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Protein

Threonine synthase

Gene

thrC

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.By similarity

Catalytic activityi

O-phospho-L-homoserine + H2O = L-threonine + phosphate.

Cofactori

Pathwayi: L-threonine biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes L-threonine from L-aspartate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Aspartokinase (lysC)
  2. Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (hom)
  4. Homoserine kinase (thrB)
  5. Threonine synthase (thrC)
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Threonine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-3806-MONOMER
UniPathwayiUPA00050; UER00065

Names & Taxonomyi

Protein namesi
Recommended name:
Threonine synthase (EC:4.2.3.1)
Short name:
TS
Gene namesi
Name:thrC
Ordered Locus Names:PA3735
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA3735

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001856391 – 469Threonine synthaseAdd BLAST469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei112N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiP29363
PRIDEiP29363

Interactioni

Protein-protein interaction databases

STRINGi208964.PA3735

Structurei

3D structure databases

ProteinModelPortaliP29363
SMRiP29363
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the threonine synthase family.Curated

Phylogenomic databases

eggNOGiENOG4105D98 Bacteria
COG0498 LUCA
HOGENOMiHOG000230745
InParanoidiP29363
KOiK01733
OMAiDIFILHP
PhylomeDBiP29363

Family and domain databases

Gene3Di3.90.1380.10, 1 hit
InterProiView protein in InterPro
IPR001926 PLP-dep
IPR000634 Ser/Thr_deHydtase_PyrdxlP-BS
IPR029144 Thr_synth_N
IPR037158 Thr_synth_N_sf
IPR004450 Thr_synthase-like
IPR036052 Trypto_synt_PLP_dependent
PfamiView protein in Pfam
PF00291 PALP, 1 hit
PF14821 Thr_synth_N, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
TIGRFAMsiTIGR00260 thrC, 1 hit
PROSITEiView protein in PROSITE
PS00165 DEHYDRATASE_SER_THR, 1 hit

Sequencei

Sequence statusi: Complete.

P29363-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYISTRGQA PALNFEDVLL AGLASDGGLY VPENLPRFTL EEIASWVGLP
60 70 80 90 100
YHELAFRVMR PFVAGSIADA DFKKILEETY GVFAHDAVAP LRQLNGNEWV
110 120 130 140 150
LELFHGPTLA FKDFALQLLG RLLDHVLAKR GERVVIMGAT SGDTGSAAIE
160 170 180 190 200
GCRRCDNVDI FIMHPHNRVS EVQRRQMTTI LGDNIHNIAI EGNFDDCQEM
210 220 230 240 250
VKASFADQGF LKGTRLVAVN SINWARIMAQ IVYYFHAALQ LGAPHRSVAF
260 270 280 290 300
SVPTGNFGDI FAGYLARNMG LPVSQLIVAT NRNDILHRFM SGNRYDKDTL
310 320 330 340 350
HPSLSPSMDI MVSSNFERLL FDLHGRNGKA VAELLDAFKA SGKLSVEDQR
360 370 380 390 400
WTEARKLFDS LAVSDEQTCE TIAEVYRSSG ELLDPHTAIG VRAARECRRS
410 420 430 440 450
LSVPMVTLGT AHPVKFPEAV EKAGIGQAPA LPAHLADLFE REERCTVLPN
460
ELAKVQAFVS QHGNRGKPL
Length:469
Mass (Da):51,795
Last modified:January 11, 2001 - v3
Checksum:i224032B86272C79C
GO

Sequence cautioni

The sequence CAA46168 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88 – 101VAPLR…NEWVL → SGAAAPVERRTNGCV (PubMed:1333566).CuratedAdd BLAST14
Sequence conflicti151 – 155GCRRC → AAAVA in CAA46168 (PubMed:1333566).Curated5
Sequence conflicti163 – 164MH → ID in CAA46168 (PubMed:1333566).Curated2
Sequence conflicti173Q → E in CAA46168 (PubMed:1333566).Curated1
Sequence conflicti181L → H in CAA46168 (PubMed:1333566).Curated1
Sequence conflicti280T → R in CAA46168 (PubMed:1333566).Curated1
Sequence conflicti294 – 304RYDKDTLHPSL → ASTRHTLTPSV in CAA46168 (PubMed:1333566).CuratedAdd BLAST11
Sequence conflicti465R → P in CAA46168 (PubMed:1333566).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65033 Genomic DNA Translation: CAA46168.1 Different initiation.
AE004091 Genomic DNA Translation: AAG07122.1
PIRiG83179
S27980 SYPSRA
RefSeqiNP_252424.1, NC_002516.2
WP_003113831.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG07122; AAG07122; PA3735
GeneIDi880336
KEGGipae:PA3735
PATRICifig|208964.12.peg.3907

Similar proteinsi

Entry informationi

Entry nameiTHRC_PSEAE
AccessioniPrimary (citable) accession number: P29363
Secondary accession number(s): Q9HXQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 11, 2001
Last modified: May 23, 2018
This is version 120 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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