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P29351

- PTN6_MOUSE

UniProt

P29351 - PTN6_MOUSE

Protein

Tyrosine-protein phosphatase non-receptor type 6

Gene

Ptpn6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 158 (01 Oct 2014)
      Sequence version 2 (11 Jul 2002)
      Previous versions | rss
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    Functioni

    Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.1 Publication

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei419 – 4191SubstrateBy similarity
    Active sitei453 – 4531Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei500 – 5001SubstrateBy similarity

    GO - Molecular functioni

    1. phosphotyrosine binding Source: MGI
    2. protein binding Source: UniProtKB
    3. protein tyrosine phosphatase activity Source: MGI
    4. SH2 domain binding Source: MGI
    5. SH3 domain binding Source: MGI
    6. transmembrane receptor protein tyrosine phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. abortive mitotic cell cycle Source: MGI
    2. B cell receptor signaling pathway Source: MGI
    3. cell differentiation Source: UniProtKB
    4. cell proliferation Source: UniProtKB
    5. cytokine-mediated signaling pathway Source: MGI
    6. hematopoietic progenitor cell differentiation Source: MGI
    7. intracellular signal transduction Source: MGI
    8. megakaryocyte development Source: MGI
    9. natural killer cell mediated cytotoxicity Source: MGI
    10. negative regulation of B cell receptor signaling pathway Source: MGI
    11. negative regulation of humoral immune response mediated by circulating immunoglobulin Source: MGI
    12. negative regulation of MAPK cascade Source: MGI
    13. negative regulation of MAP kinase activity Source: MGI
    14. negative regulation of peptidyl-tyrosine phosphorylation Source: MGI
    15. negative regulation of T cell proliferation Source: MGI
    16. negative regulation of T cell receptor signaling pathway Source: MGI
    17. peptidyl-tyrosine dephosphorylation Source: GOC
    18. peptidyl-tyrosine phosphorylation Source: Ensembl
    19. platelet aggregation Source: MGI
    20. platelet formation Source: MGI
    21. positive regulation of cell adhesion mediated by integrin Source: MGI
    22. positive regulation of cell proliferation Source: Ensembl
    23. positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
    24. protein dephosphorylation Source: MGI
    25. regulation of B cell differentiation Source: MGI
    26. regulation of ERK1 and ERK2 cascade Source: UniProtKB
    27. regulation of G1/S transition of mitotic cell cycle Source: Ensembl
    28. regulation of release of sequestered calcium ion into cytosol Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Enzyme and pathway databases

    ReactomeiREACT_198614. Growth hormone receptor signaling.
    REACT_198622. Interferon alpha/beta signaling.
    REACT_198627. Regulation of IFNA signaling.
    REACT_198645. Regulation of IFNG signaling.
    REACT_198660. Interferon gamma signaling.
    REACT_210793. Interleukin receptor SHC signaling.
    REACT_215628. Signal regulatory protein (SIRP) family interactions.
    REACT_225477. Costimulation by the CD28 family.
    REACT_225836. Interleukin-3, 5 and GM-CSF signaling.
    REACT_227425. Regulation of KIT signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 6 (EC:3.1.3.48)
    Alternative name(s):
    70Z-SHP
    Hematopoietic cell protein-tyrosine phosphatase
    PTPTY-42
    Protein-tyrosine phosphatase 1C
    Short name:
    PTP-1C
    SH-PTP1
    Short name:
    SHP-1
    Gene namesi
    Name:Ptpn6
    Synonyms:Hcp, Hcph, Ptp1C
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:96055. Ptpn6.

    Subcellular locationi

    Cytoplasm. Nucleus By similarity
    Note: In neurons, translocates into the nucleus after treatment with angiotensin II. Shuttles between the cytoplasm and nucleus via its association with PDPK1 By similarity.By similarity

    GO - Cellular componenti

    1. alpha-beta T cell receptor complex Source: MGI
    2. cell-cell junction Source: MGI
    3. cytoplasm Source: MGI
    4. cytosol Source: Reactome
    5. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Defects in Ptpn6 are the cause of the motheaten (me) or viable motheaten (mev) phenotypes. Mice homozygous for the recessive allelic mutations develop severe defects in hematopoiesis.

    Keywords - Diseasei

    Disease mutation

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 595595Tyrosine-protein phosphatase non-receptor type 6PRO_0000094759Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei64 – 641PhosphotyrosineBy similarity
    Modified residuei377 – 3771Phosphotyrosine1 Publication
    Modified residuei536 – 5361Phosphotyrosine1 Publication
    Modified residuei564 – 5641Phosphotyrosine; by LYNBy similarity

    Post-translational modificationi

    Phosphorylated on tyrosine residues. Phosphorylation at Tyr-564 enhances phosphatase activity By similarity. Binding of KITLG/SCF to KIT increases tyrosine phosphorylation.By similarity3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP29351.
    PaxDbiP29351.
    PRIDEiP29351.

    PTM databases

    PhosphoSiteiP29351.

    Expressioni

    Tissue specificityi

    Expressed predominantly in hematopoietic cells.1 Publication

    Gene expression databases

    ArrayExpressiP29351.
    BgeeiP29351.
    CleanExiMM_PTPN6.
    GenevestigatoriP29351.

    Interactioni

    Subunit structurei

    Monomer. Interacts with FCRL2, FCRL3, FCRL4, CD84 and MTUS1 By similarity. Binds PTPNS1. Interacts with CD300LF and CDK2. Interacts with MILR1 (tyrosine-phosphorylated). Interacts with KIR2DL1; the interaction is enhanced by ARRB2 By similarity. Interacts (via SH2 1 domain) with ROS1; the interaction is direct and promotes ROS1 dephosphorylation By similarity. Interacts with EGFR; inhibits EGFR-dependent activation of MAPK/ERK. Interacts with LYN By similarity. Interacts with KIT. Interacts with the tyrosine phosphorylated form of PDPK1 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Cd22P353295EBI-2620699,EBI-300059
    Stat1P422252EBI-2620699,EBI-647118
    tirB7UM992EBI-2620699,EBI-2504426From a different organism.

    Protein-protein interaction databases

    BioGridi200256. 6 interactions.
    DIPiDIP-41455N.
    IntActiP29351. 8 interactions.
    MINTiMINT-192591.

    Structurei

    3D structure databases

    ProteinModelPortaliP29351.
    SMRiP29351. Positions 1-529.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 10097SH2 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini110 – 213104SH2 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini244 – 515272Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni453 – 4597Substrate bindingBy similarity

    Domaini

    The N-terminal SH2 domain functions as an auto-inhibitory domain, blocking the catalytic domain in the ligand-free close conformation.By similarity

    Sequence similaritiesi

    Contains 2 SH2 domains.PROSITE-ProRule annotation
    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH2 domain

    Phylogenomic databases

    eggNOGiCOG5599.
    GeneTreeiENSGT00750000117233.
    HOVERGENiHBG000223.
    KOiK05697.
    OMAiQAKGEPW.
    OrthoDBiEOG7NPFST.
    PhylomeDBiP29351.
    TreeFamiTF351632.

    Family and domain databases

    Gene3Di3.30.505.10. 2 hits.
    3.90.190.10. 1 hit.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR000980. SH2.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR012152. Tyr_Pase_non-rcpt_typ-6/11.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00017. SH2. 2 hits.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000929. Tyr-Ptase_nr_6. 1 hit.
    PRINTSiPR00700. PRTYPHPHTASE.
    PR00401. SH2DOMAIN.
    SMARTiSM00194. PTPc. 1 hit.
    SM00252. SH2. 2 hits.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    SSF55550. SSF55550. 2 hits.
    PROSITEiPS50001. SH2. 2 hits.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P29351-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVRWFHRDLS GPDAETLLKG RGVPGSFLAR PSRKNQGDFS LSVRVDDQVT    50
    HIRIQNSGDF YDLYGGEKFA TLTELVEYYT QQQGILQDRD GTIIHLKYPL 100
    NCSDPTSERW YHGHISGGQA ESLLQAKGEP WTFLVRESLS QPGDFVLSVL 150
    NDQPKAGPGS PLRVTHIKVM CEGGRYTVGG SETFDSLTDL VEHFKKTGIE 200
    EASGAFVYLR QPYYATRVNA ADIENRVLEL NKKQESEDTA KAGFWEEFES 250
    LQKQEVKNLH QRLEGQRPEN KSKNRYKNIL PFDHSRVILQ GRDSNIPGSD 300
    YINANYVKNQ LLGPDENSKT YIASQGCLDA TVNDFWQMAW QENTRVIVMT 350
    TREVEKGRNK CVPYWPEVGT QRVYGLYSVT NSREHDTAEY KLRTLQISPL 400
    DNGDLVREIW HYQYLSWPDH GVPSEPGGVL SFLDQINQRQ ESLPHAGPII 450
    VHCSAGIGRT GTIIVIDMLM ESISTKGLDC DIDIQKTIQM VRAQRSGMVQ 500
    TEAQYKFIYV AIAQFIETTK KKLEIIQSQK GQESEYGNIT YPPAVRSAHA 550
    KASRTSSKHK EEVYENVHSK SKKEEKVKKQ RSADKEKNKG SLKRK 595
    Length:595
    Mass (Da):67,559
    Last modified:July 11, 2002 - v2
    Checksum:iCF17300D032638D2
    GO
    Isoform 2 (identifier: P29351-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-3: MVR → MLSRG

    Show »
    Length:597
    Mass (Da):67,717
    Checksum:iE8491CE77E06E989
    GO
    Isoform 3 (identifier: P29351-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-39: Missing.
         40-44: SLSVR → MLSRG

    Show »
    Length:556
    Mass (Da):63,179
    Checksum:iCACF025DF9D7BC2D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti240 – 2401A → R in AAA37796. (PubMed:1732748)Curated
    Sequence conflicti572 – 5721K → Q in AAA37796. (PubMed:1732748)Curated
    Sequence conflicti586 – 5861E → D in AAH12660. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti77 – 9923EYYTQ…HLKYP → VPRPHIWRAGGVTAAGQGRA LD in motheaten (me).
    Add
    BLAST
    Natural varianti100 – 595496Missing in motheaten (me).
    Add
    BLAST

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3939Missing in isoform 3. CuratedVSP_005132Add
    BLAST
    Alternative sequencei1 – 33MVR → MLSRG in isoform 2. CuratedVSP_005131
    Alternative sequencei40 – 445SLSVR → MLSRG in isoform 3. CuratedVSP_005133

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M68902 mRNA. Translation: AAA37796.1.
    M90389 mRNA. Translation: AAA40007.1.
    S63763 mRNA. No translation available.
    S63764 mRNA. No translation available.
    S63803 mRNA. No translation available.
    AC002397 Genomic DNA. Translation: AAC36009.1.
    AC002397 Genomic DNA. Translation: AAC36008.1.
    U65955
    , U65952, U65953, U65954 Genomic DNA. Translation: AAD00152.1.
    U65955
    , U65951, U65952, U65953, U65954 Genomic DNA. Translation: AAD00151.1.
    BC012660 mRNA. Translation: AAH12660.1.
    CCDSiCCDS39628.1. [P29351-1]
    CCDS51908.1. [P29351-2]
    PIRiA44390.
    RefSeqiNP_001071173.1. NM_001077705.2. [P29351-2]
    NP_038573.2. NM_013545.3. [P29351-1]
    UniGeneiMm.271799.

    Genome annotation databases

    EnsembliENSMUST00000004377; ENSMUSP00000004377; ENSMUSG00000004266. [P29351-2]
    ENSMUST00000112484; ENSMUSP00000108103; ENSMUSG00000004266. [P29351-1]
    ENSMUST00000171549; ENSMUSP00000129124; ENSMUSG00000004266. [P29351-2]
    ENSMUST00000174265; ENSMUSP00000133991; ENSMUSG00000004266. [P29351-3]
    GeneIDi15170.
    KEGGimmu:15170.
    UCSCiuc009drk.1. mouse. [P29351-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M68902 mRNA. Translation: AAA37796.1 .
    M90389 mRNA. Translation: AAA40007.1 .
    S63763 mRNA. No translation available.
    S63764 mRNA. No translation available.
    S63803 mRNA. No translation available.
    AC002397 Genomic DNA. Translation: AAC36009.1 .
    AC002397 Genomic DNA. Translation: AAC36008.1 .
    U65955
    , U65952 , U65953 , U65954 Genomic DNA. Translation: AAD00152.1 .
    U65955
    , U65951 , U65952 , U65953 , U65954 Genomic DNA. Translation: AAD00151.1 .
    BC012660 mRNA. Translation: AAH12660.1 .
    CCDSi CCDS39628.1. [P29351-1 ]
    CCDS51908.1. [P29351-2 ]
    PIRi A44390.
    RefSeqi NP_001071173.1. NM_001077705.2. [P29351-2 ]
    NP_038573.2. NM_013545.3. [P29351-1 ]
    UniGenei Mm.271799.

    3D structure databases

    ProteinModelPortali P29351.
    SMRi P29351. Positions 1-529.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200256. 6 interactions.
    DIPi DIP-41455N.
    IntActi P29351. 8 interactions.
    MINTi MINT-192591.

    PTM databases

    PhosphoSitei P29351.

    Proteomic databases

    MaxQBi P29351.
    PaxDbi P29351.
    PRIDEi P29351.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000004377 ; ENSMUSP00000004377 ; ENSMUSG00000004266 . [P29351-2 ]
    ENSMUST00000112484 ; ENSMUSP00000108103 ; ENSMUSG00000004266 . [P29351-1 ]
    ENSMUST00000171549 ; ENSMUSP00000129124 ; ENSMUSG00000004266 . [P29351-2 ]
    ENSMUST00000174265 ; ENSMUSP00000133991 ; ENSMUSG00000004266 . [P29351-3 ]
    GeneIDi 15170.
    KEGGi mmu:15170.
    UCSCi uc009drk.1. mouse. [P29351-1 ]

    Organism-specific databases

    CTDi 5777.
    MGIi MGI:96055. Ptpn6.

    Phylogenomic databases

    eggNOGi COG5599.
    GeneTreei ENSGT00750000117233.
    HOVERGENi HBG000223.
    KOi K05697.
    OMAi QAKGEPW.
    OrthoDBi EOG7NPFST.
    PhylomeDBi P29351.
    TreeFami TF351632.

    Enzyme and pathway databases

    Reactomei REACT_198614. Growth hormone receptor signaling.
    REACT_198622. Interferon alpha/beta signaling.
    REACT_198627. Regulation of IFNA signaling.
    REACT_198645. Regulation of IFNG signaling.
    REACT_198660. Interferon gamma signaling.
    REACT_210793. Interleukin receptor SHC signaling.
    REACT_215628. Signal regulatory protein (SIRP) family interactions.
    REACT_225477. Costimulation by the CD28 family.
    REACT_225836. Interleukin-3, 5 and GM-CSF signaling.
    REACT_227425. Regulation of KIT signaling.

    Miscellaneous databases

    ChiTaRSi PTPN6. mouse.
    NextBioi 287680.
    PROi P29351.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P29351.
    Bgeei P29351.
    CleanExi MM_PTPN6.
    Genevestigatori P29351.

    Family and domain databases

    Gene3Di 3.30.505.10. 2 hits.
    3.90.190.10. 1 hit.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000980. SH2.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR012152. Tyr_Pase_non-rcpt_typ-6/11.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00017. SH2. 2 hits.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000929. Tyr-Ptase_nr_6. 1 hit.
    PRINTSi PR00700. PRTYPHPHTASE.
    PR00401. SH2DOMAIN.
    SMARTi SM00194. PTPc. 1 hit.
    SM00252. SH2. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    SSF55550. SSF55550. 2 hits.
    PROSITEi PS50001. SH2. 2 hits.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13."
      Yi T., Cleveland J.L., Ihle J.N.
      Mol. Cell. Biol. 12:836-846(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: DBA/2.
    2. "Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences."
      Matthews R.J., Bowne D.B., Flores E., Thomas M.L.
      Mol. Cell. Biol. 12:2396-2405(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene."
      Schultz L.D., Schweitzer P.A., Rajan T.V., Yi T., Ihle J.N., Matthews R.J., Thomas M.L., Beier D.R.
      Cell 73:1445-1454(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS MOTHEATEN AND VIABLE MOTHEATEN.
      Strain: C57BL/6J.
      Tissue: Bone marrow.
    4. "Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6."
      Ansari-Lari M.A., Oeltjen J.C., Schwartz S., Zhang Z., Muzny D.M., Lu J., Gorrell J.H., Chinault A.C., Belmont J.W., Miller W., Gibbs R.A.
      Genome Res. 8:29-40(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 3).
    5. "Murine SHP-1 splice variants with altered Src homology 2 (SH2) domains. Implications for the SH2-mediated intramolecular regulation of SHP-1."
      Martin A., Tsui H.W., Shulman M.J., Isenman D., Tsui F.W.
      J. Biol. Chem. 274:21725-21734(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2), SUBUNIT.
      Strain: C3H.
      Tissue: Adrenal gland.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "Protein tyrosine phosphatase-1C is rapidly phosphorylated in tyrosine in macrophages in response to colony stimulating factor-1."
      Yeung Y.-G., Berg K.L., Pixley F.J., Angeletti R.H., Stanley E.R.
      J. Biol. Chem. 267:23447-23450(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 54-68; 128-135; 137-151; 242-252; 278-285; 293-308 AND 373-382, PHOSPHORYLATION.
    8. "Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification."
      Yi T., Cleveland J.L., Ihle J.N.
      Blood 78:2222-2228(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 342-451, TISSUE SPECIFICITY.
      Strain: BALB/c.
      Tissue: Myeloid leukemia cell.
    9. "High expression of inhibitory receptor SHPS-1 and its association with protein tyrosine phosphatase SHP-1 in macrophages."
      Veillette A., Thibaudeau E., Latour S.
      J. Biol. Chem. 273:22719-22728(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PTPNS1.
    10. "SHP-1 binds and negatively modulates the c-Kit receptor by interaction with tyrosine 569 in the c-Kit juxtamembrane domain."
      Kozlowski M., Larose L., Lee F., Le D.M., Rottapel R., Siminovitch K.A.
      Mol. Cell. Biol. 18:2089-2099(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KIT, FUNCTION IN MODULATING KIT SIGNALING, PHOSPHORYLATION.
    11. "CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation."
      Chung D.-H., Humphrey M.B., Nakamura M.C., Ginzinger D.G., Seaman W.E., Daws M.R.
      J. Immunol. 171:6541-6548(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CD300LF.
      Strain: C57BL/6.
    12. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
      Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
      J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-377 AND TYR-536, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Mast cell.
    13. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions."
      Hitomi K., Tahara-Hanaoka S., Someya S., Fujiki A., Tada H., Sugiyama T., Shibayama S., Shibuya K., Shibuya A.
      Nat. Immunol. 11:601-607(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MILR1.

    Entry informationi

    Entry nameiPTN6_MOUSE
    AccessioniPrimary (citable) accession number: P29351
    Secondary accession number(s): O35128
    , Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: July 11, 2002
    Last modified: October 1, 2014
    This is version 158 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3