V in CAA58147. (PubMed:7649160)Curated
    Sequence conflicti251 – 2511A → G in CAA58147. (PubMed:7649160)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X61392 mRNA. Translation: CAA43664.1. Different initiation.
    X83077 Genomic DNA. Translation: CAA58147.1.
    PIRiS24057.
    RefSeqiNP_001105437.1. NM_001111967.1.
    UniGeneiZm.72614.

    Genome annotation databases

    GeneIDi542392.
    KEGGizma:542392.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X61392 mRNA. Translation: CAA43664.1 . Different initiation.
    X83077 Genomic DNA. Translation: CAA58147.1 .
    PIRi S24057.
    RefSeqi NP_001105437.1. NM_001111967.1.
    UniGenei Zm.72614.

    3D structure databases

    ProteinModelPortali P29390.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P29390.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 542392.
    KEGGi zma:542392.

    Organism-specific databases

    Gramenei P29390.
    MaizeGDBi 25278.

    Phylogenomic databases

    KOi K00522.

    Family and domain databases

    Gene3Di 1.20.1260.10. 1 hit.
    InterProi IPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR014034. Ferritin_CS.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view ]
    PANTHERi PTHR11431. PTHR11431. 1 hit.
    Pfami PF00210. Ferritin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00540. FERRITIN_1. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Iron induces ferritin synthesis in maize plantlets."
      Lobreaux S., Massenet O., Briat J.-F.
      Plant Mol. Biol. 19:563-575(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 44-72.
      Strain: cv. Missouri 17.
      Tissue: Root and Seed.
    2. "Structure and differential expression of two maize ferritin genes in response to iron and abscisic acid."
      Fobis-Loisy I., Loridon K., Lobreaux S., Lebrun M., Briat J.-F.
      Eur. J. Biochem. 231:609-619(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: cv. B73.
      Tissue: Seedling.

    Entry informationi

    Entry nameiFRI2_MAIZE
    AccessioniPrimary (citable) accession number: P29390
    Secondary accession number(s): Q43259
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: April 11, 2003
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3