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P29390 (FRI2_MAIZE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferritin-2, chloroplastic

EC=1.16.3.1
Alternative name(s):
ZmFer2
Gene names
Name:FER2
OrganismZea mays (Maize)
Taxonomic identifier4577 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

Protein attributes

Sequence length252 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

Catalytic activity

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Subunit structure

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

Subcellular location

Plastidchloroplast. Plastid.

Tissue specificity

Ferritins accumulate in seed during maturation. Then, they are degraded during the first days of germination. Present in roots and leaves after iron treatment.

Induction

By iron.

Sequence similarities

Belongs to the ferritin family.

Contains 1 ferritin-like diiron domain.

Sequence caution

The sequence CAA43664.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processIron storage
   Cellular componentChloroplast
Plastid
   DomainTransit peptide
   LigandIron
Metal-binding
   Molecular functionOxidoreductase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processcellular iron ion homeostasis

Inferred from electronic annotation. Source: UniProtKB-KW

iron ion transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentchloroplast

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionferric iron binding

Inferred from electronic annotation. Source: InterPro

ferroxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4343Chloroplast Ref.1
Chain44 – 252209Ferritin-2, chloroplastic
PRO_0000008860

Regions

Domain81 – 234154Ferritin-like diiron
Region44 – 8037Extension peptide (EP)

Sites

Metal binding981Iron 1 By similarity
Metal binding1331Iron 1 By similarity
Metal binding1331Iron 2 By similarity
Metal binding1361Iron 1 By similarity
Metal binding1821Iron 2 By similarity
Metal binding2161Iron 2 By similarity

Experimental info

Sequence conflict2171G → V in CAA58147. Ref.2
Sequence conflict2511A → G in CAA58147. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P29390 [UniParc].

Last modified April 11, 2003. Version 2.
Checksum: D181B4A8A86ADED0

FASTA25227,749
        10         20         30         40         50         60 
MMLRVSSSPA AAVANHLSGG AAATTAPARV TAQRSGVSLS AAAAAGKGKE VLSGVVFQPF 

        70         80         90        100        110        120 
EEIKGELALV PQSPDRSLAR HKFVDDCEAA INEQINVEYN ASYAYHSLFA YFDRDNVALK 

       130        140        150        160        170        180 
GFAKFFKESS DEEREHAEKL MEYQNKRGGR VRLQSIVAPL TEFDHPEKGD ALYAMELTLA 

       190        200        210        220        230        240 
LEKLVNEKLH SLHGVATRCN DPQLIDFIES EFLEEQGEAI NKVSKYVAQL RRVGNKGHGV 

       250 
WHFDQMLLQE AA 

« Hide

References

[1]"Iron induces ferritin synthesis in maize plantlets."
Lobreaux S., Massenet O., Briat J.-F.
Plant Mol. Biol. 19:563-575(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 44-72.
Strain: cv. Missouri 17.
Tissue: Root and Seed.
[2]"Structure and differential expression of two maize ferritin genes in response to iron and abscisic acid."
Fobis-Loisy I., Loridon K., Lobreaux S., Lebrun M., Briat J.-F.
Eur. J. Biochem. 231:609-619(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. B73.
Tissue: Seedling.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X61392 mRNA. Translation: CAA43664.1. Different initiation.
X83077 Genomic DNA. Translation: CAA58147.1.
PIRS24057.
RefSeqNP_001105437.1. NM_001111967.1.
UniGeneZm.72614.

3D structure databases

ProteinModelPortalP29390.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP29390.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID542392.
KEGGzma:542392.

Organism-specific databases

GrameneP29390.
MaizeGDB25278.

Phylogenomic databases

KOK00522.

Family and domain databases

Gene3D1.20.1260.10. 1 hit.
InterProIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERPTHR11431. PTHR11431. 1 hit.
PfamPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00540. FERRITIN_1. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFRI2_MAIZE
AccessionPrimary (citable) accession number: P29390
Secondary accession number(s): Q43259
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: April 11, 2003
Last modified: February 19, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families