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P29377

- S100G_HUMAN

UniProt

P29377 - S100G_HUMAN

Protein

Protein S100-G

Gene

S100G

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi18 – 31141; low affinityAdd
    BLAST
    Calcium bindingi58 – 69122; high affinityAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: ProtInc
    2. vitamin D binding Source: UniProtKB-KW

    Keywords - Ligandi

    Calcium, Metal-binding, Vitamin D

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein S100-G
    Alternative name(s):
    Calbindin-D9k
    S100 calcium-binding protein G
    Vitamin D-dependent calcium-binding protein, intestinal
    Short name:
    CABP
    Gene namesi
    Name:S100G
    Synonyms:CABP9K, CALB3, S100D
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:1436. S100G.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. basolateral plasma membrane Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26028.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 7978Protein S100-GPRO_0000144027Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiP29377.

    PTM databases

    PhosphoSiteiP29377.

    Expressioni

    Gene expression databases

    BgeeiP29377.
    CleanExiHS_S100G.
    GenevestigatoriP29377.

    Organism-specific databases

    HPAiCAB017688.
    HPA055873.

    Interactioni

    Protein-protein interaction databases

    BioGridi107246. 1 interaction.
    STRINGi9606.ENSP00000369547.

    Structurei

    3D structure databases

    ProteinModelPortaliP29377.
    SMRiP29377. Positions 5-79.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 4836EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini45 – 7935EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the S-100 family.Curated
    Contains 2 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG39449.
    HOGENOMiHOG000246968.
    HOVERGENiHBG001479.
    InParanoidiP29377.
    KOiK14734.
    OMAiLLIQTEF.
    OrthoDBiEOG7Z3F78.
    PhylomeDBiP29377.
    TreeFamiTF332727.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    IPR028489. S100G.
    [Graphical view]
    PANTHERiPTHR11639:SF67. PTHR11639:SF67. 1 hit.
    PfamiPF00036. EF-hand_1. 1 hit.
    PF01023. S_100. 1 hit.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 1 hit.
    PS00303. S100_CABP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P29377-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTKKSPEEL KRIFEKYAAK EGDPDQLSKD ELKLLIQAEF PSLLKGPNTL   50
    DDLFQELDKN GDGEVSFEEF QVLVKKISQ 79
    Length:79
    Mass (Da):9,016
    Last modified:January 23, 2007 - v2
    Checksum:i30416A681485B690
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti79 – 791Q → S in AAA35637. (PubMed:8308886)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65869 mRNA. Translation: CAA46699.1.
    L13220 mRNA. Translation: AAA35638.1.
    L13042 Genomic DNA. Translation: AAA35637.1.
    AL445467 Genomic DNA. Translation: CAI40084.1.
    BC112174 mRNA. Translation: AAI12175.1.
    CCDSiCCDS14176.1.
    PIRiJN0246.
    RefSeqiNP_004048.1. NM_004057.2.
    UniGeneiHs.639.

    Genome annotation databases

    EnsembliENST00000380200; ENSP00000369547; ENSG00000169906.
    GeneIDi795.
    KEGGihsa:795.
    UCSCiuc004cxn.1. human.

    Polymorphism databases

    DMDMi115387.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65869 mRNA. Translation: CAA46699.1 .
    L13220 mRNA. Translation: AAA35638.1 .
    L13042 Genomic DNA. Translation: AAA35637.1 .
    AL445467 Genomic DNA. Translation: CAI40084.1 .
    BC112174 mRNA. Translation: AAI12175.1 .
    CCDSi CCDS14176.1.
    PIRi JN0246.
    RefSeqi NP_004048.1. NM_004057.2.
    UniGenei Hs.639.

    3D structure databases

    ProteinModelPortali P29377.
    SMRi P29377. Positions 5-79.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107246. 1 interaction.
    STRINGi 9606.ENSP00000369547.

    PTM databases

    PhosphoSitei P29377.

    Polymorphism databases

    DMDMi 115387.

    Proteomic databases

    PRIDEi P29377.

    Protocols and materials databases

    DNASUi 795.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000380200 ; ENSP00000369547 ; ENSG00000169906 .
    GeneIDi 795.
    KEGGi hsa:795.
    UCSCi uc004cxn.1. human.

    Organism-specific databases

    CTDi 795.
    GeneCardsi GC0XP016668.
    HGNCi HGNC:1436. S100G.
    HPAi CAB017688.
    HPA055873.
    MIMi 302020. gene.
    neXtProti NX_P29377.
    PharmGKBi PA26028.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39449.
    HOGENOMi HOG000246968.
    HOVERGENi HBG001479.
    InParanoidi P29377.
    KOi K14734.
    OMAi LLIQTEF.
    OrthoDBi EOG7Z3F78.
    PhylomeDBi P29377.
    TreeFami TF332727.

    Miscellaneous databases

    GeneWikii S100G.
    GenomeRNAii 795.
    NextBioi 3230.
    PROi P29377.
    SOURCEi Search...

    Gene expression databases

    Bgeei P29377.
    CleanExi HS_S100G.
    Genevestigatori P29377.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    IPR028489. S100G.
    [Graphical view ]
    PANTHERi PTHR11639:SF67. PTHR11639:SF67. 1 hit.
    Pfami PF00036. EF-hand_1. 1 hit.
    PF01023. S_100. 1 hit.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 1 hit.
    PS00303. S100_CABP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and chromosomal assignment of human calbindin-D9k."
      Howard A., Legon S., Spurr N.K., Walters J.R.I.
      Biochem. Biophys. Res. Commun. 185:663-669(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular cloning of the full-length cDNA encoding the human calbindin-D9k."
      Jeung E.B., Krisinger J., Dann J.L., Leung P.C.K.
      FEBS Lett. 307:224-228(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The human calbindin-D9k gene. Complete structure and implications on steroid hormone regulation."
      Jeung E.B., Leung P.C.K., Krisinger J.
      J. Mol. Biol. 235:1231-1238(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiS100G_HUMAN
    AccessioniPrimary (citable) accession number: P29377
    Secondary accession number(s): Q5JS49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3