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P29387

- GBB4_MOUSE

UniProt

P29387 - GBB4_MOUSE

Protein

Guanine nucleotide-binding protein subunit beta-4

Gene

Gnb4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

    GO - Molecular functioni

    1. GTPase activity Source: MGI
    2. protein complex binding Source: MGI
    3. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: MGI
    2. GTP catabolic process Source: GOC

    Keywords - Molecular functioni

    Transducer

    Enzyme and pathway databases

    ReactomeiREACT_210399. Glucagon signaling in metabolic regulation.
    REACT_213947. Regulation of water balance by renal Aquaporins.
    REACT_221970. Ca2+ pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanine nucleotide-binding protein subunit beta-4
    Alternative name(s):
    Transducin beta chain 4
    Gene namesi
    Name:Gnb4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:104581. Gnb4.

    Subcellular locationi

    GO - Cellular componenti

    1. heterotrimeric G-protein complex Source: MGI
    2. lysosomal membrane Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 340339Guanine nucleotide-binding protein subunit beta-4PRO_0000127703Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP29387.
    PaxDbiP29387.
    PRIDEiP29387.

    2D gel databases

    REPRODUCTION-2DPAGEP29387.

    PTM databases

    PhosphoSiteiP29387.

    Expressioni

    Gene expression databases

    BgeeiP29387.
    GenevestigatoriP29387.

    Interactioni

    Subunit structurei

    G proteins are composed of 3 units, alpha, beta and gamma.

    Protein-protein interaction databases

    DIPiDIP-604N.
    IntActiP29387. 3 interactions.
    MINTiMINT-4095682.

    Structurei

    3D structure databases

    ProteinModelPortaliP29387.
    SMRiP29387. Positions 1-340.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati53 – 9240WD 1Add
    BLAST
    Repeati95 – 13440WD 2Add
    BLAST
    Repeati141 – 17939WD 3Add
    BLAST
    Repeati182 – 22140WD 4Add
    BLAST
    Repeati224 – 26340WD 5Add
    BLAST
    Repeati268 – 30740WD 6Add
    BLAST
    Repeati310 – 33930WD 7Add
    BLAST

    Sequence similaritiesi

    Belongs to the WD repeat G protein beta family.Curated
    Contains 7 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    GeneTreeiENSGT00740000115196.
    HOGENOMiHOG000176356.
    HOVERGENiHBG000188.
    InParanoidiP29387.
    KOiK04538.
    OMAiATSFTGH.
    OrthoDBiEOG7GN2N5.
    PhylomeDBiP29387.
    TreeFamiTF106149.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR020472. G-protein_beta_WD-40_rep.
    IPR001632. Gprotein_B.
    IPR016346. Guanine_nucleotide-bd_bsu.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 7 hits.
    [Graphical view]
    PIRSFiPIRSF002394. GN-bd_beta. 1 hit.
    PRINTSiPR00319. GPROTEINB.
    PR00320. GPROTEINBRPT.
    SMARTiSM00320. WD40. 7 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    PROSITEiPS00678. WD_REPEATS_1. 3 hits.
    PS50082. WD_REPEATS_2. 6 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P29387-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSELEQLRQE AEQLRNQIQD ARKACNDATL VQITSNMDSV GRIQMRTRRT    50
    LRGHLAKIYA MHWGYDSRLL VSASQDGKLI IWDSYTTNKM HAIPLRSSWV 100
    MTCAYAPSGN YVACGGLDNI CSIYNLKTRE GNVRVSRELP GHTGYLSCCR 150
    FLDDGQIITS SGDTTCALWD IETGQQTTTF TGHSGDVMSL SLSPDLKTFV 200
    SGACDASSKL WDIRDGMCRQ SFTGHISDIN AVSFFPSGYA FATGSDDATC 250
    RLFDLRADQE LLLYSHDNII CGITSVAFSK SGRLLLAGYD DFNCSVWDAL 300
    KGGRSGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLRIWN 340
    Length:340
    Mass (Da):37,379
    Last modified:January 23, 2007 - v4
    Checksum:iF06827EBC2F0E966
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti132 – 1321N → D in AAB21609. (PubMed:1543505)Curated
    Sequence conflicti132 – 1321N → D in AAA37756. (PubMed:1543505)Curated
    Sequence conflicti132 – 1321N → D in AAA37664. (PubMed:1543505)Curated
    Sequence conflicti140 – 1401P → A in AAB21609. (PubMed:1543505)Curated
    Sequence conflicti140 – 1401P → A in AAA37756. (PubMed:1543505)Curated
    Sequence conflicti140 – 1401P → A in AAA37664. (PubMed:1543505)Curated
    Sequence conflicti238 – 2381G → V in AAM15922. (PubMed:11842130)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S86124 mRNA. Translation: AAB21609.1.
    M87286 mRNA. Translation: AAA37756.1.
    M63658 mRNA. Translation: AAA37664.1.
    AF277893 mRNA. Translation: AAF82124.1.
    AF501886 mRNA. Translation: AAM15922.1.
    AK036816 mRNA. Translation: BAC29589.1.
    AK152227 mRNA. Translation: BAE31054.1.
    AK167416 mRNA. Translation: BAE39504.1.
    BC028753 mRNA. Translation: AAH28753.1.
    CCDSiCCDS17297.1.
    PIRiJS0669. RGMSB4.
    RefSeqiNP_038559.2. NM_013531.4.
    XP_006535466.1. XM_006535403.1.
    UniGeneiMm.139192.
    Mm.393826.

    Genome annotation databases

    EnsembliENSMUST00000108234; ENSMUSP00000103869; ENSMUSG00000027669.
    ENSMUST00000155737; ENSMUSP00000121127; ENSMUSG00000027669.
    GeneIDi14696.
    KEGGimmu:14696.
    UCSCiuc008owl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S86124 mRNA. Translation: AAB21609.1 .
    M87286 mRNA. Translation: AAA37756.1 .
    M63658 mRNA. Translation: AAA37664.1 .
    AF277893 mRNA. Translation: AAF82124.1 .
    AF501886 mRNA. Translation: AAM15922.1 .
    AK036816 mRNA. Translation: BAC29589.1 .
    AK152227 mRNA. Translation: BAE31054.1 .
    AK167416 mRNA. Translation: BAE39504.1 .
    BC028753 mRNA. Translation: AAH28753.1 .
    CCDSi CCDS17297.1.
    PIRi JS0669. RGMSB4.
    RefSeqi NP_038559.2. NM_013531.4.
    XP_006535466.1. XM_006535403.1.
    UniGenei Mm.139192.
    Mm.393826.

    3D structure databases

    ProteinModelPortali P29387.
    SMRi P29387. Positions 1-340.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-604N.
    IntActi P29387. 3 interactions.
    MINTi MINT-4095682.

    PTM databases

    PhosphoSitei P29387.

    2D gel databases

    REPRODUCTION-2DPAGE P29387.

    Proteomic databases

    MaxQBi P29387.
    PaxDbi P29387.
    PRIDEi P29387.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000108234 ; ENSMUSP00000103869 ; ENSMUSG00000027669 .
    ENSMUST00000155737 ; ENSMUSP00000121127 ; ENSMUSG00000027669 .
    GeneIDi 14696.
    KEGGi mmu:14696.
    UCSCi uc008owl.1. mouse.

    Organism-specific databases

    CTDi 59345.
    MGIi MGI:104581. Gnb4.

    Phylogenomic databases

    eggNOGi COG2319.
    GeneTreei ENSGT00740000115196.
    HOGENOMi HOG000176356.
    HOVERGENi HBG000188.
    InParanoidi P29387.
    KOi K04538.
    OMAi ATSFTGH.
    OrthoDBi EOG7GN2N5.
    PhylomeDBi P29387.
    TreeFami TF106149.

    Enzyme and pathway databases

    Reactomei REACT_210399. Glucagon signaling in metabolic regulation.
    REACT_213947. Regulation of water balance by renal Aquaporins.
    REACT_221970. Ca2+ pathway.

    Miscellaneous databases

    NextBioi 286647.
    PROi P29387.
    SOURCEi Search...

    Gene expression databases

    Bgeei P29387.
    Genevestigatori P29387.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR020472. G-protein_beta_WD-40_rep.
    IPR001632. Gprotein_B.
    IPR016346. Guanine_nucleotide-bd_bsu.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 7 hits.
    [Graphical view ]
    PIRSFi PIRSF002394. GN-bd_beta. 1 hit.
    PRINTSi PR00319. GPROTEINB.
    PR00320. GPROTEINBRPT.
    SMARTi SM00320. WD40. 7 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    PROSITEi PS00678. WD_REPEATS_1. 3 hits.
    PS50082. WD_REPEATS_2. 6 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Diversity among the beta subunits of heterotrimeric GTP-binding proteins: characterization of a novel beta-subunit cDNA."
      von Weizsaecker E., Strathmann M.P., Simon M.I.
      Biochem. Biophys. Res. Commun. 183:350-356(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Differential modulation of N-type 1B and P/Q-type 1A calcium channels by different G protein subunit isoforms."
      Arnot M.I., Stotz S.C., Jarvis S.E., Zamponi G.W.
      J. Physiol. (Lond.) 527:203-212(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    3. "Cloning, tissue distribution, and functional expression of the human G protein beta 4-subunit."
      Ruiz-Velasco V., Ikeda S.R., Puhl H.L. III
      Physiol. Genomics 8:41-50(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow, Placenta and Vagina.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiGBB4_MOUSE
    AccessioniPrimary (citable) accession number: P29387
    Secondary accession number(s): Q3TJJ1, Q8R475, Q9JHX8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 125 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3