Leukocyte tyrosine kinase receptor precursor

Names and origin

Protein names

Recommended name:
    Leukocyte tyrosine kinase receptor
    EC=2.7.10.1
Alternative name(s):
    Protein tyrosine kinase 1

Gene names

Name:	LTK
Synonyms:	TYK1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	864 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	The exact function of this protein is not known. It is probably a receptor with a tyrosine-protein kinase activity.
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Expressed in non-hematopoietic cell lines and T- and B-cell lines. Ref.4
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 1 protein kinase domain.

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Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal Transmembrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Receptor Transferase Tyrosine-protein kinase
PTM	Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Ref.1 Traceable author statement. Source: ProtInc transmembrane receptor protein tyrosine kinase signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular component	integral to plasma membrane Ref.1 Traceable author statement. Source: ProtInc soluble fraction Ref.1 Traceable author statement. Source: ProtInc
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW transmembrane receptor protein tyrosine kinase activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

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Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select] Note: Additional isoforms seem to exist.

Isoform Lambda P2 (identifier: P29376-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Lambda P1 (identifier: P29376-2) The sequence of this isoform differs from the canonical sequence as follows: 170-170: G → VAAASGDGAAPAPGARAAWGPGERAFLGAGSPAQRGEAPGPRRFPPPLPAG 171-864: Missing.

Isoform Lambda P3 (identifier: P29376-3) The sequence of this isoform differs from the canonical sequence as follows: 448-448: L → GTKRLAGTVDSRLLLSSELGWVSAAGSRRQ 449-864: Missing.

Isoform 2 (identifier: P29376-4) The sequence of this isoform differs from the canonical sequence as follows: 274-334: Missing.

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 16

16

Potential

Chain

17 – 864

848

Leukocyte tyrosine kinase receptor

PRO_0000016738

Regions

Topological domain

17 – 424

408

Extracellular Potential

Transmembrane

425 – 449

25

Potential

Topological domain

450 – 864

415

Cytoplasmic Potential

Domain

510 – 786

277

Protein kinase

Nucleotide binding

516 – 524

9

ATP By similarity

Sites

Active site

643

1

Proton acceptor By similarity

Binding site

544

1

ATP By similarity

Amino acid modifications

Modified residue

672

1

Phosphotyrosine Ref.5

Modified residue

676

1

Phosphotyrosine; by autocatalysis By similarity

Modified residue

677

1

Phosphotyrosine Ref.5

Glycosylation

257

1

N-linked (GlcNAc...) Potential

Glycosylation

380

1

N-linked (GlcNAc...) Potential

Glycosylation

412

1

N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence

170

1

G → VAAASGDGAAPAPGARAAWG PGERAFLGAGSPAQRGEAPG PRRFPPPLPAG in isoform Lambda P1.

VSP_002946

Alternative sequence

171 – 864

694

Missing in isoform Lambda P1.

VSP_002947

Alternative sequence

274 – 334

61

Missing in isoform 2.

VSP_035109

Alternative sequence

448

1

L → GTKRLAGTVDSRLLLSSELG WVSAAGSRRQ in isoform Lambda P3.

VSP_002948

Alternative sequence

449 – 864

416

Missing in isoform Lambda P3.

VSP_002949

Natural variant

42

1

R → Q: dbSNP rs2305030. Ref.1 Ref.6

VAR_031569

Natural variant

384

1

C → R Ref.6

VAR_046106

Natural variant

535

1

D → N Ref.6

VAR_046107

Natural variant

569

1

R → S Ref.6

VAR_046108

Natural variant

673

1

R → Q Ref.6

VAR_046109

Natural variant

745

1

P → S Ref.6

VAR_046110

Natural variant

838

1

P → S Ref.6

VAR_046111

Experimental info

Sequence conflict

220

1

V → L in CAA43113. Ref.2

Sequence conflict

274 – 334

61

Missing in CAA43113. Ref.2

Sequence conflict

449

1

V → GTKRLAGTVDSRLLLSM in CAA36460. Ref.3

Sequence conflict

652 – 654

3

SCA → MR in CAA36460. Ref.3

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Sequences

Sequence		Length	Mass (Da)
Isoform Lambda P2 [UniParc]. Last modified April 3, 2007. Version 3. Checksum: 0617F378AA04298E Show »	FASTA	864	91,681
10 20 30 40 50 60 MGCWGQLLVW FGAAGAILCS SPGSQETFLR SSPLPLASPS PRDPKVSAPP SILEPASPLN 70 80 90 100 110 120 SPGTEGSWLF STCGASGRHG PTQTQCDGAY AGTSVVVTVG AAGQLRGVQL WRVPGPGQYL 130 140 150 160 170 180 ISAYGAAGGK GAKNHLSRAH GVFVSAIFSL GLGESLYILV GQQGEDACPG GSPESQLVCL 190 200 210 220 230 240 GESRAVEEHA AMDGSEGVPG SRRWAGGGGG GGGATYVFRV RAGELEPLLV AAGGGGRAYL 250 260 270 280 290 300 RPRDRGRTQA SPEKLENRSE APGSGGRGGA AGGGGGWTSR APSPQAGRSL QEGAEGGQGC 310 320 330 340 350 360 SEAWATLGWA AAGGFGGGGG ACTAGGGGGG YRGGDASETD NLWADGEDGV SFIHPSSELF 370 380 390 400 410 420 LQPLAVTENH GEVEIRRHLN CSHCPLRDCQ WQAELQLAEC LCPEGMELAV DNVTCMDLHK 430 440 450 460 470 480 PPGPLVLMVA VVATSTLSLL MVCGVLILVK QKKWQGLQEM RLPSPELELS KLRTSAIRTA 490 500 510 520 530 540 PNPYYCQVGL GPAQSWPLPP GVTEVSPANV TLLRALGHGA FGEVYEGLVI GLPGDSSPLQ 550 560 570 580 590 600 VAIKTLPELC SPQDELDFLM EALIISKFRH QNIVRCVGLS LRATPRLILL ELMSGGDMKS 610 620 630 640 650 660 FLRHSRPHLG QPSPLVMRDL LQLAQDIAQG CHYLEENHFI HRDIAARNCL LSCAGPSRVA 670 680 690 700 710 720 KIGDFGMARD IYRASYYRRG DRALLPVKWM PPEAFLEGIF TSKTDSWSFG VLLWEIFSLG 730 740 750 760 770 780 YMPYPGRTNQ EVLDFVVGGG RMDPPRGCPG PVYRIMTQCW QHEPELRPSF ASILERLQYC 790 800 810 820 830 840 TQDPDVLNSL LPMELGPTPE EEGTSGLGNR SLECLRPPQP QELSPEKLKS WGGSPLGPWL 850 860 SSGLKPLKSR GLQPQNLWNP TYRS « Hide
Isoform Lambda P1. Checksum: EC71C9296310B1AA Show »	FASTA	220	21,952
10 20 30 40 50 60 MGCWGQLLVW FGAAGAILCS SPGSQETFLR SSPLPLASPS PRDPKVSAPP SILEPASPLN 70 80 90 100 110 120 SPGTEGSWLF STCGASGRHG PTQTQCDGAY AGTSVVVTVG AAGQLRGVQL WRVPGPGQYL 130 140 150 160 170 180 ISAYGAAGGK GAKNHLSRAH GVFVSAIFSL GLGESLYILV GQQGEDACPV AAASGDGAAP 190 200 210 220 APGARAAWGP GERAFLGAGS PAQRGEAPGP RRFPPPLPAG « Hide
Isoform Lambda P3. Checksum: 55867ECA5C4A4CF4 Show »	FASTA	477	48,354
10 20 30 40 50 60 MGCWGQLLVW FGAAGAILCS SPGSQETFLR SSPLPLASPS PRDPKVSAPP SILEPASPLN 70 80 90 100 110 120 SPGTEGSWLF STCGASGRHG PTQTQCDGAY AGTSVVVTVG AAGQLRGVQL WRVPGPGQYL 130 140 150 160 170 180 ISAYGAAGGK GAKNHLSRAH GVFVSAIFSL GLGESLYILV GQQGEDACPG GSPESQLVCL 190 200 210 220 230 240 GESRAVEEHA AMDGSEGVPG SRRWAGGGGG GGGATYVFRV RAGELEPLLV AAGGGGRAYL 250 260 270 280 290 300 RPRDRGRTQA SPEKLENRSE APGSGGRGGA AGGGGGWTSR APSPQAGRSL QEGAEGGQGC 310 320 330 340 350 360 SEAWATLGWA AAGGFGGGGG ACTAGGGGGG YRGGDASETD NLWADGEDGV SFIHPSSELF 370 380 390 400 410 420 LQPLAVTENH GEVEIRRHLN CSHCPLRDCQ WQAELQLAEC LCPEGMELAV DNVTCMDLHK 430 440 450 460 470 PPGPLVLMVA VVATSTLSLL MVCGVLIGTK RLAGTVDSRL LLSSELGWVS AAGSRRQ « Hide
Isoform 2. Checksum: 3877888B402CE78A Show »	FASTA	803	86,213
10 20 30 40 50 60 MGCWGQLLVW FGAAGAILCS SPGSQETFLR SSPLPLASPS PRDPKVSAPP SILEPASPLN 70 80 90 100 110 120 SPGTEGSWLF STCGASGRHG PTQTQCDGAY AGTSVVVTVG AAGQLRGVQL WRVPGPGQYL 130 140 150 160 170 180 ISAYGAAGGK GAKNHLSRAH GVFVSAIFSL GLGESLYILV GQQGEDACPG GSPESQLVCL 190 200 210 220 230 240 GESRAVEEHA AMDGSEGVPG SRRWAGGGGG GGGATYVFRV RAGELEPLLV AAGGGGRAYL 250 260 270 280 290 300 RPRDRGRTQA SPEKLENRSE APGSGGRGGA AGGDASETDN LWADGEDGVS FIHPSSELFL 310 320 330 340 350 360 QPLAVTENHG EVEIRRHLNC SHCPLRDCQW QAELQLAECL CPEGMELAVD NVTCMDLHKP 370 380 390 400 410 420 PGPLVLMVAV VATSTLSLLM VCGVLILVKQ KKWQGLQEMR LPSPELELSK LRTSAIRTAP 430 440 450 460 470 480 NPYYCQVGLG PAQSWPLPPG VTEVSPANVT LLRALGHGAF GEVYEGLVIG LPGDSSPLQV 490 500 510 520 530 540 AIKTLPELCS PQDELDFLME ALIISKFRHQ NIVRCVGLSL RATPRLILLE LMSGGDMKSF 550 560 570 580 590 600 LRHSRPHLGQ PSPLVMRDLL QLAQDIAQGC HYLEENHFIH RDIAARNCLL SCAGPSRVAK 610 620 630 640 650 660 IGDFGMARDI YRASYYRRGD RALLPVKWMP PEAFLEGIFT SKTDSWSFGV LLWEIFSLGY 670 680 690 700 710 720 MPYPGRTNQE VLDFVVGGGR MDPPRGCPGP VYRIMTQCWQ HEPELRPSFA SILERLQYCT 730 740 750 760 770 780 QDPDVLNSLL PMELGPTPEE EGTSGLGNRS LECLRPPQPQ ELSPEKLKSW GGSPLGPWLS 790 800 SGLKPLKSRG LQPQNLWNPT YRS « Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein." Toyoshima H., Kozutsumi H., Maru Y., Hagiwara K., Furaya A., Mioh H., Hanai N., Takaku F., Yazaki Y., Hirai H. Proc. Natl. Acad. Sci. U.S.A. 90:5404-5408(1993) [PubMed: 7685902] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLN-42. Tissue: Placenta.
[2]	"The ltk gene encodes a novel receptor-type protein tyrosine kinase." Krolewski J.J., Dalla-Favera R. EMBO J. 10:2911-2919(1991) [PubMed: 1655406] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]	"Human ltk: gene structure and preferential expression in human leukemic cells." Maru Y., Hirai H., Takaku F. Oncogene Res. 5:199-204(1990) [PubMed: 2320375] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 416-864.
[4]	"Identification and chromosomal mapping of new human tyrosine kinase genes." Krolewski J.J., Lee R., Eddy R., Shows T.B., Dalla-Favera R. Oncogene 5:277-282(1990) [PubMed: 2156206] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 608-716, TISSUE SPECIFICITY.
[5]	"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. Comb M.J. Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-672; TYR-676 AND TYR-677, MASS SPECTROMETRY.
[6]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. Stratton M.R. Nature 446:153-158(2007) [PubMed: 17344846] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLN-42; ARG-384; ASN-535; SER-569; GLN-673; SER-745 AND SER-838.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	D16105 mRNA. Translation: BAA03679.1. X60702 mRNA. Translation: CAA43113.1. X52213 mRNA. Translation: CAA36460.1.
IPI	IPI00007716. IPI00021365. IPI00218841. IPI00218843.
PIR	A48266.
RefSeq	NP_002335.2.
UniGene	Hs.434481
3D structure databases
HSSP	HSSP built from PDB template 1FMK based on UniProtKB P12931.
ModBase	Search...
PTM databases
PhosphoSite	P29376.
Genome annotation databases
Ensembl	ENSG00000062524. Homo sapiens. [Contig view]
GeneID	4058.
Organism-specific databases
GeneCards	GC15M039583.
H-InvDB	HIX0038138.
HGNC	HGNC:6721. LTK.
MIM	151520. gene.
PharmGKB	PA30483.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P29376.
HOVERGEN	P29376.
OMA	P29376. GPAQSWP.
Enzyme and pathway databases
BRENDA	2.7.10.1. 247.
Gene expression databases
Bgee	P29376.
CleanEx	HS_LTK.
GermOnline	ENSG00000062524. Homo sapiens.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR002011. Recept_tyr_kinase-II_CS. IPR001245. Tyr_pkinase. IPR008266. Tyr_pkinase_AS. [Graphical view]
Pfam	PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PRINTS	PR00109. TYRKINASE.
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00219. TyrKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS00239. RECEPTOR_TYR_KIN_II. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	15900.
SOURCE	Search...

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Entry information

Entry name

LTK_HUMAN

Accession

Primary (citable) accession number: P29376

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	April 3, 2007
Last modified:	June 16, 2009
This is version 96 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents