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Protein

Bud emergence protein 1

Gene

BEM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for cell polarization during vegetative growth. May link the cytoskeleton to morphogenic determinants on the cell surface.1 Publication

Miscellaneous

Present with 6490 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • phosphatidylinositol-3-phosphate binding Source: SGD
  • protein-containing complex scaffold activity Source: SGD

GO - Biological processi

  • cell morphogenesis involved in conjugation with cellular fusion Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-29141-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Bud emergence protein 1
Alternative name(s):
Suppressor of RHO3 protein 1
Gene namesi
Name:BEM1
Synonyms:SRO1
Ordered Locus Names:YBR200W
ORF Names:YBR1412
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR200W
SGDiS000000404 BEM1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000649081 – 551Bud emergence protein 1Add BLAST551

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Modified residuei255PhosphoserineCombined sources1
Modified residuei258PhosphoserineCombined sources1
Modified residuei458PhosphoserineCombined sources1
Modified residuei461PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP29366
PaxDbiP29366
PRIDEiP29366

PTM databases

iPTMnetiP29366

Interactioni

Subunit structurei

Interacts with AXL2 and BUD5.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein-containing complex scaffold activity Source: SGD

Protein-protein interaction databases

BioGridi32897, 509 interactors
DIPiDIP-688N
ELMiP29366
IntActiP29366, 51 interactors
MINTiP29366
STRINGi4932.YBR200W

Structurei

Secondary structure

1551
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi160 – 164Combined sources5
Beta strandi170 – 173Combined sources4
Beta strandi178 – 182Combined sources5
Turni189 – 191Combined sources3
Beta strandi192 – 195Combined sources4
Beta strandi198 – 201Combined sources4
Beta strandi205 – 209Combined sources5
Beta strandi217 – 220Combined sources4
Helixi222 – 224Combined sources3
Helixi227 – 231Combined sources5
Turni232 – 235Combined sources4
Helixi239 – 245Combined sources7
Turni246 – 248Combined sources3
Beta strandi283 – 294Combined sources12
Beta strandi297 – 306Combined sources10
Beta strandi311 – 316Combined sources6
Helixi318 – 331Combined sources14
Turni333 – 337Combined sources5
Helixi363 – 381Combined sources19
Helixi385 – 388Combined sources4
Helixi391 – 395Combined sources5
Beta strandi401 – 404Combined sources4
Beta strandi406 – 408Combined sources3
Beta strandi479 – 483Combined sources5
Beta strandi490 – 494Combined sources5
Helixi500 – 511Combined sources12
Beta strandi516 – 520Combined sources5
Beta strandi523 – 525Combined sources3
Helixi533 – 541Combined sources9
Beta strandi546 – 550Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IP9NMR-A472-551[»]
1IPGNMR-A472-551[»]
2CZONMR-A269-418[»]
2KFKNMR-A477-551[»]
2RQVNMR-A156-260[»]
2RQWNMR-A156-260[»]
2V6VX-ray1.50A/B266-413[»]
ProteinModelPortaliP29366
SMRiP29366
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP29366

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 132SH3 1PROSITE-ProRule annotationAdd BLAST61
Domaini155 – 217SH3 2PROSITE-ProRule annotationAdd BLAST63
Domaini278 – 404PXPROSITE-ProRule annotationAdd BLAST127
Domaini478 – 551PB1PROSITE-ProRule annotationAdd BLAST74

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

HOGENOMiHOG000246638
InParanoidiP29366
KOiK11237
OMAiKRIMPYI
OrthoDBiEOG092C1KS9

Family and domain databases

CDDicd06890 PX_Bem1p, 1 hit
cd11878 SH3_Bem1p_1, 1 hit
cd11879 SH3_Bem1p_2, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR030507 Bem1/Scd2
IPR035550 Bem1/Scd2_PX
IPR035548 Bem1/Scd2_SH3_1
IPR035549 Bem1/Scd2_SH3_2
IPR000270 PB1_dom
IPR001683 Phox
IPR036871 PX_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR45397 PTHR45397, 2 hits
PfamiView protein in Pfam
PF00787 PX, 1 hit
PF00018 SH3_1, 2 hits
SMARTiView protein in SMART
SM00666 PB1, 1 hit
SM00312 PX, 1 hit
SM00326 SH3, 2 hits
SUPFAMiSSF50044 SSF50044, 2 hits
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS51745 PB1, 1 hit
PS50195 PX, 1 hit
PS50002 SH3, 2 hits

Sequencei

Sequence statusi: Complete.

P29366-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKNFKLSKR DSNGSKGRIT SADISTPSHD NGSVIKHIKT VPVRYLSSSS
60 70 80 90 100
TPVKSQRDSS PKNRHNSKDI TSPEKVIKAK YSYQAQTSKE LSFMEGEFFY
110 120 130 140 150
VSGDEKDWYK ASNPSTGKEG VVPKTYFEVF DRTKPSSVNG SNSSSRKVTN
160 170 180 190 200
DSLNMGSLYA IVLYDFKAEK ADELTTYVGE NLFICAHHNC EWFIAKPIGR
210 220 230 240 250
LGGPGLVPVG FVSIIDIATG YATGNDVIED IKSVNLPTVQ EWKSNIARYK
260 270 280 290 300
ASNISLGSVE QQQQQSITKP QNKSAKLVDG ELLVKASVES FGLEDEKYWF
310 320 330 340 350
LVCCELSNGK TRQLKRYYQD FYDLQVQLLD AFPAEAGKLR DAGGQWSKRI
360 370 380 390 400
MPYIPGPVPY VTNSITKKRK EDLNIYVADL VNLPDYISRS EMVHSLFVVL
410 420 430 440 450
NNGFDREFER DENQNNIKTL QENDTATFAT ASQTSNFAST NQDNTLTGED
460 470 480 490 500
LKLNKKLSDL SLSGSKQAPA QSTSGLKTTK IKFYYKDDIF ALMLKGDTTY
510 520 530 540 550
KELRSKIAPR IDTDNFKLQT KLFDGSGEEI KTDSQVSNII QAKLKISVHD

I
Length:551
Mass (Da):61,605
Last modified:December 1, 1992 - v1
Checksum:iFB6C525AE9A19181
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63826 Genomic DNA Translation: CAA45320.1
Z21487 Genomic DNA Translation: CAA79687.1
Z36069 Genomic DNA Translation: CAA85162.1
BK006936 Genomic DNA Translation: DAA07316.1
PIRiS23400
RefSeqiNP_009759.3, NM_001178548.3

Genome annotation databases

EnsemblFungiiYBR200W; YBR200W; YBR200W
GeneIDi852499
KEGGisce:YBR200W

Similar proteinsi

Entry informationi

Entry nameiBEM1_YEAST
AccessioniPrimary (citable) accession number: P29366
Secondary accession number(s): D6VQJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: May 23, 2018
This is version 184 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

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