Reviewed, UniProtKB/Swiss-Prot P29349 (CSW_DROME)

Names and origin

Protein names

Recommended name:
    Tyrosine-protein phosphatase corkscrew
    EC=3.1.3.48

Gene names

Name:	csw
ORF Names:	CG3954

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	845 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Required in all receptor tyrosine kinase signaling pathways. Functions downstream of the receptor tyrosine kinase torso, acting in concert with D-Raf via tailless. Also functions downstream of Egfr (epidermal growth factor receptor) and btl (fibroblast growth factor receptor). The SH2 domain suggests that csw effects its role by mediating heteromeric protein interactions. Maternally required for normal determination of cell fates at the termini of the embryo. Required for cell fate specification of the ventral ectoderm, in the developing embryonic CNS and for embryonic tracheal cell migration. Functions during imaginal development for proper formation of adult structures such as eyes, aristae, L5 wing vein and the tarsal claw. Ref.1 Ref.8
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subcellular location	Cytoplasm.
Tissue specificity	Expressed uniformly throughout all tissues during embryogenesis. Ref.1
Developmental stage	Expressed throughout development. Ref.1
Miscellaneous	The PTPase domain is interrupted by a PTPase insert which shares no homologies with other PTPase proteins. This PTPase insert is reminiscent of the kinase insert within the kinase catalytic domains of several receptor tyrosine kinases.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily. Contains 2 SH2 domains. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat SH2 domain
Molecular function	Developmental protein Hydrolase Protein phosphatase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dorsal/ventral axis specification, ovarian follicular epithelium Ref.8 Inferred from mutant phenotype. Source: FlyBase epidermal growth factor receptor signaling pathway Ref.8 Inferred from genetic interaction. Source: FlyBase epithelial cell migration, open tracheal system Ref.8 Inferred from mutant phenotype. Source: FlyBase fibroblast growth factor receptor signaling pathway Ref.8 Inferred from mutant phenotype. Source: FlyBase imaginal disc development Ref.8 Inferred from mutant phenotype. Source: FlyBase mesoderm development Inferred from mutant phenotype. Source: FlyBase mitotic cell cycle Inferred from mutant phenotype. Source: FlyBase primary branching, open tracheal system Traceable author statement. Source: FlyBase protein amino acid dephosphorylation Inferred from direct assay. Source: FlyBase regulation of compound eye photoreceptor development Inferred from mutant phenotype. Source: FlyBase sevenless signaling pathway Traceable author statement. Source: FlyBase terminal region determination Ref.1 Inferred from mutant phenotype. Source: UniProtKB torso signaling pathway Ref.1 Inferred from genetic interaction. Source: UniProtKB ventral midline development Ref.8 Inferred from mutant phenotype. Source: FlyBase
Cellular component	cytoplasm Ref.1 Non-traceable author statement. Source: UniProtKB
Molecular function	non-membrane spanning protein tyrosine phosphatase activity Ref.1 Non-traceable author statement. Source: UniProtKB protein binding Inferred from physical interaction. Source: IntAct receptor signaling protein tyrosine phosphatase activity Non-traceable author statement. Source: FlyBase
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
	Q9VHW9	1	EBI-208575,EBI-160396
	Q9VKE7	1	EBI-208575,EBI-175387
CG12963	Q9V7D5	1	EBI-208575,EBI-167573

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 2 (identifier: P29349-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: P29349-2)

Also known as: Y1229; A;

The sequence of this isoform differs from the canonical sequence as follows:
     810-845: GKMQQPAPPLRPRPGILKLLTSPVIFQQNSKTFPKT → AKFKNIPKDMIGLRPPSHAPALPPPPTPPRKT

Isoform 3 (identifier: P29349-3)

Also known as: C;

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: Missing.
     810-845: GKMQQPAPPLRPRPGILKLLTSPVIFQQNSKTFPKT → AKFKNIPKDMIGLRPPSHAPALPPPPTPPRKT

Isoform 4 (identifier: P29349-4)

Also known as: 4A; B;

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: MSSRRWFHPT...LICAEPTTER → MLFNKCLEKL...TMRVQLHGYT

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 845	845	Tyrosine-protein phosphatase corkscrew		PRO_0000094850
Regions
	Domain	6 – 101	96	SH2 1
	Domain	111 – 205	95	SH2 2
	Domain	227 – 645	419	Tyrosine-protein phosphatase
	Region	289 – 444	156	PTPase insert (Cys/Ser-rich)
Sites
	Active site	583	1	Phosphocysteine intermediate By similarity
Amino acid modifications
	Modified residue	419	1	Phosphoserine Ref.9
Natural variations
	Alternative sequence	1 – 159	159	Missing in isoform 3.		VSP_005139
	Alternative sequence	1 – 110	110	MSSRR…PTTER → MLFNKCLEKLSSSLGNVVNH KLQEKQVYNNNNINNNNNNT LNNNNAYNNQRNFEYERAIQ AHYGSKGRRSEERERSGKFK ASKGRKAKVTPPTETPEAQE PACKNCMTHDELAQIIKGVA KGADAQRNRDNRLQRRRRPL SAQPSAAASASTSTESLHRL TPSPQASYPATPTSWTATPP QFPAAFGGASCSNSTLSLLA TMRVQLHGYT in isoform 4.		VSP_005140
	Alternative sequence	810 – 845	36	GKMQQ…TFPKT → AKFKNIPKDMIGLRPPSHAP ALPPPPTPPRKT in isoform 1 and isoform 3.		VSP_005141
	Natural variant	119	1	K → T in strain: Kenya-HLa3, Kenya-HLa6, Kakamega-b1 and Makindu-b1. Ref.3
	Natural variant	749	1	G → S in strain: Ann Arbor1, DP CN BW, Kakamega-b1, Kakamega-b3, Kakamega-b4, Kenya-HLa3, Kenya-HLa6, Makindu-b5 and Reids2. Ref.3
Experimental info
	Sequence conflict	815	1	P → S in AAB02544. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 2 [UniParc]. Last modified June 1, 2001. Version 2. Checksum: 2147F0F2576202CC	FASTA	845	92,975
	10 20 30 40 50 60 MSSRRWFHPT ISGIEAEKLL QEQGFDGSFL ARLSSSNPGA FTLSVRRGNE VTHIKIQNNG 70 80 90 100 110 120 DFFDLYGGEK FATLPELVQY YMENGELKEK NGQAIELKQP LICAEPTTER WFHGNLSGKE 130 140 150 160 170 180 AEKLILERGK NGSFLVRESQ SKPGDFVLSV RTDDKVTHVM IRWQDKKYDV GGGESFGTLS 190 200 210 220 230 240 ELIDHYKRNP MVETCGTVVH LRQPFNATRI TAAGINARVE QLVKGGFWEE FESLQQDSRD 250 260 270 280 290 300 TFSRNEGYKQ ENRLKNRYRN ILPYDHTRVK LLDVEHSVAG AEYINANYIR LPTDGDLYNM 310 320 330 340 350 360 SSSSESLNSS VPSCPACTAA QTQRNCSNCQ LQNKTCVQCA VKSAILPYSN CATCSRKSDS 370 380 390 400 410 420 LSKHKRSESS ASSSPSSGSG SGPGSSGTSG VSSVNGPGTP TNLTSGTAGC LVGLLKRHSN 430 440 450 460 470 480 DSSGAVSISM AERERERERE MFKTYIATQG CLLTQQVNTV TDFWNMVWQE NTRVIVMTTK 490 500 510 520 530 540 EYERGKEKCA RYWPDEGRSE QFGHARIQCV SENSTSDYTL REFLVSWRDQ PARRIFHYHF 550 560 570 580 590 600 QVWPDHGVPA DPGCVLNFLQ DVNTRQSHLA QAGEKPGPIC VHCSAGIGRT GTFIVIDMIL 610 620 630 640 650 660 DQIVRNGLDT EIDIQRTIQM VRSQRSGLVQ TEAQYKFVYY AVQHYIQTLI ARKRAEEQSL 670 680 690 700 710 720 QVGREYTNIK YTGEIGNDSQ RSPLPPAISS ISLVPSKTPL TPTSADLGTG MGLSMGVGMG 730 740 750 760 770 780 VGNKHASKQQ PPLPVVNCNN NNNGIGNSGC SNGGGSSTTS SSNGSSNGNI NALLGGIGLG 790 800 810 820 830 840 LGGNMRKSNF YSDSLKQQQQ REEQAPAGAG KMQQPAPPLR PRPGILKLLT SPVIFQQNSK TFPKT
	Isoform 1 (Y1229) (A). Checksum: 03295DA37A8DA824	FASTA	841	92,431
	10 20 30 40 50 60 MSSRRWFHPT ISGIEAEKLL QEQGFDGSFL ARLSSSNPGA FTLSVRRGNE VTHIKIQNNG 70 80 90 100 110 120 DFFDLYGGEK FATLPELVQY YMENGELKEK NGQAIELKQP LICAEPTTER WFHGNLSGKE 130 140 150 160 170 180 AEKLILERGK NGSFLVRESQ SKPGDFVLSV RTDDKVTHVM IRWQDKKYDV GGGESFGTLS 190 200 210 220 230 240 ELIDHYKRNP MVETCGTVVH LRQPFNATRI TAAGINARVE QLVKGGFWEE FESLQQDSRD 250 260 270 280 290 300 TFSRNEGYKQ ENRLKNRYRN ILPYDHTRVK LLDVEHSVAG AEYINANYIR LPTDGDLYNM 310 320 330 340 350 360 SSSSESLNSS VPSCPACTAA QTQRNCSNCQ LQNKTCVQCA VKSAILPYSN CATCSRKSDS 370 380 390 400 410 420 LSKHKRSESS ASSSPSSGSG SGPGSSGTSG VSSVNGPGTP TNLTSGTAGC LVGLLKRHSN 430 440 450 460 470 480 DSSGAVSISM AERERERERE MFKTYIATQG CLLTQQVNTV TDFWNMVWQE NTRVIVMTTK 490 500 510 520 530 540 EYERGKEKCA RYWPDEGRSE QFGHARIQCV SENSTSDYTL REFLVSWRDQ PARRIFHYHF 550 560 570 580 590 600 QVWPDHGVPA DPGCVLNFLQ DVNTRQSHLA QAGEKPGPIC VHCSAGIGRT GTFIVIDMIL 610 620 630 640 650 660 DQIVRNGLDT EIDIQRTIQM VRSQRSGLVQ TEAQYKFVYY AVQHYIQTLI ARKRAEEQSL 670 680 690 700 710 720 QVGREYTNIK YTGEIGNDSQ RSPLPPAISS ISLVPSKTPL TPTSADLGTG MGLSMGVGMG 730 740 750 760 770 780 VGNKHASKQQ PPLPVVNCNN NNNGIGNSGC SNGGGSSTTS SSNGSSNGNI NALLGGIGLG 790 800 810 820 830 840 LGGNMRKSNF YSDSLKQQQQ REEQAPAGAA KFKNIPKDMI GLRPPSHAPA LPPPPTPPRK T
	Isoform 3 (C). Checksum: CA4F23438AC61598	FASTA	682	74,528
	10 20 30 40 50 60 MIRWQDKKYD VGGGESFGTL SELIDHYKRN PMVETCGTVV HLRQPFNATR ITAAGINARV 70 80 90 100 110 120 EQLVKGGFWE EFESLQQDSR DTFSRNEGYK QENRLKNRYR NILPYDHTRV KLLDVEHSVA 130 140 150 160 170 180 GAEYINANYI RLPTDGDLYN MSSSSESLNS SVPSCPACTA AQTQRNCSNC QLQNKTCVQC 190 200 210 220 230 240 AVKSAILPYS NCATCSRKSD SLSKHKRSES SASSSPSSGS GSGPGSSGTS GVSSVNGPGT 250 260 270 280 290 300 PTNLTSGTAG CLVGLLKRHS NDSSGAVSIS MAERERERER EMFKTYIATQ GCLLTQQVNT 310 320 330 340 350 360 VTDFWNMVWQ ENTRVIVMTT KEYERGKEKC ARYWPDEGRS EQFGHARIQC VSENSTSDYT 370 380 390 400 410 420 LREFLVSWRD QPARRIFHYH FQVWPDHGVP ADPGCVLNFL QDVNTRQSHL AQAGEKPGPI 430 440 450 460 470 480 CVHCSAGIGR TGTFIVIDMI LDQIVRNGLD TEIDIQRTIQ MVRSQRSGLV QTEAQYKFVY 490 500 510 520 530 540 YAVQHYIQTL IARKRAEEQS LQVGREYTNI KYTGEIGNDS QRSPLPPAIS SISLVPSKTP 550 560 570 580 590 600 LTPTSADLGT GMGLSMGVGM GVGNKHASKQ QPPLPVVNCN NNNNGIGNSG CSNGGGSSTT 610 620 630 640 650 660 SSSNGSSNGN INALLGGIGL GLGGNMRKSN FYSDSLKQQQ QREEQAPAGA AKFKNIPKDM 670 680 IGLRPPSHAP ALPPPPTPPR KT
	Isoform 4 (4A) (B). Checksum: CB95C38AB3038342	FASTA	945	103,768
	10 20 30 40 50 60 MLFNKCLEKL SSSLGNVVNH KLQEKQVYNN NNINNNNNNT LNNNNAYNNQ RNFEYERAIQ 70 80 90 100 110 120 AHYGSKGRRS EERERSGKFK ASKGRKAKVT PPTETPEAQE PACKNCMTHD ELAQIIKGVA 130 140 150 160 170 180 KGADAQRNRD NRLQRRRRPL SAQPSAAASA STSTESLHRL TPSPQASYPA TPTSWTATPP 190 200 210 220 230 240 QFPAAFGGAS CSNSTLSLLA TMRVQLHGYT WFHGNLSGKE AEKLILERGK NGSFLVRESQ 250 260 270 280 290 300 SKPGDFVLSV RTDDKVTHVM IRWQDKKYDV GGGESFGTLS ELIDHYKRNP MVETCGTVVH 310 320 330 340 350 360 LRQPFNATRI TAAGINARVE QLVKGGFWEE FESLQQDSRD TFSRNEGYKQ ENRLKNRYRN 370 380 390 400 410 420 ILPYDHTRVK LLDVEHSVAG AEYINANYIR LPTDGDLYNM SSSSESLNSS VPSCPACTAA 430 440 450 460 470 480 QTQRNCSNCQ LQNKTCVQCA VKSAILPYSN CATCSRKSDS LSKHKRSESS ASSSPSSGSG 490 500 510 520 530 540 SGPGSSGTSG VSSVNGPGTP TNLTSGTAGC LVGLLKRHSN DSSGAVSISM AERERERERE 550 560 570 580 590 600 MFKTYIATQG CLLTQQVNTV TDFWNMVWQE NTRVIVMTTK EYERGKEKCA RYWPDEGRSE 610 620 630 640 650 660 QFGHARIQCV SENSTSDYTL REFLVSWRDQ PARRIFHYHF QVWPDHGVPA DPGCVLNFLQ 670 680 690 700 710 720 DVNTRQSHLA QAGEKPGPIC VHCSAGIGRT GTFIVIDMIL DQIVRNGLDT EIDIQRTIQM 730 740 750 760 770 780 VRSQRSGLVQ TEAQYKFVYY AVQHYIQTLI ARKRAEEQSL QVGREYTNIK YTGEIGNDSQ 790 800 810 820 830 840 RSPLPPAISS ISLVPSKTPL TPTSADLGTG MGLSMGVGMG VGNKHASKQQ PPLPVVNCNN 850 860 870 880 890 900 NNNGIGNSGC SNGGGSSTTS SSNGSSNGNI NALLGGIGLG LGGNMRKSNF YSDSLKQQQQ 910 920 930 940 REEQAPAGAG KMQQPAPPLR PRPGILKLLT SPVIFQQNSK TFPKT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso." Perkins L.A., Larsen I., Perrimon N. Cell 70:225-236(1992) [PubMed: 1638629] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Tissue: Embryo.
[2]	"The role of the Drosophila corkscrew protein as a transducer downstream of receptor tyrosine kinases is functionally conserved." Melnick M.B., Melnick C.B., Larsen I., Perrimon N., Perkins L.A. Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS 1 AND 4). Strain: DP CN BW.
[3]	"Contrasting selection pressures on components of the Ras-mediated signal transduction pathway in Drosophila." Riley R.M., Jin W., Gibson G. Mol. Ecol. 12:1315-1323(2003) [PubMed: 12694293] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS 2 AND 4), VARIANTS THR-119 AND SER-749. Strain: 10A, Ann Arbor1, Ann Arbor20, Ann Arbor3, Ann Arbor6, Kakamega-b1, Kakamega-b3, Kakamega-b4, Kenya-HLa3, Kenya-HLa6, Kenya-HLb1, M2, Makindu-b1, Makindu-b5, Nairobi-a, PYR2, Reids2 and Sapporo.
[4]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1; 2 AND 4). Strain: Berkeley.
[5]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
[6]	"From sequence to chromosome: the tip of the X chromosome of D. melanogaster." Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G., Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Borkova D., Minana B. , Kafatos F.C., Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L., Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P., Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H., Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S., McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C., Glover D.M. Science 287:2220-2222(2000) [PubMed: 10731137] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORMS 1 AND 4). Strain: Oregon-R.
[7]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: Berkeley. Tissue: Ovary.
[8]	"The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila." Perkins L.A., Johnson M.R., Melnick M.B., Perrimon N. Dev. Biol. 180:63-81(1996) [PubMed: 8948575] [Abstract] Cited for: FUNCTION.
[9]	"Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-419, MASS SPECTROMETRY. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M94730 mRNA. Translation: AAA28433.1. U19909 Genomic DNA. Translation: AAB02543.1. U19909 Genomic DNA. Translation: AAB02544.1. AY135117 Genomic DNA. Translation: AAN17607.1. AY135117 Genomic DNA. Translation: AAN17608.1. AY135118 Genomic DNA. Translation: AAN17609.1. AY135118 Genomic DNA. Translation: AAN17610.1. AY135119 Genomic DNA. Translation: AAN17611.1. AY135119 Genomic DNA. Translation: AAN17612.1. AY135120 Genomic DNA. Translation: AAN17613.1. AY135120 Genomic DNA. Translation: AAN17614.1. AY135121 Genomic DNA. Translation: AAN17615.1. AY135121 Genomic DNA. Translation: AAN17616.1. AY135122 Genomic DNA. Translation: AAN17617.1. AY135122 Genomic DNA. Translation: AAN17618.1. AY135123 Genomic DNA. Translation: AAN17619.1. AY135123 Genomic DNA. Translation: AAN17620.1. AY135124 Genomic DNA. Translation: AAN17621.1. AY135124 Genomic DNA. Translation: AAN17622.1. AY135125 Genomic DNA. Translation: AAN17623.1. AY135125 Genomic DNA. Translation: AAN17624.1. AY135126 Genomic DNA. Translation: AAN17625.1. AY135126 Genomic DNA. Translation: AAN17626.1. AY135127 Genomic DNA. Translation: AAN17627.1. AY135127 Genomic DNA. Translation: AAN17628.1. AY135128 Genomic DNA. Translation: AAN17629.1. AY135128 Genomic DNA. Translation: AAN17630.1. AY135129 Genomic DNA. Translation: AAN17631.1. AY135129 Genomic DNA. Translation: AAN17632.1. AY135130 Genomic DNA. Translation: AAN17633.1. AY135130 Genomic DNA. Translation: AAN17634.1. AY135131 Genomic DNA. Translation: AAN17635.1. AY135131 Genomic DNA. Translation: AAN17636.1. AY135132 Genomic DNA. Translation: AAN17637.1. AY135132 Genomic DNA. Translation: AAN17638.1. AY135133 Genomic DNA. Translation: AAN17639.1. AY135133 Genomic DNA. Translation: AAN17640.1. AY135134 Genomic DNA. Translation: AAN17641.1. AY135134 Genomic DNA. Translation: AAN17642.1. AE014298 Genomic DNA. Translation: AAF45724.2. AE014298 Genomic DNA. Translation: AAG22389.2. AE014298 Genomic DNA. Translation: AAF45725.1. AL132797 Genomic DNA. Translation: CAB65870.1. AL132797 Genomic DNA. Translation: CAB65871.1. BT001484 mRNA. Translation: AAN71239.1.
PIR	A43254.
RefSeq	NP_477130.1. NP_477131.1. NP_726793.1.
UniGene	Dm.5129
3D structure databases
HSSP	HSSP built from PDB template 2SHP based on UniProtKB Q06124.
SMR	P29349. Positions 3-289.
ModBase	Search...
Protein-protein interaction databases
IntAct	P29349. 9 interactions.
Genome annotation databases
Ensembl	FBgn0000382. Drosophila melanogaster. [Contig view]
GeneID	45278.
KEGG	dme:Dmel_CG3954.
Organism-specific databases
FlyBase	FBgn0000382. csw.
Phylogenomic databases
OMA	P29349. ERWFHGN.
Enzyme and pathway databases
BRENDA	3.1.3.48. 48.
Gene expression databases
ArrayExpress	P29349.
GermOnline	CG3954. Drosophila melanogaster.
Family and domain databases
InterPro	IPR000980. SH2. IPR000387. Tyr_Pase. IPR016130. Tyr_Pase_AS. IPR000242. Tyr_Pase_rcpt/non-rcpt. [Graphical view]
Gene3D	G3DSA:3.30.505.10. SH2. 2 hits.
Pfam	PF00017. SH2. 2 hits. PF00102. Y_phosphatase. 1 hit. [Graphical view]
PRINTS	PR00700. PRTYPHPHTASE. PR00401. SH2DOMAIN.
ProDom	PD000093. SH2. 2 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00194. PTPc. 1 hit. SM00252. SH2. 2 hits. [Graphical view]
PROSITE	PS50001. SH2. 2 hits. PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50055. TYR_PHOSPHATASE_PTP. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	837970.

Entry information

Entry name

CSW_DROME

Accession

Primary (citable) accession number: P29349
Secondary accession number(s): Q24032 , Q24033, Q8I074, Q8I0H8, Q8I0S4, Q8ISD5, Q8ISD6, Q9V3H1, Q9W524

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	June 1, 2001
Last modified:	June 16, 2009
This is version 106 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project