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P29389 (FRIH_CRIGR) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferritin heavy chain

Short name=Ferritin H subunit
EC=1.16.3.1
Gene names
Name:FTH1
Synonyms:FTH
OrganismCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Taxonomic identifier10029 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeCricetulus

Protein attributes

Sequence length186 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney By similarity.

Catalytic activity

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Subunit structure

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.

Sequence similarities

Belongs to the ferritin family.

Contains 1 ferritin-like diiron domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 186186Ferritin heavy chain
PRO_0000201047

Regions

Domain16 – 165150Ferritin-like diiron

Sites

Metal binding331Iron 1 By similarity
Metal binding681Iron 1 By similarity
Metal binding681Iron 2 By similarity
Metal binding711Iron 1 By similarity
Metal binding1131Iron 2 By similarity
Metal binding1471Iron 2 By similarity

Amino acid modifications

Modified residue1841Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
P29389 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 80BE8A1662E73FC4

FASTA18621,486
        10         20         30         40         50         60 
MTTTALTTAS PSQVRQNYHQ DSEAAINRQI NLELYASYVY LSMSCYFDRD DVALKNFAKY 

        70         80         90        100        110        120 
FLHQSHEERE HAEKLMKLQN QRGGRIFLQD IKKPDRDDWE SGLNAMECAL HLEKSVNQSL 

       130        140        150        160        170        180 
LELHKLATDK NDPHLCDFIE THYLNEQVKS IKELGDHVTN LRKMGAPEAG MAEYLFDKHT 


LGHSES 

« Hide

References

[1]"Differential gene expression in wild-type and X-ray-sensitive mutants of Chinese hamster ovary cell lines."
Zhu W., Keng P., Chou W.G.
Mutat. Res. 274:237-245(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M99692 mRNA. Translation: AAB46388.1.
PIRI48109.

3D structure databases

ProteinModelPortalP29389.
SMRP29389. Positions 12-182.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP29389.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG000410.

Family and domain databases

Gene3D1.20.1260.10. 1 hit.
InterProIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERPTHR11431. PTHR11431. 1 hit.
PfamPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFRIH_CRIGR
AccessionPrimary (citable) accession number: P29389
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 23, 2007
Last modified: October 16, 2013
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families