Reviewed, UniProtKB/Swiss-Prot P29377 (S100G_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein S100-G
Alternative name(s):
    S100 calcium-binding protein G
    Vitamin D-dependent calcium-binding protein, intestinal
      Short name=CABP
    Calbindin-D9k

Gene names

Name:	S100G
Synonyms:	CABP9K, CALB3, S100D

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	79 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Belongs to the S-100 family. Contains 2 EF-hand domains.

Ontologies

Keywords
Domain	Repeat
Ligand	Calcium Vitamin D
PTM	Acetylation
Gene Ontology (GO)
Molecular function	calcium ion binding Ref.1 Traceable author statement. Source: ProtInc vitamin D binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 79	78	Protein S100-G		PRO_0000144027
Regions
	Domain	13 – 48	36	EF-hand 1
	Domain	45 – 79	35	EF-hand 2
	Calcium binding	18 – 31	14	1; low affinity
	Calcium binding	58 – 69	12	2; high affinity
Amino acid modifications
	Modified residue	2	1	N-acetylserine By similarity
Experimental info
	Sequence conflict	79	1	Q → S in AAA35637. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P29377-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 30416A681485B690	FASTA	79	9,016
	10 20 30 40 50 60 MSTKKSPEEL KRIFEKYAAK EGDPDQLSKD ELKLLIQAEF PSLLKGPNTL DDLFQELDKN 70 GDGEVSFEEF QVLVKKISQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and chromosomal assignment of human calbindin-D9k." Howard A., Legon S., Spurr N.K., Walters J.R.I. Biochem. Biophys. Res. Commun. 185:663-669(1992) [PubMed: 1610358] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Molecular cloning of the full-length cDNA encoding the human calbindin-D9k." Jeung E.B., Krisinger J., Dann J.L., Leung P.C.K. FEBS Lett. 307:224-228(1992) [PubMed: 1379540] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The human calbindin-D9k gene. Complete structure and implications on steroid hormone regulation." Jeung E.B., Leung P.C.K., Krisinger J. J. Mol. Biol. 235:1231-1238(1994) [PubMed: 8308886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	X65869 mRNA. Translation: CAA46699.1. L13220 mRNA. Translation: AAA35638.1. L13042 Genomic DNA. Translation: AAA35637.1. AL445467 Genomic DNA. Translation: CAI40084.1. BC112174 mRNA. Translation: AAI12175.1.
PIR	JN0246.
RefSeq	NP_004048.1.
UniGene	Hs.639
3D structure databases
HSSP	HSSP built from PDB template 1CB1 based on UniProtKB P02632.
SMR	P29377. Positions 2-79.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000169906. Homo sapiens. [Contig view]
GeneID	795.
KEGG	hsa:795.
Organism-specific databases
H-InvDB	HIX0056285.
HGNC	HGNC:1436. S100G.
HPA	CAB017688.
MIM	302020. gene.
PharmGKB	PA26028.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P29377.
HOVERGEN	P29377.
Gene expression databases
ArrayExpress	P29377.
CleanEx	HS_S100G.
GermOnline	ENSG00000169906. Homo sapiens.
Family and domain databases
InterPro	IPR011992. EF-Hand_type. IPR002048. EF_hand_Ca_bd. IPR001751. S100_Ca_bd. IPR013787. S100_Ca_bd_sub. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 1 hit.
Pfam	PF00036. efhand. 1 hit. PF01023. S_100. 1 hit. [Graphical view]
ProDom	PD003407. CaBP_S100. 1 hit. PD000012. EF-hand. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00018. EF_HAND_1. 1 hit. PS50222. EF_HAND_2. 1 hit. PS00303. S100_CABP. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	3230.
SOURCE	Search...

Entry information

Entry name

S100G_HUMAN

Accession

Primary (citable) accession number: P29377
Secondary accession number(s): Q5JS49

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	January 23, 2007
Last modified:	November 25, 2008
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)