P29347MTS1_STRSAModification methylase StsIM.StsI2.1.1.72Adenine-specific methyltransferase StsIType II methyltransferase M.StsIstsIMStreptococcus sanguinisBacteriaBacillotaBacilliLactobacillalesStreptococcaceaeStreptococcusCloning and sequence analysis of the StsI restriction-modification gene: presence of homology to FokI restriction-modification enzymes.NUCLEOTIDE SEQUENCE [GENOMIC DNA]FUNCTIONA nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes.NOMENCLATURESUBTYPEAn alpha subtype methylase that recognizes the double-stranded sequence 5'-GGATG-3' in one strand and 3'-CATCC-5' in the other, methylates A of both strands, and protects the DNA from cleavage by the StsI endonuclease. The 2 domains of the protein participate in modification of the two strands.a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteineMonomer.Belongs to the N(4)/N(6)-methyltransferase family.DNA-bindingMethyltransferaseRepeatRestriction systemS-adenosyl-L-methionineTransferaseMRYIGSKKLLLPEIKKMVDKHTDGSEEVFLDLFAGTNVVANYFKQFYTVYSNDMLFFSYVNAKATIENNSKPSFSKLIQAGISSPMTYLQNLEVNDETIGYYEVAYSPTGEANYLSVHNAKKLDIIRSQIESWKNQNLLTEHEYYYLLSSLIEALPFISNTTGTYGAFLKHWDKRSLNDLELQDFTIFDNSKQNKAFNEDANELVQKIKADIVYIDTPYNSRQYASNYHLLENVARNEHPTLKGITKIFDWKNLKSDYATKGKALVAMRDLIQNINSTHIILSYNNEGIISEEDLTNILKEFSVDGIVDIKKIPYRKYQSKNVSKNKEIYELLFYIQRKPFSKNKTLNKPLNNVRVSSTKKYIKSPLNYIGGKYKLLNQILPLFPKNINTFVDIFSGGANVGINVKAKKYIFNDMNTRINEMFRYFQTQPPVKLVQQIEEKIDEWGLSKTNEDAFLAFRKHYNTNPNPLDLYVLSSFSYNYQFRFNNSMEFNNPFGRNRSHFSENMRNNLLNFVTKLQTLDATFTDNYFNEFDFSNLTSNDFIYLDPPYLITTGSYNDGKRGFSDWNNTSEMKLLNFMDYLNQHGIRFALSNVTEHKGKTNQLLKDWAYSRNLNVNYLDHNYNNSSHNSKSKGSQEVLITNYETKTFNLLNTK
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