P29377 (S100G_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 107.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Protein S100-G Alternative name(s): Calbindin-D9k S100 calcium-binding protein G Vitamin D-dependent calcium-binding protein, intestinal Short name=CABP | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 79 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Sequence similarities | Belongs to the S-100 family. Contains 2 EF-hand domains. |
Ontologies
| Keywords | |
|---|---|
| Domain | Repeat |
| Ligand | Calcium Vitamin D |
| PTM | Acetylation |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Molecular function | calcium ion binding Traceable author statement. Source: ProtInc vitamin D bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 79 | 78 | Protein S100-G | PRO_0000144027 | |||||
Regions | |||||||||
| Domain | 13 – 48 | 36 | EF-hand 1 | ||||||
| Domain | 45 – 79 | 35 | EF-hand 2 | ||||||
| Calcium binding | 18 – 31 | 14 | 1; low affinity | ||||||
| Calcium binding | 58 – 69 | 12 | 2; high affinity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N-acetylserine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 79 | 1 | Q → S in AAA35637. Ref.3 | ||||||
Sequences
References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning and chromosomal assignment of human calbindin-D9k." Howard A., Legon S., Spurr N.K., Walters J.R.I. Biochem. Biophys. Res. Commun. 185:663-669(1992) [PubMed: 1610358] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Molecular cloning of the full-length cDNA encoding the human calbindin-D9k." Jeung E.B., Krisinger J., Dann J.L., Leung P.C.K. FEBS Lett. 307:224-228(1992) [PubMed: 1379540] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "The human calbindin-D9k gene. Complete structure and implications on steroid hormone regulation." Jeung E.B., Leung P.C.K., Krisinger J. J. Mol. Biol. 235:1231-1238(1994) [PubMed: 8308886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [4] | "The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. Bentley D.R.Nature 434:325-337(2005) [PubMed: 15772651] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X65869 mRNA. Translation: CAA46699.1. L13220 mRNA. Translation: AAA35638.1. L13042 Genomic DNA. Translation: AAA35637.1. AL445467 Genomic DNA. Translation: CAI40084.1. BC112174 mRNA. Translation: AAI12175.1. |
| IPI | IPI00303002. |
| PIR | JN0246. |
| RefSeq | NP_004048.1. NM_004057.2. |
| UniGene | Hs.639. |
3D structure databases | |
| ProteinModelPortal | P29377. |
| SMR | P29377. Positions 5-79. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P29377. |
PTM databases | |
| PhosphoSite | P29377. |
Polymorphism databases | |
| DMDM | 115387. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000380200; ENSP00000369547; ENSG00000169906. |
| GeneID | 795. |
| KEGG | hsa:795. |
| UCSC | uc004cxn.1. human. |
Organism-specific databases | |
| CTD | 795. |
| GeneCards | GC0XP016668. |
| H-InvDB | HIX0056285. |
| HGNC | HGNC:1436. S100G. |
| HPA | CAB017688. |
| MIM | 302020. gene. |
| neXtProt | NX_P29377. |
| PharmGKB | PA26028. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG21178. |
| GeneTree | ENSGT00530000064238. |
| HOGENOM | HBG716817. |
| HOVERGEN | HBG001479. |
| InParanoid | P29377. |
| OMA | KGPSTLD. |
| OrthoDB | EOG4NP754. |
| PhylomeDB | P29377. |
Gene expression databases | |
| ArrayExpress | P29377. |
| Bgee | P29377. |
| CleanEx | HS_S100G. |
| Genevestigator | P29377. |
| GermOnline | ENSG00000169906. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR018248. EF-hand. IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR018249. EF_HAND_2. IPR001751. S100/CaBP-9k_CS. IPR013787. S100_Ca-bd_sub. [Graphical view] |
| Gene3D | G3DSA:1.10.238.10. EF-Hand_type. 1 hit. |
| KO | K14734. |
| Pfam | PF00036. efhand. 1 hit. PF01023. S_100. 1 hit. [Graphical view] |
| PROSITE | PS00018. EF_HAND_1. 1 hit. PS50222. EF_HAND_2. 1 hit. PS00303. S100_CABP. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 3230. |
| SOURCE | Search... |
Entry information
| Entry name | S100G_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P29377 Secondary accession number(s): Q5JS49 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome X Human chromosome X: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with