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Protein

Protein S100-G

Gene

S100G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi18 – 311; low affinityAdd BLAST14
Calcium bindingi58 – 692; high affinityAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: ProtInc
  • vitamin D binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding, Vitamin D

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169906-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-G
Alternative name(s):
Calbindin-D9k
S100 calcium-binding protein G
Vitamin D-dependent calcium-binding protein, intestinal
Short name:
CABP
Gene namesi
Name:S100G
Synonyms:CABP9K, CALB3, S100D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:1436. S100G.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169906.
PharmGKBiPA26028.

Polymorphism and mutation databases

BioMutaiS100G.
DMDMi115387.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001440272 – 79Protein S100-GAdd BLAST78

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei42PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP29377.
PeptideAtlasiP29377.
PRIDEiP29377.

PTM databases

iPTMnetiP29377.
PhosphoSitePlusiP29377.

Expressioni

Gene expression databases

BgeeiENSG00000169906.
CleanExiHS_S100G.
GenevisibleiP29377. HS.

Organism-specific databases

HPAiCAB017688.
HPA055873.

Interactioni

Protein-protein interaction databases

BioGridi107246. 1 interactor.
STRINGi9606.ENSP00000369547.

Structurei

3D structure databases

ProteinModelPortaliP29377.
SMRiP29377.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 48EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini45 – 79EF-hand 2PROSITE-ProRule annotationAdd BLAST35

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J1CR. Eukaryota.
ENOG4111C34. LUCA.
GeneTreeiENSGT00530000064238.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP29377.
KOiK14734.
OMAiLLIQTEF.
OrthoDBiEOG091G137D.
PhylomeDBiP29377.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028489. S100G.
[Graphical view]
PANTHERiPTHR11639:SF73. PTHR11639:SF73. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P29377-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTKKSPEEL KRIFEKYAAK EGDPDQLSKD ELKLLIQAEF PSLLKGPNTL
60 70
DDLFQELDKN GDGEVSFEEF QVLVKKISQ
Length:79
Mass (Da):9,016
Last modified:January 23, 2007 - v2
Checksum:i30416A681485B690
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79Q → S in AAA35637 (PubMed:8308886).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65869 mRNA. Translation: CAA46699.1.
L13220 mRNA. Translation: AAA35638.1.
L13042 Genomic DNA. Translation: AAA35637.1.
AL445467 Genomic DNA. Translation: CAI40084.1.
BC112174 mRNA. Translation: AAI12175.1.
CCDSiCCDS14176.1.
PIRiJN0246.
RefSeqiNP_004048.1. NM_004057.2.
XP_016885330.1. XM_017029841.1.
UniGeneiHs.639.

Genome annotation databases

EnsembliENST00000380200; ENSP00000369547; ENSG00000169906.
GeneIDi795.
KEGGihsa:795.
UCSCiuc004cxn.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65869 mRNA. Translation: CAA46699.1.
L13220 mRNA. Translation: AAA35638.1.
L13042 Genomic DNA. Translation: AAA35637.1.
AL445467 Genomic DNA. Translation: CAI40084.1.
BC112174 mRNA. Translation: AAI12175.1.
CCDSiCCDS14176.1.
PIRiJN0246.
RefSeqiNP_004048.1. NM_004057.2.
XP_016885330.1. XM_017029841.1.
UniGeneiHs.639.

3D structure databases

ProteinModelPortaliP29377.
SMRiP29377.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107246. 1 interactor.
STRINGi9606.ENSP00000369547.

PTM databases

iPTMnetiP29377.
PhosphoSitePlusiP29377.

Polymorphism and mutation databases

BioMutaiS100G.
DMDMi115387.

Proteomic databases

PaxDbiP29377.
PeptideAtlasiP29377.
PRIDEiP29377.

Protocols and materials databases

DNASUi795.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380200; ENSP00000369547; ENSG00000169906.
GeneIDi795.
KEGGihsa:795.
UCSCiuc004cxn.2. human.

Organism-specific databases

CTDi795.
GeneCardsiS100G.
HGNCiHGNC:1436. S100G.
HPAiCAB017688.
HPA055873.
MIMi302020. gene.
neXtProtiNX_P29377.
OpenTargetsiENSG00000169906.
PharmGKBiPA26028.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1CR. Eukaryota.
ENOG4111C34. LUCA.
GeneTreeiENSGT00530000064238.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP29377.
KOiK14734.
OMAiLLIQTEF.
OrthoDBiEOG091G137D.
PhylomeDBiP29377.
TreeFamiTF332727.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169906-MONOMER.

Miscellaneous databases

GeneWikiiS100G.
GenomeRNAii795.
PROiP29377.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169906.
CleanExiHS_S100G.
GenevisibleiP29377. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028489. S100G.
[Graphical view]
PANTHERiPTHR11639:SF73. PTHR11639:SF73. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS100G_HUMAN
AccessioniPrimary (citable) accession number: P29377
Secondary accession number(s): Q5JS49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.