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P29387

- GBB4_MOUSE

UniProt

P29387 - GBB4_MOUSE

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Protein
Guanine nucleotide-binding protein subunit beta-4
Gene
Gnb4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  1. GTPase activity Source: MGI
  2. protein complex binding Source: MGI
  3. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: MGI
  2. GTP catabolic process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_221970. Ca2+ pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit beta-4
Alternative name(s):
Transducin beta chain 4
Gene namesi
Name:Gnb4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:104581. Gnb4.

Subcellular locationi

GO - Cellular componenti

  1. heterotrimeric G-protein complex Source: MGI
  2. lysosomal membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 340339Guanine nucleotide-binding protein subunit beta-4
PRO_0000127703Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP29387.
PaxDbiP29387.
PRIDEiP29387.

2D gel databases

REPRODUCTION-2DPAGEP29387.

PTM databases

PhosphoSiteiP29387.

Expressioni

Gene expression databases

BgeeiP29387.
GenevestigatoriP29387.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma.

Protein-protein interaction databases

DIPiDIP-604N.
IntActiP29387. 3 interactions.
MINTiMINT-4095682.

Structurei

3D structure databases

ProteinModelPortaliP29387.
SMRiP29387. Positions 1-340.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati53 – 9240WD 1
Add
BLAST
Repeati95 – 13440WD 2
Add
BLAST
Repeati141 – 17939WD 3
Add
BLAST
Repeati182 – 22140WD 4
Add
BLAST
Repeati224 – 26340WD 5
Add
BLAST
Repeati268 – 30740WD 6
Add
BLAST
Repeati310 – 33930WD 7
Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00740000115196.
HOGENOMiHOG000176356.
HOVERGENiHBG000188.
InParanoidiP29387.
KOiK04538.
OMAiATSFTGH.
OrthoDBiEOG7GN2N5.
PhylomeDBiP29387.
TreeFamiTF106149.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR001632. Gprotein_B.
IPR016346. Guanine_nucleotide-bd_bsu.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PIRSFiPIRSF002394. GN-bd_beta. 1 hit.
PRINTSiPR00319. GPROTEINB.
PR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29387-1 [UniParc]FASTAAdd to Basket

« Hide

MSELEQLRQE AEQLRNQIQD ARKACNDATL VQITSNMDSV GRIQMRTRRT    50
LRGHLAKIYA MHWGYDSRLL VSASQDGKLI IWDSYTTNKM HAIPLRSSWV 100
MTCAYAPSGN YVACGGLDNI CSIYNLKTRE GNVRVSRELP GHTGYLSCCR 150
FLDDGQIITS SGDTTCALWD IETGQQTTTF TGHSGDVMSL SLSPDLKTFV 200
SGACDASSKL WDIRDGMCRQ SFTGHISDIN AVSFFPSGYA FATGSDDATC 250
RLFDLRADQE LLLYSHDNII CGITSVAFSK SGRLLLAGYD DFNCSVWDAL 300
KGGRSGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLRIWN 340
Length:340
Mass (Da):37,379
Last modified:January 23, 2007 - v4
Checksum:iF06827EBC2F0E966
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti132 – 1321N → D in AAB21609. 1 Publication
Sequence conflicti132 – 1321N → D in AAA37756. 1 Publication
Sequence conflicti132 – 1321N → D in AAA37664. 1 Publication
Sequence conflicti140 – 1401P → A in AAB21609. 1 Publication
Sequence conflicti140 – 1401P → A in AAA37756. 1 Publication
Sequence conflicti140 – 1401P → A in AAA37664. 1 Publication
Sequence conflicti238 – 2381G → V in AAM15922. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S86124 mRNA. Translation: AAB21609.1.
M87286 mRNA. Translation: AAA37756.1.
M63658 mRNA. Translation: AAA37664.1.
AF277893 mRNA. Translation: AAF82124.1.
AF501886 mRNA. Translation: AAM15922.1.
AK036816 mRNA. Translation: BAC29589.1.
AK152227 mRNA. Translation: BAE31054.1.
AK167416 mRNA. Translation: BAE39504.1.
BC028753 mRNA. Translation: AAH28753.1.
CCDSiCCDS17297.1.
PIRiJS0669. RGMSB4.
RefSeqiNP_038559.2. NM_013531.4.
XP_006535466.1. XM_006535403.1.
UniGeneiMm.139192.
Mm.393826.

Genome annotation databases

EnsembliENSMUST00000108234; ENSMUSP00000103869; ENSMUSG00000027669.
ENSMUST00000155737; ENSMUSP00000121127; ENSMUSG00000027669.
GeneIDi14696.
KEGGimmu:14696.
UCSCiuc008owl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S86124 mRNA. Translation: AAB21609.1 .
M87286 mRNA. Translation: AAA37756.1 .
M63658 mRNA. Translation: AAA37664.1 .
AF277893 mRNA. Translation: AAF82124.1 .
AF501886 mRNA. Translation: AAM15922.1 .
AK036816 mRNA. Translation: BAC29589.1 .
AK152227 mRNA. Translation: BAE31054.1 .
AK167416 mRNA. Translation: BAE39504.1 .
BC028753 mRNA. Translation: AAH28753.1 .
CCDSi CCDS17297.1.
PIRi JS0669. RGMSB4.
RefSeqi NP_038559.2. NM_013531.4.
XP_006535466.1. XM_006535403.1.
UniGenei Mm.139192.
Mm.393826.

3D structure databases

ProteinModelPortali P29387.
SMRi P29387. Positions 1-340.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-604N.
IntActi P29387. 3 interactions.
MINTi MINT-4095682.

PTM databases

PhosphoSitei P29387.

2D gel databases

REPRODUCTION-2DPAGE P29387.

Proteomic databases

MaxQBi P29387.
PaxDbi P29387.
PRIDEi P29387.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000108234 ; ENSMUSP00000103869 ; ENSMUSG00000027669 .
ENSMUST00000155737 ; ENSMUSP00000121127 ; ENSMUSG00000027669 .
GeneIDi 14696.
KEGGi mmu:14696.
UCSCi uc008owl.1. mouse.

Organism-specific databases

CTDi 59345.
MGIi MGI:104581. Gnb4.

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00740000115196.
HOGENOMi HOG000176356.
HOVERGENi HBG000188.
InParanoidi P29387.
KOi K04538.
OMAi ATSFTGH.
OrthoDBi EOG7GN2N5.
PhylomeDBi P29387.
TreeFami TF106149.

Enzyme and pathway databases

Reactomei REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_221970. Ca2+ pathway.

Miscellaneous databases

NextBioi 286647.
PROi P29387.
SOURCEi Search...

Gene expression databases

Bgeei P29387.
Genevestigatori P29387.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR020472. G-protein_beta_WD-40_rep.
IPR001632. Gprotein_B.
IPR016346. Guanine_nucleotide-bd_bsu.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 7 hits.
[Graphical view ]
PIRSFi PIRSF002394. GN-bd_beta. 1 hit.
PRINTSi PR00319. GPROTEINB.
PR00320. GPROTEINBRPT.
SMARTi SM00320. WD40. 7 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Diversity among the beta subunits of heterotrimeric GTP-binding proteins: characterization of a novel beta-subunit cDNA."
    von Weizsaecker E., Strathmann M.P., Simon M.I.
    Biochem. Biophys. Res. Commun. 183:350-356(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Differential modulation of N-type 1B and P/Q-type 1A calcium channels by different G protein subunit isoforms."
    Arnot M.I., Stotz S.C., Jarvis S.E., Zamponi G.W.
    J. Physiol. (Lond.) 527:203-212(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "Cloning, tissue distribution, and functional expression of the human G protein beta 4-subunit."
    Ruiz-Velasco V., Ikeda S.R., Puhl H.L. III
    Physiol. Genomics 8:41-50(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Placenta and Vagina.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.

Entry informationi

Entry nameiGBB4_MOUSE
AccessioniPrimary (citable) accession number: P29387
Secondary accession number(s): Q3TJJ1, Q8R475, Q9JHX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 124 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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