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Protein

Ferritin-2, chloroplastic

Gene

FER2

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi98Iron 1PROSITE-ProRule annotation1
Metal bindingi133Iron 1PROSITE-ProRule annotation1
Metal bindingi133Iron 2PROSITE-ProRule annotation1
Metal bindingi136Iron 1PROSITE-ProRule annotation1
Metal bindingi182Iron 2PROSITE-ProRule annotation1
Metal bindingi216Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processIron storage
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin-2, chloroplastic (EC:1.16.3.1)
Alternative name(s):
ZmFer2
Gene namesi
Name:FER2
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Unplaced

Organism-specific databases

MaizeGDBi25278

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 43Chloroplast1 PublicationAdd BLAST43
ChainiPRO_000000886044 – 252Ferritin-2, chloroplasticAdd BLAST209

Proteomic databases

PRIDEiP29390

Expressioni

Tissue specificityi

Ferritins accumulate in seed during maturation. Then, they are degraded during the first days of germination. Present in roots and leaves after iron treatment.

Inductioni

By iron.

Gene expression databases

ExpressionAtlasiP29390 differential

Interactioni

Subunit structurei

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

Structurei

3D structure databases

ProteinModelPortaliP29390
SMRiP29390
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 234Ferritin-like diironPROSITE-ProRule annotationAdd BLAST154

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni44 – 80Extension peptide (EP)Add BLAST37

Sequence similaritiesi

Belongs to the ferritin family.Curated

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR001519 Ferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR014034 Ferritin_CS
IPR008331 Ferritin_DPS_dom
PANTHERiPTHR11431 PTHR11431, 1 hit
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS00540 FERRITIN_1, 1 hit
PS50905 FERRITIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29390-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLRVSSSPA AAVANHLSGG AAATTAPARV TAQRSGVSLS AAAAAGKGKE
60 70 80 90 100
VLSGVVFQPF EEIKGELALV PQSPDRSLAR HKFVDDCEAA INEQINVEYN
110 120 130 140 150
ASYAYHSLFA YFDRDNVALK GFAKFFKESS DEEREHAEKL MEYQNKRGGR
160 170 180 190 200
VRLQSIVAPL TEFDHPEKGD ALYAMELTLA LEKLVNEKLH SLHGVATRCN
210 220 230 240 250
DPQLIDFIES EFLEEQGEAI NKVSKYVAQL RRVGNKGHGV WHFDQMLLQE

AA
Length:252
Mass (Da):27,749
Last modified:April 11, 2003 - v2
Checksum:iD181B4A8A86ADED0
GO

Sequence cautioni

The sequence CAA43664 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti217G → V in CAA58147 (PubMed:7649160).Curated1
Sequence conflicti251A → G in CAA58147 (PubMed:7649160).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61392 mRNA Translation: CAA43664.1 Different initiation.
X83077 Genomic DNA Translation: CAA58147.1
PIRiS24057
UniGeneiZm.72614

Similar proteinsi

Entry informationi

Entry nameiFRI2_MAIZE
AccessioniPrimary (citable) accession number: P29390
Secondary accession number(s): Q43259
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: April 11, 2003
Last modified: May 23, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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